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Kim, Chung Hyon,Kim, Jung Heon,Kim, Hyun Jung,Kim, Kun Woo,Lee, Joong Yeup,Yang, Soon Ha,Choe, Jin,Hwang, Doyeong,Kim, Ki Chul,Hwang, Eung Soo The Korean Society for Microbiology 2012 Journal of Bacteriology and Virology Vol.42 No.4
Adeno-associated virus (AAV) and human papillomavirus (HPV) DNAs were found in abnormal quality semen, early abortus and female genital tissues. It was suggested that they might cause male infertility and miscarriages. This study was performed to determine the detection rate of these viruses in the semen and to assess the relationship between the presence of virus and male factor infertility and recurrent miscarriages. Sixty-three of 99 recruited male were included in this study according to the completeness of follow-up and the sample availability. Fourteen male with normal reproductive capacity were allocated to control group, 15 male with abnormal results in semen analysis were grouped as male factor infertility (MF) group, and 34 male whose spouses have had history of repeated spontaneous abortions were designated as repeated miscarriage (RM) group. AAV and HPV were detected in semen by polymerase chain reaction. The detection rate of AAV in the MF infertility group and RM group was 60.0% and 50.0%, respectively, while 14.3% in the control group (p < 0.05). However, the differences in the detection rate of HPV were not statistically significant among groups. These results suggest that AAV could be related to repeated miscarriages and male infertility.
고식적 생리적, 예측, 변형 임상 및 약식 션트 공식들에의해 계산된 션트값의 상호비교
김대현,김종성,박재현,김성덕,함병문,김광우,김정수 대한마취과학회 1997 Korean Journal of Anesthesiology Vol.32 No.4
Background: There are many factors such as diffusion abnormality, V/Q mismatch, intrapulmonary shunt, alveolar hypoventilation and FIO2 in reducing arterial hypoxemia. Intrapulmonary shunting can be due to blood going from the right to the left side of the heart without respiring with alveolar gas(true shunt mechanism) or blood that respires but achieves a PaO2 less than the ideal (shunt effect mechanism). Understanding the portion of true shunt in patients with hypoxemia is very important indicator to analyze the effects of oxygen therapy. Several equations are used for calculation of physiologic shunt. The aim of this study was to calculate and compare shunts derived from four shunt equations; classic physiologic, estimated, modified clinical and simple equations. Method: After cardiovascular stability following open heart surgery, 40 patients were mechanically ventilated with an FIO2=1.0. Arterial and mixed blood gases were measured. We calculated and compared shunts by classic physiologic [S/T=(CcO2 CaO2)/(CcO2 CO2)], estimated [S/T=(CcO2 CaO2)/ (3.5 CcO2 CO2)], modified clinical [S/T= AaDO2 0.0031/(AaDO2 0.0031 CcO2 CaO2)], and simple equations [S/T=AaDO2/20]/ Results: Shunts by classic physiologic, estimated, and modified clinical shunt equation were 26.9 8.5%, 25.1 7.1%, and 26.3 8.2%, respectively and did not differ one another significantly. Shunts by simple shunt equations was 18.8 6.2% and significantly lower than those by other 3 equations(P$lt;0.05). Conclusions: It is reasonable to conclude that in post-open heart patients with stable cardiovascular function and mechanically ventilated with an FIO2=1.0, classic physiologic, estimated, and modified clinical shunt equations show a reliable reflection of the physiologic shunt. But simple equation (AaDO2/20) might be used as a simple estimate. (Korean J Anesthesiol 1997; 32: 567∼573)
Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis
Chung, Hyo Kyun,Ryu, Dongryeol,Kim, Koon Soon,Chang, Joon Young,Kim, Yong Kyung,Yi, Hyon-Seung,Kang, Seul Gi,Choi, Min Jeong,Lee, Seong Eun,Jung, Saet-Byel,Ryu, Min Jeong,Kim, Soung Jung,Kweon, Gi Rya The Rockefeller University Press 2017 The Journal of cell biology Vol.216 No.1
<P>Reduced mitochondrial electron transport chain activity promotes longevity and improves energy homeostasis via cell-autonomous and –non-autonomous factors in multiple model systems. This mitohormetic effect is thought to involve the mitochondrial unfolded protein response (UPR<SUP>mt</SUP>), an adaptive stress-response pathway activated by mitochondrial proteotoxic stress. Using mice with skeletal muscle–specific deficiency of <I>Crif1</I> (muscle-specific knockout [MKO]), an integral protein of the large mitoribosomal subunit (39S), we identified growth differentiation factor 15 (GDF15) as a UPR<SUP>mt</SUP>-associated cell–non-autonomous myomitokine that regulates systemic energy homeostasis. MKO mice were protected against obesity and sensitized to insulin, an effect associated with elevated GDF15 secretion after UPR<SUP>mt</SUP> activation. In <I>ob</I>/<I>ob</I> mice, administration of recombinant GDF15 decreased body weight and improved insulin sensitivity, which was attributed to elevated oxidative metabolism and lipid mobilization in the liver, muscle, and adipose tissue. Thus, GDF15 is a potent mitohormetic signal that safeguards against the onset of obesity and insulin resistance.</P>
Reactive Oxygen Species, NF-кB and Prostanoid in the Aging Process
Kim, You Jung,Chung, Hae Young,Im, Young Keun,Baek, Bong Sook,Kim, Jung Won,Shim, Kyung Hee,Kim, Hyon Jeen 동국대학교 의학연구소 1999 東國醫學 Vol.6 No.-
국 문 초 록 진핵세포에 있어서의 유전자 발현은 전사조절인자에 의해 영향을 받는다. 본 총설에서는 전사 인자인 NF-κB의 redox regulation과 glucocorticoid에 의한 조절에 대해 논하고자 한다. 또한 NF-κB를 통한 COX pathway에 있어서 노화의 영향에 대해 논하고자 한다. NF-κB binding activity를 electrophoretic mobility shift assay(EMSA)로 측정한 결과, 노화된 흰쥐에 있어서 NF- κB binding activity는 상당히 증가하였고, 이러한 증가는 COX-2 mRNA와 protein level에도 나 타났으며, 또한 ROS 생성과도 일치하는 결과이다. 즉, NF-κB activation, ROS 생성, COX activity 등과 같이, COX-mediated process 모두 나이에 따라 증가된 경향을 보였다. 이상의 결과 로서, ROS가 NF-κB를 통해 COX-2를 유도하였고, 이는 또한 노화과정에서 계속 증폭될 가능성 이 시사되었다. 이러한 ROS reaction은 cellular damage와 노화과정에서의 기능적 저하에 있어 중 요한 작용을 하리라 생각된다. Abstract Gene expression in eukaryotic cells is governed by nuclear transcription factors. This review will focus on the redox regulation of nuclear factor kappa B(NF-κB) and its modulation by glucocorticoid. We will also discuss the effect of age on the regulation of COX pathway via NF-κB with our several data. The age-related changes of NF-κB were examined using electrophoretic mobility shift assay(EMSA). The binding activity of NF-κB in aged rat was significantly increased with the corresponding increase in COX-2 mRNA and protein levels. These increases were closely parallel to the increased ROS generation and gene expression of COX-2. The COX activity shown by NF-κB activation and the ROS generation by COX-mediated process were all enhanced with age. These observation suggest that ROS might induce COX-2 via NF-κB related to inflammation, which is induced and amplified in the aging process. These ROS reactions appears to play an important role in cellular damage and functional degeneration during aging.
THE EFFECT OF AGE ON CYCLOOXYGENASE-2 GENE EXPRESSION : NF-κB ACTIVATION AND IκBα DEGRADATION
KIM, HYON-JEEN,KIM, KYU-WON,YU, BYUNG-PAL,CHUNG, HAE-YOUNG 부산대학교 유전공학연구소 2000 분자생물학 연구보 Vol.16 No.-
Increased oxidative stress resulting in the activation of NF-κB is thought to play crucial role in the expression of the cyclooxygenase-2 (COX-2), which is the is the key enzyme in proinflammatory prostanoid synthesis. In the current study, we investigated whether the aging process affects the status of the rodox-sensitive NF-κB in rat kidney, and how this age-related modulation is related to COX-2 gene expression and COX-derived reactive oxygen species (ROS). We found that the aging process strongly enhanced the activation of NF-κB and its DNA-brinding activity with an increased ROS status. Accompanied with the change in the of NF-κB and its IκBα as confirmed by the increased nuclear p65 protein. Thus, these data strongly indicated that the aging process increases NF-κB activity by downregulating IκBα. A closer examination further revealed that age-related oxidative status correlated with the increased COX-derived prostanoid biosynthetic process is mediated by the increased NF-κB-regulated COX activity. This increase in NF-κB activity was accompanied by the increased COX-2 mRNA and protein levels. Based on these data, we concluded that the age-related increase in redox-sensitive NF-κB translocation and binding activities are associated with increased ROS, and further that this transactivation was modulated by the age-related decrease of IκBα. ⓒ 2000 Elsevie Science Inc.
Kim, Hyun Jung,Kim, Chung Hyon,Lee, Soo Min,Choe, Seung Ah,Lee, Joong Yeup,Jee, Byung Chul,Hwang, Doyeong,Kim, Ki Chul The Korean Society for Reproductive Medicine 2012 Clinical and Experimental Reproductive Medicine Vol.39 No.3
Objective: To review the outcomes of preimplantation genetic diagnosis (PGD) using zona drilling with acid Tyrode's solution (chemical zona pellucida drilling, chemical ZD) and those of partial zona dissection (PZD). Methods: Clinical outcomes of seventy-one couples undergoing 85 PGD cycles from January 2005 to December 2010 were included. Blastocyst formation and the hatching rate, clinical pregnancy rate, ongoing pregnancy rate, implantation rate, and fetal gender ratio of the PZD and chemical ZD groups were compared. Results: Application of PZD resulted in a significantly higher rate of clinical pregnancy (40.7% vs. 15.4%, p=0.022), ongoing pregnancy (35.6% vs. 11.5%, p=0.023), and implantation (18.1% vs. 5.7%, p=0.007) compared with chemical ZD. Among non-transferred embryos, the rate of blastocyst formation on day 5 (49.1% vs. 39.5%, p=0.016) and hatching on day 6 (47.2% vs. 26.5%, p<0.001) were also significantly higher in the PZD group. Conclusion: The mechanical zona dissection (ZD) method showed better outcomes than chemical ZD in terms of the blastocyst development and pregnancy rate. In this study, the fact that chemical ZD was conducted in different period from mechanical method should be considered in interpreting the result.
A 4-week Repeated Oral Dose Toxicity Study of Plant Sterol Esters in Sprague-Dawley Rats
Kim, Jong-Choon,Yang, Byung-Chul,Lim, Kwang-Hyeon,Kang, Boo-Hyon,Kim, Choong-Yong,Kim, Kab-Sik,Chung, Dae-Won,Chung, Moon-Koo Korean Society of ToxicologyKorea Environmental Mu 2002 Toxicological Research Vol.18 No.1
The present study was conducted to investigate the potential subacute toxicity of plant sterol esters by a 4-week repeated oral dose in Sprague-Dawley rats. The test article was administered once daily by gavage to rats at dose levels of 0, 1000, 3000, and 9000 mg/kg/day for 4 weeks. During the test period, clinical sign, mortality, body weights, food and water consumption, ophthalmoscopy, urinalysis, hematology, serum biochemistry, gross finding, organ weight, and histopathology were evaluated. A reduction in the body weight was observed in females of the 9000 mg/kg group on day 27 after the initiation of treatment, but not in males of the group. There were no treatment-related effects on mortality, clinical sign, food and water consumption, ophthalmoscopy, urinarlysis, hematology, serum biochemistry, necropsy findings, organ weights, and histopathology in any treatment group. Based on these results, it was concluded that the 4-week repeated oral dose of plant sterol esters resulted in suppressed body weight in female rats at a dose level of 9000 mg/kg/day. In the condition of this study, target organ was not observed and the no-observed-adverse-effect level (NOAEL) was considered to be 9000 mg/kg/day for males and 5000 mg/kg/day for females.