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Ye, Byeong Hyeok,Kim, Eun Jung,Baek, Seung Eun,Choi, Young Whan,Park, So Youn,Kim, Chi Dae The Korean Society of Pharmacology 2018 The Korean Journal of Physiology & Pharmacology Vol.22 No.4
${\alpha}$-Iso-cubebene (ICB) is a dibenzocyclooctadiene lignin contained in Schisandra chinensis (SC), a well-known medicinal herb that ameliorates cardiovascular symptoms, but the mechanism responsible for this activity has not been determined. To determine the role played by ICB on the regulation of vascular tone, we investigated the inhibitory effects of ICB on vascular contractile responses by adrenergic ${\alpha}$-receptor agonists. In addition, we investigated the role on myosin light chain (MLC) phosphorylation and cytosolic calcium concentration in vascular smooth muscle cells (VSMC). In aortic rings isolated from C57BL/6J mice, ICB significantly attenuated the contraction induced by phenylephrine (PE) and norepinephrine (NE), whereas ICB had no effects on KCl (60 mM)-induced contraction. In vasculatures precontracted with PE, ICB caused marked relaxation of aortic rings with or without endothelium, suggesting a direct effect on VSMC. In cultured rat VSMC, PE or NE increased MLC phosphorylation and increased cytosolic calcium levels. Both of these effects were significantly suppressed by ICB. In conclusion, our results showed that ICB regulated vascular tone by inhibiting MLC phosphorylation and calcium flux into VSMC, and suggest that ICB has anti-hypertensive properties and therapeutic potential for cardiovascular disorders related to vascular hypertension.
Dosimetry of a new P-32 ophthalmic applicator.
Choi, Chang Heon,Han, Hyon Soo,Son, Kwang-Jae,Park, Ul Jae,Lee, Jun Sig,Wee, Won Ryang,Ha, Sung Whan,Kim, Il Han,Ye, Sung-Joon The American Association of Physicists in Medicine 2011 Medical physics Vol.38 No.11
<P>The potential of P-32 ophthalmic applicator irradiation after pterygium excision has been demonstrated as an alternative to Sr???Y-90 irradiation. This study aimed to provide the clinical dosimetry for this new applicator.</P>
Han, Ye Jin,Je, Ju Hui,Kim, So Hyoung,Ahn, Sung Min,Kim, Ha Neui,Kim, Yu Ri,Choi, Young Whan,Shin, Hwa Kyoung,Choi, Byung Tae Institute for Advanced Research in Asian Science a 2014 The American journal of Chinese medicine Vol.42 No.4
<P>Dried roots of Gastrodia elata have traditionally been used in Korean medicine for the treatment of neurological disorders such as scotodinia, paralysis, and epilepsy. In our study, we attempted to investigate the neuroprotective effects of methanol extract from G. elata (MEGE) against glutamate-mediated oxidative stress and to explore underlying neuroprotective mechanisms. Analyses for cell viability, lactate dehydrogenase (LDH), flow cytometry, Western blot, and reactive oxygen species (ROS) were performed in HT22 hippocampal cells. Pretreatment with MEGE resulted in a potent neuroprotective effect against oxidative glutamate toxicity and these effects were exerted mainly by the abrogation of glutamate-induced apoptotic death. Treatment with glutamate resulted in a significant expression of both phosphorylated p38 and dephosphorylated phosphatidylinositol-3-kinase (PI3K). However, pretreatment with MEGE resulted in the inhibition of these expressions. In the inhibitor studies, treatment with PI3K inhibitor LY294002 resulted in the abrogation of the neuroprotective effect of MEGE. In addition, pretreatment with MEGE also resulted in the suppression of the glutamate-induced production of ROS. Treatment with MEGE and anti-oxidant N-acetyl-L-cysteine (NAC) resulted in the enhanced phosphorylation of both PI3K and cAMP responsive element binding protein (CREB), and, in particular, treatment with MEGE resulted in significantly enhanced expression of mature brain-derived neurotrophic factor (BDNF). These results suggest that the extract from G. elata mainly exerted neuroprotective effects through the up-regulation of the PI3K signaling pathway in association with BDNF and may be a useful therapeutic agent for treatment of oxidative neuronal death.</P>
만성 B형 간염 환자에서 재조합형 알파 인터페론(Intron-A)의 효과
김동환,최예원,박승욱,신호균,김학양,김진한,박충기,임규성,유재영 대한내과학회 1990 대한내과학회지 Vol.38 No.4
We evaluated the effect of recombinant alpha interferon(Intron-A, Schering) in 30 patients with chronic hepatitis B. They included 24 men and six women, ages 17 to 53 years(mean 37), with elevated serum AST and ALT; 41 to 789 U/㎗(mean 275) and 78 to 689 U/㎗(mean 280), respectively. All patients had serum hepatitis B surface antigen(HBeAg) longer than three years, and hepatitis B e antigen(HBeAg). Liver biopsies before therapy revealed chronic active heaptitis(CAH) in 80% and active cirrhosis in 20%. The patients were randomized into two groups: those who received Intron-A(16 patients) and those who had no therapy(14 patients). Intron-A was administered in doses of 3 million units(MU) every other day for four months and followed-up longer than one and half years. The ALT level returned to normal in 15 of 16(94%) treated patients during therapy, and 4/16 subsequently lost HBV-DNA and HBeAg. In 3/16(19%), serum ALT rebounded and HBeAg reappeared at the 21st week in one and the 54th week in the others. Serum HBeAg persisted in nine of 16 cases(56%), but serum ALT returned to normal level in five patients. In contrast, 3/14(21%) untreated patients showed improvement of serum ALT level at the 6th, 24th and 52nd week of follow-up, respectively, and two subsequently lost HBV -DNA and HBeAg. But nine of 14(64%) patients showed multiple episodes of serum ALT fluctuation during the follow-up period. This study shows that the alternate-day interferon alpha therapy for four months may be effective in some patients with chronic hepatitis B. But because of relatively low significant effect in the treated patients, compared with the untreated, studies with larger number of patients are ncessary to evaluate the duration and the dosage of interferon alpha.
Byeong Hyeok Ye,Eun Jung Kim,Seung Eun Baek,Young Whan Choi,So Youn Park,Chi Dae Kim 대한생리학회-대한약리학회 2018 The Korean Journal of Physiology & Pharmacology Vol.22 No.4
α-Iso-cubebene (ICB) is a dibenzocyclooctadiene lignin contained in Schisandra chinensis (SC), a well-known medicinal herb that ameliorates cardiovascular symptoms, but the mechanism responsible for this activity has not been determined. To determine the role played by ICB on the regulation of vascular tone, we investigated the inhibitory effects of ICB on vascular contractile responses by adrenergic α-receptor agonists. In addition, we investigated the role on myosin light chain (MLC) phosphorylation and cytosolic calcium concentration in vascular smooth muscle cells (VSMC). In aortic rings isolated from C57BL/6J mice, ICB significantly attenuated the contraction induced by phenylephrine (PE) and norepinephrine (NE), whereas ICB had no effects on KCl (60 mM)-induced contraction. In vasculatures precontracted with PE, ICB caused marked relaxation of aortic rings with or without endothelium, suggesting a direct effect on VSMC. In cultured rat VSMC, PE or NE increased MLC phosphorylation and increased cytosolic calcium levels. Both of these effects were significantly suppressed by ICB. In conclusion, our results showed that ICB regulated vascular tone by inhibiting MLC phosphorylation and calcium flux into VSMC, and suggest that ICB has anti-hypertensive properties and therapeutic potential for cardiovascular disorders related to vascular hypertension.
김주필(Joo Pil Kim),최한석(Han Seak Choi),예용택(Yong Taek Ye),예성훈(Seong Hun Ye),김태우(Tae Woo Kim),김대희(Dae Hee Kim),지승환(Seung Hwan Ji),지성현(Sung Hyun Ji),이형민(Hyung Min Lee),변진관(Jin Kwan Byun),조주완(Joo Whan Jo),박솔 한국거미연구소 2017 한국거미 Vol.33 No.2
한국거미연구회 회원들은 2017 년 8월 2일부터 3일까지 인천광역시 남동구 소재 소래습지생태공원을 김주필, 최한석, 예용택, 예성훈, 김태우, 김대희, 지승환, 지성현, 변진관, 이형민, 조주완, 박솔민, 이형진, 이태후, 이승후, 조윤규, 조원규, 이준이, 신정애, 이영경, 최라미, 이윤정, 이용화, 한주연, 윤혜원, 김형주 등 26명이 주야로 채집한 결과 14과 38속 50종을 발표 보고하는 바이다. From August 2 to 3 in 2017. Koran Arachnological Study members investigated the Spiders in the whole area Incheon Namdong-gu, and reported 14 Families, 38 Genus 50 Species of spiders. The collected spiders are placed (stored) in the Joo-Pil Spider museum.
김주필(Joo Pil Kim),최한석(Han Seak Choi),예용택(Yong Taek Ye),예성훈(Seong Hun Ye),김태우(Tae Woo Kim),김대희(Dae Hee Kim),지승환(Seung Hwan Ji),지성현(Sung Hyun Ji),이형민(Hyung Min Lee),변진관(Jin Kwan Byun),조주완(Joo Whan Jo),박솔 한국거미연구소 2017 한국거미 Vol.33 No.2
한국거미연구회 회원들은 2017년 8월 3일부터 4일까지 경기도 안산시 소재 시화호 갈대습지공원을 김주필, 최한석, 예용택, 예성훈, 김태우, 김대희, 지승환, 지성현, 변진관, 이형민, 조주완, 박솔민, 이형진, 이태후, 이승후, 조윤규, 조원규, 이준이, 신정애, 이영경, 최라미, 이윤정, 이용호, 한주연, 윤혜원, 김형주 등 26명이 주야로 채집한 결과 18과 49속 71종을 발표 보고하는 바이다. From August 3 to 4 in 2017. Koran Arachnological Study members investigated the Spiders in the whole area Gyeonggi-do Ansan-si, and reported 18 Families, 49 Genus 71 Species of spiders. The collected spiders are placed (stored) in the Joo-Pil Spider museum.