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Lim, Yong Taik,Kim, Jin Kyeong,Chung, Bong Hyun IOP Pub 2006 Nanotechnology Vol.17 No.15
<P>The optical properties of polymer nanospheres were tuned by <I>in situ</I> transformation of metal structures on their surfaces. Silver nanoparticles (NPs) deposited on the polystyrene nanospheres were transformed into metal hollows made of gold/silver alloy by a galvanic replacement reaction. The metal hollows made of gold/silver alloy were finally changed into solid gold nanoparticles by the additional treatment of chloroauric acid. Through the transformation process, the optical resonance peak of metal-coated polystyrene (PS) nanospheres was tuned in the 410 to 820 nm region. The transformation of metal nanostructures on the surface of PS nanospheres was monitored and characterized by UV–visible–near infrared (NIR) spectroscopy and transmission electron microscopy. The described protocols should be applied to prepare the metal-coated polymer nanospheres with tunable surface plasmon resonance (from 450 to 820 nm) which would be very useful for biological assays. </P>
Lim, Yong Taik,Noh, Young-Woock,Kwon, Ji-Na,Chung, Bong Hyun The Royal Society of Chemistry 2009 Chemical communications Vol.2009 No.45
<p>A novel type of bimodal imaging nanoprobe based on <SUP>19</SUP>F-based magnetic resonance imaging and near-infrared optical imaging has been synthesized and applied for the labeling and imaging of dendritic cells both <I>in vitro</I> and <I>in vivo</I>.</p> <P>Graphic Abstract</P><P>A novel type of bimodal imaging nanoprobe based on <SUP>19</SUP>F-based MR and NIR optical imaging has been synthesized and applied for the labeling and imaging of dendritic cells both <I>in vitro</I> and <I>in vivo</I>. <img src='http://pubs.rsc.org/ej/CC/2009/b914006a/b914006a-ga.gif'> </P>
Lim, Yong Taik,Cho, Mi Young,Choi, Bang Sil,Noh, Young-Woock,Chung, Bong Hyun IOP Pub 2008 Nanotechnology Vol.19 No.37
<P>We describe the development of hollow-type gold nanoparticles (NPs) for the photonic-based imaging and therapy of macrophage cells. The strong light-absorption and light-scattering properties of gold NPs render them to be useful as molecular imaging agents as well as therapeutic moieties. By controlling the geometry of the gold NPs, the optical resonance peak was shifted to around the near-infrared (NIR) region, where light transmission through biological tissue is known to be fairly high. Hollow-type gold NPs modified with dextran were phagocytosed by macrophage cells. Using dark-field microscopy, it was possible to image macrophage cells targeted with NPs. After NIR irradiation, macrophages labeled with NPs were selectively destroyed by the photothermal effect. FACS analysis revealed that the photothermal effect caused principally late apoptosis-related cell death or secondary necrosis. The experimental results showed that hollow-type gold NPs conjugated with dextran could be used not only as optical imaging contrast agents but also as a component of a novel anti-macrophage therapeutic strategy. </P>
Multifunctional Silica Nanocapsule with a Single Surface Hole
Lim, Yong Taik,Kim, Jin Kyeong,Noh, Young-Woock,Cho, Mi Young,Chung, Bong Hyun WILEY-VCH Verlag 2009 Small Vol.5 No.3
<B>Graphic Abstract</B> <P>Multifunctional silica nanocapsules containing magnetic nanoparticles and fluorescent quantum dots with a single surface hole fabricated by a single-step emulsion-mediated process are described. The silica nanocapsules (see images) are easily internalized by phagocytic dendritic cells and show a high potential as bimodal imaging contrast agents (for fluorescence and magnetic resonance imaging) in vivo as well as in vitro. <img src='wiley_img/16136810-2009-5-3-SMLL200800935-content.gif' alt='wiley_img/16136810-2009-5-3-SMLL200800935-content'> </P>
Plasmonic Magnetic Nanostructure for Bimodal Imaging and Photonic-Based Therapy of Cancer Cells
Lim, Yong Taik,Cho, Mi Young,Kim, Jin Kyeong,Hwangbo, Seol,Chung, Bong Hyun WILEY-VCH Verlag 2007 Chembiochem Vol.8 No.18
<B>Graphic Abstract</B> <P>Two in one. Multifunctional hollow-type gold nanostructures that encapsulate iron oxide nanoparticles have been developed for biomedical imaging and targeted cancer therapy applications. The combination of the magnetic character of iron oxide nanoparticles with the near-infrared-light-absorbing (and scattering) gold nanostructures rendered the synthesized nanoparticles useful as bimodal imaging contrast agents (for MRI and optical imaging) as well as for photonic-based therapeutic materials. <img src='wiley_img/14394227-2007-8-18-CBIC200700416-content.gif' alt='wiley_img/14394227-2007-8-18-CBIC200700416-content'> </P>