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Dynamic assembly of Hda and the sliding clamp in the regulation of replication licensing
Kim, Jin S.,Nanfara, Michael T.,Chodavarapu, Sundari,Jin, Kyeong S.,Babu, Vignesh ,M. ,P.,Ghazy, Mohamed A.,Chung, Scisung,Kaguni, Jon M.,Sutton, Mark D.,Cho, Yunje Oxford University Press 2017 Nucleic acids research Vol.45 No.7
<P><B>Abstract</B></P><P>Regulatory inactivation of DnaA (RIDA) is one of the major regulatory mechanisms of prokaryotic replication licensing. In RIDA, the Hda–sliding clamp complex loaded onto DNA directly interacts with adenosine triphosphate (ATP)-bound DnaA and stimulates the hydrolysis of ATP to inactivate DnaA. A prediction is that the activity of Hda is tightly controlled to ensure that replication initiation occurs only once per cell cycle. Here, we determined the crystal structure of the Hda–β clamp complex. This complex contains two pairs of Hda dimers sandwiched between two β clamp rings to form an octamer that is stabilized by three discrete interfaces. Two separate surfaces of Hda make contact with the β clamp, which is essential for Hda function in RIDA. The third interface between Hda monomers occludes the active site arginine finger, blocking its access to DnaA. Taken together, our structural and mutational analyses of the Hda–β clamp complex indicate that the interaction of the β clamp with Hda controls the ability of Hda to interact with DnaA. In the octameric Hda–β clamp complex, the inability of Hda to interact with DnaA is a novel mechanism that may regulate Hda function.</P>
중첩 격자 기법이 적용된 대각 내재적 조화균형법을 이용한 헬리콥터 로터 블레이드의 비정상 공력 해석
임동균(D. K. Im),최성임(S. I. Choi),박수형(S. H. Park),김유진(E. Kim),권장혁(J. H. Kwon) 한국전산유체공학회 2011 한국전산유체공학회 학술대회논문집 Vol.2011 No.11
In this paper, diagonal implicit harmonic balance method with overset grid technique is applied to analyze helicopter rotor blade flow in hover and forward flight condition. The chimera grid need interpolation time with sub-grid and background grid in moving problem such as forward flight on every time step. Present method is available enough to reduce the grid module interpolation time. In order to demonstrate present method, Caradonna & Tungs rotor blades are used and the results are compared to other researchers result and experimental data.
UPPER LIMITS ON THE NUMBER OF SMALL BODIES IN SEDNA-LIKE ORBITS BY THE TAOS PROJECT
Wang, J.-H.,Lehner, M. J.,Zhang, Z.-W.,Bianco, F. B.,Alcock, C.,Chen, W.-P.,Axelrod, T.,Byun, Y.-I.,Coehlo, N. ,K.,Cook, K. H.,Dave, R.,de Pater, I.,Porrata, R.,Kim, D.-W.,King, S.-K.,Lee, T.,Lin, American Institute of Physics 2009 The Astronomical journal Vol.138 No.6
<P>We present the results of a search for occultation events by objects at distances between 100 and 1000 AU in light curves from the Taiwanese-American Occultation Survey. We searched for consecutive, shallow flux reductions in the stellar light curves obtained by our survey between 2005 February 7 and 2006 December 31 with a total of ~4.5 × 10<SUP>9</SUP> three-telescope simultaneous photometric measurements. No events were detected, allowing us to set upper limits on the number density as a function of size and distance of objects in Sedna-like orbits, using simple models.</P>