Slide Session : OS-IFD-07 ; Infectious Disease : In Vitro Antiviral Activity of Ribavirin Against Severe Fever with Thrombocytopenia Syndrome Virus

( Myung Jin Lee ),( Kye Hyung Kim ),( Jong Youn Yi ),( Su Jin Choi ),( Chung Jong Kim ),( Nak Hyun Kim ),( Kyoung Ho Song ),( Pyoeng Gyun Choi ),( Ji Hwan Bang ),( Wan Beom Park ),( Eu Suk Kim ),( San 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

In Vitro Antiviral Activity of Ribavirin Against Severe Fever with Thrombocytopenia Syndrome Virus Myung Jin LEE1, Kye-Hyung KIM1, Jongyoun YI2, SuJin CHOI1, Chung-Jong KIM1, Nak- Hyun KIM1, Kyoung-Ho SONG1, Pyoeng Gyun CHOI1, Ji-Hwan BANG1, Wan Beom PARK1, Eu Suk KIM1, Sang-Won PARK1, Hong Bin KIM1, Nam Joong KIM1, Myoung- Don OH1 Seoul National University College of Medicine, Korea1, Pusan National University School of Medicine, Korea2 Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel Bunyavirus, severe fever with thrombocytopenia syndrome virus (SFTSV). No effective antiviral therapy is proven yet, but clinical use of ribavirin (RBV) has been tried. We investigated the antiviral effect of RBV against SFTSV in vitro. Methods: To test for cytotoxicity of RBV, Vero cells were treated with different concentrations of RBV (3.90 to 500 μg/mL, two-fold dilution) and analyzed by cell viability MTS assay 48h post-infection. To determine antiviral activity of RBV against SFTSV, Vero cells were infected with SFTSV strain Gangwon/Korea/2012 at 100 TCID50 (50% tissue culture infective dose) per well in a 96-well plate, and RBV was added at the concentrations showing no or minimal cytotoxicity. Viral RNAs were extracted from the culture supernatants and quantifi ed using one-step real-time reverse transcription- PCR to amplify the partial large segment of SFTSV. Statistical analysis was done by one-way ANOVA with Tukey`s post hoc test. Results: Cytotoxicity due to RBV was not observed at RBV concentration =31.3 μg/ mL. Viral RNAs at 24h post-RBV treatment were reduced with increasing RBV concentrations (1-32 μg/mL), compared with those of mock-treated cells (P <0.01, Figure). Half maximal inhibitory concentration (IC50) of RBV was 3.69 μg/mL at 24h post-RBV treatment. Conclusions: Our study shows that RBV has antiviral effect against SFTSV in a dose-dependent manner. Further studies are required to evaluate the effi cacy of RBV in SFTS.

유도 허벅다리걸기 기술발휘 시 받기의 자세와 저항수준에 따른 중심변인 분석 사례연구(Ⅱ)

김의환,김성섭,정재욱 한국운동역학회 2005 한국운동역학회지 Vol.15 No.1

E. H. KIM, S. S. KIM, C. W. CHUNG. A Case Study on Center of Gravity Analysis when Performing ilchimata by Posture and Voluntary Resistance Levels of Uke in Judo[ II]. Korean Journal of Sport Biomechanics, Vol. 15, No. 1, pp. 237.-257, 2005. It was to study as a following-research of "A Case Study on Center of Gravity(COG) Analysis when Performing Uchimata(inner thigh reaping throw) by Posture and Voluntary Resistance Levels(VRL) of Like in Judo[1]". The purpose of this study was to analyze the COG variables when performing uchimata(inner thigh reaping throw) by two postures and voluntary resistance Jevels(VRL) of uke(reciver) in Judo. The subjects, who were one male judoka(YH) for 1992 Barcelona Olympic Games Olympian(silver medalist), and one male trainee; Y.I.University representative member (SDK), and were filmed on two S-VHS 16mm video cameras(60fields/sec.) through 3-dimensional motion analysis methods, that postures of uke were shizenhontai (straight natural posture) and jigohontai(straight defensive posture), VRL of uke were 0% and 100%, respectively. The kinematical variable was COG variable, distance of COG, and distance of resultant COG between uke and tori(the thrower), velocity and acceleration of COG. The data of this study collection were digitized by SIMI Motion Program computed the mean values and the standard deviation calculated for each variables. When performing uchinwta according to each posture and VRL of uke and classifying. From the data analysis and discussion, the conclusions were as follows : 1. Displacement of COG Subject YH, COG was the highest in kuzushi(balance -breaking), vertical COG was low when following in tsukuri(positioning; set-up), kake(application; execution), and COG was pattern of same character each postures and resistance, respectively. Subject SDK, COG was low from kumikata(engagement positioning) to kake, and COG was that each postures and resistance were same patterns, respectively. Subject YH, SDK, each individual, postures and resistance, vertical COG was the lowest in kake phase, when performing. 2. Distance of COG between uke and tori The distance of COG between uke and tori when performing, subject YH was 0.64-0.70cm in kumikata, 0.19-0.28cm in kake, and SDK was 0.68-0.72cm in kumikata, 0.30-0.42 cm in kake. SDK was wider than YH. 3. Distance of resultant COG between uke and tori The distance of resultant COG between uke and tori when performing, subject YH was 0.27-0.73cm from kumikata to kake. and SDK was 0.14-0.34cm in kumikata, 0.28- 0.65cm in kake. Jigohontai(YH:0.43-0.73cm,SDK:0.59-0.65cm) was more moved than shizenhontai(YH:0.27-0.53cm, SDK: 0.28- 0.34cm). 4. Velocity of COG The velocity of COG when performing uchimata, subject YH was fast anterior-posterior direction in kuzushi, ant-post. and vertical direction fast in tsukuri and kake. SDK was lateral, ant.-post. and vertical direction in kuzushi, ant.-post. and vertical direction in tsukuri and ant.-post. direction in kake, respectively. 5. Acceleration of COG The acceleration of COG when performing uchimata, The trend of subject YH was showed fast vertical direction in kuzushi and tsukuri, ant-post. and vertical direction fast in kake. The trends of SDK showed lateral direction in kuzushi, lateral and ant.-post. direction in tsukuri and ant.-post direction in kake, respectively.

忠南黑石溪谷 住民의 肺, 肝디스토마 感染率 및 그 中間宿主 調査

金鍾煥,鄭奉晳,金玉千 醫藥係社 1955 綜合 醫學 Vol.12 No.12

하악골 절제술후 재이식된 돌결자가골 재이식 : 치험 3례

김 식,김수관,김운규,김수민,류종희,이준길,조경안,김수흥,정태영,여환호 대한악안면성형재건외과학회 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.2

We described three cases of immediate reimplantation of a frozen-thawed autogenous mandible composed of a mixture of iliac bone, marrow, and particulate hydroxyapatite in tumors of the mandible. Acceptable outcomes were obtained in three patients who underwent immediate autogenous mandibular graft reconstruction. The conditions leading to successful outcome of the procedure are also discussed. Reimplantation of frozen autogenous lesioned mandible was performed in three patients with mandibular tumors. Two reimplanted grafts survived without complications following surgery. One case had postoperative infection that resolved with appropriate antibiotic treatment. There were no recurrences of the primary lesions. Satisfactory facial contour after surgery was achieved. These results are most promising, and we believe that, with further refinement, this technique will offer a new and acceptable modality for facial reconstruction in patients with cancer.

네모나프라이드의 유효성 및 추체외로 부작용 : Haloperidol 및 Risperidone과의 자연관찰적 개방형 비교연구 A Naturalistic Open Comparative Study with Haloperidol and Risperidone

서영수,김용관,신동환,공보금,이정구,박정환,윤성환,정치영,이상경,김영훈 대한생물치료정신의학회 2001 생물치료정신의학 Vol.7 No.2

Objectives : This open prospective study was performed in order to evaluate the efficacy and extrapyramidal adverse effects of nemonapride in the schizophrenic patients, and was compared wit one of typical antipshchotics. haloperidol and one of atypical antipsychotics, risperidone. Methods : Thirty male and female schizophrenic patients(DSM-Ⅳ) were treated for 12 weeks with haloperidol(n=10), risperidone(n=10) and nemonapride(n=10). The overall efficacy was assessed at baseline, 1st week, 2nd week, 4th week, 8th week, and 12th week by the Positive and Negative Syndrome Scale for Schizophrenia(PANSS). Also the overall safety was assessed in the same time period by the Extrapyramidal Symptom Rating Scale(ESRS). Results : There were no significant differences in PANSS scores(total, positive, negative, and general psycho­pathology subscale) among haloperidol, risperidone, and nemonapride groups, Treatment responders, defined as at least 20% reduction of baseline total PANSS score, were achieved by 8 patients(80%) in haloperidol group, 10 patients(100%) in risperidone group, and 8 patients(80%) in nemonapride group. And there were no significant differences in ESRS total scores among haloperidol, risperidone, and nemonapride group. Inter-group comparison among haloperidol, risperidone and nemonapride group, as assessed by the ESRS, revealed no significant differences in the shifts to the maximum score, 9.4(±9.4), 6.2(±8.4), and 11.3(±8.1) respectively, and also revealed no significant differences in the mean time reaching the maximum score, 4.5(±4.5) week, 7.8(±4.8) week, and 4.6(±4.4) week, respectivily. Conclusion : There wee no significant differences in the efficacy and extrapyramidal adverse effects among haloperidal, rispecridone and nemonapride groups. These results suggest that nemonapride was as efficacious and safe in he treatment of schizophrenia, as well known and widely used antipsychotics, haloperidol and risperidone.

스포츠 산업의 현황과 발전방안 : 제주특별자치도를 중심으로

김응식,고충환 朝鮮大學校 스포츠科學硏究所 2006 스포츠科學硏究 Vol.17 No.-

As sports of our country enters in the 1980s, economy development is accelerated and 86 Asian games and 88 Seoul Olympics by meter awareness change about change of people consciousness about sports, interest about health and leisure practical use happen. Human by development of scientific civilization is undergoing fast change of life-style by standard of living improvement, leisure time extension etc since 20C. That sports catches seat by some of human life in such phenomenon consumer's desire about sports gradually more various. Jejudo is doing many efforts for (the domestic, the foreign countries) sports contest, electric cell training, golf tourists infancy to activate sports signtseeing that connect sports and signtseeing. But, can speak that side effect by businesses that propel without effective business analysis or strategy is real condition that is led. Therefore, speak that the matter that grope Jejudo sports industry development is important. 1) Jejudo sports participation arrival guest change trend Jejudo sports participation arrival guest change is showing, and shows increase aspect of about 26% than 2001 years tu 548,823 peopie all in 2002 by about 436,435 including international, domestic contest, electric cell training, golf tourists in 2001. In 2003 years, is expose that about 44% increases than 2001 years to 627,710 people all, and this was expose that arrival guest is increasing gradually. 2) change of Jejudo sports participation consumption expenses Was expose by 64 billion wons all by shopping rain 10,300,000,000 wons, charge for board and lodging 36,100,000,000 wons, other 17,500,000,000 wons in the case of international contest, did not show alternative aspect with international contest by 66,500,000,000 wons all by shopping rain 9100 million wons, charge for board and lodging 42,500,000,000 wons, other 14,800,000,000 wons in the case of national convention. Showing low level of 9100 million wons all by shopping rain 6 billion wons, charge for board and lodging 5400 million wons, other 3100 million wons in the case of electric cell training, showed the most consumption expenseses by 217,300,000,000 wons all by shopping rain 22,700,000,000 wons, charge for board and lodging 68,700,000,000 wons, other 125,800,000,000 wons in the case of golf course tourists.

만성정신질환자의 계속입원치료 심사에 관한 연구

정인원,박환규,정연복,김수일,원구연,김교형,신철진 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.6

연구목적: 정신보건법에 근거하여 매월 정기적으로 개최된 충청북도 정신보건심판위원회를 통하여 정신질환자의 계속입원치료 청구 심사의 현황과 문제점을 파악하고 개선사항을 지적함으로써 정신질환자의 효율적인 관리를 유도하고 인권남용의 여지를 차단하고자 한다. 방 법: 충청북도 내의 정신의료기관에서 계속입원치료 심사청구서 및 진단서, 보호의무자의 동의서 등을 제출한 정신질환자들을 대상으로 계속입원치료 청구에 대한 승인 여부를 매달 정기적으로 심사하였다. 1년 6개월여동안 심사한 자료를 정리하여 진단 및 보호의무자, 의료보장별 특성과 불승인률 등을 분석하였다. 결 과: 충청북도 심판위원회에 계속입원치료를 청구한 정신질환자는 21차례의 위원회 동안 총 7,981명이었으며, 진단별로 정신분열병은 80.9%, 알콜중독은 8.1%, 치매 등 기타는 11.0%이었다. 또한 보호의무자는 시장 또는 군수가 29.8%, 부모가 26.9%, 형제가 26.1%, 부부가 6.3%, 자녀가 5.9%, 기타가 5.0%로 나타났으며, 의료보장은 의료보호가 73.0%, 의료보험이 27.0%이었다. 이들 중에서 196명이 계속입원치료를 불승인받아서 전체 불승인률은 2.46%이었으며 정신분열병과 알콜중독 환자의 진단별 불승인률은 각각 0.73%와 17.6%이었다. 결 론: 정신과 병상의 대부분이 장기적으로 입원하는 만성 정신질환자들로 구성되어 있어서 이들에 대한 별도의 대책이 시급하다. 또한 계속입원치료가 불승인되어 퇴원한 환자들의 재활 및 사회적응을 위한 사회적 지지 체계가 부족하며, 특히 환자의 인권보호를 위한 구체적인 기준 등이 필요하다. Objectives: This study was to develop effective managements and to avoid the abuse of human rights in mentally-ill patients. The Mental Health Judgement Board of Chungchongbuk-do province has been held monthly since August, 1997 according to the Mental Health Act. In this study, the procedures and the problems of judging continuing hospitalization of chronic mentally-ill patients were reviewed. Methods: The mentally-ill patients who submitted the request for continuing hospitalization with the certificate of charged doctor and the agreement of caregiver were reviewed by the Mental Health Judgement Board of Chungchongbuk-do province. The analysis of the diagnoses, caregivers, medical care systems, and rejection rate for the patients were done. Results: Total mumber of mentally-ill patients who requested for continuing hospitalization were 7,981 from twenty-one monthly meetings. The diagnostic distributions were 80.9% for schizophrenic patients, 8.1% for alcoholics and 11.0% for others including dementia. As for the caretakers, the rate of majors was 29.8%, parents 26.9%, sibling 26.1%, spouse 6.3%, offspring 5.9%, and others 5.0%. And 73.0% of the patients were on Medicaid and 27.0% were insured. The patients who got the rejection for continuing hospitalization were 196 at the rate of 2.46%. And the rejection rates of schIzophrenic and alcoholic patients were 0.73% and 17.6%, respectively. Conclusions: New policies for decreasing longterm hospitalization of chronic mentally-ill patients are required. And the social support systems for psychiatric rehabilitation and readjustment are presently insufficient for the already discharged mentally-ill. Moreover, the practical guidelines for human rights of patients remains to be suggested.

치근단X선사진을 이용한 만곡치의 연구

김정우,황의환,이상래 大韓口腔顎顔面 放射線學會 1990 Imaging Science in Dentistry Vol.20 No.2

The purpose of this study was to evaluate the incidence and several radiographic features of dilacerated teeth in 2132 full month radiograms in Korean. The results were as follows : 1. The occurrence was revealed to 2.7% in total examined teeth, and these anomalies were occurred in maxilla(52.4%) more than in mandible(47.6%). 2. There was a predilection for occurrence of dilaceration in female, which included 12.8% of the female compared to 11.3% in male. 3. The frequency of dilaceration in male, which included 40.5% in maxilla and 59.5% in mandible. The frequency of dilaceration in female, which included 52.4% in maxilla and 47.6% in mandible. 4. The order of frequency of dilaceration was second premolar, first premolar, lateral incisor, canine in maxilla, and first premolar, second premolar, canine, lateral incisor, central incisor in mandible. 5. In classifying of dilacerated teeth into 3 types by following appearances such as root curvature. Distal dilaceration was by far most common containing 65.8% of the cases. The least frequent was mesial dilaceration, which included 6.5% of the cases.

兩耳競聽法을 이용한 精神病患者의 大腦機能側向化

金相勳,李廷南,楊秉換 大韓神經精神醫學會 1985 신경정신의학 Vol.24 No.2

Lateralized functions of the cerebral hemispheres using the dichotic listening test were surveyed in subjects who consisted of 17 schizophrenic patients (10 males, 7 females), 18 bipolar disorder patients (10 males, 8 females) and 18 normal controls (10 males, 8 females). The results were as follows; 1. As to the comparison of total correct answers, there is no significant difference among each group and between both sex. 2. As to the comparison of correct answers according to the type of test, total subjects has significantly higher scores in word test (32.4±6.82) than in digit test (23.8±5.67), (p<0.01). And also, each group has the same results (p<0.01). 3. As to the comparison of correct answers recognized through the right ear or left one, total sucjects has significanly higher scores in right ear (30.9±5.51) than in left one (25.3±6.06), (p<0.05). 4. As to the correlation between the type of test and correct answers recognized through the right ear or left one, total subjects has significantly higher scores in word test than in digit test, in which both right and left (p<0.05). 5. Although there is no evidence of definitive ear asymmetry in both psychotic groups, bipolar disorder patients show a tendency of right ear dominance in digit test but it has no statistical significance.

고속 플라즈마 진단용 능동회로의 설계 및 응용

김두환,이우근,박정후 釜山大學校生産技術硏究所 1995 生産技術硏究所論文集 Vol.49 No.-

본 논문에서는 자화 플라즈마의 파라메타를 측정할 수 있는 고속 푸르브 구동시스템을 구현하였다. 이 시스템은 1[msec] 이내에 -40 - +40[V]에 이르는 톱니파 전압을 푸르브에 인가시킬 수 있을 뿐만 아니라, 2회 연속 미분을 행하여 전자에너지 분포함수를 구할 수 있었다. 이와 같이 고속 푸르브 구동시스템 및 2회 연속 미분회로를 이용하여 고속으로 거의 전형적인 푸르브 특성곡선을 얻을 수 있었고 2회 연속 미분회로로써 얻어진 전자에너지 분포하수에서 플라즈마의 중심부 보다 플라즈마의 가장자리에 고에너지를 가진 전자들이 많이 분포함을 알 수 있었다. In this paper ,we have realized the high speed probe driving circuit system which can measure the plasma parameters of magnetoplasma. By this system, the probe voltage can be seeped in a 1[msec] order. In addition, we can obtain the electron energy distribution function in magnetoplasma by using two differentiators. In this study, we obtain a complete probe characteristics, and find that the electron energy measured at the edge of plasma is larger than of electron measured at the center of plasma