Voice Mismatch Meets Neurolinguistics

Gui-Sun Moon,Sun-Woong Kim,Jeong-Ah Shin,Hae-Kyung Wee,Jong Un Park,Myung-Kwan Park,Wonil Chung 현대문법학회 2018 현대문법연구 Vol.99 No.-

Gui-Sun Moon, Sun-Woong Kim, Jeong-Ah Shin, Hae-Kyung Wee, Jong Un Park, Myung-Kwan Park, and Wonil Chung. 2018. Voice Mismatch Meets Neurolinguistics. Studies in Modern Grammar 99, 85-115. This paper aims to investigate Korean advanced L2 English learners’ strategies for ellipsis resolution during sentence processing. Ellipsis resolution is known to involve several stages of information processing from the initial step of detecting an ellipsis-licensing element by the parser to the final stage of integrating the ellipsis site with the information retrieved from the antecedent of the ellipsis site. In examining these steps, we have manipulated three factors: (i) TP vs. VP-ellipsis; (ii) two types of discourse coherence relations (resemblance(-contrast) vs. cause-effect relations); (iii) voice match vs. mismatch. We found through the ERP recordings that voice mismatch in TP ellipsis elicited N400, followed by P600, irrespective of discourse coherence relations. In contrast, voice mismatch in VP-ellipsis registered N400 only in resemblance(-contrast) relation, but not in cause-effect relation. These findings lead us to conclude that Korean advanced L2 learners of English seem to undergo the full sequence of processing stages required for ellipsis resolution.

Comparison of Melanoma Subtypes among Korean Patients by Morphologic Features and Ultraviolet Exposure

( Hong Sun Jang ),( Jee Hung Kim ),( Kyu Hyun Park ),( Jae Seok Lee ),( Jung Min Bae ),( Byung Ho Oh ),( Sun Young Rha ),( Mi Ryung Roh ),( Kee Yang Chung ) 대한피부과학회 2014 Annals of Dermatology Vol.26 No.4

Background: Genetic alterations have been identified in melanomas according to different levels of sun exposure. Whereas the conventional morphology-based classification provides a clue for tumor growth and prognosis, the new classification by genetic alterations offers a basis for targeted therapy. Objective: The purpose of this study is to demonstrate the biological behavior of melanoma subtypes and compare the two classifications in the Korean population. Methods: A retrospective chart review was performed on patients found to have malignant melanoma in Severance Hospital from 2005 to 2012. Age, sex, location of the tumor, histologic subtype, tumor depth, ulceration, lymph node invasion, visceral organ metastasis, and overall survival were evaluated. Results: Of the 206 cases, the most common type was acral melanoma (n=94, 45.6%), followed by nonchronic sun damage-induced melanoma (n=43, 20.9%), and mucosal melanoma (n=40, 19.4%). Twenty-one patients (10.2%) had the chronic sun-damaged type, whereas eight patients (3.9%) had tumors of unknown primary origin. Lentigo maligna melanoma was newly classified as the chronic sun-damaged type, and acral lentiginous melanoma as the acral type. More than half of the superficial spreading melanomas were newly grouped as nonchronic sun-damaged melanomas, whereas nodular melanoma was rather evenly distributed. Conclusion: The distribution of melanomas was largely similar in both the morphology-based and sun exposure-based classifications, and in both classifications, mucosal melanoma had the worst 5-year survival owing to its tumor thickness and advanced stage at the time of diagnosis. (Ann Dermatol 26(4) 485~490, 2014)

Elevated TRAF2/6 expression in Parkinson's disease is caused by the loss of Parkin E3 ligase activity.

Chung, Ji-Yun,Park, Hee Ra,Lee, Su-Jin,Lee, Sun-Hye,Kim, Jin Sik,Jung, Youn-Sang,Hwang, Sang Hyun,Ha, Nam-Chul,Seol, Won-Gi,Lee, Jaewon,Park, Bum-Joon United States and Canadian Academy of Pathology [e 2013 Laboratory investigation Vol.93 No.6

<P>Parkinson's disease (PD) is the second leading neurodegenerative disease, and is known to be induced by environmental factors or genetic mutations. Among the verified genetic mutations of PD, Parkin, isolated from the PARK2 locus, shows an autosomal recessive inheritance pattern and is known to be an E3 ligase. However, the physiological target of Parkin and the molecular mechanism of Parkin-deficiency-induced PD have not been clearly demonstrated until now. It has recently been proposed that inflammation, suggesting as a causal factor for PD, is enhanced by Parkin deficiency. Thus, we examined the relationship between inflammation-related factors and Parkin. Here, we provide the evidence that Parkin suppresses inflammation and cytokine-induced cell death by promoting the proteasomal degradation of TRAF2/6 (TNF-α receptor-associated factor 2/6). Overexpression of Parkin can reduce the half-lives of TRAF2 and TRAF6, whereas si-Parkin can extend them. However, mutant Parkins did not alter the expression of TRAF2/6. Thus, loss of Parkin enhances sensitivity to TNF-α- or IL-1β-induced JNK activation and NF-κB activation. Indeed, si-Parkin-induced apoptosis is suppressed by the knockdown of TRAF6 or TRAF2. We also observed elevated expression levels of TRAF6 and a reduction of IκB in an 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced PD mouse model. Moreover, elevated expression levels or aggregation of TRAF6 were detected in approximately half of the human PD tissues (7/15 cases) and 2 cases, respectively. In addition, TRAF6 and Parkin expression levels show a reverse relationship in human PD tissues. Our results strongly suggest that the reduction of Parkin or overexpression of TRAF2/6 by chronic inflammation would be the reason for occurrence of PD.</P>

기업광고의 기업 이미지 변화 효과에 관한 실험연구

정희선,박철 德成女子大學校 1993 德成女大論文集 Vol.22 No.-

Hi-sun Chung & Cheol Park. An Experimental Study of Corporate Advertising Effectiveness on Corporate Image Change. The purpose of this study is to examine the effectiveness of corporate advertising on corporate image through an experimental research design. The major findings of the study are as follows: (1) the corporate advertising has a positive effect on the corporate image change, but it is not strong enough to be of any statistical significance; (2) a significant difference in audience response is found with varying types of corporate advertising and also with varying nature of the pre-existing corporate image-the sympathetic advertisements are more successful than the persuasive ones in inducing the more positive response, and the groups with favorable pre-existing image showed a more positive response than those with hostile pre-existing image; and (3) the nature of pre-existing corporate image is more influential than the nature of corporate advertising in shaping new corporate image.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

의복행동에 관한 이론적 고찰(Ⅰ) : 의복의 동조성, 유행, 개성, 흥미성, 실용성, 심미성 중심으로 Conformity, Fashionability, Individuality, Interest, Practicality, and Aesthetics

박광희,정인향,최선영,한정숙 啓明大學校 生活科學硏究所 1998 科學論集 Vol.24 No.-

This is the first of two papers in which we review clothing behavior literature found in the field of clothing and textiles. Articles dealt with at least one of six aspects of clothing behavior (conformity, fashionablity, individuality, interest, practicality, and aesthetics) were analyzed 1) to generate each composite definitions of conformity, fashiooablity, individuality, interest, practicality, and aesthetics, 2) to examine scales used from the perspective validity and reliability, and 3) to investigate the results of studies for exploring the possibility of developing new measurements of clothing behavior.

호스피스들의 임종환자에 대한 태도조사

박인준,정한용,한선호 순천향대학교 1990 논문집 Vol.13 No.3

As the modern medicine advances with time, the chronic debilitating disease has become the leading cause of death, and the terminally ill and dying patients has been increased. So the managent of dying patients has become important problem in the medical practices and it is difficult for doctors to tell the patient that he or she is an dying. Whether to tell the truth or not, has been a major problem for the dying patients. The authors conducted a research to investigate the attitudes of 43 hospices toward the dying patients. 1) The 92.8% of the respondents agreed to informing the dying patinet of his prognosis. The most common rationale for informing the patient was that the patient should prepare for death psychologically, and the patient must be given the opportunity to take remaining affairs. 2) The most frequently considered pre-requisite for disclosure was the emotional stability. And items such as agreement of families, and religion were followed. 3) The 54.8% of respondents thought that it was most proper to tell the patient when he vaguely knew about his prognosis. 4) The 42.9% of respondents chose the physician-in-charge as the most appropriate person to inform the patient, the families of patinet, a minister were followed. 5) The 60.5% of respondents replied that the method of telling the truth was "to take several days with step by step". 6) As to what a dying patient needed most, more frequently chosen items were religious help, hospice care & care of family members. 7) The 55.8% of respondents agreed that psychiatric treatment for a dying patient i good idea. 8) The 41.9% of respondents thought that a dying patient suffered from fear of unknown. Fact, physical discomfort and separation were followed. 9) In the questionaire of "If you are on the process of dying, whether you want to know or not the truth of impending death", all respondents (100%) replied that they want to know the truth. 10) In the questionaire of "The meaning of death", the 45.2% of respondents chose that the death is lie and a beginning of the new life. 11) 52.4% of respondents preferred a dying patient to be cared by hospice after telling the truth. 12) In the questionaire of "Are you satisfied with the treatment of a dying patient", 51.3% of respondents replied that they are poorly satisfied with a emotional and psychological support to a dying patient.

자연관에 근거한 전통마을의 공간 구조분석에 관한 연구

선은수,박정근,박철민 제주대학교 공과대학 첨단기술연구소 2006 尖端技術硏究所論文集 Vol.17 No.1

As a plan to actively utilize an alley in a single residential complex, a circular road and a passage of a village should be divided, and the former should be used as a means for vehicle they should play both roles of activity space for children and place for social life among residents. An opportunity to meet among residents should be prepared by preparing a public space, a sense of community among village residents should be formed by supervising various village events, and a natural sense of community should be encouraged around a cross in a residential district or an alley with change in its width. In addition, a sense of community should be guaranteed by introducing elements of landmark in the entrance and center of the village. It is meaningful that this study found elements for community formation at alleys and yards of Korean traditional villages, and this study will be basic data to plan and design traffic line in exclusive residential complexes. For this, a conversion of recognition from that alleys and yards just have functions of movement and illuminance to that they are places for community formation, and related institutions should be supported.

백서 뇌에서 전기경련 충격에 의해 발현이 조절되는 새로운 유전자

정선주,박정은,강웅구,구영진,박주배,김용식 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.5

연구목적: 이 연구는 백서 뇌에서 전기경련 충격(Electroconvulsive shock, ECS)에 의해 발현이 조절되는 새로운 유전자를 검색하고, 발달단게 및 뇌 조직에 따른 발현양상을 관찰하기 위하여 시행되었다. 방법: 생후 7일, 21일된 어린 웅성 백서에 전기경련 충격을 가한 후 mRNS differential display-PCR(DD-PCR) 기법을 시행하여 발현의 차이를 나타내는 유전자를 검색한 후 서열분석을 실시하였다. 생후 7일 및 21일된 백서의 뇌와 성년 백서의 대뇌피질, 해마를 이용한 Northern blot 분석을 시행하여 검색된 유전자의 ECS 처치 후 시간경과에 따른 유전자 발현양상을 관찰하였다. 결과: ECS 처치군과 위충격군간에 발현의 차이를 나타낸 유전자 4개를 검색할 수 있었으며, 이중 ECS에 의해 발현이 증가되는 1개의 유전자를 선정하여 서열분석을 실시한 결과 EST 서열만이 보고된 새로운 유전자임이 밝혀졌다. 이 유전자는 생후 7일된 백서의 뇌에서는 ECS 처치 후 180분에 발현양의 증가가 최고치에 도달하였으나, 생후 21일된 백서의 뇌와 성년백서의 대뇌피질 및 해마에서는 360분 경과시까지 지속적으로 발현 양이 증가하였다. 결론: 이같은 결과는 ECS에 의해 생체 내에서 유전자 발현의 조절이 이루어짐을 시사하며, 향후 이러한 유전자의 세포 내 기능에 관한 연구를 시행함으로써, ECS에 의한 생체의 반응과 치료기전에 대한 이해를 넓힐 수 있을 것으로 기대된다. 중심단어:전기경련 충격·DD-PCR·유전자·백서 뇌. Objectives: This study was performed to identify genes regulated by electroconvulsive shock (ECS) and to observe the pattern of expression of genes according to different developmental stages and brain regions. Method: ECS(130V, 0.5 sec) was given to male Sprague-Dawley rats with age of postnatal day 7 and 21(P7, P21 respectively). After screening genes regulated by ECS with mRNA diffe-rential display-PCR(DD-PCR), we selected one clone among them and observed the induction of this gene after ECS by time-dependent Northern blot analysis of rat brain of P7, P21 and adult rat cortex and hippocampus. Results: By DD-PCR method, we have identified four clones whose expression was regulated by ECS. Among them, one(CP 10-2) was proved to be a new gene by sequencing and BLAST search. Its expression was increased after ECS in P7, P21, and adult rat brain. The expression of CP 10-2 reached peak level at 180 minutes after ECS in P7 rat brain, but was further increased until 360 minutes after ECS in P21 and adult rat brain. Conclusion: In this study, a new gene was identified in rat brain which showed up-regulated expression in response to ECS. Cloning and characterization of this new gene would be helpful to elucidate the effect of ECS in rat brain. KEY WORDS:Electroconvulsive shock·Differential display-PCR·Gene·Rat brain.

呈才 服食 色彩에 관한 硏究

정은혜,박재선 忠南大學校體育科學硏究所 2002 體育科學硏究誌 Vol.20 No.1

The purpose of this study was to know the different styles and symbolic meaning of Jeong-Jae's costumes. For the purpose of this study, it was conducted based on the various variables identified in an extensive review of related literature in the reigns of Sun-Jo(28th and 29th), Hun-Jong(14th), Go-Jong(24th), and Kwang-Mu(6th). The findings of this study were following as; (1)our traditional clothing was influenced by the incoming of the dress system of china which was attributed to the principles of Um-Yang, and the five elements and to the concept of Tae-Il. This foreign color concept was applied to the Jeong-Jae: (2) the Jeong-Jae had been changing in its many aspects through the time. But according to the five colors, the dress and its color had been changing: (3) with the color of the dress and its omament, there is a difference between the upper and lower suit in the colors of the Yang are blue, red, yellow, black, white and the Um are red, green , dark blue, jade green and black green. These compound colors were used in a very colorful way and the principles of Um-Yang and the five elements lie at the root of using these colors particularly in blue, white, red, black and yellow: (4) in the 29th year of Sun-Jo's reign, the Lee-Nam-Saek-Sang-Pyo-Hong-Cho-Sang was used widely. This used colors could not be used by a non-official civilian. There was the strict restriction of dress and omament. So, the queen wore dresses with yellow and red, the queen and the crown princess with red and the princess and the woman in a noble family with green. But in the Jeong-Jae dress and its omament, there was no classification: (5) the Mu-Go and the Cheo-Yung dancing dress which use the five colors clearly have their dress and its omament by the principles of Um-Yang, and the five elements. The Jeong-Jae-Yeo-Ryeong dress has the basic dress and its omament. The findings of these results implied that with isokinetic exercise programs used in this study, it is possible to recover muscular function in athletes with chronic ankle sprain. It was also indicated that extensive training involving a high number of repetitions and eccentric contractions was safe, effective, and well tolerated for the athletes with chronic ankle sprain.