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Insulin Resistance Does Not Influence Gene Expression in Skeletal Muscle
Nguyen, Lisa L.,Kriketos, Adamandia D.,Hancock, Dale P.,Caterson, Ian D.,Denyer, Gareth S. Korean Society for Biochemistry and Molecular Biol 2006 Journal of biochemistry and molecular biology Vol.39 No.4
Insulin resistance is commonly observed in patients prior to the development of type 2 diabetes and may predict the onset of the disease. We tested the hypothesis that impairment in insulin stimulated glucose-disposal in insulin resistant patients would be reflected in the gene expression profile of skeletal muscle. We performed gene expression profiling on skeletal muscle of insulin resistant and insulin sensitive subjects using microarrays. Microarray analysis of 19,000 genes in skeletal muscle did not display a significant difference between insulin resistant and insulin sensitive muscle. This was confirmed with real-time PCR. Our results suggest that insulin resistance is not reflected by changes in the gene expression profile in skeletal muscle.
Three “DS” - Elements for Successful Weight Loss Outcomes: Role of Healthcare Professionals
( Dror Dicker ),( Assim A Alfadda ),( Pernille Auerbach ),( Ian D Caterson ),( Ada Cuevas ),( Jason Halford ),( Masato Iwabu ),( Jae-Heon Kang ),( Rita Nawar ),( Ricardo Arturo Reynoso Mendoza ),( Nic 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: In people with obesity (PwO), body weight loss of ≥5% is generally considered to be clinically meaningful. Some PwO do receive treatment and guidance from healthcare professionals (HCPs), but there remains a substantial unmet medical outcomes and weight maintenance need. To identify aspects that might contribute to a successful weight loss outcome (WLO; ≥5% body weight loss maintained for ≥1 year), we investigated the characteristics and experience of PwO with and without successful WLOs using data from the ACTION-IO study (NCT03584191). Methods: An online survey was completed by adults with obesity and HCPs in 11 countries: Australia, Chile, Israel, Italy, Japan, Mexico, Saudi Arabia, South Korea, Spain, UAE and UK. A successful WLO was defined as ≥5% body weight loss in the past 3 years maintained for ≥1 year. Results: A total of 14,502 PwO completed the survey. General characteristics were similar between those who had a successful WLO (n=1,559; 11%) vs those who had not (n=12,943; 89%): 53% vs 52% were male; the mean age was 49 vs 48 years; the mean number of comorbidities was 2.0 vs 1.8. The mean number of serious weight loss attempts was 4 for both groups. However, more PwO who had a successful WLO weighed themselves every day (20%) compared with those who had not had a successful WLO (10%). In terms of interactions with HCPs, more PwO who had a successful WLO had discussed weight (58%) with an HCP within the past 5 years than those who did not have a successful WLO (53%). In addition, more PwO who had a successful WLO compared with those who did not had been diagnosed with obesity (42% vs 35%) and had subsequent direction through the scheduling of a follow-up appointment (25% vs 21%). Conclusions: A 3D approach from HCPs (diagnosis, discussion and direction) appears to be a key element in facilitating a successful WLO. Neither gender, nor age, nor number of weight loss attempts was associated with a successful WLO.
Huxley, Rachel R,Barzi, Federica,Lam, Tai Hing,Czernichow, Sebastien,Fang, Xianghua,Welborn, Tim,Shaw, Jonathan,Ueshima, Hirotsugu,Zimmet, Paul,Jee, Sun Ha,Patel, Jeetesh V,Caterson, Ian,Perkovic, Vla American Heart Association, etc.] 2011 CIRCULATION - Vol.124 No.19
<P>Previous studies have suggested that there is a novel dyslipidemic profile consisting of isolated low high-density lipoprotein cholesterol (HDL-C) level that is associated with increased risk of coronary heart disease, and that this trait may be especially prevalent in Asian populations.</P>