Purge & Trap-GC를 이용한 의약품 필름코팅 정제 중 잔류용제에 관한 연구

장준식,이명자,소유섭,문춘선,이주헌,박희라,김진숙,강경모,이선옥,방성연,유미자,유문균,금오성,이병욱 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-

의약품은 약물을 생체에 적풋하기 위하여 유효성분의 효과가 언제나 일정하게 확보되고 사응에 편리하도록 만들어지는 것이므로 유효썽분 이외에 약효에 영향을 주지 않는 성분이 첨가되는 경운가 많다. 이 때 사용되는 용매들은 제피의 광택 및 건쪼시간의 단축 등을 위하여 휘발점이 낮을 용매들이 주로 사용되어진다. 본 연구는 의약품 필름코팅정제 중 잔류용매 4종(chlorofonr benzen, trichloro ethylen, 1,4-dioxane)에 대한 변형된 pirge & trap-GC 장치를 이용한 동시분석방법을 개발하였으며, 각 표준품의 RSD 값은 chloroform 3.03%, benzen 3.17%, trichloroethylen 3.69% and 1,4-dioxane 3.41%였다. 또한 시중 유통중인 의약품 50종에 대하여 잔류웅매 양을 측정하였으며, 검출되는 잔류용매는 한 건도 없었다. This study nras carried out to develope the analytical method for the mixture of chlorefonn, benzen, trichloroethylen and 1,4-dioxane simultaneously and determine the remainingorgauic solvents in coating tablets by Purge & Trap-GC. The results were as follouFs ; 1. Chloroform, benzen, trio:tloroethylen and 1,4-dioxane separated by tenax #5 trap by HP-624GC column by terrlperature programming. The peaks were separated completely at retentiontime of 6.88min for chloroform, 8.21min for benzen, 10.38miu for trichloroethylen and 11.95minfor 1,4-dioxane. 2. Standard RSD were individually chloroform 3.03%, benzen 3.17%, trichloroethylen 3.69%and 1,4-diorane 3.41%. 3. 60 samples were not detrcted chloroform, benzen, trichloroethylen and 1,4-dioxane.

구리 인근 경기 동북 지역에서의 피부질환의 통계적 관찰

이창우,유희준,양홍윤,전재홍 한양대학교 의과대학 1996 한양의대 학술지 Vol.16 No.2

We reviewed 4,173 new out-patients visited dermatology clinic of Hanyan University Kuri Hospital (from November 1995 to October 1996) to study the prevalence of common dermatoses occurring in this region (northeastern area of Kyounggi province) and compared to those of other Korean data. Among 4,173 new out-patient, 1,866(44.7%) were male, and 2,307(55.3%) were female. Fifteen common dermatoses were found to be contact dermatitis(13.0%), dermatophytosis(9.1%), atopic dermatitis(8.4%), seborrheic dermatitis(8.1%), other eczemas(7.8%), urticaria(6.4%), acne vulgaris(4.9%), herpes zoster(3.4%), drug eruption(2.5%), bacterial infection(2.1%), psoriasis(1.9%), verruca(1.8%), vitiligo(1.4%), syphilis(0.5%), and scabies(0.5%) in order of frequency. The most frequently visited age group was those between the age 21 to 30 years old constituting 20.4% of total patients. On monthly visited number of patients, the highest was in January, and the lowest was November. The results suggest that age, sex and monthly distribution patterns in northeastern area of Kyounggi province are similar to those of other epidemiological reports in Korea except for the higher prevalences of contact dermatitis, seborrheic dermatitis and herpes zoster.

동종 조혈모세포이식 후 발생한 치명적 홍역 폐렴 1예

백창렬,이동건,최정현,정현화,조유경,박훈준,이승훈,박윤희,이교영,민우성,김춘추,신완식 대한감염학회 2001 감염 Vol.33 No.4

As a result of the enlarging pool of unvaccinated children and young adults, there has been an increase in measles in our countries. In these situation, it has been reported that measles associated pneumoinia is easily complicated with fatal respiratory failure, espycially in immunocompromised patients. Herein we report the case of lethal measles pneumonia after allogenic hematopoietic stem cell transplantation in adults proven by autopsy. Recently, one case of measles was encountered in 39-year-old female patients after allogenic bone marrow transplanted case (chronic myelogenous leukemia), who progressed into interstitial pneumonia pattern, despite treatment including antibiotics, immunoglobulin. The patient died of giant cell pneumonia compatible with that of measles which was comfirmed in the section of necropsy lung specimen. (Korean J Infect Dis 33:301∼309, 2001)

鐵筋콘크리트 보에서 剪斷鐵筋이 휨耐力에 미치는 影響

고유신,기진호,김병호,은희창,서일교 제주대학교 산업기술연구소 2000 尖端技術硏究所論文集 Vol.11 No.2

Shear reinforcement has an important role to strengthen shear capacity of reinforced concrete beam. Although the flexural design corresponding to design code does not consider the effects of the shear reinforcement, its utilization in flexural region leads to the improved ductility and the enhanced strength by confining concrete. It allows to design the over-reinforcement beam. In this study, we considered the effects of the shear reinforcement on the flexural ductility and strength of reinforced concrete beam according to the spacing of shear reinforcement, steel ratio, and shear span ratio. The flexural capacity depends on the amount of longitudinal bars and the ductility the confinement degree by the shear reinforcement. The flexural analysis varies with the stress-strain relation of confined concrete. The analytical results based on the stress-strain relation presented by Chung almost corresponded to the experimental ones. It was observed that the proper design of shear reinforcement leads to utilize the over-reinforcement concrete beam.

남편의 폭력이 아내의 정신병리에 미치는 영향 : 자아 탄력성, 대처양식, 사회적 지지를 중재변인으로

홍창희,박유숙 부산대학교 심리과학연구소 2001 심리과학연구 Vol.2 No.-

본 연구는 남편의 폭력이 아내의 정신병리에 미치는 영향을 알아보고자 하였다. 아내의 자아 탄력성, 대처양식, 사회적 지지가 매개변인 혹은 중재변인으로 고려되었다. 연구대상은 남편에게 폭력을 당하지 않는 아내 45명과 남편에게 폭력을 당하는 아내 159명이었다. 본 연구의 결과는 다음과 같다. 1. 남편에게 폭력을 당하는 아내는 폭력을 당하지 않는 아내에 비해 자아 탄력성이 낮고 사회적 지지를 덜 받았다. 그리고 적극적인 대처와 소극적인 대처를 많이 하였다. 2. 남편에게 폭력을 당하는 아내는 폭력을 당하지 않는 아내에 비해 PTSD 증상과 우울, 무기력이 심했다. 3. 남편에게 폭력을 당하는 아내의 PTSD 증상은 폭력 3~7년 사이에 가장 심하였고 우울은 폭력 기간의 초기 4년까지 심해지다가 그 이후에는 고착되는 경향이 있었으며 무기력은 시간이 지나면서 점차 누적되는 경향이 있었다. 4. 적극적 대처는 기존 연구와는 달리 폭력정도, PTSD 증상과 정적 상관이 있었다. 5. 자아 탄력성은 남편의 폭력에 중재변인 보다는 매개변인으로서 효과가 있었다. 본 연구의 결과는 남편의 폭력이 장기적으로 아내를 우울, 무기력하게 만드는 외상적인 사건으로 개념화 될 수 있음을 시사한다. 또한 가정폭력에 대한 적극적인 사회적 구호체제의 확립과 조기 개입의 필요성을 시사한다. 아울러 아내의 자아탄력성이 개입프로그램에서 우선적으로 고려해야할 개념임을 시사한다. 마지막으로 본 연구의 의의와 한계점이 논의되었다. The purpose of this study was to examine the effects of violence of husband on psychopathology of wife. Ego-resiliency, coping styles of wife, and social support were considered as mediating or moderating variables. Subjects were 45 non-battered wives and 159 battered wives. The results of this study as follows : 1. In case of battered wives, ego-resiliency and social support were low. And they showed more active and passive coping. 2. Battered wives showed severe symptoms of PTSD, depression and helplessness. 3. For battered wives the symptoms of PTSD were severe in 3-7 years of violence. Depression seemed to be most severe in first 4 years and didn't make such changes after that. Helplessness became stronger. 4. Inconsistent with early studies, active coping skills correlate positively with intensity of violence and PTSD. 5. Ego-resiliency is most appropriate as a mediator. The results of this study suggest that violence of husbands can be considered as a traumatic event witch makes wives to be depressive and helpless for long time. Social support network and early interventions for battered wives are requested. Also the results suggest ego-resiliency of battered wives should be considered first in the intervention program. Lastly, implication and limitation were discussed.

산발성 장형 위선암 환자의 Microsatellite Instability와 병리학적 양상

조창희,홍유찬,안지현,최경현,이상호,신영명,윤기영,정민정,장희경 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Background : Through many researches, microsatellite is expected to be a good diagnositic and prognostic factor in colorectal cancer, endometrial cancer, gastric cancer, and the others. The prevalence of microsatellite instability (MSI) in gastric carcinoma has reported variously, 13~44%. Purpose : We aimed to determine the prevalence of MSI-high and the relationship between MSI and pathological characteristics of sporadic intestinal type adenocarcinoma of stomach. Material and Methods : We analyzed 106 sporadic intestinal type adenocarcinoma specimens excised from patients who were over thirty-five years old to determine the statue of microsatellite by DNA sequencing. The tissues were formalin-fixed and paraffin embedded. DNA were extracted and amplified by polymerase chain reaction (PCR). MSI was determined using five markers recommended by National Cancer Institute (NCI). Specimens were also studied with five patholical factors-differenciation of tumor cells, depth of invasion, lymph node metastasis, vessel invasion, and perineural invasion- to determine pathological state. Result : The microsatellite statue was determined as MSI-High in 5 cases (4.7%), no MSI-low, and MSS (microsatellite stable) in 101 cases (95.3%). Within the frequency, there was no large gap in the distinction of gender in MSI cases, but in MSS cases, there was three-times more cases in male. MSI cases had moderate-to-poor differenciation and trend to invade toward serosa. All MSI cases showed no perineural invasion. But we could not find any statistical significance between MSI and pathological characteristics of sporadic intestinal type adenocarcinoma. Conclusion : Results suggest that MSI can not make any certain pathological significance in sporadic intestinal type adenocarcinoma. Even though less than 5% of sporadic intestinal type adenocarcinoma patients showed MSI, it can be used as a influential prediagnostic factor of gastric cancer. Further study with large scale of cases will be followed to verify these results.

철근콘크리트 보에서 전단철근이 휨내력에 미치는 영향

고유신,기진호,김병호,은희창,서일교 濟州大學校 産業技術硏究所 2000 산업기술연구소논문집 Vol.11 No.2

정신분열병과 Neuregulin 1 유전자의 연합연구

박동연,이유상,조은영,조승희,장용이,전현옥,장수연,윤세창,김종원,홍경수 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.3

Objectives : The authors recently found a suggestive evidence of linkage of chromosome 8p21-12 to schizophrenia in Korean multiplex families. Neuregutin 1 (NRGI) was identified in this locus as a positional and functional candidate gene for Schizo-phrenia, through several independent studies with European and Chinese populations. The purpose of this study is to determine whether NRGl is associated with schizophrenia in Korean population. Methods : Three SNPs (SNP8NRG221533, SNP8NRG241930, SNP8NRG243177) and two microsatellites markers (478B14-848,420M9-1395) located at the 5' end of NRGI were genotyped for 242 unrelated schizophrenia patients and the same num-ber of normal controls. Genetic association was tested by χ²-test (df=1). Not only for the whole patients group but also for asubgroup of patients with auditory hallucination. This subtype showed stronger linkage with chromosome 8p12 in the prior study of the authors with multiplex families. Results : G allele of SNP8NRG241930 was significantly in excess in the subgroup of patients with auditory hallucination compared to the control group (p=0.03, 0R=1.76). We also found that 3 SNPs haplotype TTC (p=0.04, 0R=0.58) and five markers haplotype TTC53 (p=0.01,0R=0.49) were associated with schziophrenia with a protective effect. Three SNPs haplotype CGT which is a part of the at-risk haplotype of the Icelandic schizophrenia families was found in excess in the patients group but no significant association was observed. Conclusion : NRGI might either play a mle in the predisposition to schizophrenia or be in linkage disequilibrium with a causal locus of this illness.

뇌성마비아의 모발내 중금속 함량 분석

안경희,김희상,유창현,윤동환,홍장혁,유승돈,이준원 경희대학교 2001 慶熙醫學 Vol.17 No.1

부인과 암수술에 있어서 외과의사의 역할

최평화(Pyong Wha Choi),유창식(Chang Sik Yu),정상훈(Sang Hun Jung),김대동(Dae Dong Kim),홍동현(Dong Hyun Hong),김희철(Hee Cheol Kim),김진천(Jin Cheon Kim) 대한외과학회 2008 Annals of Surgical Treatment and Research(ASRT) Vol.74 No.4

Purpose: Resection of the bowel or solid organs may be required for pelvic tumor surgery. The present study was performed to assess combined surgical procedures and determine the role of the general surgeon in gynecologic oncology surgery Methods: We performed a retrospective study of 135 patients with gynecologic malignancy who underwent a combined operation with a general surgeon between January 2000 and December 2005 at Asan Medical Center. The purpose of the combined operation was categorized into 3 groups: a tumor debulking operation, a resolution of intraoperative complications by a gynecologic surgeon, or an intraoperative diagnostic change. Results: The incidence of combined operations for debulking, resolution of intraoperative complications, and intraoperative diagnostic changes were 103 cases (76.3%), 22 cases (16.3%), and 10 cases (7.4%), respectively. Ovarian cancer was the most common gynecologic malignancy (74.1%) and the rate of a combined operation with a general surgeon in ovarian cancer was 18.5% during the time period. Colorectal resection was the most common procedure by a colorectal surgeon (61.5%). Twenty four patients (17.8%) experienced postoperative complications, including ileus, wound infection, pancreas leakage, and stomal necrosis, with no significant differences according to the purpose of combined operation, pathologic diagnosis, or bowel preparation. The rate of a preoperative consultation to a general surgeon by gynecologic surgeons in cases with colorectal or solid organ invasion preoperatively was 53.2%. Conclusion: A general surgeon is an important consultant in a debulking operation of gynecologic malignancies, especially ovarian cancer, or treatment of complications. Thorough preoperative evaluation, bowel preparation, and preoperative consultation to a general surgeon is important in gynecologic oncology surgery.