http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Dae-Hyuk Heo,Yu Min Kang,송경호,Jun-Won Seo,Jeong-Han Kim,June Young Chun,전강일,강창경,Song Mi Moon,Pyoeng Gyun Choe,Wan Beom Park,Ji Hwan Bang,Eu Suk Kim,Hong Bin Kim,Sang-Won Park,Won Sup Oh,Nam Joong Kim,M 대한의학회 2020 Journal of Korean medical science Vol.35 No.11
Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease with high mortality in East Asia. This study aimed to develop, for primary care providers, a prediction score using initial symptoms and basic laboratory blood tests to differentiate between SFTS and other endemic zoonoses in Korea. Methods: Patients aged ≥ 18 years diagnosed with endemic zoonoses during a 3-year period (between January 2015 and December 2017) were retrospectively enrolled from 4 tertiary university hospitals. A prediction score was built based on multivariate logistic regression analyses. Results: Of 84 patients, 35 with SFTS and 49 with other endemic zoonoses were enrolled. In multivariate logistic regression analysis, independent predictors of SFTS included neurologic symptoms (odds ratio [OR], 12.915; 95% confidence interval [CI], 2.173–76.747), diarrhea (OR, 10.306; 95% CI, 1.588–66.895), leukopenia (< 4,000/mm3 ) (OR, 19.400; 95% CI, 3.290– 114.408), and normal C-reactive protein (< 0.5 mg/dL) (OR, 24.739; 95% CI, 1.812–337.742). We set up a prediction score by assigning one point to each of these four predictors. A score of ≥ 2 had 82.9% sensitivity (95% CI, 71.7%–87.5%) and 95.9% specificity (95% CI, 88.0%–99.2%). The area under the curve of the clinical prediction score was 0.950 (95% CI, 0.903–0.997). Conclusion: This study finding suggests a simple and useful scoring system to predict SFTS in patients with endemic zoonoses. We expect this strategic approach to facilitate early differentiation of SFTS from other endemic zoonoses, especially by primary care providers, and to improve the clinical outcomes.
Sang-Jin Kim(김상진),Young Joo Jeong(정영주),Sun Hee Choi(최선희),Chun Yeon Choi(최춘연),Hee Jae Jun(전희재),Il Soo Moon(문일수),Dae-Hyun Seog(석대현),Won Hee Jang(장원희) 한국생명과학회 2012 생명과학회지 Vol.22 No.9
γ-Aminobutyric acid (GABA)는 신경세포 밖으로 분비된 후 GABA 수송체들(GATs)에 의하여 다시 신경세포 안으로 재흡수 된다. 그러나, GABA 수송체들이 어떻게 연접전막의 위치에 안정적으로 존재하는지 또한 어떤 단백질과 결합하여 조절을 받는지는 알려져 있지 않다. 본 연구에서 효모 two-hybrid system을 이용하여 betaine-γ-aminobutyric acid transporter 1 (BGT-1/mGAT2)의 C-말단과 특이적으로 결합하는 Munc-18-interacting (Mint) 단백질을 분리하였다. BGT-1/mGAT2의 C-말단에 존재하는 “T-H-L” 아미노산배열은 Mint2와의 결합에 필수적으로 관여하였다. Mint2은 BGT-1/mGAT2와는 결합하지만, 다른 종류의 GAT와는 결합하지 않았다. 또한 HEK-293T 세포에 Mint2와 BGT-1/mGAT2을 동시에 발현시켜 면역침강한 결과 두 단백질은 같이 면역침강하였으며, 두 단백질은 세포 내에서 세포막 부위에 같이 존재함도 확인하였다. 이러한 결과들은 Mint2가 BGT-1/mGAT2와 결합하여 BGT-1/mGAT2을 조절하는 역할을 함을 시사한다. The action of neuronally released γ-aminobutyric acid (GABA) is terminated by uptake into the neurons by GABA transporters (GATs). The mechanism underlying the stabilization and regulation of GAT2 has not yet been elucidated. We used the yeast two-hybrid system to identify proteins that interact with and, thereby, regulate betaine-γ-aminobutyric acid transporter 1 (BGT-1/mGAT2). We found an interaction between BGT-1/mGAT2 and Munc-18-interacting proteins (Mints). The “T-H-L” motif at the C-terminal end of BGT-1/mGAT2 was essential for the interaction with Mint2 in the yeast two-hybrid assay. Mint2 bound to the tail region of BGT-1/mGAT2, but not to other GAT members. When co-expressed in HEK-293T cells, Mint2 was co-immunoprecipitated with BGT-1/mGAT2. In addition, we demonstrated the cellular co-localization of BGT-1/mGAT2 and Mint2 in the cells. These results suggest that Mint2 contributes to the regulation of BGT-1/mGAT2.
Effect of β-carotene on Cell Growth Inhibition of KB Human Oral Cancer Cells
Sung-Su Yang,Su-Gwan Kim,Byung-Sun Park,Dae-San Go,Sun-Kyoung Yu,Chun Sung Kim,Jeongsun Kim,Do Kyung Kim 대한구강생물학회 2016 International Journal of Oral Biology Vol.41 No.3
β-carotene is present in carrots, pumpkins, and sweet potatoes. It suppresses many types of cancers by regulating cellular proliferation and apoptosis through a variety of mechanisms. However, the effects of β -carotene on oral cancer cells have not been clearly established. The main goal of this study was to investigate the effects of β-carotene on cell growth and apoptosis in oral cancer cells. Our results demonstrate that treatment with β-carotene induced inhibition of cell growth, and that the effect was dependent on β-carotene treatment time and concentration in KB cells. Furthermore, treatment with β-carotene induced nuclear condensation and fragmentation in KB cells. β-carotene promoted proteolytic cleavage of procaspase-3, -7, -8 and –9 with associated increases in the concentration of cleaved caspase-3, -7, -8 and –9. In addition, the level of cleaved PARP was increased by β-carotene treatment in KB cells. These results suggest that β-carotene can suppress cell growth and induce apoptosis in KB human oral cancer cells, and that it may have potential usefulness in anti-cancer drug discovery efforts.
Poster Session 1 : Isoproterenol modulates the expression of RGS2 in C6 rat glioma cells
( Sung Dae Kim ),( Hui Min Lee ),( Hye Jin Sung ),( Sun Kyu Park ),( Tae Wan Kim ),( Kil Soo Kim ),( Jae Chan Song ),( Seung Chun Park ),( Won Gi Min ),( Jae Youl Cho ),( Man Hee Rhee ) 한국생화학분자생물학회 (구 한국생화학회) 2005 생화학분자생물학회 춘계학술발표논문집 Vol.2005 No.-
Case report of a pancreatic squamoid cyst
Dae-Gwang Yoo,Shin Hwang,Dae-Wook Hwang,Ki-Hun Kim,Chul-Soo Ahn,Tae-Yong Ha,Gi-Won Song,Dong-Hwan Jung,Gil-Chun Park,Sung-Gyu Lee 한국간담췌외과학회 2013 한국간담췌외과학회지 Vol.17 No.4
Squamoid cyst of the pancreas is a very rare disease and it has been proposed only recently as a distinct pathologic lesion. We herein present a case of pancreatic squamoid cyst in a patient who underwent laparoscopic resection. A 60-year-old woman had an abdominal computed tomography (CT) scan for a routine check-up, and a multi-cystic lesion of 1.8-cm in size was incidentally found in the tail of the pancreas. Biochemical laboratory tests were within normal limits. At first, we presumed that the most likely diagnosis of the cystic lesion was an intraductal papillary mucinous neoplasm. To treat this lesion, we performed laparoscopic spleen-saving distal pancreatectomy. The patient showed the usual routine postoperative course and she was discharged 10 days after surgery. On examination of the resected specimen, a well-defined, oligolocular cystic mass was found in the pancreatic tail, without a solid portion. Histologic examination revealed that the cysts had linings ranging from flat squamoid cells to transitional cells with non-keratinization. After immunohistochemical staining, the final diagnosis was confirmed to be squamoid cyst of the pancreas. This lesion appears to be regarded as a benign entity, thus an extended operation should be avoided and resection of the lesion can be performed minimally.
( Sung Woo Chun ),( Jae Yeol Jang ),( Dae Won Park ),( Hee Chul Woo ),( Jong Shik Chung ) 한국화학공학회 1997 Korean Journal of Chemical Engineering Vol.14 No.3
The catalytic performance of some metal oxides in the selective oxidation of H₂S in the stream containing water vapor and ammonia was investigated in this study. Among the catalysts tested, Co₃O₄/SiO₂was the most promising catalyst for practical application. It showed very small amount of SO₂ emission even in the presence of excess water and ammonia. The solid product formed in the reaction was a mixture of elemental sulfur, ammonium thiosulfate and ammonium sulfate.
Sung Ji Yeon,Seo Jong Do,Ko Dae-Hyun,박민정,Hwang Sang Mee,Oh Sohee,Chun Sail,성문우,Song Junghan,Song Sang Hoon,Park Sung Sup 대한진단검사의학회 2021 Annals of Laboratory Medicine Vol.41 No.2
Background: Reference intervals defined for adults or children of other ethnicities cannot be applied in the evaluation of Korean pediatric patients. Pediatric reference intervals are difficult to establish because children are in their growing stage and their physiology changes continuously. We aimed to establish reference intervals for routine laboratory tests for Korean pediatric patients through retrospective multicenter data analysis. Methods: Preoperative laboratory test results from 1,031 pediatric patients aged 0 month–18 years who underwent minor surgeries in four university hospitals were collected. Age- and sex-specific reference intervals for routine laboratory tests were defined based on the Clinical and Laboratory Standards Institute (CLSI) EP28-A3c guidelines. Results: The pediatric reference intervals determined in this study were different from existing adult reference intervals and pediatric reference intervals for other ethnicities. Most tests required age-specific partitioning, and some of those required sex-specific partitioning for at least one age-partitioned subgroup. Erythrocyte sedimentation rate, monocyte percentage, basophil percentage, activated partial thromboplastin time, glucose, cholesterol, albumin, bilirubin, chloride, and C-reactive protein did not show any difference between age- or sex-partitioned subgroups. Conclusions: We determined Korean pediatric reference intervals for hematology, coagulation, and chemistry tests by indirect sampling based on medical record data from multiple institutions. These reference intervals would be valuable for clinical evaluations in the Korean pediatric population.