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A Molecular Approach to Studies of Growth and Development
K Palme,C Konez,A .Spena,J Schell 한국유전학회 1990 Genes & Genomics Vol.12 No.4
The molecular mechanisms underlying control of growth and differentiation in higher plant cells remain unknown. In order to systematically isolate and functionally characterize genes from higher plant cells involved in control of growth and differentiation, we have applied both conventional and novel strategies. We have used modern microanalytical techniques to isolate and study various auxin-binding proteins. We shall discuss the molecular structure of different putative auxin-receptor genes from Z. mays and A. thaliana. Using homology probing we have identified and isolated a series of genes involved in plant signalling processes including members of the RAS-gene family. The isolation of other genes relies on the study of different procaryotic genes known to have a marked effect on plant differentiation. These are T-DNA linked genes from A. tumefaciens and A. rhizogenes as well as genes from Rhizobiacae. Finally various gene tagging approaches will be discussed that are presently used to identify and isolated genes involved in developmental control of plants.
Jan C. Purrucker,Kirsten Haas,Marcel Wolf,Timolaos Rizos,Shujah Khan,Peter Kraft,Sven Poli,Rainer Dziewas,Johannes Meyne,Frederick Palm,Sebastian Jander,Markus Möhlenbruch,Peter U. Heuschmann,Roland V 대한뇌졸중학회 2017 Journal of stroke Vol.19 No.1
Background and Purpose To evaluate the frequency and outcome of haemorrhagic transformation (HT) after ischaemic stroke in patients treated with non-vitamin K antagonist oral anticoagulants (NOACs). Methods Patients with stroke on treatment with a NOAC were prospectively enrolled in this multicentre observational study between February 2012 and 2015. Brain imaging at admission and follow-up imaging until day 7 were reviewed for HT. Functional outcome was assessed by the modified Rankin scale (mRS) before the index event, at discharge, and at 3-months. Results 231 patients without recanalisation therapy (no-RT), and 32 patients with RT were eligible for analysis. Any HT was present at admission in 9/231 no-RT patients (3.9%, 95% CI 2.0 to 7.3) and in none of the patients with RT. In patients with follow-up imaging (no-RT, n=129, and RT, n=32), HT was present in 14.0% (no-RT; 95% CI, 8.9 to 21.1), and 40.6% (RT, 95% CI, 25.5 to 57.8), respectively. After adjustment for stroke severity, this difference between the no-RT and RT groups became non-significant. Symptomatic ICH was observed in 1 patient per group. HT was not associated with unfavourable outcome (mRS 3-6) at 3-months in multivariable analysis. Resumption of OAC after stroke was delayed in patients with HT compared to those without (15 d [IQR, 5–26] vs. 1 d [0–4], P<0.001). Conclusions The frequency and severity of HT after stroke on NOAC appears similar to previous reports for vitamin K antagonists and no anticoagulation. Whether asymptomatic HT should delay resumption of preventive anticoagulation requires further investigation.
Kely N. de Oliveira,Helena C. Castro,Márcia M. Souza,Plínio Cunha Sathler,Uiaran O. Magalhães,Carlos R. Rodrigues,Patrícia R. Palm,Maicon Sarda,Pablo E. Perotto,Sabrina Cezar,Monique A. de Brito,Arian 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.10
In this paper, we describe the antinociceptive activity, molecular modeling and in silico ADMET screening of a series of sulphonyl-hydrazone and sulphonamide imidobenzene derivatives. Among these compounds, the sulphonyl-hydrazones 9 and 11 showed the most potent analgesic activity (ID50 = 5.1 and 6.8 μmol/kg, respectively). Interestingly, all derivatives evaluated in this study have a better analgesic profile than the control drugs, acetyl salicylic acid and acetaminophen. Derivative 9 was the most promising compound; with a level of activity that was 24 times higher than the control drugs. Our SAR study showed a relationship among the distribution of the frontier orbital HOMO coefficients, HOMO-LUMO energy gap of these molecules and their reactivity. The best analgesic compounds (including 6, 9, 10, 11 and 12) fulfilled the Lipinski “rule-of-five”, which is theoretically important for good drug absorption and permeation.
Thermal Analysis on MnBi in High Magnetic Fields up to 45 T
Yoshifuru Mitsui,Yuki Ikehara,Kazuo Watanbe,Eun Sang Choi,Eric C. Palm,Keiichi Koyama 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.62 No.12
Differential thermal analysis (DTA) equipment for utilization in a high magnetic field of 45 T wasdeveloped. From the DTA experiments, the decomposition temperature (MnBi ! Mn1.08Bi+liquid:632 K at zero field) Tt was found to increase linearly at a rate of 2 KT−1 in fields up to 18 T andto deviate from that linear increase above 20 T. In addition, the peritectic temperature (Mn1.08Bi! Mn + liquid: 721 K at zero field) Tm was slightly increased by applying a magnetic field. At amagnetic field of 45 T, Tt and Tm reached 714 K and 726 K, respectively. The behaviors of Tt andTm for MnBi and Mn1.08Bi under high magnetic fields are discussed, and the magnetic energies arecalculated on the basis of mean field theory.