Methazolamide와 Acetazolamide 복용 후 유발된 천식 1예

이건화,이영목,김양기,김기업,어수택,박춘식 대한알레르기학회 2004 천식 및 알레르기 Vol.24 No.2

혼합모형분석을 위한 통계패키지의 비교

이장택,윤춘식 단국대학교 1998 論文集 Vol.33 No.-

Statistical packages have provided many procedures of analysis for mixed models most recently. This paper presents how to choose some procedures of analysis for mixed models and compares special characters of SAS with SPSS, S­PLUS and MINITAB.

원발성 폐암 환자의 생존율에 관한 보고

김현태,이상무,어수택,박춘식,정성환,허승재,남충희,강창희,김용훈 순천향대학교 1994 논문집 Vol.17 No.4

We analysed 404 patients with primary lung carcinoma who were treated at Soonchunhyang University Hospital from July, 1985 to september, 1993 in order to investigate the survival rate and epidemiolgical properties of primary lung cancer. They were 330 males and 74 females. The most prevalent decade was seventh. In terms of cell type, the squamous cell was 225 patients (55%), and adenocarcinoma, small cell, mixed type was 21%, 19%, 4%, respectively. Among non-small cell lung carcinoma, stage Ⅲa was the most prevalent one(92%). In case of small cell carcinoma, the limited stage was 64%. The 12-, 24-, 36- month survival rate of total patients was 57%, 31%, 22%, respectivley and median sruvival time was 15 months. The 36-month survival rate tended to be longer in non-small cell lung carcinoma than that of small cell lung cancer, but there was no difference between two groups, statistically. In non-small cell carcinoma, The 36-month survival rate and meidan survival time were longer in the stage Ⅰ and Ⅱ than those of Ⅲa, Ⅲb, Ⅳ (80% versus 38%, 22%, 0%, p<0.05). According to involvement of lymph node, the 36-month survival rate was longer in NO and N1 than those of N2, N3 (61.9%, 48.7% versus 17.7%, 17.3%, p<0.05). In small cell carcinoma, The 36-month survival rate and median survival rate were higher and longer in limited stage than those of extensive stage(16.1% and 13 month vs 10% and 8 month, p<0.05). In conclusion, we report here the incidence of primary lung carcinoma and the survival rate of paients with primary lung carcinoma who were treated in Soonchunhyang University Hospital.

ZnSe 단결정에 대한 열자극 발광과 열자극 전류의 동시측정

전경남,유승철,고석룡,신용규,김택성,이춘호 全北大學校 基礎科學硏究所 1994 基礎科學 Vol.17 No.-

두 종류의 ZnSe 분말을 사용하여 sublimation 방법으로 성장한 ZnSe 단결정(as grown)에 대하여 TSC와 TSL을 동시 측정하였으며, PL과 DLTS를 측정하였다. PL 측정으로 I_1, I_2와 DAP 발광을 관측하였으며 DLTS에 의한 깊은준위를 관측하였다. TSL과 TSC의 동시 측정으로부터 얻은 그로우 곡선을 점근 해법으로 분해하여 세개의 준위를 얻었으며 그들의 활성화에너지값은 0.22 eV, 0.30 eV, 0.39 eV이었다. PL spectrum과 열자극 완화과정의 동시 측정 결과로부터 0.22 eV 근방에 impurity에 의한 주게준위와 native defect에 의한 받게준위가 각각 전도대의 아래와 가전자대의 위에 존재하는 것으로 판명되었다. DLTS 측정과 동시측정 결과로부터 0.30 eV와 0.39 eV의 준위는 V_se vacancy와 관련되는 주게 준위임을 알았다. Simultaneous measurements of TSL were carried out on ZnSe single crystals grown by high pressure Bridgman technique and the PL and DLTS signals were observed. Photoluminescence spectrum at 10 K on the ZnSe crystal reveals I_1 and I_2 lines, as well as DAP emission line. DLTS spectrum on the ZnSe crystal show electron trap at 0.33 eV. Two TSC and TSL peaks were observed near 215 K and 230 K, which are identified as having originated from two donor trap levels at 0.30 eV and 0.39 eV, respectively, below the bottom of the conduction band. We also observed single TSL and TSC peaks at 150 K which were identified as having originated from a donor and acceptor trap levels at about 0.22 eV below the conduction band and over the top of the valence band, respectively.

위암세포주에서 Recombinant Human Interferon-r와 Adriamycin의 투여순서가 항암효과에 미치는 영향

홍원선,손영숙,김창민,강윤구,이춘택,김유철,임영혁,남현석,이진오,강태웅 大韓免疫學會 1993 大韓免疫學會誌 Vol.15 No.-

Numerous previous studies, both in vitro and in vivo, have demonstrated that the cytotoxicity can be enhanced by the combination of chemotherapeutic agent and interferons(IFNs) in various types of cancer cells. We have previously reported that combined treatment of MKN-45, human gastric adenocarcinoma cells, with adriamycin(ADM) and recombinant human interferon-r(rh-IFN-r) increased in the cytotoxicity. In this study, the effects of combination timing of rh-IFN-r and ADM on the cytotoxicity against MKN-45 were investigated using MTT assay. MKN-45 was treated with rh-IFN-r and ADM in vitro on three schedules : Treat A ; rh-IFN-r and ADM were treated simultaneously, Treat B ; rh-IFN-r was treated 24 hours after the treatment with ADM, Treat C ; rh-IFN-r was treated for 72 hours and followed by the treatment with ADM. The survival of MKN -45 was inhibited by ADM dose-dependently. 102 and 103U/ml of rh-IFN-r significantly inhibited the survival of MKN-45(% survival : 35.1 ±-1.2% and 34.4 ±1.1% in Treat A and 42.5 ± 2.1% and 45.9-±2.5% in Treat C, respectively). However no difference in the survival was observed between 102 and 103U/ml of rh-IFN-r. Combined treatment with rh-IFN-r and ADM significantly augmented the cytotoxicity at low concentrations of ADM. Combined effects of rh-IFN-r and ADM were evaluated using IC30(,ag/ml) to ADM. IC30s of MKN-45 in Treat A, B and C at 102 U/ml of rh -IFN-r _ were 0.019 -?- 0.003, 0.045 :I:0.001 and 0.054 ± 0.012, respectively, while IC30 of MKN-45 treated with ADM alone was 0.052±0.004. IC30s of MKN-45 in ADM alone group, Treat A, Treat B and Treat C at 103U/ml of rh-IFN-r were 0.047 ±0.003, 0.004 -±0.001, 0.031 ±0.004 and 0.056 0.008, respectively. These results indicate IC30s of Treat A and B were significantly lower than those of ADM alone(p<0.05) and IC30s of Treat A was significantly lower than those of Treat B(p <0.01). IC30s of Treat C, however, were not different from those of ADM alone. From these results demonstrating that cytotoxic effects were increased by the combination of rh-IFN-r and ADM in the order, Treat A > Treat B> Treat C, it can be concluded that the simultaneous administration of rh-IFN-r and ADM may be the most effective method to combine these two therapeutic modalties.

Blockade of NF-κB activation by IκBα gene therapy enhances radiation sensitivity and abolishes acquired resistance to radiation.

Lee, Choon-Taek,Park, Mi Young,Kim, Dal Rae,Choi, Eun Kyung,Yoo, Chul-Gyu,Kim, Young Whan,Han, Sung Koo,Shim, Young-Soo,Kim, Yeon-Soo D. A. Spandidos 2009 MOLECULAR MEDICINE REPORTS Vol.2 No.3

<P>Radiation is one of the main treatment modalities in lung cancer, but low sensitivity and acquired resistance of lung cancer cells to radiation frequently result in treatment failure. The activation of nuclear factor (NF)-κB is reportedly the main mechanism by which cancer cells exhibit resistance to external stresses, such as chemotherapy or radiation therapy. In this study, we blocked the activation of NF-κB by adenovirus-expressing IκBα-SR and investigated the effect this had on radiation sensitivity. Transduction with ad-IκBα effectively blocked the activation of NF-κB by radiation in all the cancer cell lines tested, except for NCI H460. Clonogenic assay after radiation demonstrated that ad-IκBα transduction enhanced the sensitivity to radiation of the lung cancer cell lines and HeLa cells, except for NCI H460. The radiosensitizing effect of IκBα was more potent in lung cancer cell lines with radioresistance (SKMESres) (sensitizer enhancement ratio 1:61). From these findings, NF-κB blockade by ad-IκBα enhanced the radiation sensitivity and also abolished the acquired radiation resistance of lung cancer cell lines. This study provides a therapeutic rationale for combining an NF-κB-blocking strategy with radiation to both increase sensitivity and overcome acquired resistance to radiation.</P>

Cancer Gene Therapy with Adenovirus-murine GM-CSF

( Choon Taek Lee ),( Shan Wu ),( Ilja F. Ciernik ),( David P. Carbone ) 대한결핵 및 호흡기학회 1995 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.81 No.-

CDMA-Based Ubiquitous $SaO_2$ Monitoring System for Oxygen Therapy Patients

Lee, Seung-Yup,Kang, Jae-Min,Shin, Il-Hyeung,Lee, Jae-Ho,Lee, Choon-Taek,Kim, Hee-Chan The Korean Society of Medical and Biological Engin 2006 의공학회지 Vol.27 No.5

In this paper, we propose a ubiquitous $SaO_2$ monitoring system for patients using oxygen therapy. For these patients, the ability to monitor oxygen saturation ubiquitously is very important fur accurate adjustment of ventilator's flow rate to match the patient's time-varying requirements with the shortest lag time possible. We have developed a portable device to measure $SaO_2$ and transmit it to hospital in real-time or in store-and-forward mode through the integration of $Bluetooth^{TM}$ technology and the code division multiple access (CDMA) cellular network. We also developed software for doctors to receive and manage the patients' $SaO_2$ information. Performance of the developed system was evaluated as acceptable by assessing the accuracy of the measured oxygen saturation value and the stability of communication network. Test results in real clinical setting demonstrate that our system is feasible for immediate use in home oxygen therapy.

Successful Removal of Endobronchial Blood Clots Using Bronchoscopic Cryotherapy at Bedside in the Intensive Care Unit

Lee, Hongyeul,Leem, Cho Sun,Lee, Jae Ho,Lee, Choon-Taek,Cho, Young-Jae The Korean Academy of Tuberculosis and Respiratory 2014 Tuberculosis and Respiratory Diseases Vol.77 No.4

Acute airway obstruction after hemoptysis occurs due to the presence of blood clots. These conditions may result in lifethreatening ventilation impairment. We report a case of obstruction of the large airway by endobronchial blood clots which were removed using bronchoscopic cryotherapy at the bedside of intensive care unit. A 66-year-old female with endometrial cancer who had undergone chemotherapy, was admitted to the intensive care unit due to neutropenic fever. During mechanical ventilation, the minute ventilation dropped to inadequately low levels and chest radiography showed complete opacification of the left hemithorax. Flexible bronchoscopy revealed large blood clots obstructing the proximal left main bronchus. After unsuccessful attempts to remove the clots with bronchial lavage and forceps extraction, blood clots were removed using bronchoscopic cryotherapy. This report shows that cryotherapy via flexible bronchoscopy at the bedside in the intensive of intensive care unit is a simple and effective alternative for the removal of endobronchial blood clots.

Adenoviral Gene Therapy for Lung Cancer

Lee, Choon-Taek 가톨릭 의과학연구원 1997 가톨릭 의과학연구원 국제학술대회 Vol.1 No.-