방사선조사가 백서의 치주조직에 미치는 영향에 관한 실험적 연구

박대희,이상래 大韓口腔顎顔面 放射線學會 1986 Imaging Science in Dentistry Vol.16 No.1

It is known that radiation therapy is a kind of treatment choices of the maxillofacial tumors. This study is designed to investigate the irradiation effects on rat's periodontal tissues as functional tissues which relate to tooth-support, hard tissue formation and destruction. 20 rats (Sprague-Dowley branch, male) were devided into control group of 4 and experimental groupe of 16. Experimental group was singly exposed to Co-60 irradiation with 10 Gy in the head and neck region. Animals were sacrificed on 2 bays, 1 week, 2 weeks and 3 weeks after the irradiation. The specimens were observed by histopathological examination employing H-E stain, van-Gieson stain and PA-ACH fluorescent stain. The results were as follows: 1. Cementoblasts and osteoblasts were gradually lost and rearranged along the external surfaces of the cementum and alveolar bone, but osteoclasts were almost not affected. 2. The cell numbers of the periodontal ligament were decreased due to the cellular atrophy and degeneration, but recovered almost normally on the 3rd week after irradiation. 3. The collagen fibers within the periodontal ligament were irregularly oriented, became finer and decreased in number. 4. The vessels of the periodontal ligament were decreased at the initial stage but increased again on the 2nd week after irradiation, and the hemorrhagic appearances, occurred within the tissues, due to the arterial destruction, were lasted until 3 weeks after irradiation. 5. The glycogen within the periodontal ligament was gradually and stored in the matrices of the cemental side on the 1st week after irradiation, but recovered almost normally on the 3rd week after irradiation.

1,2-Benzisothiazol-3-one-1,1-Dioxide 유도체의 합성

정대일,정희철,변석인,이용균,박유미,최순규,한정태 東亞大學校附設基礎科學硏究所 2002 基礎科學硏究論文集 Vol.19 No.1

사카린 유도체는 제초제, 항독성, 살균제 등에 광범위하게 연구되어져 오고 있다. 새로운 농략 활성을 가진 물질을 합성하기 위해 먼저 선도물질로 사카린 1을 산화, 염소화 시킨 3-chloro-1,2-benzisothiazol-1,1-dioxide(BID-CI) 2와2cholromethy-1,2-benzisohizol-3-one1,1-dioxide 4를 합성하였다. 선도물질, amines, imidazoles, trones등과 반응시켜 다음과 같은 물질들을 얻었다. ; 3-cyclohexylamino-1,2-benzisothiazol-1,1-dioxide 6, 3-furylamino-1,2-benzisothiazol-1,1-dioxide 8, 3-(3-imidazol)-1,2-benzisothiazol-1,1-dioxide 10, 3-(2-methy-3-imidazol)-1,2-benzisothaizol-1,1-dioxide 12, 2-(3-imidazol)methy-1-1,2-benzisothiazol-3-one-1,1-dioxide 13, and 2-(-3-imidazol)methyl- 1,2-benzisothiazol-1,1-dioxide 14.

박테리아의 生育에서 Aspergillas flavus 抽出物과 SH group의 相關作用

李大熙,崔鎬亨 공주대학교 사범대학 과학교육연구소 1987 과학교육연구 Vol.19 No.1

Aspergillus flavus 抽出物과 Aflatoxin 및 ρCMB가 박테리아의 생장과 증식과정에 미치는 형태와 억제의 정도 및 작용의 유사성을 조사하기 위하여 이들 각각의 저해 물질들을 배양액에 처리하여 박테리아를 배양 실험하였다. 또한 SH group이 이들 저해물질들의 저해작용을 완화할 수 있는지의 여부를 조사하기 위하여 각 저해물질과 glutathione을 同量으로 처리하여 박테리아의 증식변화를 추적하였다. 얻어진 결과는 다음과 같았다. 1. Aspergillus flavus 抽出物 1mg(dry weight) 은 박테리아 증식을 50% 억제하였다. 2. Aflatoxin B₁을 농도별로 배양액에 처리한 결과 박테리아 증식은 10??M 에서 45% 10??M에서 21%정도 억제되었다. 3. ρCMB 10??M에서 박테리아 생장과 증식은 45% 억제되었다. 4. Aflatoxin B₁과 ρCMB는 박테리아의 생육억제의 크기나 형태변화 유발등에서 유사하였다. 그러나 생육장해를 주는 방법에 있어서는 서로 차이가 있었다. 5. ρCMB의 장해는 glutathione에 의하여 보완적이었으나 Aflatoxin B₁에 의한 장해는 거의 보완되지 않았다. 6. Aspergillus flavus 抽出物에 의하여 박테리아의 증식이 억제되었을 경우 glutathione처리를 하였을 때 14%정도 보완되었다. 7. Aspergillus flavus 抽出物중에서 박테리아 生育을 억제하는 성분은 Aflatoxin만이라고 한정할 수 없었으며 또한 그 저해작용은 SH아미노산에 의하여 상당히 보완될 수 있었다. In order to examine mode and rate of inhibition and the similarity of biochemical process that Aspergillus flavus extract aflatoxin and ρCMB effect on the process of its growth and reproduction of bacteria, it was experimented as treating each inhibitor into bacterial culture medium. In order to examine whether SH group could be on the decrease in the rate of inhibition, the reproductive mode in bacteria was investigated by means of treating as the same amount of each inhibitor and glutathione. Reproduction and groth of bacteria was decreased about 50% by Aspergillus flavus extract lmg(dry weight) Reproduction of bacteria was inhibited about 45% in 10??M and 21% in 10??M. The reproduction of the bacteria was decreased 45% in 10??M ρCMB-treated medium. Aflatox B₁and ρCMB showed the similar tendency of the inhibition rate in reproduction and causing the alternation of morphologic modification of bacteria. However, there were dissimiliar to the phenomenon of inhibition. The inhibition of ρCMB was offset by glutathione in the large percentage but the inhibition by aflatoxin was not almost offset by aflatoxin. Inhibition by Aspergillus flavus extract was offseted about 14% by treatment of 10??M glutathione. Inhibitory components of Aspergillus flavus extract could not define only aflatoxin and inhibition could be same offset by glutathione.

Nortropinone 유도체로부터 Nortropane Spirohydantoin 유도체의 합성

정대일,박유미,박종훈,김윤영,정두희,김인식 東亞大學校 1998 東亞論叢 Vol.35 No.-

The nortropinones 11 (tropinone lla, N-isopropylnortropinone 11b, N-Carbethoxynortropinone 11c, N-furfurylnortropinone 11d, N-(p-methoxyphenyl)nortropinone 11e) were respectively synthesized by the treatment of acetonedicarboxylic acid 8 with, 2, 5-dimethoxytetrahydrofurane 9 in various amines 10 (methylamine 10a, N-isopropylamine 10b, ethylcarbamate 10c, furfurylamine 10d, p-anisidine 10e). The nortropane spirohydantoins 14 (tropane spirohydanttoin 14a, N-isopropylnortropane spirohydantoin 14b, N-Carbethoxynortropane spirohydantoin 14c, N-furfurylnortropane spirohydantion 14d, n_(p-methoxyphenyl) nortropane spirohydantoin 14e) were respectively synthesized by the treatment of synthesized nortropinones 11 (tropinone 11a 54%, N-isopropylnortropinone 11b 50%, N-Carbethoxynortropinone 11c 58%, N-furfurylnortropinone 11d 31%, N-(p-methoxyphenyl) nortropinone 11e, 70%) with potassium cyanide 12, ammonium carbonate 13.

영양표시정착화사업(Ⅱ) : 식품참고량설정에 관한 연구 Study on the Establishement of the Reference Amount in Foods

김대병,장영미,김인복,이혜영,장재희,김보영,이정구,김창민,정해랑 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-

본 연구는 영양표시에서 1회분량 및 영양소함량표시의 기준으로 사용되는 "식픔창고량"에 관한 연구를 수행하므로써 합리적이고 일관성있는 영양표시기준 개선을 위한 기초자료로 활용코자 하였다. 이를 위하여 미국 및 캐나다를 중심으로 제외국의 현황 및 식품참고량 설정방법을 조사 ·연구 하으며 제도도입 및 개선 방안을 강구하였파. 또한, 시판 제품의 영양료시현황 및 음료류 둥의 포장단위 등을 피악하여 식품참고량설정을 위한 기초자료로 활용코자 하였다. 앞으로 국민건강 ·영양조사자료의 체계적인 통계분석, 가공식품의 섭취량조사 등을 통하여 우리나라 국민의 1인 1회 섭취량자료의 축적이 선행되어야 할 것이다. The purpose of this ?roject is to study on the reference amounts customarily consumed per eating occasion to improve the nutrition labelling standards. We Performed to study on the methodology to establish the reference amounts on the basis of the review on the advanced counITy's status. And we investigated the packaged unit ofprocessed foods. Further study is needed to establlsh the customarily consumed amount per eating occasionthrough the statistical analysis of nationwide food consumption data. Our results will be helpful information to improve nutrition labelling system in Korea.

Thioamide와 Benzothiazole 유도체의 합성

정대일,신규하,김인식,김윤영,정두희,이용균 東亞大學校 1998 東亞論叢 Vol.35 No.-

The thioamides; {N-(6-methyl-2-pyridinecarbothionyl)-3-methoxyaminobenzene (27), N-(6-methyl-2-pyridinecarbothionyl)-4-methoxyaminobenzene (29), N-(6-methyl-2-pyridine-carbothionyl)-3-ethoxyaminobenzene (31), N-(6-methyl-2-pyridinecarbothionyl)-4-ethoxyamion-benzene (33), N-(6-methyl-2-pyridinecarbothionyl)-3-bromoaminobenzene (35), N-(6-methyl-2-pyridinecarbothionyl)4-bromoaminobenzene (37), N-(6-methyl-2-pyridinecarbothionyl)-3-chloroaminobenzene (39), N-(6-methyl-2-pyridinecarbothionyl)-4-chloroaminobenzene (41)} were synthesized by the treatment of 2,6-lutidine(22) with sulfur in aniline derivatives (23). The benzothiazole derivatives; {5-methoxy-2-(6-methylpyridy)benzothiazole (46) and 6-ethoxy-2-(6-methylpyridyl)benzothiazole (47)} were respecively synthesized by the treatment of synthesized thioamides; N-(6-methyl-2-pyridinecarbothionyl)-3-methoxy-aminobenzene (27) and N-(6-methyl-2-pyridinecarbothionyl)-4-ethoxyaminobenzene (33) with zirconium (Ⅳ) oxide catalyst in sodium carbonate solution.

TiO₂를 이용한 프로필렌 가스의 광촉매 산화반응

정대일,이동희,김용환,김현숙,이용균,박유미,최순규,김동현 동아대학교 환경문제연구소 2001 硏究報告 Vol.24 No.1

Photocatalyzed degradation of propylene gas was carried out over precoated titanium dioxide(anatase) illuminated W light in a flow reactor. photocatalytic oxidation of propylene gas indicated high conversion rates (78.0%) to CO₂ gas. And photocatalytic oxidation of gas according to a fold, twofold, and threefold of titanium dioxide(anatase) respectively gave high conversion rate. The longer reaction time was, the higher conversion rate to CO₂ gas showed.

용매침윤 수지에 의한 중금속 회수에 관한 연구

李大云,李垣,金珠姬,李承頀 연세대학교 대학원 1981 延世論叢 Vol.18 No.1

The application of the solvent-impregnated resin(SIR), 5,7-dibromo-8-hydroxyquinoline(DBQ)-impregnated polyurethane foam, to the selective recovery of some heavy metal ions from aqueous solution was investigated. The adsorption behavior of DBQ on polyurethane foam was studied to determine the optimum conditions for preparing the SIR. It was found that SIR impregnated with DBQ had adsorption capacity about 5×10-2 mmol M(II) per gram foam. The conditions for recovery and readsorption of metal ions were determined.

청소년기에 있어서의 정신의학적 위험도 평가

이대희,최희정 大韓神經精神醫學會 1982 신경정신의학 Vol.21 No.3

청소년기 학생들의 정신과적 위험도를 평가하는데 Anthony's Risk Profile의 적용가능성과 방법론상의 문제점들을 알아보기 위해서 청소년 640명과 청소년기 정신과 환자 23명에게 설문지법으로 조사한바 다음과 같은 결과를 얻었다. 1. 총위험도점수는 발달시기별, 남녀별 차이는 없었으나, 도시보다 농촌에서 높은 경향을 보였다. 2. 각 소제목별 비교에 있어서는 「체질부담」, 「발달부담」, 「신체질환부담」 및 「환경부담」이 도시보다 농촌에서 높은 것으로 나타났다. 그리고 「발달부담」, 「환경부담」과 「충격부담」은 여자보다는 남자에서 높은 것으로 나타났으며 「충격부담」은 나이가 들어감에 따라 증가하는 것으로 나타났다. 3. 환자군은 정상군에 비해 높은 총위험도 점수를 나타냈으며, 「출산부담」을 제외한 모든항목 특히 「유전부담」과 「충격부담」이 현저히 높은 것으로 나타났다. 4. 결론적으로 청소년의 정신과적 위험도를 측정하는데 ARP설문지를 이용할 수 있을 것으로 보이며 다만 더 자세한 조사를 위해서는 몇몇 항목의 수정이나 첨가가 필요할 것으로 생각된다. The purpose of this study was to investigate the discriminating power and the applicability of the 'Anthony's Risk Profile(ARP) which is a tool for assessment of psychiatric risk of an individual. After translation into Korean, the ARP questionnaires were sent to the parents of 160 preadolescents, 240 early adolescents and 240 middle alolescents. (Male: Female=1:1, Urban:Rural 1:1) Six hundred and eight questionnaires were returned and the data of 578 questionnaires were analyzed statistically. Then the stratified sample of 23 rural boys were chosen and compared with a 23 psychiatric patient group. Some of the results and conclusions are as follows: 1. All subjects but one belonged to the range of low risk of 0 to 13 scores. 2. The subjects whose total risk score ranged between 7-13 were significantly more in rural samples than in the urban probably due to increased environmental and subsequent physical ill-health loading. 3. The developmental, environmental and traumatic loading were greater in male samples than in the female. 4. Patient group showed higher total risk score and higher risk of all sub-categories except reproductive loading than normal group 5. In conclusion, the ARP questionnaire was found to have some discriminating power between different groups and found applicable to Korean abolescents. The authors hinted at a possibility of revising some items and addition of new items such as sibling rivalry or parental overprotection.

韓牛 末梢血液 淋巴球의 在來山羊 赤血球 Rosette形成

宋憙鍾,金鍾冕,姜明大,蔡孝錫 全北大學校 附設 畜産開發硏究所 1988 畜産開發硏究報告 Vol.2 No.-

In order to enumerate the T lymphocytes in bovine peripheral blood lymphocytes(PBL) by E rosette assay, KGRBC were treated with various concentration of 2-aminoethylisothiouronium bromide hydrobromide(AET) and dextran(Dex), singte or combination. The PBL from 10 clinically normal Korean native cattle were formed as low percentage of spontaneous E rosette(6.7±2.4%) in control group, whereas KGRBC treated with 0.1M AET for 20 minutes and 8%Dex were formed as 37.3±2.7% and 45.1±2.1%, respectively. And the synergistic effects were noted no less than 66.5±5.6% when the KGRBC treated with 0.1M AET and 8% Dex subsequently. These results suggest that the KGRBC would be a useful agent for the enumeration of T tymphocytes by E rosette assay in bovine PBI.