http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Cheong Won CHO (검색결과 276 건)
- 무료
- 기관 내 무료
- 유료
-
홍삼 내 ginsenosides의 경구용 제제 개발을 위한 전략수립
연원기,조정원 충남대학교 약학대학 의약품개발연구소 2013 藥學論文集 Vol.28 No.-
Ginsenosides saponins are phytochemically extracted from red ginseng, and have been regarded as the principal components manifesting the pharmacologic activities. Saponins are very soluble in water but poorly absorbed when administrated orally. Moreover, they have some disadvantages including the decomposition in acid medium. Therefore various designs and techniques have been studied for development of optimal formulation and modification of release profile. This review focused on pH-response polymer and bioadhesive polymer considering the low stability in acid medium and the low permeability in mucosal membrane of saponins. The application of these polymers are considered as potential strategy for improvement of bioavailability in oral delivery of saponins.
-
Rocuronium의 애별투여방법이 모지내전근의 이완에 미치는 영향
최영균,김승수,이원진,조광래,이상은,김영환,임세훈,이정한,이근무,정순호,김영재,신치만 인제대학교 2009 仁濟醫學 Vol.30 No.-
Objective : There are controversies in pnmmg technique of rocuronium whether it can or can't shorten the onset time. We want to compare the effects of two different priming doses and intervals of rocuronium. Materials and Methods : After giving propofol, 50 patients were randomly assigned to 5 groups. Group I received a placebo, followed 3 min later by rocuronium 0.6 mg/kg. Priming doses and intervals of Group II, Ill, N, V were 0.06 rng/kg and 2 min, 0.12 mg/kg and 2 min, 0.06 rug/kg and 3 min, 0.12 mg/kg and 3 min, respectively. Total dose of rocuronium was 0.6mg/kg. Train of four (TOF) count or ratio and 1st twitch height of TOF (T1) were monitored with 15 secondsintervals. TOF ratio of each groups just before bolus injection, duration for TOF count to reach zero and duration for Tl to reach 95% depression after bolus injection were compared. Results : Duration for TOF count to reach zero and duration for Tl to reach 95% depression after bolus injection were decreased in priming groups compared to Group 1 (P < 0.01) In group V, significant depression of TOF ratio just before bolus injection was seen (P < 0.05). Conclusion : Priming technique with rocuronium is effective method to shorten the onset of neuromuscular block. But priming dose of rocuronium itself could cause hypoxia and aspiration in awake patients and should be used carefully. Priming dose of rocuronium 0.06 mg/kg and 2 minutes interval maybe relatively safe method.
-
Association of Interleukin-18 Gene Polymorphisms with Hepatitis B Virus Clearance
Cheong, Jae Youn,Cho, Sung Won,Oh, Bermseok,Kimm, Kuchan,Lee, Kee Myung,Shin, Sung Jae,Lee, Jung A.,Park, Byung Lae,Cheong, Hyun Sub,Shin, Hyoung Doo,Cho, Bo Young,Kim, Jin Hong Springer-Verlag 2010 Digestive diseases and sciences Vol.55 No.4
-
A novel mutation of CLCNKB in a Korean patient of mixed phenotype of Bartter-Gitelman syndrome
Cho, Hee-Won,Lee, Sang Taek,Cho, Heeyeon,Cheong, Hae Il The Korean Pediatric Society 2016 Clinical and Experimental Pediatrics (CEP) Vol.59 No.no.sup1
Bartter syndrome (BS) is an inherited renal tubular disorder characterized by low or normal blood pressure, hypokalemic metabolic alkalosis, and hyperreninemic hyperaldosteronism. Type III BS is caused by loss-of-function mutations in CLCNKB encoding basolateral ClC-Kb. The clinical phenotype of patients with CLCNKB mutations has been known to be highly variable, and cases that are difficult to categorize as type III BS or other hereditary tubulopathies, such as Gitelman syndrome, have been rarely reported. We report a case of a 10-year-old Korean boy with atypical clinical findings caused by a novel CLCNKB mutation. The boy showed intermittent muscle cramps with laboratory findings of hypokalemia, severe hypomagnesemia, and nephrocalcinosis. These findings were not fully compatible with those observed in cases of BS or Gitelman syndrome. The CLCNKB mutation analysis revealed a heterozygous c.139G>A transition in exon 13 [p.Gly(GGG)465Glu(GAG)]. This change is not a known mutation; however, the clinical findings and in silico prediction results indicated that it is the underlying cause of his presentation.
-
-
A novel mutation of CLCNKB in a Korean patient of mixed phenotype of Bartter-Gitelman syndrome
Hee-Won Cho,Sang Taek Lee,Hee Yeon Cho,Hae Il Cheong 대한소아청소년과학회 2016 Clinical and Experimental Pediatrics (CEP) Vol.59 No.no.sup1
Bartter syndrome (BS) is an inherited renal tubular disorder characterized by low or normal blood pressure, hypokalemic metabolic alkalosis, and hyperreninemic hyperaldosteronism. Type III BS is caused by loss-of-function mutations in CLCNKB encoding basolateral ClC-Kb. The clinical phenotype of patients with CLCNKB mutations has been known to be highly variable, and cases that are difficult to categorize as type III BS or other hereditary tubulopathies, such as Gitelman syndrome, have been rarely reported. We report a case of a 10-year-old Korean boy with atypical clinical findings caused by a novel CLCNKB mutation. The boy showed intermittent muscle cramps with laboratory findings of hypokalemia, severe hypomagnesemia, and nephrocalcinosis. These findings were not fully compatible with those observed in cases of BS or Gitelman syndrome. The CLCNKB mutation analysis revealed a heterozygous c.139G>A transition in exon 13 [p.Gly(GGG)465Glu(GAG)]. This change is not a known mutation; however, the clinical findings and in silico prediction results indicated that it is the underlying cause of his presentation.
-
-
( Hyo Jung Cho ),( Soon Sun Kim ),( Seung Kyung Lee ),( Ga Won Song ),( Dong Joon Kim ),( Seong Gyu Hwang ),( Jin Mo Yang ),( Young Bae Kim ),( Young Nyun Park ),( Sung Won Cho ),( Jae Youn Cheong ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Background/Aims: Significant inflammation is generally considered as indication for antiviral therapy in patients with chronic hepatitis B (CHB). The aim of this study was to determine the serum markers which predict significant inflammation in patients with CHB. Methods: Between October 2005 and June 2009, 388 subjects with CHB, who have performed liver biopsy, were enrolled in this study. The assessed serum biochemical parameters included matrix metalloproteinase-2, tissue inhibitor of metalloproteinase-1, procollagen III N-terminal peptide (PIIINP), hyaluronic acid (HA), α2-macroglobulin, apolipoprotein A1, haptoglobin, cytokeratin-18 fragments, and α1-antitrypsin. Significant inflammation was defined as inflammatory grade ≥ 3 activities using the Batt-Ludwig scoring system. Results: Significant inflammation was present in 217 patients (54.6%) (Grade 3; 32.7%, grade 4;21.9%). Multiple logistic regression analysis by stepwise forward selection identified the ALT (p=0.000), HA (p=0.043) and PIIINP (p=0.001) as independent predictors of significant inflammation. We created a new variable of 0 or 1 by making cut-off value of each markers (ALT=62.5 U/L, HA=36.9 ng/mL, PIIINP=5.25 μg/L) and constructed a formula for predicting significant inflammation. Significant inflammation (SI) score = 1.773 × ALT score + 1.599 × PIIINP score + 0.677 × HA score o 1.962. The AUROC of the SI score for predicting significant inflammation was 0.831. The sensitivity, specificity, positive predictive value and negative predictive value of the SI score were 79.5%, 70.8%, 76.8% and 74.3%, respectively, at a cut-off value of 0.0625. Conclusion: The index including ALT, PIIINP and HA is an accurate noninvasive predictor of significant inflammatory activities in patients with CHB.
-
( Hyo Jung Cho ),( Sun Young Park ),( Ga Won Song ),( Seun Joo Ahn ),( Ho Joong Kim ),( Joo An Hwang ),( Soon Sun Kim ),( Sung Won Cho ),( Jae Youn Cheong ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Background/aims: Liver biopsy remains the gold standard to assess hepatic fibrosis. To identify new candidate markers for liver fibrosis, we performed serum based proteomic approach in patients with chronic hepatitis B (CHB). Methods: Sera were obtained from 12 patients with CHB at the time of liver biopsy. Batt-Ludwig classification was used for staging liver fibrosis. Proteins in pooled sera of mild fibrosis (F1 or F2, n=6) and liver cirrhosis (F4, n=6) were compared and analyzed by using 2D gel electrophoresis. Protein spots varying among two groups were excised, digested and submitted for tandem mass spectrometry for protein identification. Validation study was done for new markers among 293 CHB patients who underwent liver biopsies. Results: We identified 147 proteins which were increased or decreased significantly in hepatic cirrhosis. Among these 147 proteins, we found 7 candidate biomarkers which were supposed to be correlated with liver fibrosis. Alpha2-macroglobulin, kininogen1, transferrin and alph1-antitrypsin (A1AT) were increased whereas inter-alpha inhibitor H2, apolipoprotein A4 and apolipoprotein A1 were decreased in patients with cirrhosis. We performed validation study for A1AT and transferrin which were suitable for quantification in 293 patients with CHB. However, A1AT and trasnferrin were not significantly associated with liver cirrhosis in validation cohort. Conclusions: We identified several candidate biomarkers for predicting liver cirrhosis in patients with CHB using proteomics technology, but could not be confirmed in large validation cohort. Further advances in proteomics techniques and establishment of simple and quantitative methods are required to identify non-invasive diagnostic marker of liver fibrosis.
-
교육개혁조치의 근본이념과 현장 적용성에 대한 연구 : 학교운영위원회 제도를 중심으로 A Stdudy on the School-Site Council
조경원(Kyung Won Cho),정진곤(Jeen Gon Cheong),김용식(Yong Sick Kim) 한국초등교육학회 1997 초등교육연구 Vol.11 No.1
이 연구는 정부에서 발표한 다양한 교육개혁조치 가운데 학교현장에 많은 변화를 가져올 것으로 기대되어 왔던 '학교운영위원회'를 선택하여, 그 제도가 추구하고자 하는 목적과 근본이념이 무엇이며, 과연 그러한 목적이 학교현장에서 원래의 의도대로 시행되고 있으며, 그렇지 않다면 그 원인은 무엇이며, 이를 달성하기 위하여 어떤 방향으로 개선되어야 할 것인가를 탐색하였다. 학교운영위원회 제도의 근본이념과 취지는 이제까지의 교장중심의 독단적인 학교운영에서 탈피하여 학교 사회의 주된 구성원인 교장, 교사, 학부모, 지역사회인사 등이 함께 모여 학교의 주요한 일들을 협의해 가는 '학교운영의 민주화'라고 할 수 있다. 그러나 학교현장에서는 이 제도가 위원의 선출, 안건의 상정과 심의 및 의사결정과정 등에서 원래의 취지대로 운영되지 못하고, 비민주적인 방식으로 운영되고 있다. 그 주된 원인은 제도자체의 미비점, 졸속적인 시행과 준비부족, 제도정착을 위한 노력의 미흡, 학교장의 권위주의적 태도 그리고 학부모의 전통적 교육관과 의식 등에서 찾아 볼수 있다. 이를 개선하기 위해서는 학교 급별, 지역별, 학교별로 다양한 형태의 위원회를 구성하여 운영할 수 있도록 허용하고, 위원의 선출과정과 절차의 준수, 위원들의 역할과 권한에 대한 철저한 교육 등이 이루어져야 한다. Korean government like any other countries believes that his future depends on the quality of education. Most people think that current educational systems are not effectively working and students do not study worthwhile knowledges and skills eventhough they work very hard. Such as increasing world-wide competitiveness, technological development requires educational reform. If the future generation continues to concentrate on memorizing inert and tedious informations in these situations, the nations may face serious danger. The Presidential Committee on Educational Reform was organized in 1994 and tried to reestablish educational system of our country. The Committee suggested many educational agenda. Most people at that time appreciated their efforts and hoped their success. The School-Site Council(SSC)is one of such educational reforms of the Committee. The school is not democratic and parents cannot participate in school government. Only the principal has monopolic power in decision and management of the school. The study is to make clear what the fundamental purpose of SSC is. Even though the Presidential Committe suggested three purposes, enhancing the diversity of schoolings, trying to make parents and teachers participate in school administration, and connecting the school with the community, they can be summarized with making the school democtratic. The study finds out how SSC is democratically organized and performing in school. In other words we want to know whether educational ideal of SSC is really achieved in school or not. However, the answer is negative. The procedures and management of electing the members of the council are, first of all, undemocratic. The council members of the parents do not represent them because very few parents among the whole participate in the election. The members in some schools are appointed by the principal. The principal in some cases ask the council to pass the agenda because they are already informed to the parents. The coucil easily agrees with his asking. Such as an agenda about the management of school curriculum is never argued even though the council is to touch upon it. Why is SSC not so effectively working in school? The members, first of all, do not know what their roles are. Most of them are never heard of them and educated. They only guess that SSC is similar with the past parent association which was organized in order to collecting money from the parents for the development of the school. The second reason is that the principal is very authoritarian in most cases. He or she thinks the council do not know what is going in school and cannot make good decision. Most parents are very obedient and seldom against the principal. How can we make achieve the ideal purpose of SSC? We must allow the diversity of SSC. The school district should make an effort to educate the members what they do for the school. The members are to be elected in such ways to represent the whole parents and they are able to do their roles and work hard.
KISS연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
