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- 저자 : Changxi Li (검색결과 4 건)
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Yinghao Song,Changxi Li,Jingjing Guan,Cheng Li,Haisheng Wu,Xinzhi Cheng,Bingyu Ling,Jinglang Zhang 대한통증학회 2022 The Korean Journal of Pain Vol.35 No.1
Background: Percutaneous transforaminal endoscopic discectomy (PTED) has been widely used in the treatment of lumbar degenerative diseases. Epidural injection of steroids can reduce the incidence and duration of postoperative pain in a short period of time. Although steroids are widely believed to reduce the effect of surgical trauma, the observation indicators are not uniform, especially the long-term effects, so the problem remains controversial. Therefore, the purpose of this paper was to evaluate the efficacy of epidural steroids following PTED. Methods: We searched PubMed, Embase, and the Cochrane Database from 1980 to June 2021 to identify randomized and non-randomized controlled trials comparing epidural steroids and saline alone following PTED. The primary outcomes included postoperative pain at least 6 months as assessed using a visual analogue scale (VAS) and the Oswestry Disability Index (ODI). The secondary outcomes included length of hospital stay and the time of return to work. Results: A total of 451 patients were included in three randomized and two nonrandomized controlled trials. The primary outcomes, including VAS and ODI scores, did not differ significantly between epidural steroids following PTED and saline alone. There were no significant intergroup differences in length of hospital stay. Epidural steroids were shown to be superior in terms of the time to return to work (P < 0.001). Conclusions: Intraoperative epidural steroids did not provide significant benefits, leg pain control, improvement in ODI scores, and length of stay in the hospital, but it can enable the patient to return to work faster.
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Xingyuan Zhang,Fang Zhang,Changxi Zhang,Jie Li 연세대학교의과대학 2021 Yonsei medical journal Vol.62 No.5
Purpose: Multiple pathways are involved in inducing liver fibrosis, which can damage the integrity of liver. Among them, miR-125b has been found to exert an activating action on hepatic stellate cells. Endoplasmic reticulum stress and autophagy lead toliver disorders. Here, we evaluated the therapeutic influence of miR-125b on the endoplasmic reticulum function in injured liverssubmitted to bile duct ligation. Materials and Methods: For inducing injury, bile duct ligation was done on miR-125b transgenic rats (miR-125b-Tg) in wild typerats. The rat T-6 cells received transfection of miR-125b mimic and Tunicamycin. Protein expressions were observed by westernblot analysis. Results: Compared to wild type rats, liver-injured rats showed significant impairment of liver function as assessed by the total bilirubinlevels. The miR-125b-Tg rats showed decrease in activity of aspartate transaminase and alanine transaminase. Liver tissuesof miR-125b-Tg rats showed weaker fibrotic matrix formation. Upregulation of miR-125b decreased the bile duct ligation-mediatedhepatic disturbances for the expressions of endoplasmic reticulum kinase, inositol-requiring kinase 1alpha, sXBP1, CHOP, LC3,p62, ULK, and caspase-3/-8/-9. T-6 cells transfected with miR-125b mimic and treated with Tunicamycin caused decrease in levelsof cleaved caspase-3, sXBP1, CHOP, and LC3. The miR-125b signaling showed protective effect on the liver tissues subjected to injuryand fibrosis histopathology. Conclusion: This study demonstrates a novel insight into the miR125b-mediated stabilization of endoplasmic reticulum integrity,which slows the progression of injury-induced hepatic deterioration.
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Role of Rab GTPases in Bacteria Escaping from Vesicle Trafficking of Host Cells
Xu Huiling,Wang Shengnan,Wang Xiaozhou,Zhang Pu,Zheng Qi,Qi ChangXi,Liu Xiaoting,Li Muzi,Liu Yongxia,Liu Jianzhu 한국미생물학회 2024 The journal of microbiology Vol.62 No.8
Most bacteria will use their toxins to interact with the host cell, causing damage to the cell and then escaping from it. When bacteria enter the cell, they will be transported via the endosomal pathway. Rab GTPases are involved in bacterial transport as major components of endosomes that bind to their downstream effector proteins. The bacteria manipulate some Rab GTPases, escape the cell, and get to survive. In this review, we will focus on summarizing the many processes of how bacteria manipulate Rab GTPases to control their escape.
ScienceON
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