위식도 역류성 질환과 원발성 식도운동장애

宋致旭 대한의사협회 1999 대한의사협회지 Vol.42 No.9

다발성 전이 양상을 보인 경부의 평활근육종 - 증례보고

최치훈, 이동욱, 송형근 충북대학교 의학연구소 2016 忠北醫大學術誌 Vol.26 No.2

본문참고

혈액투석중인 만성신부전 환자에서 골대사 지표로써의 Osteocalcin치

송치운,이진홍,안미애,윤환중,윤상임,성기양,이강현,송민호,이강욱,신영태,김영건,노흥규 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2

Background : Serum osteocalcin is synthesized by osteoblast and has been shown to be sensitive indicator of bone turnover inpatients with various metabolic bone disease. In renal osteodystrophy, serum osteocalcin is elevated due to decreased renal clearance and elevated level of PTH. This study was done to evaluate the usefulness of serum osteocalcin as a marker of bone metabolism and the correlation with other biochemical markers of bone metabolism. Methods : We measured serum osteocalcin, calcium, phosphorus, ALP(alkaline phosphatase) and PTH(parathyroid hormone) in 37 patients with end stage renal disease on hemodialysis. Osteocalcin was determined by radioimmunoassay and PTH was determined by radioimmunometric assay. Results : 1) The mean level of serum osteocalcin in ESRD patients was 233.8± 218.2ng/ml which was significantly higher than that of controls(p<0.0001). 2) The mean level of serum PTH in ESRD patients was 40.5± 43.8pg/ml was significantly higher than that of controls(p<0.005). 3) There was a significant positive correlation between the level of serum PTH, ALP and the level of serum osteocalcin in ESRD patients. 4) By using multiple regression, PTH is most reliable factor that affect to elevated level of serum osteocalcin ( beta coefficient = 0.687, Sig T<0.05). Conclusion : Serum osteocalcin as a marker of bone metabolism in ESRD patients is more useful than other biochemical marker such as serum calcium, phosphorus, ALP and PTH is a most reliable factor that affect to elevated level of serum osteocalin.

農科大學 扶餘 演習林의 植生調査

李壽煜,金智文,宋鎬京 충남대학교 농업과학연구소 1977 農業技術硏究報告 Vol.4 No.2

The experimental forest of Chungnam National University is located in Naryung-Ri, Eunsan-Myen, Buyeo-Gun, Chungcheongnamdo. The climax vegetations of Quercus species grown in central temperate zone are supposed to be destroyed before pure pine stands as a semi-climax vegetation are established on the southern aspect and along the ridges. Variability of vegetations is rather high and dominant species are such as Pinus densiflora, Quercus acutissima, Quercus variabilis, Quercus aliena, Quercus serrata, Lindera erythrocarpa, Platycarya strobilacea, and so on. There are 203 woody plants and 128 herbal plants. According to the use of vegetations they can be classified as follows; 60 familia and 154 species for edible source, 63 familia and 143 species for medicinal, 51 familia and 140 species for forage, 32 familia and 78 species for ornamental, and 12 familia and 27 species for timber source.

지연성 방사선 뇌괴사 -1예 보고-

강신광,송준호,이규호,주인욱,지제근 대한병리학회 1988 Journal of Pathology and Translational Medicine Vol.22 No.3

Effects of Levosulpiride in Patients with Functional Dyspepsia Accompanied by Delayed Gastric Emptying

(Chi Wook Song),(Hoon Jae Chun),(Chang Duck Kim),(Ho Sang Ryu),(Jin Hai Hyun),(Jae Gol Choe) 대한내과학회 1998 The Korean Journal of Internal Medicine Vol.13 No.1

N/A Objectives:Levosulpiride is the levo-enantiomer of sulpiride, a well-known anti- emetic, antidyspeptic and antipsychotic drug. This study was undertaken to investigate the effects of levosulpiride on dyspeptic symptoms and gastric motor function in a group of patients with functional dyspepsia showing delayed gastric emptying. Method:Forty two eligible patients were entered into a 3 week, double-blind randomized comparison of 25mg of levosulpiride or placebot.i.d.. Symptom assess- ment and gastric scintigraphy following the intake of scrambled egg sandwich, were performed in each patient before and after treatment. Results:The improvement of symptom score in levosulpiride group was higher than the placebo group(p<0.05). We assessed global efficacy, which was excellent in 1(6%), good 11(65%), fair 4(24%), nil 1(6%) of those receiving levosulpiride, and fair 9(60%), nil 5(33%), poor 1(6%) of those receiving placebo. Levosulpiride tended to be more effective than placebo in relieving the dyspeptic symptoms especially in the subgroups of dysmotility-like(p<0.05) and nonspecific(p<0.05) as compared to other subgroups(p=0.16). The reduction of gastric emptying time after levosulpiride treatment was more marked than Placebo group(p<0.05). We found a significant correlation between changes of symptom score and gastric emptying time(r=0.47, p=0.01). No serious adverse effects were reported after administration of either levosulpiride or placebo. Only two patients reported mild somnolence during levosul- piride administration. Conclusions:Levosulpiride is effective and well tolerated in patients with func- tional dyspepsia accompanied by delayed gastric emptying. Its efficacy may be related to its action on the gastric motor function by improving the delayed gastric emptying.

아칼라지아 치료에서 풍선확장술과 보툴리늄 독소 주사요법의 비교연구

송치욱(Chi Wook song),엄순호(Soon Ho Um),현진해(Jin Hai Hyun) 대한소화기학회 1997 대한소화기학회지 Vol.29 No.4

N/A Background/Aims: Preliminary studies have suggested that intrasphincteric injection of the lower esophageal sphincter(LES) with botulinum toxin(BoTx) is a safe and effective alternative to pneumatic balloon dilation(BD) in the treatment of achalasia. We have compared the efficacy between BoTx and BD in an ongoing prospective study. Methods: In a randomized trial, 16 patients with achalasia received either intrasphincteric injection of BoTx(100 units) or BD(Rigiflex 3.0 cm in diameter). Among 8 patients treated with BoTx, 3 to them had been treated unsuccessfu]- ly beforehand with BD. After one month and after three months, Treatment responses were assessed on the basis of changes in the symptom scores and parameters of esophageal manometric study. Results: Both BoTx without prior BD(n=5) and BD group(n=8) showed a decreased symptom score, LES pressure and gastroesophageal pressure gradient(GEPG) at 1 month also decreased. LES pressure at 3 months increased in the BoTx group. No patient treated within the BD group failed at 3 months, but 1(20%)patient in the BoTx without previous BD did fail. The failed BoTx group with prior BD didnt show a decreased symptom score. LES pressure and GEPG also didnt decrease and 2(66.7%) patients failed at 3 months after treatment. No significant complications were seen in both the BoTx and the BD group. Conclusions: Both BoTx injection and BD were effective treatments for achalasia. BD may provide a more effective long term treatment, as compared to BoTx, for achalasia. However BoTx injection in patients who failed prior BD showed a poor response and a high failure rate. Long term evaluation of safety and efficacy will be required to fully understand the utility of BoTx injection vs BD for achalasia. (Korean J Gastroenterol 1997;29:423-429)

이산 제조 공정에서의 수율 향상을 위한 분석 프레임워크의 개발에 관한 연구

송치욱 ( Song Chi-wook ),노금종 ( Roh Geum-jong ),박동진 ( Park Dong-jin ) 한국정보시스템학회 2017 情報시스템硏究 Vol.26 No.2

Purpose It is a major goal to improve the product yields during production operations in the manufacturing industry. Therefore, factory is trying to keep the good quality materials and proper production resources, also find the proper condition of facilities and manufacturing environment for yields improvement. Design/methodology/approach We propose the hybrid framework to analyze to dataset extracted from MES. Those data is about the alarm information generated from equipment, both measurement and equipment process value from production and cycle/pitch time measured from production data these covered products during production. We adapt a data warehousing techniques for organizing dataset, a logistic regression for finding out the significant factors, and a association analysis for drawing the rules which affect the product yields. And then we validate the framework by applying the real data generated from the discrete process in secondary cell battery manufacturing. Findings This paper deals with challenges to apply the full potential of modeling and simulation within CPPS(Cyber-Physical Production System) and Smart Factory implementation. The framework is being applied in one of the most advanced and complex industrial sectors like semiconductor, display, and automotive industry.

비심인성 흉통환자에서 식도운동검사의 의의

송치욱(Chi Wook song),구양서(Yang Suh Koo),이홍식(Hong Sik Lee),이상우(Sang Woo Lee),최재현(Jai Hyun Choi),김창덕(Chang Duck Kim),류호상(Ho Sang Ryu),현진해(Jin Hai Hyum) 대한소화기학회 1995 대한소화기학회지 Vol.27 No.4

N/A Background/Aims: Recently the esophagus is considered a major source of recurrent noncardiac chest pain to patients in whom exercise stress test and/or cardiac catheterization have excluded a cardiac etiology. To investigate the esophageal origin of noncardiac chest pain, esophageal motility tests including manometry, provocation test, and radioisotope esophahgeal transit study(RETS) were studied in patients with noncardiac chest pain. Methods: A total of l26 patients with noncardiac chest pain were assessed;they included 41 patients with normal coronary angiogram and 85 patients with normal noninvasive cardiac tests such as echocardiogram and exercise stress test done in Korea University Hospital from Feb. l993 to Aug. 1994. Results: 56 out of 126 patients(44.4%) with noncardiac chest pain had abnormal manometric findings which included 20(35.7%) nonspecific esophageal motility disorder, 17(30.4%) hypertensive lower esophageal sphincter, 9(16.1%) hypo- tensive lower esophageal sphincter, and 2(3.6%) nutcracker esophagus. Thirty eight out of 126(30.1 %) patients had abnormal manometric findings but no reproducible chest pain by provocation test and were considered to have a probable esophageal chest pain. When patients having positives for both provocation tests are counted as a single positive, 39 out of l26(3l /o) patients had their chest pain reproduced and were considered to have a defini(e esophageal chest pain. The combination of patients with definite esophageal chest pain(31%) and probable(30.17c) gave an overall diagnostic yield of 61.1% for our esophageal laboratory. There was no significant difference between invasive cardiac test group and noninvasive cardiac test group in the results of esophageal motility tests. RETS merely reflected the peristaltic abnonnalities with no more informations for esophageal chest pain. Conclusions: These results reveal that esophagus is considered a source of noncardiac chest pain in 61.1%. Provocation test complements esophageal manometry alone and increases diagnostic yield. RETS can be used in diagnosis of noncardiac chest pain accompanied by peristaltic abnormality of the esophagus. (Korean J Gastroenterol 1995;27:381-387)

아칼라지아 풍선확장술후 증상호전과 재발의 예측인자에 대한 고찰

송치욱(Chi Wook song),진윤태(Yoon Tae Jeen),엄순호(Soon Ho Um),김창덕(Chang Duck Kim),류호상(Ho Sang Ryu),현진해(Jin Hae Hyun) 대한소화기학회 1997 대한소화기학회지 Vol.29 No.3

N/A Background/Aims: Pneumatic balloon dilation(BD) is considered to be the first line of treatment in patients with achalasia. However there have been little reports about whether the parameters of esophageal manometry and scintigraphy predict the long-term results after BD. The aims of this study were to determine the relationship between changes in symptom improvetnent and esophageal motor function in response to BD. Methods: 21 patients with primary achalasia treated by BD were included. We used a balloon dilator(Rigiflex, 3.0 cm in diameter) and dilated twice for 1 minute each at a pressure of 7-15 psi, at a 5 minute interval. A comprehensive assessment of their symptoms and esophageal manometry and scintigraphy was performed before, 1 month after wards and again 1 year after BD. Results: 1) One year after BD, four people had recurrence of symptoms and the remaining 17 patients(81%) had been successfully treated. 2) There was no relationship between patients age, sex, duration of symptoms and the symptom improvement scores of a year later. 3) Significant correlation was detected between changes in the symptom score of a year later and parameters of esophageal motor function such as reduction of lower esophageal sphincter pressure, normalized reversed gastroesophageal pressure gradient, and different configuration of simultaneous contractions after BD. Conclusions: We conclude that the changes in objective responses such as lower esophageal sphincter pressure, gastroesophageal pressure gradient and configuration of simultaneous contractions are reliable predictors of symptom irnprovernent and recurrence in patients with achalasia treated by BD. (Korean J Gastroenterol 1997;29: 279 - 288)