정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

소아기 붕괴성 장애 1례

강병구,조수철,홍강의 대한소아ㆍ청소년정신의학회 1996 소아청소년정신의학 Vol.7 No.1

Rat의 복강내에 투여한 5-fluorouracil-polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

강대영,송규상,최정목,노승무,정경수,오정연,김진향,양준묵,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

For more effective intraperitoneal chemotherapy, the authers made 5-fluorouracil-polyglycolic acid composite disks(FU-PGA disks) with 5-fluorouracil and polyglycolic acid, a biodegradable polymer. We inserted the FU-PGA disk into the peritoneal cavites of Sprague-Dawley male rats, the control and three experimental groups; one FU-PGA disk insert group(300mg/kg), two FU-PGA disk insert group(600mg/kg), and three FU-PGA disk insert group(900mg/kg). The control group received a similar number of PGA disk inserts. A pharmacokinetic study was performed to measure the 5-fluorouracil concentration in the peritoneal fluid, blood, and tissues(liver, kidney and heart) at 24 hours, 72hours and 168 hours after insertion of the FU-PGA disk. Light and electron microscopic studies were done. The results were as follows: 1) The number of white blood cells and platelets decreased after FU-PGA insertion. The degree was proportional to the duration and amounts inserted. The change in the number of red blood cells varied slightly. 2) Light microscopically, slight changes were noted at 168 hours in the 3 disk insert group (900mg/kg). Mild fatty change and hepatocyte degeneration around the central veins of the liver were noted, with vacuolar degeneration in the proximal convoluted tubules of the kidney. 3) Electron microscopically,the liver showed focal increases of lipid droplets in the hepatocytes, and irregular nuclear membrane with focal nucleolar segregation of the fibrillar and granular elements. Also the double membranous structure of the hepatocytes and Kupffer cells was widened with bleb formation. The kidney showed wide separation of the nuclear double membrane in the proximal convoluted tubular cells and mesangial cells, with vacuolation and myelin figure formation in the mitochondria of the proximal convoluted tubular cells, at 72 hours and 168 hours in the 2 to 3 FU-PGA insert groups. The heart showed focal loss of cristae,vacuolation and myelin figure formation in the mitochondria of the 2 to 3 FU-PGA insert groups. In conclusion, despite the large amont of FU-PGA inserted, the histopathological changes in the liver, kidney and heart were slight, and consonant with the very low amount of 5-fluorouracil concentrations detected in the liver, kidney and heart. The above results suggest that the FU-PGA composite can serve as a new device for releasing drugs in a controlled manner and easily targeted to intraperitoneal organs. This device can improve the efficacy of intraperitoneal chemotherapy for gastric cancer.

實學的 意味에서 본 龜岩 許 浚의 業績

康秉秀 동국대학교 한의학연구소 1992 東國韓醫學硏究所論文集 Vol.1 No.-

Practical science means open and objective attitude as a new scholarly tone which gets out of Confucianism tradition and its closeness. It is concerned about practical aspect and its thought prevailed from the mid-16th century to the mid-19th century in feudal system. It is, also, the attitude seeking truth based on the facts, which is removed from the falsehood in politics, economics and social life. It is regarded as a social revolution which governs the country economically and is utilized to stabilize and enrich a human living life. The new academic. tradition appeared in the process of development of modernization proclaimed it to be utilized in modern-oriented independency. Modern historians have greatly studied the knowledge of early philosophy, while Korean oriental medicine has developed, basing on the cultivation of the mind, virtue, and benevolence through Han Bak-Keun(who showed much Interest in realistic, economic and social system) and Jung Yak-Youg;( who compiled all avaitable data into one book). From KO-Ryo dynasty lo the mid-Yi dynasty Korean oriental medicine scholars struggled to develop oriental medicine in an attitude searching truth based on the facts. Among them Huh Jun s achievements and the content of his writings suggest many things with a view of practical science. These are neglected by most scholars so far, but I have surveyed as follows : 1) the revolution in oriental medical science system 2) the standardization of pharmacy appliance 3) the popularization of medicine supplies 4) cooperation of industry and academy in medical science field From the above I concluded as follows : practical science in Korean medical science began from Ka-Rp dynasty and compiled in Ku Am Huh Jun in the period of King Sun-Jo of Li dynasty. With this repetct, the pioneer in practical science in Korea is Ku Am Huh Jun. To search the pioneer in practical science rightly we should study the history of Korean medical science.

액체식품의 건조시 방향물질의 보존 제1보 : 평판건조시 방향물질의 보존

강안수,이병철 明知大學校 産業技術硏究所 1993 産業技術硏究所論文集 Vol.12 No.-

The aroma retention in the drying of light foods. which is an important factor fur determining the quality of products, was analysed by a theoretical model and was investigated through experiments. Model liquid foods were made of aqueous solutions of sugar, sucrose and maltodextrine, to which fixed ratios of benzaldehyde were added. It was assumed that aroma component and water in drying material were transported by molecular diffusion. The system was treated as a pseudo-binary system when the transport of volatiles is considered and as a binary system of water and sugar when the transport of water is considered. Approximate solutions of the diffusion equation were obtained for the case of fast drying and fur the case of slow drying. In solving the diffusion equation, the shrinkage of the specimen was in proportion to the amount of water evaporated in the slow drying case and that the specimen behaved as a semi-infinite body in the fast drying case. The experimental results showed that the aroma retention was high when the initial concentration of sugar was high. The higher the molecular weight of sugar and aroma components, the lower the diffusion coefficients of aroma in sugar solution, so that the aroma retention was high. And when the concentration of aroma components was below 1.000ppm. it's concentration had no influence on the aroma retention.

재발성 일과성 허혈 발작을 주소로 내원한 비-안와-대뇌 모균증 1예

강우열,이주헌,성영희,최일수,송홍기,이병철 대한노인병학회 2002 대한노인병학회지 Vol.6 No.3

Trioctylamine에 의한 유기산의 추출

강안수,이병철,이한섭,안형환,이영주,류운형 明知大學校 産業技術硏究所 1993 産業技術硏究所論文集 Vol.12 No.-

For elucidation of various parameter's effect on the reactive extraction of organic acidstrioctylamine(TOA)-diluents system, the association model, equilibrium constants and extraction factors(loading) were investigated . The organic acids rosed were propionic. succinic, masonic, and benzoic acid. Extractant was tertiary amine, TOA and diluents were butylaeohol, hexane, and benzene. It was concluded that the loading of monobasic acid of propionic acid were higher than that of dibasic acids of oxalic, and malonic acid with extranctant TOA. In the extraction of monobasic acid the extraction factor was not affected by the initial concentration of extractant amine, but in the extraction of dibasic acids the extraction factor was getting better with decreasing the initial concentration of amine. There was a strong effect of diluents upon the extractien factor, and the order of these factor was as shown below: xylene<Benzene<butylalcohol<choloroform<methylisobutylketone.

수 종의 도재 수복물에 부착된 세라믹 브라켓의 전단접착강도와 파절양상에 열순환이 미치는 영향

강상욱,손우성,박수병,김성식 대한치과교정학회 2009 대한치과교정학회지 Vol.39 No.4

본 연구는 도재 수복물에 부착된 단결정 세라믹 브라켓의 전단접착강도와 파절양상에 열순환과 도재 수복물의 종류가 어떤 영향을 미치는지 알아보기 위해 시행되었다. 도재전장관에 사용되는 재료들 중 Ceramco 3, Empress II, Zi-ceram/Vintage ZR 세 가지를 선택하여 각 20개씩 총 60개의 시편을 원반형태(두께 2 mm, 직경 12 mm)로 제작하였다. 동일한 접착 술식으로 세라믹 브라켓을 부착한 후 열순환을 시행한 실험군과 시행하지 않은 대조군, 두 군으로 나누어 전단접착강도와 파절양상을 평가하였다. 열순환을 하지 않은 대조군의 전단접착강도는 Ceramco 3는 7.06 ± 1.76 MPa, Empress II는 7.55 ± 2.38 MPa 그리고 Zi-ceram/Vintage ZR은 7.19 ± 1.38 MPa로 추천되는 전단접착강도(6 - 8 MPa)에 적합한 강도를 보였으나 열순환을 시행한 실험군은 전단접착강도가 유의하게 감소하였으며(p < 0.05) 열순환 후의 전단접착강도는 Ceramco 3는 4.88 ± 1.00 MPa, Empress II는 5.46 ± 1.35 MPa 그리고 Zi-ceram/ Vintage ZR은 4.84 ± 1.01 MPa로 임상적으로 추천되는 것보다 다소 낮은 값을 보였다. 도재의 종류에 따른 전단접착강도에는 유의한 차이가 없었다. 파절양상은 대조군에서는 모두 브라켓 기저부와 접착제 사이에서 파절이 일어났으며, 실험군에서는 2개의 시편(Ceramco 3과 Zi-ceram/Vintage ZR군에서 각 1개)만이 접착제내 파절을 보였으며 28개의 시편은 브라켓 기저부와 접착제 사이에서 파절이 일어났다. 이상의 연구 결과에서 보았을 때 도재 수복물의 종류에 따른 차이는 없었으나 열순환에 의해 전단접착강도가 약화되므로 실제 임상에서 고려되어야 할 것이다. Objective: The purpose of this study was to investigate the effect of thermocycling and type of porcelain restoration on shear bond strength (SBS) and mode of failure of monocrystalline ceramic brackets. Methods: A total of 60 porcelain discs were made and divided into three equal groups as follows: Ceramco 3, IPS Empress II, Zi-ceram/Vintage ZR. ceramic brackets were bonded to the prepared porcelain surfaces in the same manner. Each group was divided randomly into two subgroups: thermocycled group and non-thermocycled group (control). All samples were tested in shear mode on an universal testing machine. Results: SBS of the non-thermocycled group was clinically acceptable (Ceramco 3: 7.06 ± 1.76 MPa, IPS Empress II: 7.55 ± 2.38 MPa, Zi-ceram/ Vintage ZR: 7.19 ± 1.38 MPa). But, SBS of the thermocycled group was significantly reduced (Ceramco 3: 4.88 ± 1.00 MPa, IPS Empress II: 5.46 ± 1.35 MPa, Zi-ceram/Vintage ZR: 4.84 ± 1.01 MPa, p < 0.05). There was no difference between the shear bond strength by type of porcelain restoration. All bonding failure occurred between bracket base and adhesive, except for 2 samples. Conclusions: The results of this study suggest that the type of porcelain restoration did not affect SBS, but thermocycling weakened SBS. Therefore, the effect of thermocycling should be considered when using ceramic brackets in practice.

저선량방사선이 햄스터의 협낭 기저세포 분열지수에 미치는 영향에 관한 연구

강병철,유동수 大韓口腔顎顔面 放射線學會 1993 Imaging Science in Dentistry Vol.23 No.2

The purpose of the study was to investigate the effects of the low level irradiation on the mitotic index of the basal cells in the buccal pouch of hamsters(golden hamster: APG strain). After colchicine was administrated to the hamsters through the intraperitoneal. the low level radiation(5460mR) was exposed on the buccal pouch of hamsters. The mitotic index of the basal cells was estimated 2 hours after irradiation. The results were as follows: 1. The mean mitotic index of the control group was 4.32. 2. The mean mitotic index of the irradiated group was 2.46. 3. T-test of data in the irradiated group showed significant difference from the mitotic index in the control group. These results suggested the lowered mitotic index of the irradiated group resulted from the low level irradiation.

골격성 Ⅱ급 성인 부정교합자에서 혀와 두개안면골격 및 악간공간과의 상관관계에 관한 연구

강현희,박수병 대한치과교정학회 1999 대한치과교정학회지 Vol.29 No.5

골격성 Ⅱ급 부정교합자 중 성장이 완료되었다고 생각되는 만 18세 이상의 여자 37명, 만 20세 이상의 남자 23명을 선정하여 정상 성인의 안면비를 기준으로 hyperdivergent group(n=30)과 hypodivergent group(n=30)으로 나누어 두부 방사선 규격사진의 투사도를 작성하였으며 두개안면골격 및 혀의 크기, 높이 그리고 자세를 나타내는 항목을 계측하였고, 두 군간의 차에 대한 유의성 검정 및 혀와 두개안면골격 그리고 악간공간 사이의 상관관계를 조사하여 다음과 같은 결론을 얻었다. 1. 두 군의 혀와 악간공간의 계측항목 비교시 악간공간에 대한 혀의 면적비(TS/IS)는 hyperdivergent group에서 더 크게 나타났으며, PIH(posterior intermaxillary height)와 IS(intermaxillary space)는 hypodivergent group에서 더 크게 나타났으나 혀의 높이와 자세를 나타내는 항목에서는 두 군간에 유의할 만한 차이가 없었다. 2. 혀와 두개안면골격의 상관관계 비교시 두 군 모두에서 혀의 면적(TS), 길이(TGL) 그리고 높이(TH)를 나타내는 계측 항목이 전안모고경(AFH)과 가장 높은 상관관계를 나타냈으며, 또한 hypodivergent group에서는 후안모고경(PFH)과도 높은 상관성을 보였다(p<0.01). 3. 혀와 악간공간의 상관관계 비교시 두 군 모두 혀에 관한 대부분의 항목(H-P제외)이 악간공간(IS)과 가장 높은 상관성을 보였으며, 혀의 높이(TGH)와 면적(TS)을 나타내는 항목은 악간공간의 AIH 및 PIH와 높은 상관성을 보였다(p<0.01). This study was designed to evaluate the correlations between tongue with skeletal pattern and intermaxillary space in Class Ⅱ malocclusion adult patients. Craniofacial skeletal pattern was analyzed on the lateral cephalometric radiograph and the subjects were devided two groups by facial ration, the 30 subjects of hyperdivergent group and the 30 subjects of hypodivergent group. The size and posture of tongue and intermaxillary space were measured on the lateral cephalometric radiograph. These data were statistically analyzed to examine significant differences between both groups and compared the correlation between tongue with skeletal measurements and intermaxillary space in each group. The results of this study were as follows.: 1. In comparison of the tongue and intermaxillary space, the measurement of TS/IS showed significantly larger in hyperdivergent group and PIH and IS showed significantly larger in hypedivergent group. There were no statistically significant differences in the measurements of the height and posture of tongue. 2. In correlation between tongue with craniofacial skeletal measurements. the length and height of tongue showed the highest correlation with AFH(anterior facial height) in both groups(p<0.01). And that measurements showed high correlation with PFH(posterior facial height) in hypodivergent group. 3. In both groups, most measurements of tongue showed high correlation with intermaxillary space and the height and space of tongue showed high correlation with AIH and PIH(p<0.01).