http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Chuanhui Li,c Wei Hu (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
-
Chuanhui Zong,Yiang Sun,Na Zhang,Fei Wang,Aixiang Li,Qiuhong Li,Zijian Lyu 한국고분자학회 2019 Macromolecular Research Vol.27 No.8
Tumors have emerged as the number one cause of death with the incidence rate rising rapidly due to various factors. Nanoparticle-mediated PolyI:C (PIC) delivery is a promising approach in the treatment of various tumors. However, the delivery of PIC to target cells is very difficult. Therefore, it is necessary to develop carriers which can safely deliver PIC to the target cells. In this study, chitosan-g-poly (ethylene glycol)-g-polyethyleneimine copolymer (CS-g-PEG-g-PEI) which delivers PIC as a carrier was synthesized by carbonyldiimidazole (CDI) coupling method using ionic liquid as the reaction medium. The results of Fourier transform infrared spectroscopy (FT-IR), nuclear magnetic resonance spectroscopy (1H NMR and 13C NMR), elemental analysis and gel permeation chromatography (GPC) showed that PEG and PEI were grafted onto CS successfully. The result of cytotoxicity assay indicated low levels of cytotoxicity in CS-g-PEG-g-PEI. The positively charged CS-g-PEG-g-PEI self-assembled with the negatively charged PIC to form composite nanoparticles whose physicochemical properties were studied. The results of stability experiments and subsequent gel electrophoresis indicated that the stability of nanoparticles solution was good with water as a solvent, CS-g-PEG-g- PEI as a carrier, the ratio of nitrogen/phosphorus (N/P) is 8, and the concentration of PIC as 0.5 mg/mL. CS-g-PEG-g-PEI could bind to PIC almost completely and effectively protect it from degradation of Rnase A at N/P=8, and the PIC encapsulation efficiency was over 87%. The results of morphological characterization showed that nano-sized self-assembled aggregates with core-shell structure could be prepared successfully. This provides a new carrier for long-circulation and research of solid tumor drug delivery system.
-
Identifying gas hydrate occurrence state by seismic P-wave attenuation in northern South China Sea
Danqing Dai,Xuewei Liu,Chuanhui Li 한국지질과학협의회 2018 Geosciences Journal Vol.22 No.3
In the process of gas hydrates exploration, the gas hydrate occurrence state is the key factor to determine the exploiting method. In this paper, we find a way to identify gas hydrate occurrence states by seismic P-wave attenuation. We find that the P-wave attenuation characteristics are different between the pore-filling hydrate-bearing sediments and the fracture-filling hydratebearing sediments. The attenuation is prominent in fracture-filling hydrate-bearing sediments. However, the pore-filling hydratebearing sediments have week attenuation effect. We use this difference to identify the gas hydrate occurrences state and apply it in northern South China Sea. The results depict that the P-wave attenuation is an effective attribute to identify gas hydrate occurrence states, which lays a foundation for the identification of gas hydrate occurrence state by seismic P-wave attenuation.
-
Mohamad Abdalkader,Stephanos Finitsis,Chuanhui Li,c Wei Hu,Xinfeng Liu,Xunming Ji,Xiaochuan Huo,Fana Alemseged,Zhongming Qiu,Daniel Strbian,Volker Puetz,James E. Siegler,Shadi Yaghi,Kaiz Asif,Piers Kl 대한뇌졸중학회 2023 Journal of stroke Vol.25 No.1
Background and Purpose The optimal management of patients with acute basilar artery occlusion (BAO) is uncertain. We aimed to evaluate the safety and efficacy of endovascular thrombectomy (EVT) compared to medical management (MM) for acute BAO through a meta-analysis of randomized controlled trials (RCTs). Methods We performed a systematic review and meta-analysis of RCTs of patients with acute BAO. We analyzed the pooled effect of EVT compared to MM on the primary outcome (modified Rankin Scale [mRS] of 0–3 at 3 months), secondary outcome (mRS 0–2 at 3 months), symptomatic intracranial hemorrhage (sICH), and 3-month mortality rates. For each study, effect sizes were computed as odds ratios (ORs) with random effects and Mantel-Haenszel weighting. Results Four RCTs met inclusion criteria including 988 patients. There were higher odds of mRS of 0-3 at 90 days in the EVT versus MM group (45.1% vs. 29.1%, OR 1.99, 95% confidence interval [CI] 1.04–3.80; P=0.04). Patients receiving EVT had a higher sICH compared to MM (5.4% vs. 0.8%, OR 7.89, 95% CI 4.10–15.19; P<0.01). Mortality was lower in the EVT group (35.5% vs. 45.1%, OR 0.64, 95% CI 0.42–0.99; P=0.05). In an analysis of two trials with BAO patients and National Institutes of Health Stroke Scale (NIHSS) <10, there was no difference in 90-day outcomes between EVT versus MM. Conclusion In this systematic review and meta-analysis, EVT was associated with favorable outcome and decreased mortality in patients with BAO up to 24 hours from stroke symptoms compared to MM. The treatment effect in BAO patients with NIHSS <10 was less certain. Further studies are of interest to evaluate the efficacy of EVT in basilar occlusion patients with milder symptoms.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
