장기간 보관한 멸균물품의 오염 상태에 관한 연구

주홍순,조순덕,정재심,신동분,임바올라,노은지,이선희,송영미,최정화,백병윤,김미나 대한병원감염관리학회 2003 의료관련감염관리 Vol.8 No.1

머리염색이 인체에 미치는 영향

윤형식,황성호,이현륭,김수호,박연석,권낙현,정호진,김동훈,노현주,홍성호,박병찬,이관,정해관 東國大學校醫學硏究所 2002 東國醫學 Vol.9 No.1

일상생활에서 모발염색은 흔히 접할 수 있는 미용의 한 종류로 특히 젊은층을 중심으로 폭발적으로 유행하고 있다. 염색을 위항 사용하는 약제는 표백제와 발색제 등 각종 화학약품이 사용되고 있으나 이로 인한 건강장해에 대한 연구는 그리 많지 않다. 저자들은 염색이 인체의 모발건강에 미치는 영향을 파악하기 위하여 염색과 관련된 주관적 증상과 모발의 변화에 대한 실험적 연구를 시행하였다. 동국대학교 경주 캠퍼스 재학생 80명을 대상으로 설문조사를 시행하여 염색 유 ·무 및 염색 후에 경험한 증상에 대해 설문 조사하였고, 의과대학 재학생 46명을 대상으로 피부 반응 테스트를 실시하였다. 또한 염색 전후의 모발 탄성도를 측정하였고 모발의 상태를 파악하기 위해 전자 현미경검사를 실시하였다. 설문조사 결과 염색 전에 비하여 염색 후 안구혼탁, 안구건조, 시력저하, 발진 및 접촉성 피부염, 모발손상, 모근손상 등의 증상을 더 많이 경험한다고 호소하였다(p<0.05). 모발손상과 모근손상은 헤어드라이어 사용 빈도에 따라 증가하는 것으로 조사되었다(p<0.05). 피부반응검사에서 가려움증이 가장 많은 증상이었으며 이는 여성보다는 남성에서 높은 것으로 조사되었다. 염색 전후의 모발장력은 염색 전 134.5±10.37g, 염색 128.0±30.69g, 염색 이틀 후 112.5±19.69g으로 나타났다. 염색 전후의 모발의 전자현미경 케라틴 층이 현저히 감소하고 모발이 가늘어지는 차이를 보였다. 염색은 모발손상, 모발 케라틴 손상 및 모근 손상, 발진 및 접촉성 피부반응, 안구혼탁, 안구건조, 시력 저하를 유발한다. 따라서 염색약으로 인한 손상에 대한 주의와 예방이 필요하다고 생각한다. 예방대책으로 염색 전 피부테스트를 통한 적합성 여부를 판단하는 것이 필요하며 가급적 염색을 피하는 것이 좋을 것이다. 염색약에 발암물질이 포함되어있다는 보고도 있어 염색 제조사의 철저한 실험과 염색 물질의 선별이 염색으로 인한 부작용을 최소화하는데 중요한 역할을 할 것이다. Hair coloring has became one of the most popular cosmetic activities to younger generations during last decade. However, there are few studies on the health effect of widespread use of chemical dyes. This study was conducted to study the effects of hair coloring dye on hair and other systems. We conducted a questionnaire survey of 80 persons in Kyongju campus, Dongguk University. We have done open patch skin test on 46 medical students. We also conducted scanning electron microscopy to examine the hair strength and structure before and after hair coloring process. Injury of hair and hair bulb, contact dermatitis, turbid eyes, xerophthalmia, and poor visual acuity were the main symptoms complained after hair coloring (p<0.05). Injury of hair and hair bulb were increased by frequency of hair-dryer use(p<0.05). In open patch test, pruritus was complanined by more than half of the subjects. Mean strength of hairs before and after hair coloring was as follows; 134.5 (SD 10.37)g before hair coloring, 128.0 (SD 30.69)g immediately after hair coloring, and 112.5 (SD 19.69)g after two days. The scanning electron microscopic findings of hair surface before and after hair coloring showed decreased keratin layer and thinning of the hair. Hair coloring induces injury to hair, its keratin layer, and hair bulb as well as contact dermatitis, turbid eyes, xerophthalmia, and poor visual acuity. Therefore, we think that precaution is needed in use of hair coloring dye. To prevent complications induced by hair coloring dye, it is necessary, especially to those with allergy or skin disorders, to perform skin test before action and avoid hair coloring whenever possible. Longterm health effects of hairdye should be studied and manufacturing companies should try to minimize complications induced by hair coloring dye.

한국인에서의 무과립구증 발병율 조사연구 -제4상 임상시험을 위한 기초자료조사-

안윤옥,박병주,이무송,김병국,구홍회,서철원 大韓臨床藥理學會 1993 臨床藥理學會誌 Vol.1 No.1

Alcohol 섭취가 치은열구상피의 투과성에 미치는 영 향

朴秉石,李東柱,韓敬潤 대한치과페리오학회 1988 大韓齒周學會誌 Vol.18 No.2

만성 불면증 환자의 성격특성

함병주,서광윤,김인 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.2

연구배경 :임상 실제에서 만성 불면증을 진단. 치료하는데 있어 환자의 성격적 특성을 이해한다는 것은 매우 중요하다. 이에 본 저자들은 만성 불면증환자의 성격적 특성을 파악하여 불면증의 취약성에 관여하는 성격적 요인을 보다 명확히 하고자 본 연구를 시행하였다. 연구방법 :만성 불면증의 진단에는 ICSD진단기준을 적용하였고 평가척도로는 환자의 성격 성향을 평가할 수 있는 성격요인검사 및 대처방식척도를 이용하였다. 1995년 11월부터 1996년 12월까지 불면증을 주소로 고려대학교 병원 수면장애 크리닉에 내원하여 정신생리성 불면중, 부적절한 수면위생 그리고 수면제 의존성 불면증으로 진단된 만성 불면증환자는 21명이었다. 이들과 성별, 연령. 학력을 고려하여 정상인 26명을 무작위로 추출하였고 이를 정상대조군으로 하였다. 연구결과: 만성 불면증환자들은 성격요인검사상 대조군보다 자아강도(C 요인 : 4.57±1.89 vs 7.35±1.83), 지능도요인(B 요인 : 3.76±2.23 vs 6.54±1.96). 동기왜곡척도(MD 요인 : 5.05±1.72 vs6.62±1.53)에서 유의하게 낮은 점수를 나타내었으며 , 죄책감 요인(0 요인 ; 6.67±2.11 vs 3.81±1.65). 불안감 요인(0,요인 ; 7.57±2.29 vs 3.46±1.88)에서 유의하게 높은 점수를 나타내었다(p<.05).대처척도상에서는 만성불면증 환자들이 대조군보다 감정집중적 대처척도(30.30±9.53 vs 24.52±5.71) 상 유의하게 높은 점수를 나타내었다. 대처양식을 적극적, 소극적 대처로 분류하였을 경우 환자군이 소극적 대처(50.75±13.76 vs 43.26±8.73)에서 통계적으로 유의하게 보다 높은 점수를 보였다. 결 론 : 만성불면증 환자들은 낮은 자아강도, 놓은 불안감과 죄책감 때문에 스트레스 상황에서 일반인들보다 더욱 쉽게 우울해지거나 불안상태에 빠지기 쉽게 되고 따라서 보다 높은 각성과 조건화가 유발될 것이라는 것이 시사되었다. 또한 만성불면증 환자들은 소극적이고 감정집중적 대처양식을 사용함으로써 스트레스 상황시 외적으로 반응하지 뭇하고 내향화하기 쉬우며. 결과적으로 생긴 고조된 감정적 각성과 생리적 활성 상태의 유발이 불면증을 일으키고 만성화시킨다고 추정할 수 있었다. Objectives: It is very important to understand the personality characteristics of chronicinsomniacs for diagnosis and treatment in clinical practice. The authors investigated the personality factors and the ways of coping to define the personality characteristics which underly the development of insomnia. Methods :The authors used the diagnostic criteria of International Classification of Sleep Disorders to diagnose chronic insomnia, and performed 16 Personality Factors(PF) test and the Ways of Coping Checklist to both chronic insomniacs and normal controls. The diagnosis of chronic insomnia included psychophysiologic insomnia, poor sleep hygiene, and hypnotics dependent insomnia. The subjects were 21 chronic insomniacs and 26 normal controls: Results: The chronic insomniacs showed significantly lower stableness(C factor ; 4.57±1.89VS 7.38± 1.83), intelligence(B factor : 3.76±2.23 VS 6.54±1.96), motivation distorsion(B factor ; 3.76±2.23 VS 6.54±1.96) factor scores, and higher guilt-proneness(0 factor ,6.67± 2.11 VS 3.81 ±1.65), tension and anxiety(0₄ factor .7.57±2.29 VS 3.46±1.88) factor scores than controls in 16 PF. The chronic insomniacs had significantly higher emotional-focused coping(30.30±9.53 VS 24.52± 5.71) and passive coping pattern scores(50.75 ± 13.76 VS 43.26±8.73) than controls in the Ways of Coping Checklist. Conclusion : The authors suggest that chronic insomniacs are characterized by depressive mood and anxiety-proneness from low ego strength, high levels of anxiety and guilty feelings, and passive and emotion-concentrated coping pattern. This traits are supposed to be factors contributing the state of emotional arousal and resultant physiological activation that has developed and maitained the insomnia.

잔류종업원의 해고 관련 지각과 조직유효성

안상윤,유병주 한국생산성학회 1999 生産性論集 Vol.13 No.3

This study is to examine how survivors' perceived variables concerning layoff affects organizational effectiveness, and this study has the following major objectives. 1. To examine how perception of survivors about layoff(perceived justice, perceived co-workers' reactions, perceived identity feelings with layoff victims, perceived job insecurity) would affects in job satisfaction and organizational commitment. 2. To find if survivors' perception of concerning layoff affects the change of job satisfaction and organizational commitment, demographic factors will operate as moderate variables. To examine the above objectives, empirical study is conducted: seven companies were selected as samples for this study and 743 questionnaires were analysed. The findings show that job satisfaction and organizational commitment decreased after layoff. The perceived of co-workers reactions influence job satisfaction and organizational commitment. The perceived of identity with layoff victims negatively influence job organizational commitment. The relations between perceived job insecurity and job satisfaction and organizational commitment are not significantly correlated. The moderating effects of demographic variables were found in union membership, and marital status. Finally, the implications of this study are that employees' job satisfaction and organizational commitment as job attitude variables are decreased after layoffs. Therefore, human resources manager are required to consider the survivor's perception and try to maintain their psychological stability in jobs. Perceived justice of layoff has a positive influence on organizational effectiveness, do personnel manager should consider the procedural and distributive justice about layoff.

내시경적 점막절제술로 치험한 식도 과립상 세포종 1례

강혁주,김성욱,최석진,이중현,장재식,서영범,윤병구,박건욱,김성자,김용섭,강승완,이구,양창헌,이창우,김욱년,이광헌,서정일 동국대학교 의학연구소 2000 東國醫學 Vol.7 No.-

과립상 세포종은 Schwann 세포 기원으로 생각되며 인체에 비교적 드물게 발생한다. 과립상 세포종은 전신 어느 곳에서나 발견될 수 있으나 주로 혀, 구강, 피부 혹은 유방 등에서 호발하며 드물게 위장관에서 발견된다. 위장관에서는 식도에서 가장 호발하며 다음으로 위, 대장 순이다. 과립상 세포종은 대부분, 특히 위장관에서는 양성이며 소수의 악성 병변이 보고되었다. 이러한 이유와 함께 수술 전의 진단이 어렵기 때문에 과립상 세포종에 대한 근본적인 치료는 현재까지 외과적 절제술이다. 최근에 시도되는 치료방법들로는 내시경적 레이저 치료, 용종절제술, 내시경적 점막 절제술 등이 있다. 저자들은 상부 소화관 내시경검사를 시행하여 식도 과립상 세포종을 진단하고 내시경적 점막 절제술을 시행하여 합병증 없이 퇴원하여 현재 재발없이 경과 관찰중인 1례를 경험하였기에 보고하는 바이다. Granular cell tumors, which occur infrequently, are probably of Schwann cell origin. They can occur almost anywhere in the body but usually affect the tongue, oral cavity, skin, or breasts and are rarely found in the gastrointestinal tracts. The esophagus is the most frequent gastrointestinal site, followed by the stomach and the colon. Granular cell tumors are generally benign, especially in the gastrointestinal tract, some malignant lesions have been reported. For this reason, and also because preoperative diagnosis is difficult, the standard treatment for granular cell tumor has until now been surgical excision. In recent years, other therapeutic methods is endoscopic laser therapy (ELT), polypectiomy, endoscopic mucosal resection (EMR). We report a case of esophageal granular cell tumor which was diagnosed by an endoscopy and managed using an endoscopic mucosal resection without complication.

모래쥐(Gerbil)에서 지속적 및 간헐적 뇌혈류차단이 뇌부종과 허혈성 신경세포 손상에 미치는 영향

전병윤,주진양,이규창,김태승 대한신경외과학회 1995 Journal of Korean neurosurgical society Vol.24 No.7

Temporary occlusion of the cerebral blood flow is an effective maneuver to prevent and/or to control excessive bleeding during neurosurgical operations. Many studies have been reported employing single occlusion of various durations. However, there has been only a few studies examing the consequences of repeated occlusions on the development of cerebral edema and neuronal injury in the gerbil. Three separate episodes of 5-minute ischemia spaced at varied time interval was produced in Mongolian gerbils by occlusion of bilateral common carotid arteries. Quantitative estimates of cerebral edema and neuronal injury were obtained 24 hours after the third occlusion. The result was compared to that of single 15-minute occlusion. In gerbils with three 5-minute occlusions at 10-minute intervals. cerebral edema was not significant. However, the animals killed 24 hours after three 5-minute occlusions at 1-hour intervals or single 15-minute occlusion showed severe cerebral edema. Such animals showed significantly more neuronal injury than in animals with three 5-minute occlusions at 10-minute intervals. These results suggest that ischemic brain damage may be reduced with repeated vascular occlusions spaced at short intervals.

GT rotary file을 이용한 만곡 근관형성시 작업 효율 및 file 변형 발생에 관한 연구

신주희,백승호,배광식,임성삼,윤수한,김병현 대한치과보존학회 2001 Restorative Dentistry & Endodontics Vol.26 No.5

Root canal preparation process is of utmost importance in successful treatment of root canal. Also, one of the most important purpose of the root canal preparation is to enlarge the root canal three dimensionally without changing the curvature of the root canal. However, as the curvature of the root canal increases, there are many difficulties involved in formation of optimum root canal. Therefore, in order to solve the above mentioned problems, new developments in methods of root canal preparation and equipments for such purposes were made. Recently, vigorous studies about newly introduced engine-driven nitckel-ti-tanium rotary file are conducted. As shown in research results to dates, it is well established that the use of nickel-titanium file is better suited for curved root canal than stainless steel file in maintaining the curvature of root canal and reducing the deformation of root canal. However, it is also acknowledged that there are a few discrepancies in research results according to protocol, due to failure to remove variables in experiments. In addition, although it is recommended by the manufacturer that the GT rotary file should maintain a low rotational speed of 150∼350rpm and 'light pressure' as light as not to break the lead of a pencil, academic studies about the vertical force which is not yet standardized are not sufficiently explored. Therefore, this research devised and utilized a special research equipment to standardize the appropriate range of vertical force for GT rotary file through experiments by breaking of the lead of a pencil as expressed by the manufacturer and to accurately measure factors involved through repeating and recreating the environment of root canal preparation. Forming nine experimental groups by varying the vertical forces (150g, 220g, 300g) and rpm (150rpm, 250rpm, 350rpm), the effects of changing vertical forces and rpm on working efficiency were measured in terms of time expended in root canal preparation by crown-down method using a transparent resin block with 35 degree curvature and GT rotary file (z-test). The following research using this special research equipment that involved nine experimental groups and varying the vertical force for root canal preparation from 300g which is within the normal vertical force range to 700g and 1000g which fall outside the normal rpm range. The results were as follows : 1.Analysis of the experiment results revealed that the tome spent in root canal preparation decreased as the vertical forces and rpm increased (p<0.05). Also, the effects of rpm were greater than those of the vertical forces within the normal vertical force range (β-weight test) . 2.Observation of the deformation of GT rotary file revealed that deformation increases in a direct correlation with the vertical force increase and in a reverse correlation with the rpm decrease, In the case of the vertical forces close to the normal range, the probability of GT rotary file deformation were quite different depending on the rpm changes. In the case of◎eater tier◎cal forces, the occurrences of deformation of the file were more frequent regardless of the rpm changes. 3.Deformation and breakage of file were also commonly observed in the expended time measurement experiments and GT rotary file deformation experiments in which low speed rpm (150rpm) was used and at the curved portion of the resin block. Key words : GT rotary file, Crown-down method, Working efficiency, Vertical force, Rpm, Deformation and breakage of file

일부 제조업 사업장의 작업환경실태 및 특수건강진단에 대한 조사 연구

황주성,황규윤,안규동,이병국 순천향대학교 산업의학연구소 1997 순천향산업의학 Vol.3 No.1

The purpose of this study was to obtain information on the working environment, rate of environmental measurement over TLVs, the number of workers who were exposed to hazardous agents and, the examined rate of special health examination(SHE) in different types of industries. Authors investigate the reports on the working environmental status of the 101 industries in Cheonan area and result of SHE of those industries. The results were as follows : 1. Out of 101 industries under study, only 54 industries took special health examination. 2. While 85.3%(6,590) of 7,726 workers working in 101 industries were exposed to one or more hazardous agents, 88.4% of 5,867 workers working in 54 industries with special health examination were exposed to those agents & 75..4% of 1,859 workers working in 47 industries without any special health examination were exposed to those agents. But according to the criteria of selecting eligible workers for special health examination, only 32%(1,935/5,867) of total workers in the later industries were classified as eligible for the special health examination. 3. While rate of environment measurement of 101 industries TLVs who 25.5%, that of 54 industries with SHE was 29.8 & that of 47 industries without SHE was 16.1%, while the rate of noise and dust measurement over TLVs of 54 industries with SHE was 31.7%, and 25.3%, those of 47 industries without SHE was 13.6% & 35.6%, among 54 industries with SHE the rate of environmental measurement over TLVs was highest in clothes & leathers(47.0%) and that of foods(32.3%) and primary metal(31.3%). One the other hand, among 47 industries without SHE the rate of environmental measurement over TLVs was highest in paper & printing(44.9%) and that primary metal(15.8%), metaloid mineral(15.5%). 4. The examined rate of SHE of 54 industries was 92.7% as a whole. By type of industries the rate of primary metal(221.4%), foods(181.7%), chemicals(120.4%) were exceeded expected percent(100%) but the rate of metalloid mineral(53.0%), paper & printing(63.8%), machinery(72.2%) were far below the expected percent. 5. Only 4.7% of total workers working in 47 industries without SHE were classified as eligible workers for SHE. Among those eligible workers 48.9% were belonged to potential workers for SHE of noise. 6. The response rate of questionnaire was 70.4%(38/54) in 54 industries wirh SHE & 48.9%(23/47) in 47 industries. The necessity of environment measure was positively answer in 81.6% of 38 with SHE & 87% of 23 without SHE. On the other hand, the necessity of SHE was positively answered in 68.4% with SHE & 21.7% without SHE.