Long-term Reliability of Diurnal Intraocular Pressure Patterns in Healthy Asians

Yeoun Sook Chun,In Ki Park,Ko Un Shin,Joon Mo Kim 대한안과학회 2017 Korean Journal of Ophthalmology Vol.31 No.2

Purpose: To determine the long-term repeatability of diurnal intraocular pressure (IOP) patterns in healthy Asian subjects without glaucoma. Methods: Twenty-three eyes in 23 healthy Asian subjects without glaucoma underwent diurnal IOP measurements using Goldmann applanation tonometry every 2 hours from 9 AM to 11 PM during two visits that were 8 weeks apart. To validate repeatability between visits, we calculated intra-class correlation coefficients (ICCs) mean IOP, peak IOP, minimum IOP, and IOP fluctuation at each time point and expressed the results as the difference between peak IOP and minimum IOP or as the standard deviation of all diurnal IOP values in the diurnal IOP curve. Results: IOP repeatability was excellent at all time points, with ICCs ranging from 0.812 to 0.946 (p < 0.001). The 9 AM IOP showed the best repeatability between visits (ICCs, 0.946). Repeatability of mean IOP, peak IOP, and minimum IOP was also excellent (ICCs ranging from 0.899 to 0.929). However, IOP fluctuations showed poor repeatability, with an ICC lower than 0.15. Conclusions: Long-term repeatability of diurnal IOP patterns in healthy Asian subjects was excellent. These findings suggest that IOP measurements at standardized times of the day will be useful for assessing the effectiveness of glaucoma therapy.

10 Gb/s 광전송 시스템 설계

이성은(Sung-Un Lee),고정훈(Jeong-Hoon Ko),전경규(Kyung-Gyu Chun),이유경(Yoo-Kyeong Lee),이만섭(Man-Seop Lee) 대한전자공학회 1996 대한전자공학회 학술대회 Vol.1996 No.11

최근 10년간 강원도내 소아의 혈중 칼슘농도의 변화

전고운,심준용,이재승,김병길,남궁미경,Chun Ko-Un,Shim Jun-Yong,Lee Jae-Seung,Kim Pyung-Kil,NamGoong Mee-Kyung 대한소아신장학회 2002 Childhood kidney diseases Vol.6 No.2

목적 : 최근 우리 나라의 음식물에는 칼슘을 보강한 제품이 널리 유통되고 있고, 사람들의 칼슘섭취에 대한 인식도 달라지고 있다. 최근 본원에서는 혈뇨를 주소로 내원하여 검사를 시행한 환아에게서 고칼슘뇨증 소견에 합당한 경우가 늘어나 이에 본원을 방문한 소아를 대상으로 최근 10년간의 혈중 칼슘치와 그에 관계된 혈중 ALP, 크레아티닌, 나트륨, 칼륨, 혈중 중탄산염과 요중 pH와의 상관관계 및 변화 양상을 비교 분석해 보았다. 대상 및 방법 : 1991년, 1992년과 2000년, 2001년 본원에서 편도선 및 아데노이드 제거수술과 고환 고정술 및 탈장 봉합술을 시행한 환아를 대상으로, 혈중 칼슘, ALP, 크레아티닌, 나트륨, 칼륨, 중탄산염과 요중 pH 값을 조사하였다. 연도군 별로는 1991년, 1992년에 355명의 환아와 2000년, 2001년에 488명의 환아를 대상으로 하여 각 연령군 간에 t-test를 통해 분석하였다. 결과 : 2001년도군에서는 칼슘, ALP, 크레아티닌, 나트륨, 칼륨, 소변 pH의 값이 각각 $9.91{\pm}0.50\;mg/dL,\;248.58{\pm}94.98\;U/L,\;0.61{\pm}0.14\;mg/dL,\;138.64{\pm}2.22\;mM/L,\;4.35{\pm}0.40\;mM/L,\;6.18{\pm}0.86$으로 1991년도군의 각 각의 값인 $9.13{\pm}0.68;mg/dL,\;198.26{\pm}79.34\;U/L,\;0.433{\pm}0.18\;mg/dL,\;137.86{\pm}2.67\;mM/L,\;4.22{\pm}0.36\;mM/L,\;5.83{\pm}0.95$에 비해 모두 P-value 0.05이하의 유의한 증가를 보였고, 혈중 중탄산염은 2001년도군에서는 $23.64{\pm}2.57\;mM/L$로 1991년도군의 $24.60{\pm}2.23\;mM/L$에 비해 P-value 0.000으로 통계적으로 유의한 감소를 보였다. 각 연령별, 성별 비교에서도 같은 양상을 보인다. 결론 : 최근 10년간의 강원도 소아의 혈중 칼슘치는 의미 있게 증가하였다. 이는 칼슘의 경구 섭취량의 증가에 기인한 것이 큰 영향을 미친다고 사료되며 이에 대한 재인식과 교육이 필요하다고 생각한다. Purpose : Nowadays, drinks, foods and snacks have frequently been intensified with calcium and the insights into the importance of calcium-intake in general has developed in Korea. In this decade, we found the numbers of children who was visited to our hospital for evaluation of hematuria defined with hypercalciuria were increased. So we tried to compare the mean levels of serum calcium, alkaline phosphate, sodium, potassium, chloride, BUN, creatinine, bicarbonate and urinary pH who visited our hospital in 1991, 1992 with in 2000, 2001. Materials and methods : Between January 1991 to December 1992, and between January 2000 to December 2001, each 366 children and 488 children, aged 1 month to 15 years, who presented in our hospital for tonsilectomy and adenoidectomy or for inguinal herniorrhaphy were enrolled in the study, The children in the study were checked the level of serum calcium, alkaline phosphate, sodium, potassium, chloride, BUN, creatinine, bicarbonate and urinary pH with the machine which was corrected the similar levels of practical chemical levels in serum. We compared each mean levels in 1991s' group with in 2001s' group totally and separately through the age and sex. We used t-test to analysis data. Results : The levels of serum calcium, alkaline phosphate, creatinine, sodium, potassium, and urinary pH of 2001s' group were significantly higher than the levels of 1991s' group(P<0.05). The each level was $9.91{\pm}0.50\;mg/dL,\;248.58{\pm}94.98\;U/L,\;0.61{\pm}0.14\;mg/dL,\;138.64{\pm}2.22\;mM/L,\;4.35{\pm}0.40\;mM/L,\;6.18{\pm}0.86$ in 2001s' and $9.13{\pm}0.68;mg/dL,\;198.26{\pm}79.34\;U/L,\;0.433{\pm}0.18\;mg/dL,\;137.86{\pm}2.67\;mM/L,\;4.22{\pm}0.36\;mM/L,\;5.83{\pm}0.95$ in 1991s'. And the levels of serum bicarbonate, $23.64{\pm}2.57\;mM/L$ in 2001s' was significantly lower than the 1991s', $24.60{\pm}2.23\;mM/L$(P<0.05). The similar results were detected each age and sex group. Conclusion : The levels of serum calcium increase in this decade. The results will be used as a basic data for the national health plan in the years to come.

Joubert 증후군 1례

최희원(Hee Won Choi) 전고운(Ko Un Chun) 김황민(Hwang Min Kim) 차병호(Byung Ho Cha) 대한소아신경학회 2004 대한소아신경학회지 Vol.12 No.1

저자들은 18개월 된 여아에서 주기성 빈호흡과 무호흡, 정신 발달 지체, 안구 운동 이상의 소견을 보여 실시한 뇌 자기공명 영상에서 소뇌 충부의 완전 결손을 보여 Joubert 증후군으로 진단된 1례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Joubert syndrome is a rare autosomal recessive condition characterized by dysgenesis of the cerebellar vermis, hypotonia, developmental delay, ataxia, abnomial eye movements, and a respiratory pattern of alternating tachypnea and apnea. Brain MRI shows the molar tooth sign resulting from dysplasia of the isthmic segment of the brain stem, superior cerebellar peduncles, and vermis. We experienced a case of Joubert syndrome, who was a 18 month-old female with episodic hyperpnea, developmental delay, abnormal eye movements and complete agenesis of the cerebellar vermis. We present this case with a brief review of literature.

유산소운동이 여자 아동의 뇌세포 생성 관련인자에 미치는 영향

Mi-Young Pyun(편미영),Han-Sam Cho(조한샘),Jae-Young Jeon(전재영),Jong-Won Kim(김종원),Kyung-Hee Lee(이경희),Chun-Kyu Lim(임춘규),Tae-Un Kim(김태운),Hyun-Jun Kim(김현준),Yi-Sub Kwak(곽이섭),Ki-Jun Ko(고기준) 한국생명과학회 2010 생명과학회지 Vol.20 No.6

운동은 신경의 생성, 적응, 보호 기능을 통해 뇌 기능 및 생성에 긍정적인 영향을 미치며, 유산소운동은 뇌신경 성장인자(GH, IGF-1, estrogen, serotonin)를 변화시키는 것으로 보고되었다. 본 연구는 여자 아동의 뇌기능 발달 및 뇌세포 생성 유도인자의 유산소운동 효과를 알아보고자 유산소운동 프로그램에 따른 뇌신경 성장인자(GH, IGF-1, estrogen, serotonin)의 변화를 분석하여 다음과 같은 결론을 얻었다. 반복측정 분산분석에 의해 운동군과 대조군의 평균을 비교한 결과 유산소운동은 집단간 유의한 차이를 보이며 체중, BMI, 체지방량, 체지방률을 감소시켰으며, 제지방률을 증가시켰다. 또한 뇌신경 성장인자인 serotonin을 감소시켰으며, GH와 IGF-1을 증가시켰다. 본 연구결과 유산소운동 프로그램이 아동의 체중, BMI, 체지방, 체지방률 감소와 제지방률 증가에 효과적이다. 또한 serotonin이 운동 후 감소된 결과를 볼 때 유산소운동 프로그램이 아동의 중추피로 감소에 효과적이며, GH, IGF-1의 운동 후 증가된 결과를 볼 때 유산소운동이 아동의 뇌기능 발달 및 뇌세포 생성 유도에 긍정적인 프로그램임을 알 수 있다. Exercise can favorably influence brain plasticity by facilitating neurogeneration, neuroadaptivity, and neuroprotection. Aerobic exercise has been reported to change brain nerve growth factors (growth hormone, insulin like factor-1, estrogen and serotonin). The purpose of this study was to demonstrate the effects of aerobic exercise for 12 weeks on brain nerve growth factors in girls. Fourteen female participants in elementary school grades 1 through 3 were randomly allocated to the exercise group (EG, n=6) and control group (CG, n=8). The EG participated in 60 minutes of modified ballet exercise as aerobic training three days a week for 12 weeks. Based on comparison between groups by two-way ANOVA with repeated measures, aerobic exercise program participants experienced decreased weight (p<0.01), BMI (p<0.01), fat mass (p<0.001), fat percent (p<0.001) and increased LBM (lean body mass) percent (p<0.001). In addition, we detected that aerobic exercise decreased the level of serotonin (p<0.05) and increased the level of GH (p<0.05) and IGF-1 (p<0.05). These findings suggest that aerobic exercise programs can be an efficient intervention to change body composition, alleviate central fatigue, improve brain function, and induce brain cell proliferation in girls.

산업재해의 관련 요인

고대석,최순석,정수진,박준한,이헌,손병철,엄상화,이채언,배기택,전진호 大韓産業醫學會 1997 대한직업환경의학회지 Vol.9 No.1

This study was conducted to estimate the causing factors of industrial accident, and to prepare the fittable control program for accident through the evaluation of views of the patients who suffered from accidents. From January 5 to February 6 1993, questionnaire survey was executed on 166 persons who were injured and covered by the insurance under industrial accident compensation law at four university hospitals in Pusan. The results were as follows : 1. Most of subjects worked in the manufacturing(56.6%) and constrution(29.5%), and in the small factory less than 49 workers(56.0%). They were thirties and fourties(63.8%), less than 3 years tenure(53.6%), habitual drinker(69.2%). And, 72.3% worked for above 9 hours per day, 53.6% worked as near clerks, 89.2% thought that work is rather suitable to his own personality. 2. Self-recognition for the causing factor of industrial accident was the other's malfunction(19.3%), carelessness(15.1%), lack of education for satefy(15.1%), and they thought the accident occured by mainly some defect of establishment and working environment (34.9%), unskillfulness(22.9%0, self-carelessness(22.3%). 3. The interests and recognition on safety was insufficient, 88.6% require job education, but 53% pointed out the necessity for strengthening of present status - rather incomplete with relying on self-education(40.9%), no previous participation in safety education(29.5%), etc. 4. For the kind of accident, fall-down(16.3%), crash(13.3%), falling(12.7%) was frequent, head(24.7%) and fracture(41.0%) was frequent for the part and type of injury, respectively. And, they had more injured by cooperative work(82.5%) than single work. As results, improvement of working environment and strengthening education program would be emphasized for the effective control of industrial accident. And, there should be prepared the specific prevention program for the small scale industries.

반측성 안면경련 18례의 Stylomastoid Foramen주위의 고주파 응고술 치료

박영섭,김문찬,박춘근,강준기,송진언 대한신경외과학회 1986 Journal of Korean neurosurgical society Vol.15 No.1

Patients with hemifacial spasm were treated with a radiofrequency stimulating assisted percutaneous radiofrequency facial nerve coagulation around the stylomastoid foramen. The initial series of 18 cases of facial spasm are described. The series included 10 men and 8 women, aged from 19 to 75 years. All patients had classical type intractable persistent hemifacial spasm. Although severe facial weakness was made after the procedure to control the heperactive dysfunction of facial nerve in all patient immediately after making lesion, all of them recovered within 6 months follow-up. The longest follow up has been 26 months and only one patient had repeated procedure who experienced recurrence of hemifacial spasm 6 months after initial procedure. The procedure is simple, easy to perform and has no definite complication except transient facial palsy.