홍씨 앞방각측정법의 임상적 유용성

강신희,박기호,홍철,김동명,Shin Hee Kang,M,D,Ki Ho Park,M,D,Chul Hong,M,D,Dong Myoung Kim,M,D 대한안과학회 2007 대한안과학회지 Vol.48 No.3

Purpose: To compare the Hong`s grading method, utilized for slit-lamp grading of the mid-peripheral angle, with other conventional grading methods. Actual angle was measured by ultrasound biomicroscopy (UBM) for comparison. Methods: Fifteen eyes with narrow angles and eighteen eyes with wide angles were studied. The average age of thirty-three subjects was 46.8±19.2, and the male to female ratio was 1:3.7. The mid-peripheral angle was graded by Hong`s, van Herick`s and Spaeth`s grading system. The actual anterior chamber angle was evaluated by UBM and the correlation between each grading system and actual angle was investigated. Results: The results from the Hong`s grading (r=0.802, R2=0.643, p<0.01), Spaeth`s grading (r=0.728, R2=0.530, p<0.01) and van Herick`s grading (r=0.618, R2=0.382, p<0.01) methods correlated significantly with the actual angles. Conclusions: The Hong`s grading method was an easy and effective tool to evaluate anterior chamber angle. In addition, the results of the Hong`s grading method were closer to the actual angle than the other methods.

The Gospel Implied in the Passover

Hong,Sung-Chul 한국신학교육연구원 2006 Korea Journal of Theology Vol.5 No.-

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

냉간시동 중 스파크 점화 엔진의 탄화수소 배출에 관한 연구

홍명석,안철봉,장원 조선대학교 에너지.자원신기술연구소 1999 에너지·자원신기술연구소 논문지 Vol.21 No.2

The emission characteristics of hydrocarbons during the cold start have been investigated. The measurements are focused upon the first 20 seconds of operation after starting with the engine and coolant initially at ambient temperature because this period has a major effect on HC emissions, over the FTP cycle, therefore decreasing cold start enrichment and decreasing the time to catalyst light-off are desirable. The engine examined is a 4-cylinder, 4-valve SI engine. The Motec engine control system is used to control ignition timing and fuel injector pulse width throughout the starting and warm-up transient. The engine started using the starter motor. Speciated HC emissions from the exhaust system of the engine have been obtained with 3 second time resolution during cold start using a exhaust gas sampling equipment. The emissions were initially enriched in light fuel alkanes and depleted in heavy aromatic species. The light alkanes feIl rapidly while the lower vapor pressure aromatics increased over a period of 50 sec. These results indicate early retention of low vapor pressure fuel components in the intake manifold and exhaust system. The atmospheric reactivity of the exhaust HC emissions for photochemical smog formation increases as the engine warms.

삼일열 말라리아에 합병된 비장 파열 1예

홍경욱,이정아,김원진,박철민,권혜리,박혜원,엄중식 대한감염학회 2007 감염과 화학요법 Vol.39 No.5

국내의 토착형 말라리아는 삼일열 말라리아로, 1993년부터 재유행이 시작되었다. 말라리아의 중요한 합병증으로 드물지만 비장 파열이 있는데, 이는 주로 삼일열 말라리아에 의해서 발생되며, 국내에서는 1999년 말라리아에 의한 비장 파열로 비장 절제술을 시행한 예가 보고된 바 있다. 현재까지는 비장 파열이 있을 때 비장 절제술이 일차적인 치료로 되어 있으나, 비장 절제술 후의 감염 위험성이 크므로, 활력 징후가 불안정하거나, 출혈이 지속되는 소견이 보이지 않으면 가급적 보존적 치료를 하는 것이 추천된다. 저자들은 비장 파열이 동반된 말라리아 환자에서 비장 절제술을 시행하지 않고 보존적 치료로 호전된 예를 경험하여 보고하는 바이다. Plasmodium vivax has been the predominant Plasmodium species in the Republic of Korea and reemerged in 1993. Spontaneous rupture of malarial spleen is a rare but important complication associated with P. vivax infection. Only one case of spontaneous rupture of malarial spleen was reported in Korea in 1999. Splenectomy is still accepted as the treatment of choice in cases of spontaneous rupture of the spleen. But, considering increased risk of postsplenectomy infecion, splenectomy should be reserved for those patients with severe rupture or those with continued or recurrent bleeding. And conservative treatment should be considered in selected, closely monitored patients. We report a patient with P. vivax malaria who developed a spontaneous splenic rupture and was improved by conservative treatment.

韓·日의 도구시스템과 생활시스템의 異同에 관한 연구

홍철순,이형복,김희규,김소철 慶南專門大學 1999 論文集 Vol.27 No.1

포트 분사 4밸브 엔진에서의 첫 번 크랭크 사이클 중 실린더 내부의 연료전달

홍명석,안철봉,박용태 조선대학교 동력자원연구소 1997 動力資源硏究所誌 Vol.19 No.1

Fuel transport was visualized within the cylinder of a port injected four-valve SI engine having a transparent cylinder liner. Measurements were made while motoring at 250rpm to simulate cranking conditions prior to the first firing cycle, and at 750rpm to examine the effects of engine speed. A production GM Quad-4 cylinder head was used, and the stock single-jet port fuel injector was used to inject indolene. A digital camera was used to capture back-lighted images of cylinder wall wetting for open and closed intake valve injection. In addition, two-dimensional planar imaging of Mie scattering from the indolene fuel droplets was used to characterize the fuel droplet distribution as a function of crank angle for open and closed intake valve injection. LDV was used to measure the droplet and air velocities near the intake valves during fuel injection. It was found that with open-valve injection a large fraction of the fuel impinged on the cylinder wall opposite the intake valves. This fuel did not completely vaporize over the engine cycle and built up over successive motored cycles. The small droplets that impinged upon the cylinder wall coalesced quickly due to surface tension forces, which impeded fuel vaporization from the cylinder wall. For closed-valve injection the fuel was stripped from the intake valves and ports very shortly after intake valve opening by the incoming air. There was very little impingement of fuel on the cylinder walls with closed-valve injection, but some fuel droplets apparently impinged on the piston top. It was observed that the droplets from closed-valve injection tend to be larger than those from open-valve injection, although this was not quantified. With closed-valve injection, droplets entering the cylinder had lower velocities than the incoming air. With open-valve injection, the early droplets entering the cylinder had higher velocities than the incoming air, but the droplets and air velocities were very close for most of the injection period.

FNN을 이용한 직류 전동기의 온-라인 위치제어기 설계

홍철호,김문수,김정도 三陟大學校 2000 論文集 Vol.33 No.1

In this paper we propose a structure of controller using a fuzzy-neural network(FNN) which includes both advantages of the fuzzy logic and the neural networks. The basic idea of the FNN is to realize the fuzzy rule-base and the process of reasoning by neural network and to make the corresponding parameters be expressed by the connection weights of neural the performance and applicability of the proposed structure of controller.

Quinlolone 유도체 국소도포에 의한 좌창치료의 임상적 연구

권철욱,노영석,김재홍,조소연,강형철,함정희 大韓臨床藥理學會 1994 臨床藥理學會誌 Vol.2 No.2

中.長距離 달리기의 最適戰略에 關한 數理的 模型

洪盛杓,全鍾貴,崔哲圭 忠南大學校體育科學硏究所 1988 體育科學硏究誌 Vol.6 No.1

The mathematical theory of competitive running by Keller, which is based on the Newton's second law of motion, is applied to analyze the track records of the Asian and Korean athlets. In addition, the empirical formular proposed by Toots is used to represent the aver age speed of the runners for various races. The main conclusions arrived at are as follows. 1. According to the Keller theory, running at a constant speed is an optimum strategy throughout the races except the initial two seconds and the final 3 seconds, approximately, for distances greater than certain critical distances. But it is effective to run at a full speed with maximum propulsion, for the short distance sprints. 2. The critical distances obtained from the records are 291m for the World records, and 298 (320m for women) and 303m (330m for women) for Asian and Korean records, respectively. Thus the 400m race may be considered the reference item for the mid-range race. 3. Korean athletes show rather inferior physiological characteristics for the most cases analyzed, with the only exception for the oxygen supply rate of male athelets, which is somewhat greater than that of the Asian records. This may indicate a passilility of future development of superior mid and long distance runner from Korean athletes.