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RISS 인기검색어
- 검색키워드
- 저자 : Cai Wenrong (검색결과 2 건)
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Li Miaomiao,Cai Wenrong,Jiang Lihua,Li Junyao,Li Shan,Tang Tongtong,Kong Yong 대한화학회 2023 Bulletin of the Korean Chemical Society Vol.44 No.12
Mesoporous manganese dioxide (mMnO 2 ) was first synthesized for the loading of methotrexate (MTX), and then dopamine was in situ polymerized on the surface of the MTX‐loaded mMnO 2 (mMnO 2 ‐MTX) in an alkaline solution to encapsulate the drug in the mesopores of mMnO 2 . Both low pH and glutathione (GSH) can result in the degradation of mMnO 2 and poly(dopamine) (PDA), and thus the delivery of MTX from the mMnO 2 ‐MTX‐PDA can be triggered by low pH and GSH. Near‐infrared (NIR) light‐responsive delivery of MTX can be achieved owing to the outstanding photothermal conversion capability of PDA; on the other hand, the mMnO 2 ‐MTX‐PDA can be utilized for photothermal therapy under the irradiation of NIR light due to the elevated temperature. The results of cytotoxicity test demonstrate that the pH, GSH, and NIR light tri‐responsive drug‐controlled delivery system has excellent biocompatibility, while exhibits pronounced growth inhibition against murine breast tumor cell line 4T1. Mesoporous manganese dioxide (mMnO2) was first synthesized for the loading of methotrexate (MTX), and then dopamine was in situ polymerized on the surface of the MTX-loaded mMnO2 (mMnO2-MTX) in an alkaline solution to encapsulate the drug in the mesopores of mMnO2. Both low pH and glutathione (GSH) can result in the degradation of mMnO2 and poly(dopamine) (PDA), and thus the delivery of MTX from the mMnO2-MTX-PDA can be triggered by low pH and GSH. Near-infrared (NIR) light-responsive delivery of MTX can be achieved owing to the outstanding photothermal conversion capability of PDA; on the other hand, the mMnO2-MTX-PDA can be utilized for photothermal therapy under the irradiation of NIR light due to the elevated temperature. The results of cytotoxicity test demonstrate that the pH, GSH, and NIR light triresponsive drug-controlled delivery system has excellent biocompatibility, while exhibits pronounced growth inhibition against murine breast tumor cell line 4T1.
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Rui Qian,Yin Zheng‐Zhi,Cai Wenrong,Li Junyao,Wu Datong,Kong Yong 대한화학회 2022 Bulletin of the Korean Chemical Society Vol.43 No.5
A simple drug controlled delivery system is facilely designed for pH-responsive delivery of methotrexate (MTX), an anticancer drug. Aminated mesoporous silica nanoparticles (AMSNs) were first synthesized for the loading of MTX, and then the MTX-loaded AMSN (AMSN-MTX) was encapsulated with hyaluronic acid (HA) through electrostatic attractions. Successful preparation of the HAencapsulated AMSN-MTX (AMSN-MTX-HA) is confirmed by different characterizations such as scanning electron microscopy, Fourier transform infrared, x-ray diffraction, and so on. Because the protonation/deprotonation of HA is closely related to pH, the electrostatic interactions between HA and AMSN depend closely on the pH of the medium and thus pH-responsive delivery of MTX is achieved. The release kinetic data of MTX from the carrier fit well to Higuchi and Korsmeyer-Peppas models. Cell experiments indicate that the developed AMSN-MTX-HA displays high inhibitory effect on hepatoma (SMMC-7721) cells while the drug-free carrier of AMSN-HA has good biocompatibility.
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