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인공지능 교육 플랫폼 개발을 위한 기능 및 서비스 분석
김수환(Soohwan Kim),김갑수(Kapsu Kim),김성훈(Seonghun Kim),김영식(Yungsik Kim),김재현(Jaehyoun Kim),김종범(Jongbeom Kim),김한일(Hanil Kim),김현배(Hyunbae Kim),김현철(Hyeoncheol Kim),김홍래(Hongrae Kim),박다솜(Dasom Park),박선주(SunJu Pa 한국컴퓨터교육학회 2021 컴퓨터교육학회 논문지 Vol.24 No.2
본 연구는 K-12 대상의 AI 교육 플랫폼 개발을 위한 기능 및 서비스를 제안하는 연구이다. AI 교육 플랫폼 개발을 위한 로드맵을 마련하기 위해 AI 교육의 개념, 교육과정, 온라인 플랫폼 등을 분석하였고, 전문가 검토를 통해 적절성을 판단하였다. 연구결과, AI 교육 플랫폼의 활용 대상은 유아에서 성인까지 전국민을 포괄할 필요가 있으며, 제공 콘텐츠는 인공지능, 데이터과학, 윤리 등 폭넓은 내용을 다양한 학습자의 수준을 고려하여 제공할 필요가 있는 것으로 분석되었다. 기능면에서는 웹에서 실습이 가능하고 학습자의 관심과 흥미를 반영한 다양한 데이터 셋을 제공할 필요가 있는 것으로 분석되었다. 구조면에서는 학습 및 콘텐츠 관리 시스템, 체험 및 실습지원 시스템, 데이터 관리 시스템을 구축할 필요가 있는 것으로 분석되었다. This research is a study proposing functions and services for the development of an AI education platform for K-12. In order to prepare a roadmap for AI education platform development, the concept of AI education, curriculum, and online platform were analyzed, and appropriateness was determined through expert review. As a result of this study, the target of the AI education platform needs to cover the whole country from infants to adults. In addition, it was analyzed that the provided contents need to provide a wide range of contents such as artificial intelligence, data science, and ethics in consideration of the level of various learners. In terms of function, it was analyzed that it is necessary to provide various data sets that can be practiced on the web and reflect learners" interests and interests. In terms of structure, it was analyzed that it is necessary to establish a learning and content management system, an experience and practice support system, and a data management system.
Identification of DNA Aptamers toward Epithelial Cell Adhesion Molecule via Cell-SELEX
Kim, Ji Won,Kim, Eun Young,Kim, Sun Young,Byun, Sang Kyung,Lee, Dasom,Oh, Kyoung-Jin,Kim, Won Kon,Han, Baek Soo,Chi, Seung-Wook,Lee, Sang Chul,Bae, Kwang-Hee Korean Society for Molecular and Cellular Biology 2014 Molecules and cells Vol.37 No.10
The epithelial cell adhesion molecule (EpCAM, also known as CD326) is a transmembrane glycoprotein that is specifically detected in most adenocarcinomas and cancer stem cells. In this study, we performed a Cell systematic evolution of ligands by exponential enrichment (SELEX) experiment to isolate the aptamers against EpCAM. After seven round of Cell SELEX, we identified several aptamer candidates. Among the selected aptamers, EP166 specifically binds to cells expressing EpCAM with an equilibrium dissociation constant (Kd) in a micromolar range. On the other hand, it did not bind to negative control cells. Moreover, EP166 binds to J1ES cells, a mouse embryonic stem cell line. Therefore, the isolated aptamers against EpCAM could be used as a stem cell marker or in other applications in both stem cell and cancer studies.
Comparison of Culture, Conventional and Real-time PCR Methods for Listeria monocytogenes in Foods
Kim, Dong-Hyeon,Chon, Jung-Whan,Kim, Hyunsook,Kim, Hong-Seok,Choi, Dasom,Kim, Young-Ji,Yim, Jin-Hyeok,Moon, Jin-San,Seo, Kun-Ho Korean Society for Food Science of Animal Resource 2014 한국축산식품학회지 Vol.34 No.5
We compared standard culture methods as well as conventional PCR and real-time PCR for the detection of Listeria monocytogenes (L. monocytogenes) in milk, cheese, fresh-cut vegetables, and raw beef that have different levels of background microflora. No statistical differences were observed in sensitivity between the two selective media in all foods. In total, real-time PCR assay exhibited statistically excellent detection sensitivity (p<0.05) and was less time consuming and laborious as compared with standard culture methods. Conventional culture methods showed poor performance in detecting L. monocytogenes in food with high levels of background microflora, generating numerous false negative results. While the detection of L. monocytogenes in fresh cut vegetable by culture methods was hindered only by L. innocua, various background microflora, such as L. innocua, L. welshimeri, L. grayi, and Enterococcus faecalis appeared on the two selective media as presumptive positive colonies in raw beef indicating the necessity of improvement of current selective media. It appears that real-time PCR is an effective and sensitive presumptive screening tool for L. monocytogenes in various types of foods, especially foods samples with high levels of background microflora, thus complementing standard culture methodologies.
Dasom Kim,Joon Shik Yoon,Seok Kang,Byungheon Kang,Beom Suk Kim,Jae Young Kim,Im Joo Rhyu 대한체질인류학회 2021 대한체질인류학회 학술대회 연제 초록 Vol.64 No.-
Ultrasound guidance may improve the accuracy of botulinum toxin injection, but studies of its potential for cervical dystonia treatment are lacking. So, to determine the accuracy of ultrasound-guided injection in the sternocleidomastoid muscle (SCM). In total, 36 SCMs from 18 embalmed cadavers were examined. One physician performed scans to divide each SCM into quarters and evaluated its cross-sectional area (CSA) and thickness at each of three meeting points between adjacent quarters. Under ultrasound guidance, another experienced physician injected methylene blue solution at one of the three points, using the in-plane technique (12 specimen per point; right SCM 3 mL, left SCM 5 mL). One anatomist dissected all cadavers and measured the distance of dye dispersion along the longitudinal axis of each muscle. Dispersion ratio was calculated as longitudinal dye dispersion divided by SCM length. As a result, SCM thickness and CSA were greatest at the middle injection point (mean ± SD of 6.6 ± 2.0 mm and 1.4 ± 0.6 cm<sup>2</sup> respectively). All injections were successful, except in one case where the SCM was thin and the dye reached the omohyoid muscle. Mean longitudinal dye dispersion and dispersion ratio were significantly greater when the volume was 5 mL. There were no statistically significant differences in dispersion patterns among the three injection points. Ultrasound-guided intramuscular injection can be performed with good accuracy in the SCM, as ultrasound can be used to evaluate SCM thickness and CSA. Higher volumes of injection solution appear to diffuse better, but further clinical studies are required to determine optimal injection volume.
Oral Supplementation with Cocoa Extract Reduces UVB-Induced Wrinkles in Hairless Mouse Skin
Kim, Jong-Eun,Song, Dasom,Kim, Junil,Choi, Jina,Kim, Jong Rhan,Yoon, Hyun-Sun,Bae, Jung-Soo,Han, Mira,Lee, Sein,Hong, Ji Sun,Song, Dayoung,Kim, Seong-Jin,Son, Myoung-Jin,Choi, Sang-Woon,Chung, Jin Ho Elsevier 2016 The Journal of investigative dermatology Vol.136 No.5
<P>Cacao beans contain various bioactive phytochemicals that could modify the pathogeneses of certain diseases. Here, we report that oral administration of cacao powder (CP) attenuates UVB-induced skin wrinkling by the regulation of genes involved in dermal matrix production and maintenance. Transcriptome analysis revealed that 788 genes are down-or upregulated in the CP supplemented group, compared with the UVB-irradiated mouse skin controls. Among the differentially expressed genes, cathepsin G and serpin B6c play important roles in UVB-induced skin wrinkle formation. Gene regulatory network analysis also identified several candidate regulators responsible for the protective effects of CP supplementation against UVB-induced skin damage. CP also elicited antiwrinkle effects via inhibition of UVB-induced matrix metalloproteinases-1 expression in both the human skin equivalent model and human dermal fibroblasts. Inhibition of UVB-induced activator protein-1 via CP supplementation is likely to affect the expression of matrix metalloproteinases-1. CP supplementation also downregulates the expression of cathepsin G in human dermal fibroblasts. 5-(3',4'-Dihydroxyphenyl)-gamma-valerolactone, a major in vivo metabolite of CP, showed effects similar to CP supplementation. These results suggest that cacao extract may offer a protective effect against photoaging by inhibiting the breakdown of dermal matrix, which leads to an overall reduction in wrinkle formation.</P>
Branching Patterns and Anatomical Course of the Common Fibular Nerve
Goo Young Kim,Chae Hyeon Ryou,Ki Hoon Kim,Dasom Kim,Im Joo Rhyu,Dong Hwee Kim 대한재활의학회 2019 Annals of Rehabilitation Medicine Vol.43 No.6
Objective To present the branching patterns and anatomical course of the common fibular nerve (CFN) and its relationship with fibular head (FH). Methods A total of 21 limbs from 12 fresh cadavers were dissected. The FH width (FH_width), distance between the FH and CFN (FH_CFN), and thickness of the nerve were measured. The ratio of the FH_CFN to FH_width was calculated as follows: <1, cross type and ≥1, posterior type. Angle between the CFN and vertical line of the lower limb 5 cm proximal to the tip of the FH was measured. Branching patterns of the lateral cutaneous nerve of the calf (LCNC) were classified into four types according to its origin and direction as follows: type 1a, lateral margin of the CFN; type 1b, medial margin of the CFN; type 2, lateral sural cutaneous nerve (LSCN); and type 3, CFN and LSCN. Results In the cross type (15 cases, 71.4%), the ratio of FH_CFN/FH_width was 0.83 and the angle was 13.0°. In the posterior type (6 cases, 28.6%), the ratio was 1.04 and the angle was 11.0°. In the branching patterns of LCNC, type 2 was the most common (10 cases), followed by types 1a and 1b (both, 5 cases). Conclusion Location of the CFN around the FH might be related to the development of its neuropathy, especially in the cross type of CFN. The LCNC showed various branching patterns and direction, which could be associated with difficulties of electrophysiologic testing.