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강병준(Byungjun Kang),조승한(Seunghan Jo),류찬열(Chanryeol Rhyou),이형석(Hyungsuk Lee) 대한기계학회 2016 대한기계학회 춘추학술대회 Vol.2016 No.12
Actin, one of primary cytoskeletal proteins, forms bundles or networks which provide mechanical rigidity to cells. Those high-order structures are rather heterogeneous than homogeneous in order to perform various cellular functions including migration, division, and contraction. However, the effect of mechanical stimulation on actin network organization remains unclear. We hypothesize that the shear produced by the intracellular flow plays a role in determining the heterogeneity of actin networks. Here we develop a computational model of actin filament network and investigate how the mechanical flow influences on the network organization. We compare actin networks formed in the absence and presence of mechanical stimulation in terms of degree of filament alignment and thickness of actin bundle. Our results suggest that the mechanical stimulation contributes to the spatiotemporal regulation of the actin cytoskeleton structures.