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Eu Suk Kim,Bum Sik Chin,강창경,Nam Joong Kim,Yu Min Kang,Jae-Phil Choi,Dong Hyun Oh,Jeong-Han Kim,Boram Koh,Seong Eun Kim,Na Ra Yun,Jae Hoon Lee,Jin Yong Kim,Yeonjae Kim,Ji Hwan Bang,송경호,Hong Bin Kim,Ki- 대한의학회 2020 Journal of Korean medical science Vol.35 No.13
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected pneumonia emerged in Wuhan, China in December 2019. In this retrospective multicenter study, we investigated the clinical course and outcomes of novel coronavirus disease 2019 (COVID-19) from early cases in Republic of Korea. Methods: All of the cases confirmed by real time polymerase chain reaction were enrolled from the 1st to the 28th patient nationwide. Clinical data were collected and analyzed for changes in clinical severity including laboratory, radiological, and virologic dynamics during the progression of illness. Results: The median age was 40 years (range, 20–73 years) and 15 (53.6%) patients were male. The most common symptoms were cough (28.6%) and sore throat (28.6%), followed by fever (25.0%). Diarrhea was not common (10.7%). Two patients had no symptoms. Initial chest X-ray (CXR) showed infiltration in 46.4% of the patients, but computed tomography scan confirmed pneumonia in 88.9% (16/18) of the patients. Six patients (21.4%) required supplemental oxygen therapy, but no one needed mechanical ventilation. Lymphopenia was more common in severe cases. Higher level of C-reactive protein and worsening of chest radiographic score was observed during the 5–7 day period after symptom onset. Viral shedding was high from day 1 of illness, especially from the upper respiratory tract (URT). Conclusion: The prodromal symptoms of COVID-19 were mild and most patients did not have limitations of daily activity. Viral shedding from URT was high from the prodromal phase. Radiological pneumonia was common from the early days of illness, but it was frequently not evident in simple CXR. These findings could be plausible explanations for the easy and rapid spread of SARS-CoV-2 in the community.
설득적 글쓰기와 정서 표현 글쓰기에 나타난 표현 양상 -강원국·김민식의 저서와 강연 분석을 중심으로-
권순희 ( Kwon Soonhee ),김여흘 ( Kim Yeoheul ),신소연 ( Shin Soyeon ),안병현 ( Ahn Byeonghyun ),원보람 ( Won Boram ) 서울대학교 국어교육과 2021 先淸語文 Vol.49 No.-
In order to examine the connection between logical and emotional writing and writing theory, Kang Wonguk’s book ‘President‘s writing’ and Kim Minsik’s book ‘Did you write every morning?’ were selected as the texts to analyze, and ‘Time to change the world, 15 minutes’, ‘How to Write Moving People (Kang Wonguk)’ and ‘Writing that Changes Pain to Pleasure (Kim Minsik)’ were selected for analysis. The analysis results are shown in the table below. The above difference comes from the difference between the purpose and direction of discourse between Kang Wonguk and Kim Minsik. Kang Wonguk explains his speeches and talks to persuade others in his writings and lectures. Therefore, Kang Wonguk’s writing focuses on logical writing, and the direction of writing is directed to the outside. Kim Minsik, on the other hand, mentions diaries and personal blog posts and talks about self-reflective and internal discourse. The direction of writing is directed inward, communicating with the self, and in the process of self-healing through writing.
Kim, Hae Jin,Kim, Yeryung,Park, Su Jung,Bae, Boram,Kang, Hye-Ryun,Cho, Sang-Heon,Yoo, Hae Young,Nam, Joo Hyun,Kim, Woo Kyung,Kim, Sung Joon The Korean Society of Pharmacology 2015 The Korean Journal of Physiology & Pharmacology Vol.19 No.1
Asthma is a chronic inflammatory disease characterized by airway hyperresponsiveness (AHR) and reversible airway obstruction. Methacholine (MCh) is widely used in broncho-provocation test to evaluate airway resistance. For experimental investigation, ovalbumin-induced sensitization is frequently used in rodents (Ova-asthma). However, albeit the inflammatory histology and AHR in vivo, it remains unclear whether the MCh sensitivity of airway smooth muscle isolated from Ova-asthma is persistently changed. In this study, the contractions of airways in precision-cut lung slices (PCLS) from control, Ova-asthma, and IL-13 overexpressed transgenic mice (IL-13TG) were compared by analyzing the airway lumen space (AW). The airway resistance in vivo was measured using plethysmograph. AHR and increased inflammatory cells in BAL fluid were confirmed in Ova-asthma and IL-13TG mice. In the PCLS from all three groups, MCh concentration-dependent narrowing of airway lumen (${\Delta}AW$) was observed. In contrast to the AHR in vivo, the $EC_{50}$ of MCh for ${\Delta}AW$ from Ova-asthma and IL-13TG were not different from control, indicating unchanged sensitivity to MCh. Although the AW recovery upon MCh-washout showed sluggish tendency in Ova-asthma, the change was also statistically insignificant. Membrane depolarization-induced ${\Delta}AW$ by 60 mM $K^+$ (60K-contraction) was larger in IL-13TG than control, whereas 60K-contraction of Ova-asthma was unaffected. Furthermore, serotonin-induced ${\Delta}AW$ of Ova-asthma was smaller than control and IL-13TG. Taken together, the AHR in Ova-asthma and IL-13TG are not reflected in the contractility of isolated airways from PCLS. The AHR of the model animals seems to require intrinsic agonists or inflammatory microenvironment that is washable during tissue preparation.
Kim, Ho Cheol,Jung, Chi Young,Cho, Deog Gon,Jeon, Jae Hyun,Lee, Jeong Eun,Ahn, Jin Seok,Kim, Seung Joon,Kim, Yeongdae,Kim, Young-Chul,Kim, Jung-Eun,Lee, Boram,Won, Young-Joo,Choi, Chang-Min The Korean Academy of Tuberculosis and Respiratory 2019 Tuberculosis and Respiratory Diseases Vol.82 No.2
Background: Lung cancer is a leading cause of morbidity and mortality worldwide, and the incidence continues to rise. Although many prognostic factors have been identified, the clinical characteristics and outcomes in Korean lung cancer patients are not well defined. Methods: Of the 23,254 new lung cancer cases registered at the Korea Central Cancer Registry in 2013, total 489 patients from 19 hospitals were abstracted by the Korean Central Cancer Registry. The clinical data retrospectively analyzed, patients were followed up until December 2015. Results: The median age was 69 years (interquartile range, 60-74 years); 65.4% were male and 62.1% were ever-smokers. Cough was the most common initial symptom (33.5%); 13.1% of patients were asymptomatic. While squamous cell carcinoma was the most common subtype in male patients (37.2%), adenocarcinoma was the most frequent histological type in all patients (48.7%) and females (76.3%). The majority of patients received treatment (76.5%), which included surgery, radiation therapy, and chemotherapy. Older age (hazard ratio [HR], 1.037), lower body mass index (HR, 0.904), ever-smoker (HR, 2.003), small cell lung cancer (HR, 1.627), and distant metastasis (HR, 3.990) were independent predictors of mortality. Patients without symptoms (HR, 0.387) and without treatment (HR, 0.364) were associated with a favorable outcome in multivariate Cox analysis. Conclusion: Lung cancer in Korea occurs predominantly in elderly patients, with adenocarcinoma being the most frequent subtype. The prognosis was poorer in ever-smokers and older, malnourished, and untreated patients with advanced lung cancer.
A Novel Missense PRKAR1A Variant Causes Carney Complex
Boram Kim,장한나,Kyung Shil Chae,Ho Seop Shin,Yong Hwy Kim,Sujin Kim,Moon-Woo Seong,김정희 대한내분비학회 2022 Endocrinology and metabolism Vol.37 No.5
The Carney complex (CNC) is an autosomal dominant disorder characterized by endocrine and nonendocrine tumors. Loss-of-function variants of protein kinase A regulatory subunit 1 alpha (PRKAR1A) are common causes of CNC. Here, we present the case of a patient with CNC with a novel PRKAR1A missense variant. A 21-year-old woman was diagnosed with CNC secondary to acromegaly and adrenal Cushing syndrome. Genetic analysis revealed a novel missense heterozygous variant of PRKAR1A (c.176A>T). Her relatives, suspected of having CNC, also carried the same variant. RNA analysis revealed that this variant led to nonsense-mediated mRNA decay. In vitro functional analysis of the variant confirmed its role in increasing protein kinase A activity and cyclic adenosine monophosphate levels. This study broadens our understanding of the genetic spectrum of CNC. We suggest that PRKAR1A genetic testing and counseling be recommended for patients with CNC and their families.
Kim, Yeon-Joo,Park, Won,Ha, Boram,Park, Boram,Joo, Jungnam,Kim, Tae Hyun,Park, In Hae,Lee, Keun Seok,Lee, Eun Sook,Shin, Kyung Hwan,Kim, Haeyoung,Yu, Jeong Il,Choi, Doo Ho,Huh, Seung Jae,Wee, Chan Woo 대한암학회 2017 Cancer Research and Treatment Vol.49 No.4
<P><B>Purpose</B></P><P>The purpose of this study was to evaluate the impact of postmastectomy radiotherapy (PMRT) on loco-regional recurrence-free survival (LRRFS), disease-free survival (DFS), and overall survival (OS) in pT1-2N1 patients treated with taxane-based chemotherapy. </P><P><B>Materials and Methods</B></P><P>We retrospectively reviewed the medical data of pathological N1 patients who were treated with modified radical mastectomy and adjuvant taxane-based chemotherapy in 12 hospitals between January 2006 and December 2010. </P><P><B>Results </B></P><P>We identified 714 consecutive patients. The median follow-up duration was 69 months (range, 1 to 114 months) and the 5-year LRRFS, DFS, and OS rates were 97%, 94%, and 98%, respectively, in patients who received PMRT (PMRT [+]). The corresponding figures were 96%, 90%, and 96%, respectively, in patients who did not receive PMRT (PMRT [–]). PMRT had no significant impact on survival. Upon multivariable analysis, only the histological grade (HG) was statistically significant as a prognostic factor for LRRFS and DFS. In a subgroup analysis of HG 3 patients, PMRT (+) showed better DFS (p=0.081).</P><P><B>Conclusion </B></P><P>PMRT had no significant impact on LRRFS, DFS, or OS in pT1-2N1 patients treated with taxane-based chemotherapy. PMRT showed a marginal benefit for DFS in HG 3 patients. Randomized studies are needed to confirm the benefit of PMRT in high risk patients, such as those with HG 3.</P>
Kim, Sun-Young,Kim, Bo Kyung,Gwon, Mi-Ri,Seong, Sook Jin,Ohk, Boram,Kang, Woo Youl,Lee, Hae Won,Jung, Hee-Yeon,Cho, Jang-Hee,Chung, Byung Ha,Lee, Sang-Ho,Kim, Yeong Hoon,Yoon, Young-Ran,Kim, Chan-Duck Elsevier 2019 Journal of chromatography. B, Analytical technolog Vol.1118 No.-
<P><B>Abstract</B></P> <P>To improve early renal allograft function, it is important to develop a noninvasive diagnostic method for acute T cell-mediated rejection (TCMR). This study aims to explore potential noninvasive urinary biomarkers to screen for acute TCMR in kidney transplant recipients (KTRs) using untargeted metabolomic profiling.</P> <P>Urinary metabolites, collected from KTRs with stable graft function (STA) or acute TCMR episodes, were analyzed using liquid chromatography-mass spectrometry (LC-MS). Multivariate statistical analyses were performed to discriminate differences in urinary metabolites between the two groups. Receiver operating characteristic (ROC) curve analysis was used to evaluate the diagnostic performance of potential urinary biomarkers.</P> <P>Statistical analysis revealed the differences in urinary metabolites between the two groups and indicated several statistically significant metabolic features suitable for potential biomarkers. By comparing the retention times and mass fragmentation patterns of the chemicals in metabolite databases, samples, and standards, six of these features were clearly identified. ROC curve analysis showed the best performance of the training set (area under the curve value, 0.926; sensitivity, 90.0%; specificity, 84.6%) using a panel of five potential biomarkers: guanidoacetic acid, methylimidazoleacetic acid, dopamine, 4-guanidinobutyric acid, and <I>L</I>-tryptophan. The diagnostic accuracy of this model was 62.5% for an independent test dataset.</P> <P>LC-MS-based untargeted metabolomic profiling is a promising method to discriminate between acute TCMR and STA groups. Our model, based on a panel of five potential biomarkers, needs to be further validated in larger scale studies.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We explored urinary biomarkers for acute TCMR using LC-MS-based metabolomics. </LI> <LI> OPLS-DA well distinguished between acute TCMR and STA groups. </LI> <LI> Multivariate statistical analyses revealed differences in urinary metabolites. </LI> <LI> ROC curve analysis evaluated the performance of potential urinary biomarkers. </LI> </UL> </P>