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- 저자 : Chi K. Hoang (검색결과 2 건)
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Chi K. Hoang,Cuong H. Le,Dat T. Nguyen,Hang T. N. Tran,Chinh V. Luu,Huong M. Le,Ha T. H. Tran 한국균학회 2023 Mycobiology Vol.51 No.4
Genus Penicillium comprising the most important and extensively studied fungi has beenwell-known as a rich source of secondary metabolites. Our study aimed to analyze andinvestigate biological activities, including in vitro anti-cancer, anti-inflammatory and anti-diabeticproperties, of metabolites from a marine-derived fungus belonging to P. levitum. Thechemical compounds in the culture broth of P. levitum strain N33.2 were extracted withethyl acetate. Followingly, chemical analysis of the extract leaded to the isolation of threeergostane-type steroid components, namely cerevisterol (1), ergosterol peroxide (2), and(3b,5a,22E)-ergosta-6,8(14),22-triene-3,5-diol (3). Among these, (3) was the most potent cytotoxicagainst human cancer cell lines Hep-G2, A549 and MCF-7 with IC50 values of 2.89,18.51, and 16.47 mg/mL, respectively, while the compound (1) showed no significant effectagainst tested cancer cells. Anti-inflammatory properties of purified compounds were evaluatedbased on NO-production in LPS-induced murine RAW264.7 macrophages. As a result,tested compounds performed diverse inhibitory effects on NO production by the macrophages,with the most significant inhibition rate of 81.37 ± 1.35% at 25 mg/mL by the compound(2). Interestingly, compounds (2) and (3) exhibited inhibitory activities againstpancreatic lipase and a-glucosidase enzymes in vitro assays. Our study brought out newdata concerning the chemical properties and biological activities of isolated steroids from aP. levitum fungus.
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Vo, Kieu Thi Xuan,Lee, Sang-Kyu,Halane, Morgan K.,Song, Min-Young,Hoang, Trung Viet,Kim, Chi-Yeol,Park, Sook-Young,Jeon, Junhyun,Kim, Sun Tae,Sohn, Kee Hoon,Jeon, Jong-Seong Korean Society for Molecular and Cellular Biology 2019 Molecules and cells Vol.42 No.9
Effector-triggered immunity (ETI) is an effective layer of plant defense initiated upon recognition of avirulence (Avr) effectors from pathogens by cognate plant disease resistance (R) proteins. In rice, a large number of R genes have been characterized from various cultivars and have greatly contributed to breeding programs to improve resistance against the rice blast pathogen Magnaporthe oryzae. The extreme diversity of R gene repertoires is thought to be a result of co-evolutionary history between rice and its pathogens including M. oryzae. Here we show that Pii is an allele of Pi5 by DNA sequence characterization and complementation analysis. Pii-1 and Pii-2 cDNAs were cloned by reverse transcription polymerase chain reaction from the Pii-carrying cultivar Fujisaka5. The complementation test in susceptible rice cultivar Dongjin demonstrated that the rice blast resistance mediated by Pii, similar to Pi5, requires the presence of two nucleotide-binding leucine-rich repeat genes, Pii-1 and Pii-2. Consistent with our hypothesis that Pi5 and Pii are functionally indistinguishable, the replacement of Pii-1 by Pi5-1 and Pii-2 by Pi5-2, respectively, does not change the level of disease resistance to M. oryzae carrying AVR-Pii. Surprisingly, Exo70F3, required for Pii-mediated resistance, is dispensable for Pi5-mediated resistance. Based on our results, despite similarities observed between Pi5 and Pii, we hypothesize that Pi5 and Pii pairs require partially distinct mechanisms to function.
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