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최재수(Jae Sue Choi),최진호(Jin-Ho Choi),박종철(Jong Cheol Park),양한석(Han Suk Young) 한국생약학회 1987 생약학회지 Vol.18 No.1
Previouslyl we reported on the isolation and structure elucidation of quercetin, avicularin, quercitrin and hyperin from the leaves of Rhododendron brachycarpum D. Don (Ericaceae). In this communication, the isolation of diterpenoid, grayanotoxin I, mp 247∼8˚ [α]_D=-5˚will be presented. 1) Choi, J.S., Choi, J.H., Young, H.S., Park, J.C. and Woo, W.S., Proceedings of 35th annual convention of the Pharmaceutical Society of Korea, 1986, p.108.
The NMR assignments of anthraquinones from Cassia tora
Choi, Jae-Sue,Jung, Jee-Hyung,Lee, Hee-Jung,Kang, Sam-Sik The Pharmaceutical Society of Korea 1996 Archives of Pharmacal Research Vol.19 No.4
The $^1H- and^{13}C-NMR$ spectra of alaternin, aurantio-obtusin, chryso-obtusin, obtusin and 2-glucosyl obtusifolin isolated from the seeds of Cassia tora have been assigned based on HMBC, long-range HETCOR, fully $^1H-coupled {13}^C-NMR$, deuterium isotope experiment, and by comparison with the model compounds.
Nitrite Scavenging Effect by Flavonoids and Its Structure-Effect Relationship
Choi, Jae-Sue,Park, Si-Hyang,Choi, Jin-Ho The Pharmaceutical Society of Korea 1989 Archives of Pharmacal Research Vol.12 No.1
Nineteen flavonoids, five phenolics, two coumarins, maltol and L-ascorbic acid were tested as scavenger of nitrite which is believed to participate in the formation of N-nitroso compounds. Many were found to be potent scavenger and the five most potent ones were (+)-catechin, (-)-epicatechin, phloroglucinol, caffeic acid and L-ascorbic acid. The nitrite scavenging effect was higher at pH 1.2 than pH 3.0 and increased when the incubation time was longer. The possible relationship of structures to scavenging effect of the flavonoids tested was discussed.
Choi, Jae-Sue,Lee, Hee-Jung,Kang, Sam-Sik The Pharmaceutical Society of Korea 1994 Archives of Pharmacal Research Vol.17 No.6
Radical scavenging principles on 1, 1-diphenyl-2-picylhydrazyl(DPPH) radical were isolated from the seeds of Cassis tora L. Assignments of the^1H-{\;}and{\;}^{13}C-NMR$ data showed the active components to be an anthraquinone, alatemin nad two naphthopyrone glycosides, nor-rubro-fusarin-6-.betha.-D-glucoside(cassiaside) and rubrofusarin-6- -D-gentiobioside. Altemin showed more potent radical sacvenging effect than the others.
Choi, Jae Sue,Chung, Hae Young,KIM, Hyeung Rak,Kim, Jong 한국수산학회 1999 Fisheries and Aquatic Sciences Vol.2 No.1
Antioxidant activity of a methanol extract of Symphyocladia latiuscula was evaluated by the thiocyanate method in the linoleic acid system. The methanol extract inhibited the peroxidation of linoleic acid in a dose-dependent manner. The MeOH extract was then sequentially partitioned with n-hexane, CH₂Cl₂, EtOAc, n-BuOH and H₂O. The antioxidant activity of the fractions increased in order of CH₂Cl₂, n-hexane, EtOAc, and n-BuOH. There was no activity found in H₂O partitoned fraction by the thiocyanate method Especially, the activities of the fractions of n-hexane and CH₂Cl₂were comparable to that of 2,6-di-tert butylhydroxytoluene (BHT). Column chromatography of the CH₂Cl₂fraction over silica gel yielded cholesterol (1) and 2,3,6-tribromo 4,5-dihydroxybenzyl methyl ether (2) which were identified by instrumental analysis of MS and ¹H- and ^(13)C-NMR The latter (2) demonstrated significant antioxidant activity.
Phytochemical Study on Prunus davidiana
Choi, Jae-Sue,Woo, Won-Sick,Young, Han-Suk,Park, Jong-Hee The Pharmaceutical Society of Korea 1990 Archives of Pharmacal Research Vol.13 No.4
From the stem of Prunus davidiana, naringenin and its glucoside, kaempferol and its glucoside, dihydrokaempferol, kaempferide glucoside, hesperetin glucoside, quercetin glucoside, d-catechin and $\beta$-sitosterol glucoside were isolated.
A Flavonol Diglucoside from the Leaves of Brassica juncea
Jae Sue Choi,Jung Eun Kim,Jae I Kim,Hong Sik Cheigh,Takako Yokozawa 한국생약학회 2000 Natural Product Sciences Vol.6 No.4
A flavonol diglucoside was isolated from the leaves of Brassica juncea L. The structure of the compound was elucidated as isorhamnetin 3,7-di-O-β-D-glucopyranoside (1) on the basis of chemical and spectral evidence.
Jae Sue Choi,Ji Hyeon Lee,Hae Jin Park,Hyung Geun Kim,Han Suk Young,Sook Im Mun 한국생약학회 1994 생약학회지 Vol.24 No.4
The antioxidant activity of methanol extracts of plants and marine algae was tested by using 1, 1-diphenyl-2-picrylhydrazyl(DPPH), Five plant extracts(Prunus davidiancc, Eriobotrya japonica, Artemisia iwayomogi, Stirodella tolyrrhiza and Ulmus davidiana) and two algae (Ecklonia stolonifera .and Symphycoladia latiuscula) were found to be the most effective in DPPH radical scavenging activity. The methanol extract obtained from the stems of Prunus davicliana was fractionated with several solvents. The ethylacetate soluble fraction exhibiting the strongest antioxidant activity was further purified by repeated silica gel and Sephadex LH-20 column chromatography. Antioxidant flavonoids and flavonoid glycosides were isolated and the most active ones was identified as (+)-catechin by MS, ¹H-NMR and <sup>13</sup>C-NMR. Its antioxidant activity was higher than that of vitamin C.
Jae Sue CHOI,Hyun Ah Jung,Himanshu Kumar Bhakta,Hajime Fujii,민병선,Chan Hum Park,Takako Yokozawa 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.3
Oligonol is a low-molecular-weight form of polyphenol that is derived from lychee fruit extract and contains catechin-type monomers and oligomers of proanthocyanidins. This study investigates the anti-diabetic activities of oligonol via a-glucosidase and human recombinant protein tyrosine phosphatase 1B (PTP1B) assays, as well as its anti-Alzheimer activities by evaluating the ability of this compound to inhibit acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and b-site amyloid precursor protein cleaving enzyme 1 (BACE1). Oligonol exhibited potent concentration-dependent anti-diabetic activities by inhibiting a-glucosidase and PTP1B with IC50 values of 23.14 lg/mL and 1.02 lg/mL, respectively. Moreover, a kinetics study revealed that oligonol inhibited a-glucosidase (Ki = 22.36) and PTP1B (Ki = 8.51) with characteristics typical of a mixed inhibitor. Oligonol also displayed potent concentration-dependent inhibitory activity against AChE and BChE with IC50 values of 4.34 lg/mL and 2.07 lg/mL, respectively. However, oligonol exhibited only marginal concentrationdependent BACE1 inhibitory activity with an IC50 value of 130.45 lg/mL. A kinetics study revealed mixed-type inhibition against AChE (Ki = 4.65) and BACE1 (Ki = 58.80), and noncompetitive-type inhibition against BChE (Ki = 9.80). Furthermore, oligonol exhibited dosedependent inhibitory activity against peroxynitrite (ONOO-)-mediated protein tyrosine nitration. These results indicate that oligonol has strong preventative potential in diabetes mellitus and in Alzheimer’s disease.