Relationships between erectile dysfunction, prostate cancer treatment type and inflatable penile prosthesis implantation

Chan Shen,Kunj Jain,Tejash Shah,Eric Schaefer,Shouhao Zhou,Dennis Fried,Drew A. Helmer,Hossein Sadeghi-Nejad 대한비뇨의학회 2022 Investigative and Clinical Urology Vol.63 No.3

Purpose: The prevalence of erectile dysfunction (ED) and the utilization of inflatable penile prosthesis (IPP) among prostate cancer patients are understudied. The aim of the study was to examine the relationships between ED, prostate cancer treatment type and IPP implantation in a national cohort. Materials and Methods: We identified a retrospective cohort of Surveillance, Epidemiology, and End Results (SEER)-Medicare patients diagnosed with locoregional prostate cancer between 2006 and 2011 and treated with surgery or radiation. Chi-square tests were used to detect significant differences in ED rates as well as use of IPP among the subset with ED. Multivariable logistic regression was used to examine factors associated with the use of IPP. Results: Among 31,233 patients in our cohort, 10,334 (33.1%) received prostatectomy and 20,899 (66.9%) received radiation. ED within 5 years was significantly more common in the prostatectomy group relative to those the radiation group (65.3% vs. 33.8%, p<0.001). In the subset of 13,812 patients with ED, the radiation group had greater median time to ED diagnosis compared to the prostatectomy group (346 vs. 133 days, p<0.001). IPP implantation was more frequent for prostatectomy patients than for radiation patients (3.6% vs. 1.4%, p<0.001). Cancer treatment type, race, and marital status were significantly associated with IPP utilization. Conclusions: ED is highly prevalent among prostate cancer patients, and IPP implantation is be underutilized. ED rates, time to ED diagnosis and utilization of IPP differed significantly by prostate cancer treatment type.

Survive the climate variability?

I-Ching Chen,Sheng-Feng Shen,Shih-Fan Chan 한국응용곤충학회 2013 한국응용곤충학회 학술대회논문집 Vol.2013 No.10

Climate and its variability characterize abiotic environment for species on the earth. Increased seasonality in higher latitude and/or pronounced diurnal temperate range in higher ground as well as decreasing mean temperature are major climate gradients to which organisms must adapt through physiological and behavioral plasticity. IPCC AR5 pointed out that climate variability and its regional behavior remain top concerns, which may well pose great challenges to climate change biology. We use Nicrophorus nepalensis (Coleoptera: Silphidae) a wide-distributed burying beetle in low latitude Asia as model species to investigate possible impacts of climate variability on species performance. N. nepalensis is a scavenging species exploring carcasses for feeding and reproduction. To consider their breeding performance, we baited N. nepalensis by small mouse carcasses and measured the rate at which they successfully buried the carcasses into soil. We look at climate variability along elevational gradients of intact forest and open habitats exposure to agricultural activities. The probability of successful breeding is higher in intact forest than that in open habitat with unimodal fashion of peak at 1800m. We found that local climate variability, more specifically, the diurnal temperature range (DTR), impedes successful breeding of N. nepalensis. Despite variable environmental conditions associated with habitat opening, such as increased soil density, reduced leaf litter amount and relative humidity, enlarged DTR seems to be the principal cause of failure. The negative effects of greater DTR on breeding success were confirmed by laboratory experiments. DTR remains stable in primary forests, in contrast to its increase in more disrupted habitats along the same transect. Reducing vegetation cover exposes mountains to radiant heating, a trend with significant elevational effect, resulting in large DTR in high lands. Although N. nepalensis is widely distributed in the mountain areas, non-forest patches support only part of their life cycle, different function groups to support decomposition process at open habitats are expected. Climate change and habitat degradation are among the major drivers of biodiversity loss. Our study highlights land-use and land-cover change (LULCC) in altering local temperature variability and reinforces the concern of its interplay with climate change.

Addressing the challenges of missed parathyroid glands in ultrasonography for secondary hyperparathyroidism: a retrospective observational study

Shen-En Chou,Cheng-Hsi Yeh,Shun-Yu Chi,Fong-Fu Chou,Yi-Ju Wu,Yen-Hsiang Chang,Yi-Chia Chan 대한외과학회 2024 Annals of Surgical Treatment and Research(ASRT) Vol.107 No.3

Purpose: Preoperative localization plays an important role in secondary hyperparathyroidism (SHPT) surgery. The advantages of neck ultrasound (US) include high availability and low cost. However, the reported sensitivity of US is 54%– 76%, and the reason for missed parathyroid glands (PGs) on US has been rarely addressed. Methods: Fifty-four patients who were diagnosed with renal SHPT from September 2020 to March 2022 were included in this retrospective study. Preoperative localization included surgeon-oriented US and technetium 99m-sestamibi single- photon emission CT (SPECT)/CT. Results: A total of 212 PGs were pathologically confirmed, resulting in a success rate of 96.2% (52 of 54). Using echo, 193 PGs (91.0%) were accurately localized, while 19 glands (9.0%) were not identified, including those in ectopic positions (n = 12, at thymus or intrathyroid or others), of small size (<1 cm, n = 6), or overlapping with an ipsilateral PG (n = 1). US accurately detected 4 PGs in 36 (66.7%) patients, while SPECT/CT localized 4 glands in 19 patients (35.2%). Although the number of US-detectable PGs was not associated with success rate, it showed a significant negative correlation with surgical time (rs = –0.459, P = 0.002). Conclusion: US detected 4 glands in 66% of SHPT patients with a sensitivity of 90% for localization. Ectopic position and small size were the most common reasons for the failure to detect PG on US. Complete preoperative echo localization might shorten operating time.

Prediction of Failure Mode in Hole Clinching of Al Alloy and Advanced High-Strength Steel

Shen, Guo,Lee, Chan Joo,Lee, Jeong Min,Kang, Gil Seok,Park, Joon Hong,Kim, Byung Min,Ko, Dae Cheol Trans Tech Publications, Ltd. 2016 Key Engineering Materials Vol.716 No.-

<P>Common joining methods used in automotive industry are welding, adhesive bonding, friction stir welding, mechanical fastening, self-piercing rivets, mechanical clinching and so on, for multi-material designed automotive bodies. Among different joining methods, mechanical clinching which achieves geometrical interlocking by plastic deformation has several advantages such as no need of additional joining elements and fast joining. But mechanical clinching is difficult to join a ductile material with a high-strength or low ductility material. Therefore the hole clinching as a new mechanical clinching process has been proposed to join these material combinations. In the hole clinching process, as punch force is applied to a upper sheet (a ductile material), it is indented into hole of lower sheet (low ductile material) on die and then interlocked by plastic deformation. It is very important for a successful design of hole clinching to predict the failure mode such as neck fracture and button separation and the strength of hole-clinched joint. For this an analytical approach was carried out for the hole clinching process of Al6061 and DP980. Tool geometry used in hole clinching was designed by the predicted failure mode. Preliminary finite element simulation was performed to validate the geometrical interlocking and joinability. The predicted failure mode and strength were verified by the results of cross tension test.</P>

An Iterative Image Dehazing Method With Polarization

Shen, Linghao,Zhao, Yongqiang,Peng, Qunnie,Chan, Jonathan Cheung-Wai,Kong, Seong G. IEEE 2019 IEEE transactions on multimedia Vol.21 No.5

<P>This paper presents a joint dehazing and denoising scheme for an image taken in hazy conditions. Conventional image dehazing methods may amplify the noise depending on the distance and density of the haze. To suppress the noise and improve the dehazing performance, an imaging model is modified by adding the process of amplifying the noise in hazy conditions. This model offers depth-chromaticity compensation regularization for the transmission map and chromaticity-depth compensation regularization for dehazing the image. The proposed iterative image dehazing method with polarization uses these two joint regularization schemes and the relationship between the transmission map and dehazed image. The transmission map and irradiance image are used to promote each other. To verify the effectiveness of the algorithm, polarizing images of different scenes in different days are collected. Different algorithms are applied to the original images. Experimental results demonstrate that the proposed scheme increases visibility in extreme weather conditions without amplifying the noise.</P>

Identification of aberrant overexpression of long non-coding RNA MALAT1 and role as a regulatory microRNA in liver cancer

Woo Chan Shin,Jung Woo Eun,Qingyu Shen,Hyung-Seok Kim,Hee Doo Yang,Sang Yean Kim,Young Min Ahn,박원상,이정용,Suk Woo Nam 대한독성 유전단백체 학회 2017 Molecular & cellular toxicology Vol.13 No.4

MALAT1 is deregulated in various cancers. The underlying mechanisms of MALAT1-mediated tumorigenesis are unclear. We found that MALAT1 was highly overexpressed and its overexpression was significantly associated with poor prognosis of liver cancer patients analyzed from the TCGA Liver Hepatocellular Carcinoma and Gene Expression Omnibus databases of the National Center for Biotechnology Information. Microarray analysis to identify the miRNAs deregulated by silencing MALAT1 in two liver cancer cell lines, HepG2 and Hep3B, revealed the common deregulation of 16 miRNAs including miR-574 and miR-20b in both cell lines. The predicted targets of miR-574 and miR-20b were cancer-related pathways including the RAS, MAPK and Wnt/β-catenin pathways. Aberrant expression of MALAT1 might contribute to liver cancer tumorigenesis by deregulation of cancer-associated miRNAs.

The characteristic of chemical wastewater degradation by advanced oxidation process

Ran Shen,김명희(Ming Ji Jin),Tae Seop Jeong,Chan Hee Won 대한환경공학회 2006 대한환경공학회 학술발표논문집 Vol.2006 No.12

中國 企業家精神과 創業動機

表旻燦(Min-Chan Pyo),權聖容(Kwon Sung-yong),張沈偉(Zhang Shen-Wei) 동아인문학회 2009 동아인문학 Vol.16 No.-

This paper analyzes Chinese entrepreneurship and motivation for start-up entrepreneurs since economic reforms at the end of 1978. We classify the background of Chinese entrepreneurs into three categories: (1) entrepreneurs from peasant stock, (2) entrepreneurs from professional experts, and (3) ex-government officials. Each category has unique start-up motivations and procedures. Entrepreneurs from peasant stock start their businesses as a means of living and prefer to diversify their business. Entrepreneurs from professional experts start their enterprises to be compensated for their professional knowledge and skills. Entrepreneurs from government officials are conservative in starting their own businesses because of high opportunity cost of quitting their stable jobs. Ex-government officials have close relationship(guanxi) with government authorities, leading ex-government officials ease to access resources necessary for start-up. Earlier firm-level studies on Chinese enterprises have discussed the competitiveness of Chinese firms, but these studies could not explain the source of competitiveness. This paper provides valuable insights into the source of competitiveness and motivation for start-up entrepreneurs by analysing start-up entrepreneur cases since 1978. Based on this paper, future studies may empirically investigate whether or not the background of Chinese entrepreneurs has a effect on start-up motivation and procedures.

중국 경제특구의 외자유치제도에 관한 고찰

김부찬(Boo Chan Kim),이영신(Yong Shen Lee) 중앙법학회 2006 中央法學 Vol.8 No.2

Enhancement of the Polar Coercive Force for Annealed Co/Ir(111) Ultrathin Films

Wen-Yuan Chan,Du-Cheng Tsai,Wei-Hsiang Chen,Cheng-Hsun-Tony Chang,Jyh-Shen Tsay 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.62 No.12

The alloy formation and the magnetic properties of Co/Ir(111) ultrathin films have been investigated. As the temperature is increased above 400 K, interdiffusion of Co and the Ir substrate occurs. Due to a compositional change in the surface layers, the polar coercive force is greatly enhanced. At temperatures above 600 K, magnetic hysteresis appears only in the polar configuration. Thisshows that the easy axis of the magnetization of Co/Ir(111) may be stabilized in the direction ofthe surface normal by thermal-annealing treatments. From systematic investigations of Co/Ir(111)ultrathin films thinner than 4 monolayers, a magnetic phase diagram has been established. Accordingto the compositional changes and related magnetic properties, the phase diagram can beseparated into three regions. In region I at temperatures below 400 K, Co films are ferromagnetic. In region II where atomic interdiffusion occurs in the surface layers, an enhanced polar coerciveforce is observed. The phase transition from phase I to II is related to the interdiffusion betweenthe Co overlayer and the iridium substrate. In region III for low coverage or at high temperatures,a nonferromagnetic behavior is observed. The phase transition from phase II to III is mainly dueto the reduced atomic percent of cobalt in the Co-Ir alloy and to the lowered Curie temperaturecaused by a reduction in the thickness of the magnetic layers.