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Proteomics as a Tool for Understanding Schizophrenia
Daniel Martins-de-Souza 대한정신약물학회 2011 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.9 No.3
Schizophrenia is likely to be a multifactorial disorder, consequence of alterations in gene and protein expression since the neurodevelopment that together to environmental factors will trigger the establishment of the disease. In the post-genomic era, proteomics has emerged as a promising strategy for revealing disease and treatment biomarkers as well as a tool for the comprehension of the mechanisms of schizophrenia pathobiology. Here, there is a discussion of the potential pathways and structures that are compromised in schizophrenia according to proteomic findings while studying five distinct brain regions of post-mortem tissue from schizophrenia patients and controls. Proteins involved in energy metabolism, calcium homeostasis, myelinization,and cytoskeleton have been recurrently found to be differentially expressed in schizophrenia brains. These findings may encourage new studies on the understanding of schizophrenia biochemical pathways and even new potential drug targets.
Phase Lock Loop Design and Novel Test Schemes for Islanding Detection
Daniel Martin,Kuan-Hung Wu,Chien-Liang Chen,Jih-Sheng Lai 전력전자학회 2011 ICPE(ISPE)논문집 Vol.2011 No.5
Islanding detection is necessary to detect the loss of the electric power system (EPS). The standard requirement for island detection is described in “IEEE 1547 Standard for Interconnecting Distributed Resources with Electric Power Systems” [1] where an island must be detected within 2 seconds to turn off the distributed resource. Anti-islanding schemes use the fact that each distributed resource (DR) must synchronize to the EPS and the DR cannot regulate voltage. Many methods are possible to detect an island. The methods can be separated in four separate groups: active, passive, hybrid, and supervisory control and data acquisition (SCADA). This paper will discuss a passive method and a few active methods under the non-detection zone and parallel case. Two SCADA methods will be discussed briefly. Based off those results, a few suggestions of improvements and future work will be made.
Martin H. Pham,Luis Daniel Diaz-Aguilar,Vrajesh Shah,Michael Brandel,Joshua Loya,Ronald A. Lehman 대한척추신경외과학회 2021 Neurospine Vol.18 No.2
Single position lateral fusion reduces the need for a secondary surgery and robotic guidance allows for potentially higher accuracy of screw placement. We expand the role of robotics with a simultaneous workflow where 2 surgeons can work in single position surgery and discuss the technical feasibility of placement of S2-alar-iliac (S2AI) screws in the lateral position. A 70-year-old male presented with chronic back pain and bilateral leg pain with the left side worse than the right. He subsequently underwent an L3–S1 oblique lumbar interbody fusion (OLIF) with a minimally invasive L3-ilium robotic posterior spinal fixation simultaneously in single lateral position with S2AI screws. The software planning requisite of robotics allowed for a preoperative plan where lumbar cortical screws were used to line up with bilateral S2AI screws. Intraoperatively, the OLIF was performed anterior to the patient which allowed for a second surgeon to perform the posterior stage of screw placement simultaneously in overlapping fashion during OLIF exposure. Once all screws were placed, the OLIF discectomy and cage placement were completed. As the OLIF incision is closed, rodding proceeds posteriorly with subsequent closure simultaneously as well. Operative time from skin incision to skin closure was 3 hours and 47 minutes. We present here a novel technical report on the recommended workflow of simultaneous robotic single position surgery OLIF and demonstrate the feasibility of placement of sacroiliac fixation in the lateral decubitus position. We believe this technique to be minimally invasive, effective, with the benefit of shortening valuable operating room case time.
Role of endoscopy in gastroesophageal reflux disease
Daniel Martin Simadibrata,Elvira Lesmana,Ronnie Fass 대한소화기내시경학회 2023 Clinical Endoscopy Vol.56 No.6
In general, gastroesophageal reflux disease (GERD) is diagnosed clinically based on typical symptoms and/or response to proton pumpinhibitor treatment. Upper gastrointestinal endoscopy is reserved for patients presenting with alarm symptoms, such as dysphagia,odynophagia, significant weight loss, gastrointestinal bleeding, or anorexia; those who meet the criteria for Barrett’s esophagus screen-ing; those who report a lack or partial response to proton pump inhibitor treatment; and those with prior endoscopic or surgical an-ti-reflux interventions. Newer endoscopic techniques are primarily used to increase diagnostic yield and provide an alternative to med-ical or surgical treatment for GERD. The available endoscopic modalities for the diagnosis of GERD include conventional endoscopywith white-light imaging, high-resolution and high-magnification endoscopy, chromoendoscopy, image-enhanced endoscopy (nar-row-band imaging, I- SCAN, flexible spectral imaging color enhancement, blue laser imaging, and linked color imaging), and confocallaser endomicroscopy. Endoscopic techniques for treating GERD include esophageal radiofrequency energy delivery/Stretta procedure,transoral incisionless fundoplication, and endoscopic full-thickness plication. Other novel techniques include anti-reflux mucosecto-my, peroral endoscopic cardiac constriction, endoscopic submucosal dissection, and endoscopic band ligation. Currently, many of thenew endoscopic techniques are not widely available, and their use is limited to centers of excellence.
TMD effectiveness in nonlinear RC structures subjected to near fault earthquakes
Martin N. Domizio,Daniel Ambrosini,Oscar Curadelli 국제구조공학회 2019 Smart Structures and Systems, An International Jou Vol.24 No.4
The use of Tuned mass dampers (TMD) has proved to be effective in reducing the effects of vibrations caused by wind loads and far-field seismic action. However, its effectiveness in controlling the dynamic response of structures under near-fault earthquakes is still under discussion. In this case, the uncertainty about the TMD performance arises from the short significant duration of near-fault ground motions. In this work, the TMD effectiveness for increasing the safety margin against collapse of structures subjected to near-fault earthquakes is investigated. In order to evaluate the TMD performance in the proposed scenario, the nonlinear dynamic response of two reinforced concrete (RC) frames was analyzed. TMDs with different mass values were added to these structures, and a set of near-fault records with frequency content close to the fundamental frequency of the structure was employed. Through a series of nonlinear dynamic analysis, the minimum amplitude of each seismic record that causes the structural collapse was found. By comparing this value, called collapse acceleration, for the case of the structures with and without TMD, the benefit produced by the addition of the control device was established.