Chlamydia pneumonia의 omp1 유전자 염기서열 분석

최태열,김덕언,금동극 대한임상병리학회 1999 대한임상병리학회지 Vol.19 No.5

원형톱에 의한 속성수 절단 소요 동력에 관한 연구

최윤성 ( Yun Sung Choi ),김대현 ( Dae Hyun Kim ),오재헌 ( Jae Heun Oh1 ) 한국임학회 2014 산림과학 공동학술대회 논문집 Vol.2014 No.-

본 연구에서는, 단벌기 바이오매스 생산림(Short rotation forest, SRF)에 식재되어 있는 속성수인 이태리포플러( Populus euramericana)을 이용하여 수확 시 소요되는 동력을 측정하여 수확기계동력원을 선정하기 위한 기초자료를 제공하기 위하여 수행되었다. 실험 수준은 밀기속도(0.41, 1.25,2.5 m/s) 3수준, 절단속도(800, 1,000, 1,200 rpm) 3수준, 직경(50, 70, 90, 110, 130 ㎜) 5수준으로 선정하였다. 실험결과, 밀기속도에 따른 최대토크는 0.41 m/s 일 때 30.4 N-m, 최소동력은 191.37 W로나타났다. 밀기속도 1.25 m/s 일 때 최대토크와 최소동력은 각각 30.1 N-m, 194.88 W, 2.5 m/s 일때 최대토크와 최소동력은 각각 31.9 N-m, 204.10 W로 나타났다. 또한 밀기속도 0.41 m/s 보다 2.5m/s 일 때 최대토크는 각각 4.8, 10, 7.2%, 최소동력은 6.8, 10, 11.8%가 증가하였으며, 밀기속도 0.41m/s 인 경우보다 6.8% 많은 동력을 필요로 하는 것으로 나타났다. 따라서, 실험결과를 바탕으로 측정된 소요 동력 기준으로 수확기계의 동력원을 선정할 수 있을 것으로 판단된다. In this study, Italy poplar( Populus euramericana) was selected for test specimen to measure cutting power when it harvested. Three levels of feed rate (0.41, 1.25, 2.5 m/s), three levels of sawing speed (800, 1,000, 1,200 rpm), and five levels of stem diameter (50, 70, 90, 110, 130 ㎜) were used as test variables. As results, the maximum torque, 30.4 N-m for feed rate 0.41 m/s, the minimum power, 191.37 W. The maximum torque and power, such as 30.1 N-m, 191.37 W for feed rate 1.25 m/s. The maximum torque and power, such as 31.9 N-m, 204.10 W for feed rate 2.5 m/s. Also, feed rate 0.41 m/s than feed rate 1.25 m/s, the maximum torque such as 4.8, 10, 7.2%, minimum power 6.8, 10, 11.8% increased. The feed rate 0.41 m/s than 6.7% many power to required. Using the results of this experiment as the base, The measured power source of the power requirements by the harvesting machine is determined to be able to select.

갑상선 종양에서 Heat Shock Protein70과 Heat Shock Protein90의 발현 양상

최진욱,김진영,박철영<SUP>1<.SUP>,오기원<SUP>1<.SUP>,임성희<SUP>1<.SUP>,박성우<SUP>1<.SUP>,조현득<SUP>2<.SUP>,이명준<SUP>3<.SUP>,김이수,Jin Wook Choi,M.D.,Jin Yong Kim,Cheol Young Park,M.D.<SUP>1<.SUP>,Ki Won Oh,M.D.<SUP>1<.SUP> 대한갑상선-내분비외과학회 2004 The Koreran journal of Endocrine Surgery Vol.4 No.2

Purpose: Heat shock proteins (hsps) are synthesized by cells in response to various stress conditions, including carcinogenesis. The expression of hsps in neoplasia has been implicated in the regulation of cell signaling pathway such as cell survival and apoptosis. This study aimed to determine whether hsps expression in various thyroid neoplasia are significant and to identify the possibility as a therapeutic molecular target. Methods: We examined the expression of the hsp70 and hsp90 on tissue section from 53 thyroid tissues (16 normal tissues; 11 nodular hyperplasia; 12 follicular adenomas; 14 papillary carcinomas) using immunohistochemistry. Hsps expression was scored according to the percentage of positively stained cells (grade 0 to grade III). Results: For hsp70, all of the 53 tissues showed over- expression. 100% (16/16) of normal thyroid tissue and 87.0% (20/23) of benign tissue were categorized as grade I or II. In comparison, the carcinoma tissues showed expression in 64.3% with grade III. For hsp90, almost of normal thyroid tissue and benign tumors showed no expression (87.5% in normal tissues, 91.3% in benign tumors). However, all of carcinoma tissues showed expression and 78.6% (11/14) of carcinoma were in grade II or III. Conclusion: In current study, the pattern of expression for hsp70 and hsp90 in normal, benign, malignant thyroid tissues suggests that heat shock proteins might have some role in tumorigenesis in thyroid. Since there have been no reports on heat shock proteins and thyroid, further study is necessary and could give us clinically significant clue for diagnosis and treatment. (Korean J Endocrine Surg 2004; 4:79-84)

Enantiomeric Resolution of α-Amino Acid Derivatives on Two Diastereomeric Chiral Stationary Phases Based on Chiral Crown Ethers Incorporating Two Different Chiral Units

Hee Jin Kim1,Hee Jung Choi,Yoon Jae Cho,현명호 대한화학회 2010 Bulletin of the Korean Chemical Society Vol.31 No.6

Two diastereomeric chiral stationary phases (CSPs) were applied to the liquid chromatographic resolution of various racemic α-amino methyl esters, α-amino N,N-diethylamides and α-amino N-propylamides. The CSP incorporating (R)-3,3’-diphenyl-1,1’-binaphtyl and (R,R)-tartaric acid unit as chiral barriers did not show any chiral recognition. In contrast,the CSP incorporating (R)-3,3’-diphenyl-1,1’-binaphtyl and (S,S)-tartaric acid unit as chiral barriers was found to show excellent chiral recognition especially for the two enantiomers of α-amino N-propylamides. Some of α-amino methyl esters and α-amino N,N-diethylamides were also resolved on the CSP incorporating (R)-3,3’-diphenyl-1,1’-binaphtyl and (S,S)-tartaric acid unit. From these results it was concluded that the two chiral units composing the diastereomeric CSPs can show “matched” or “mismatched” effect on the chiral recognition according to their absolute stereochemistry.

Development of a Reduction Algorithm of GEO Satellite Optical Observation Data for Optical Wide Field Patrol (OWL)

Sun-youp Park,Jin Choi1,Jung Hyun Jo,Ju Young Son,Yung-Sik Park,Hong-Suh Yim,Hong-Suh Yim,Hong-Kyu Moon,Young-Ho Bae,Jang-Hyun Park 한국우주과학회 2015 Journal of Astronomy and Space Sciences Vol.32 No.3

An algorithm to automatically extract coordinate and time information from optical observation data of geostationary orbit satellites (GEO satellites) or geosynchronous orbit satellites (GOS satellites) is developed. The optical wide-field patrol system is capable of automatic observation using a pre-arranged schedule. Therefore, if this type of automatic analysis algorithm is available, daily unmanned monitoring of GEO satellites can be possible. For data acquisition for development, the COMS1 satellite was observed with 1-s exposure time and 1-m interval. The images were grouped and processed in terms of “action”, and each action was composed of six or nine successive images. First, a reference image with the best quality in one action was selected. Next, the rest of the images in the action were geometrically transformed to fit in the horizontal coordinate system (expressed in azimuthal angle and elevation) of the reference image. Then, these images were median-combined to retain only the possible non-moving GEO candidates. By reverting the coordinate transformation of the positions of these GEO satellite candidates, the final coordinates could be calculated.

기저세포 상피암에 대한 임상적 및 조직학적 관찰

최혜민,명기범,국홍일 梨花女子大學校 醫科大學 醫科學硏究所 1984 EMJ (Ewha medical journal) Vol.7 No.1

The clinical and histopathological analysis was done on 28 cases of basal cell epithelioma encountered in the Department of Dermatology, Ewha Womans University Hospital during the past 7 1/2 years period from January 1976 to June 1983. The results obtained were summarized as follows : 1) Of 28 patients, 15 cases were male and 13 cases were female with ratio of 1.16:1. 2) Average age was 53.5 years ranging from 15 to 90 years with the highest incidence rate in the age group 60-69 years. 3) Three cases of basal cell epithelioma in the young age group developed from xeroderma pigmentosum. 4) The average duration of disease was 7.5 years ranging from 1 to 20 years. 5) Twenty seven cases(96.4%) occured on face comprising 11 cases on nose, 8 cases on lower eyelid, 3 cases on cheek, each 1 case on forehead, eyebrow, upper lip, angle of mouth and mandible, and remaining 1 case occured on back. 6) The most common noduloulcerative lesion was observed in 7 cases(25.0%), and then followed by(in order)adenoid type and sclerosing type 6 cases (21.4%) respectively, mixed type 5 cases(17.9%) and keratotic type 4 cases(14.3%).

재생불량성빈혈, 골수이형성증후군, 발작성야간혈색소뇨증에서 CD59의 분석 및PIG-A 유전자 돌연변이 선별검사

장윤환,조한익,박성섭,박명희,이동순,이영준,허미나,김병국,박선양,최영희 대한임상병리학회 2000 대한임상병리학회지 Vol.20 No.3

갑상선 유두암과 동반된 갑상선 MALT 림프종 1예

최영현,오성수,이광민<SUP>1<.SUP>,주명진<SUP>1<.SUP>,Young-Hyun Choi,M.D.,Sung-Soo Oh,M.D.,Kwang-Min Lee,M.D.<SUP>1 <.SUP>and Myung-Jin Joo,M.D.<SUP>1<.SUP> 대한갑상선-내분비외과학회 2002 The Koreran journal of Endocrine Surgery Vol.2 No.1

There are thyroid lymphoma and thyroid papillary cancer in thyroid disease which can happen being associated with Hashimoto's thyroiditis. Thyroid lymphoma is a rare disease consisting of less than 1% of lymphoma and of 5% of thyroid cancer. It occurs with Hashimoto's thyroiditis in 75%, and the cause is the immune reaction in which autoantibodies originated from thyroid are exposed B-cell continually. Also, the incidence of thyroid cancer, especially thyroid papillary cancer, increases in Hashimoto's thyroiditis. The reason is that the genetic change-RET/PTC mutation- of Hashimoto's thyroiditis is specific to thyroid papillary cancer than to other cancer. Patients usually complain neck nodule or sudden neck mass growing, hoarseness and respiratory difficulty. FNA, USG, Neck CT, MRI, and RI scan can be used for diagnosis. We can choose radiation, operation, and chemotherapy in single form or combined form according to the stage and the location of disease. If a patient who has neck mass, the pathologic finding of it is similar to that of Hashimoto's thyroiditis, and it is resistant to thyroid hormonal therapy, we should consider that it can be thyroid lymphoma or thyroid papillary cancer associated with Hashimoto's thyroiditis. We report a case of thyroid MALT lymphoma combined with occult papillary cancer which was resistant to thyroid hormonal therapy and which was successfully treated by operation and radiation therapy. (Korean J Endocrine Surg 2002;2:42-46)

연구논문 : 경영전략과 자본비용

유현수(제1저자) ( Hyun Soo Ryu ),김갑순(교신저자) ( Kap Soon Kim ),최규담(공동저자) ( Gyu Dam Choi ) 한국회계학회 2015 회계저널 Vol.24 No.6

본 연구는 Miles and Snow (1978, 2003) 경영전략 이론에 따라 기업의 전략을 선도형, 분석형 및 방어형으로 구분하고 각 유형에 따라 기업의 가중평균자본비용이 어떻게 달라지는지에 대하여 실증적으로 분석한 것이다. 즉, 각 기업의 최고경영진의 경영철학이 표출되어 있는 경영전략은 매우 포괄적이기는 하지만 기존의 개별적인 기업특성변수들이 제공하지 못하는 중요한 정보가치를 내포하고 있다면, 선행연구에서 자본비용을 설명하는 개별적인 요소들을 모두 통제한 후에도 경영전략이 자본비용을 설명할 수 있을 것이라는 것이 본 연구에서 확인하고자 하는 가설의 배경이다. 본 연구는 2000년부터 2013년까지 유가증권시장과 코스닥시장에 상장된 기업을 대상으로 6,005개의 표본을 대상으로 방어형(defender)보다 선도형(prospector)형에 가까울수록(즉, 경영전략지수가 높아질수록)자본비용 수준이 더 높을 것이라는 가설을 검증하였다. 자본비용은 NICE신용평가정보(주)가 제공하는 가중평균자본비용을 사용하였고 경영전략의 측정은 Miles and Snow(1978, 2003)이론에 따라 경영전략의 유형별 특성을 구분하여 측정할 수 있는 6가지 요소를 기초로 종합점수를 산출한 뒤 이를 연속변수로 사용하거나 선도형(prospector), 분석형(analyzer) 및 방어형(defender)으로 구분하여 더미변수로 활용하였다. 분석 결과, 연속변수인 경영전략지수가 높아지는 경우 1% 유의수준에서 자본비용이 증가하였고, 선도형인 경우가 유의하게 분석형 또는 방어형인 경우보다 자본비용이 더 높았다. 경영자지분율이 높은 수준을 5%, 10% 및 20% 이상으로 측정하여 경영자지분율을 추가로 통제한 경우에도 경영전략지수가 높아지는 경우 유의하게 자본비용이 증가하는 결과는 달라지지 않았다. 대부분의 통제변수는 유의성에 다소 차이는 있었지만 선행연구에 근거하여 예측한부호와 대체로 방향성이 일치하였다. 본 연구 결과는 자본비용에 영향을 미치는 요소로 선행연구와 같이 개별적인 기업특성변수 대신 보다 포괄적인 ``경영전략지수``라는 종합측정치를 사용하였다는 점에서 큰 의미가 있다. The ``tone at the top`` the executives set or the executives`` willingness to take strategic risks in their competitive markets spill over into specific operation areas including the business and financial risk, willingness to take the uncertainty, stability or complexity of organizational structure, the value of assets secured and attitude towards growth and corporate governance, etc. Furthermore, such top management``s tone are also most effectively implemented into a firm``s business strategy. Accordingly, it might be inferred that a firm``s business strategy has other separate and comprehensive information value than a firm``s specific individual information factors. While many prior studies are investigating what can more explain the level of cost of capital, a firm``s business strategy may provide the approach which is more comprehensive and generalizable across industries than those specific individual variables. The business strategy provides a theoretical background for an even broader understanding of the factors that are ex ante determinants of cost of capital level. Ittner et al.(1997), Higgins et al.(2015) and Bentley et al.(2013) are main prior accounting researches that used a comprehensive and composite measure of business strategy as an explanatory variables for the quality of accounting information. Such prior research are all based on Miles and Snow(1978, 2003)``s strategy theory. Prospectors defined by Miles and Snow(1978, 2003) focus on innovation, pursue new products and geographic markets and have high growth potential and high level of capital needs, which are positively related to the business and financial risks and the uncertainty demanding higher level of cost of capital. However, defenders focus on comparatively sound, stable and predictable areas and their aversion to risk and uncertainty would lead to be lower level of cost of capital. Using business strategy typology defined by Miles and Snow (1978, 2003), this study examines the relation between a firm``s business strategy and its cost of capital. We investigate whether a firm``s business strategy is associated with its cost of capital and predict that firms close to prospector show higher level of cost of capital than those close to analyzer and defender (Hypothesis 1). According to the Miles and Snow(1978, 2003), prospectors focus on innovation, pursue new products and geographic markets and are more likely to be aggressive, which have relatively more tax planning opportunities. Further, given that their products tend not to have readily available substitutes, prospectors are less concerned about negative publicity arising from tax avoidance. By contrast, defenders focus on comparatively sound, stable and predictable areas and put the stress on the economy of scale. defenders`` aversion to risk and uncertainty also suggests that given the set of tax opportunities available, they would avoid tax less aggressively. Since their products have viable substitutes, defenders could incur reputation costs associated with tax avoidance. To address our research questions, we used publicly available weighted averaged cost of capital (WACC). We also compute a discrete STRATEGY composite index measure (STRATEGY) based on variables from prior literature (Higgins et al. 2015) that reflect different facets of the strategy: (1) the ratio of research and development to sales, (2) the ratio of employees to sales, (3) a growth opportunity measure (market-to-book ratio), (4) the ratio of marketing (SG&A) to sales, (5) employee fluctuations (standard deviation of total number of employees), and (6) capital intensity (net PPE scaled by total assets). Each is intended to capture different elements of a firm``s business strategy. We find from the test of Hypothesis 1 that STRATEGY is positively related to WACC at 1% significance level and prospector``s WACC are higher than those of analyzer and defender, which is consistent with our anticipation. The results above suggest that a firm closer prospector(defender) group has higher(lower) cost of capital. From the robust test adding as control variable whether management ownership is higher level (which is defined as the shareholding by directors and officers exceeds 5%, 10% or 20%), we further find that adding management ownership does not change previous the main results(i.e., a firm closer prospector group has higher cost of capital) while the firms with higher level of management ownership show higher level of cost of capital. Our study contribute to a better understanding of a firm``s cost of capital. While prior studies have focused individual factors explaining the level of cost of capital, our study investigate a firm``s business strategy which plays a broader and more comprehensive role than those specific individual variables. The distinguishing feature of our study is that it is grounded in a theoretical framework that is used to make clear predictions regarding the link between a firm``s business strategy and its cost of capital.

<SUP>18</SUP>F-FDG PET-CT에서 진단된 갑상선 우연종의 악성종양 발견율 및 특징

이강영,고건<SUP>1<.SUP>,김선국<SUP>1<.SUP>,고진철<SUP>1<.SUP>,김행수,최상용,박신희,박용휘<SUP>2<.SUP>,Kang Young Rhee,Gun Koh,<SUP>1<.SUP>,Sun Kuk Kim,<SUP>1<.SUP>,Jin Chul Koh,<SUP>1<.SUP>,Haeng Soo Kim,Sang Yong Choi,Shin 대한갑상선-내분비외과학회 2008 The Koreran journal of Endocrine Surgery Vol.8 No.1

<B>Purpose: </B>PET-CT is often used to differentiate benign or malignant thyroid incidentalomas. In this retrospective study, we evaluated whether the <SUP>18</SUP>F-FDG uptake pattern and PET-CT findings improved accuracy over the standardized uptake value (SUV). <B>Methods:</B> <SUP>18</SUP>F-FDG PET-CT was performed on 2,178 subjects from August, 2004, to October, 2007, in Sung-ae Hospital. PET-CT was performed on 806 patients (37%) with suspected or known nonthyroidal cancer and 1,372 healthy subjects (63%) without a previous history of cancer. We investigated the clinical characteristics of patients, history, standardized uptake value (SUV), ultrasonography, and hormone levels in blood. Thyroidal cancer was confirmed by ultrasonography-guided fine needle aspiration and pathology after thyroid operation. <B>Results:</B> The prevalence of focal thyroid lesions on PET-CT was 8.8% (191/2178). Thyroid cancer confirmation was 7.9% (15/191). The maximum SUV of malignant thyroid lesions were significantly higher than that of benign lesions (7.00±3.08 vs. 4.49±1.84, P<0.001). <B>Conclusion:</B> PET-CT image interpretation that includes 18F-FDG uptake and SUV is better than PET-CT alone for differentiating benign and malignant lesions. Thyroid cancer risk increases as SUVmax levels increase. <B>(Ko</B><B></B><B>rean J Endocrine Surg 2008;8:38-42)</B>