ENERGY TRANSDUCTION IN MOLECULAR MACHINES

CHENG-HUNG CHANG,TIAN YOW TSONG 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2007 NANO Vol.2 No.5

An applied force may cause the conformation and thus, the activity of a biological molecule to change. Here we consider a system in which an oscillating or fluctuating electric field is used to actuate membrane protein activities. Most proteins have electric dipoles and net charges in the structure and their conformations are susceptible to the electric and magnetic perturbation. The shape of a cell may also amplify an electric field across its plasma membrane. Therefore, a membrane integral protein such as an ion channel, an ion pump, or a molecular motor, is especially amenable to electric perturbation. The theory of electroconformational coupling addresses the functional implication of this field effect. When an alternating electric field or a fluctuating electric field is employed to actuate a two-state protein oscillator, the dynamics of the conformational change of the protein can be synchronized with the applied field. Through this two-state protein oscillator, we construct a four-state catalytic wheel by coupling an energy transducer mechanism to the two-state protein oscillator. Analysis shows that the catalytic wheel can extract energy from a disordered external energy source, be it electrical, mechanical, or chemical, and convert this stochastic energy source to a usable energy format. The catalytic wheel is tested with the experimental data on the electric field-stimulated cation pumping of Na, K-ATPase. A dipole ratchet model based on the electroconformational coupling concept will also be discussed and compared with the ATP-dependent rotation of a rotary motor F1-ATPase. Since the working principle of this model is simpler than that of F1-ATPase, it provides an easier way to realize a nanoscale rotary motor than artificially reconstructing a F1-ATPase.

Research on the Characteristic of Diesel Elastic-plate Impingement Spray

( Chang Yuan Wang ),( Yong Shang ),( Xiang Rong Li ),( Fu Shui Liu ),( Cheng Hui Yu ) 한국액체미립화학회 2010 한국액체미립화학회 학술강연회 논문집 Vol.2010 No.-

A series of experimental research results on the characteristic of diesel elastic-plate impingement spray using High Speed Photography camera are presented in this paper. The experiments were carried out in a constant volume chamber specially designed, which can hold a high ambiance pressure. The special fixed device was designed so that the elastic-plate can be fixed on the spray path, meanwhile the spray incident angle and height can be changed. The free jet spray and elastic-plate impingement spray was compared under the same experimental condition including different injection pressure and different background pressure. Experimental research showed that impingement spray droplets diffuse more quickly than free jet spray.

Association between Thioridazine Use and Cancer Risk in Adult Patients with Schizophrenia-A Population-Based Study

Cheng-Chen Chang,Ming-Hong Hsieh,Jong-Yi Wang,Nan-Ying Chiu,Yu-Hsun Wang,Jeng-Yuan Chiou,Hsiang-Hsiung Huang,Po-Chung Ju 대한신경정신의학회 2018 PSYCHIATRY INVESTIGATION Vol.15 No.11

Objective Several cell line studies have demonstrated thioridazine’s anticancer, multidrug resistance-reversing and apoptosis-inducing properties in various tumors. We conducted this nationwide population-based study to investigate the association between thioridazine use and cancer risk among adult patients with schizophrenia. Methods Based on the Psychiatric Inpatient Medical Claim of the National Health Insurance Research Database of Taiwan, a total of 185,689 insured psychiatric patients during 2000 to 2005 were identified. After excluding patients with prior history of schizophrenia, only 42,273 newly diagnosed patients were included. Among them, 1,631 patients ever receiving thioridazine for more than 30 days within 6 months were selected and paired with 6,256 randomly selected non-thioridazine controls. These patients were traced till 2012/12/31 to see if they have any malignancy. Results The incidence rates of hypertension and cerebrovascular disease were higher among cases than among matched controls. The incidence of hyperlipidemia, coronary artery disease and chronic pulmonary disease did not differ between the two groups. By using Cox proportional hazard model for cancer incidence, the crude hazard ratio was significantly higher in age, hypertension, hyperlipidemia, cerebrovascular disease, coronary artery disease and chronic pulmornary disease. However, after adjusting for other covariates, only age and hypertension remained significant. Thioridazine use in adult patients with schizophrenia had no significant association with cancer. Conclusion Despite our finding that thioridazine use had no prevention in cancer in adult patients with schizophrenia. Based on the biological activity, thioridazine is a potential anticancer drug and further investigation in human with cancer is warranted.

Study on Simulation Analysis of Reduce Speed Effect for Wind Nets in Front of Crop

( Cheng-chang Lien ),( Zhu-yun Yeh ),( Wei-ling Sun ),( Jeng-liang Lin ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1

Due to frequent strong winds from its geographical location in Taiwan, which caused serious damage to vegetables and fruit trees, leading to a large loss of agricultural production. Wind nets can be used to reduce the wind speed in front of fruits and vegetables in order to reduce the impact of wind speed. The purpose of this study is to use Computational Fluid Dynamics(CFD), CFD simulation Software was used to simulate wind tunnel experiments with wind nets before fruits and vegetables to understand the wind tunnel with different ventilation rates under certain wind speed 40 m/s, to simulate the change of wind speed and the distribution of flow field behind the wind nets, Analyze and analyze the change of wind field and the effect of reducing the wind. The size of the wind net was 12m^*6m. According to the CFD simulation results, when the strong wind blows through the wind nets, a negative pressure zone will be generated at a horizontal distance of 0h to 10h in the windshield leeway, and the height of the negative pressure zone will gradually decrease as the horizontal distance increases. The height of the negative pressure zone also decreases with the increase of the ventilation rate of the windbreak. In addition, the analysis results show that the ventilation rate of 40% of the windbreak, the negative pressure vortex gradually disappear, and have the best effect of reducing the wind.

APPLY OZONATION TO PRETREAT ACRYLIC RESIN ( ABS ) MANUFACTURER WASTEWATER

( Cheng Nan Chang,Bo Chuan Cho ) 한국물환경학회 1997 제6차 국제수질보전학회 아시아 태평양지역 학술회의 Vol.2 No.-

Acute Hepatitis Due to Agomelatine Use in Elderly Women with Depression: Case Series

Cheng-Chen Chang,Yen-Jen Chen,Yu-An Chen,Yi-Cheng Liao 대한정신약물학회 2021 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.19 No.4

Although agomelatine may be associated with an increased risk of hepatotoxicity, the incidence rate of acute hepatitis seemed divergent between clinical trials and daily practice. Whether aging or gender is a risk factor in developing hepatotoxicity due to agomelatine is not clear. We present 3 older female cases with acute hepatitis occurring due to highly probable idiosyncratic drug-induced liver injury caused by agomelatine. From these cases, regular surveillance on liver function in the older women taking antidepressants would be of benefits.

A TQM case of Centralized Sequential Decision-making Problem

Chang, Cheng-Chang,Chu, Yun-Feng 한국품질경영학회 2003 The Asian Journal on Quality Vol.4 No.1

This paper considers that a public department under specialized TQM manpower constraints have to implement multiple total quality management (TQM) policies to promote its service performance (fundamental goal) by adopting a centralized sequential advancement strategy (CSAS). Under CSAS, the decision-makers (DMs) start off by focusing specialized TQM manpower on a single policy, then transfer the specialized TQM manpower to the next policy when the first policy reaches the predetermined implementation time limit (in terms of education and training). Suppose that each TQM policy has a different desirous education and training goal. When the desirous goals for all TQM policies are achieved, we say that the fundamental goal will be satisfied. Within the limitation of total implementation period of time for all policies, assume the desirous goals for all TQM policies cannot be achieved completely. Under this premise, the optimal implementation sequence for all TQM policies must be calculated to maximize the weighted achievement of the desirous goal. We call this optimization problem a TQM case of “centralized sequential decision-making problem(CSDMP)”. The achievement of the desirous goal for each TQM policy is usually affected by the experience in prior implemented policies, which makes solving CSDMP quite difficult. As a result, this paper introduces the concepts of sequential effectiveness and path effectiveness. The structural properties are then studied to propose theoretical methods for solving CSDMP. Finally, a numerical example is proposed to demonstrate CSDMP’s usability.

A Single-Stage LED Tube Lamp Driver with Input-Current Shaping for Energy-Efficient Indoor Lighting Applications

Cheng, Chun-An,Chang, Chien-Hsuan,Cheng, Hung-Liang,Chung, Tsung-Yuan,Tseng, Ching-Hsien,Tseng, Kuo-Ching The Korean Institute of Power Electronics 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.4

This study proposes a single-stage light-emitting diode (LED) tube lamp driver with input-current shaping for T8/T10-type fluorescent lamp replacements. The proposed AC-DC LED driver integrates a dual-boost converter with coupled inductors and a half-bridge series-resonant converter with a bridge rectifier into a single-stage power conversion topology. This paper presents the operational principles and design considerations for one T8-type 18 W-rated LED tube lamp with line input voltages ranging from 100 V rms to 120 V rms. Experimental results for the prototype driver show that the highest power factor (PF = 0.988), lowest input current total harmonic distortion (THD = 7.22%), and highest circuit efficiency (η = 92.42%) are obtained at an input voltage of 120 V. Hence, the proposed driver is feasible for use in energy-efficient indoor lighting applications.

Electrochemical Analytical Method for Determination of Available Cadmium in Soil with Screen-Printed Carbon Electrodes

Chang Jie Cheng,Shan-Li Wang 한국토양비료학회 2014 한국토양비료학회 학술발표회 초록집 Vol.2014 No.6

Xin Yu Lou: Unrepeatable Commercial Miracle in Chinese Retailing Industry

Chang Xue,Cheng Jiang,Xing Youhong Academy of Asian Business (AAB) 2017 Academy of Asian Business Review Vol.3 No.1

In order to change the impression of businessman, Zhang Hongrui engaged in business by ethics. He set up Xin Yu Lou in 1984, with the representation of honesty and credibility. This article begins with Xin Yu Lou’s ethics: honesty in business and credibility in nature, then exhibits its unique management feature: enjoyable work and happy life. Based to special governance structure, Xin Yu Lou gets along well with all the stakeholders: Xin Yu Lou regards customer as friend, shows consideration to staff, becomes friend with counterpart and safeguards profit of suppliers. The purpose of this case study is to illustrate the miracle of Xin Yu Lou. The first is the position of human nature – unconditional return, no performance assessment, employee holiday in traditional festival, no heritage on stock which is linked with the post. The second is that desire is substituted by belief – credibility is the premise, and honesty is the beginning. The third is the orientation of target – transcending money, creating happiness, holy land in working, guiding development, all-round life fulfillment. Under the whole circumstance of low credibility in retailing industry, the big advantage of Xin Yu Lou depends on solving information asymmetry (such as guaranteed quality, trial commodity, unconditional return, and etc.), which can save transaction cost. The focus of this case analysis is win-win relations among all the stakeholders, including customers, staff, counterparts, suppliers, which is insisting on the principle of benefit sharing. Business longevity, staff happiness and successful life, customer satisfaction, growing up together with suppliers, joint development with business partners, consumer gains the benefit in the end as a result of win-win. The importance of study is to affirm that the most significant winner is the unit that has thought for others since the beginning in repeated game experiments.