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Effects of β-Glucan from Aureobasidium pullulans on Acute Inflammation in Mice
Hyeong-Dong Kim,Bok-ryeon Park,Hee-Jeong Jang,Lin-Su Kim,Hyeung-Sik Lee,Sae-Kwang Ku,Hyung-Rae Cho,Seung-bae Moon,Hyun-Dong Shin,Kun-Ju Yang 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.3
The effects of β-glucan isolated from Aureobasidium pullulans were observed on acute xyleneinduced inflammation. β-glucan at a dose of 62.5, 125 or 250 mg/kg were administered once orally to xylene-treated mice (0.03 mL of xylene was applied on the anterior surface of the right ear to induce inflammation), and the body weight change, ear weight, histological profiles and histomorphometrical analyses of ear were conducted upon sacrifice. The xylene was topically applied 30min after dosing with β-glucan. The results were compared to those of diclofenac, indomethacin and dexamethasone (15 mg/kg injected once intraperitoneally). All animals were sacrificed 2 h after xylene application. Xylene application resulted in marked increases in induced ear weights compared to that of intact control ear; hence, the differences between intact and induced ear were also significantly increased. The histological characteristics of acute inflammation, such as severe vasodilation, edematous changes of skin and infiltration of inflammatory cells, were detected in xylene-treated control ears with marked increase in the thickness of the ear tissues. However, these xylene-induced acute inflammatory changes were significantly and dose-dependently decreased by β-glucan treatment. We conclude that β-glucan from A. pullulans has a somewhat favorable effect in the reduction of the acute inflammatory responses induced by xylene application in mice.
Decreased annexin A3 expression correlates with tumor progression in papillary thyroid cancer.
Jung, Eun-Jung,Moon, Hyeong-Gon,Park, Soon-Tae,Cho, Bok-Im,Lee, Sun-Min,Jeong, Chi-Young,Ju, Young-Tae,Jeong, Sang-Ho,Lee, Young-Joon,Choi, Sang-Kyung,Ha, Woo-Song,Lee, Jong Sil,Kang, Kee Ryeon,Hong, Wiley - VCH Verlag GmbH Co. KGaA 2010 PROTEOMICS CLINICAL APPLICATIONS Vol.4 No.5
<P>The aim of this study is to identify the potential tumor markers that function in carcinogenesis and tumor progression, thus providing important diagnostic and prognostic information.</P>
Single Oral Dose Toxicity Studies of Polycan, β-Glucan Originated from Aureobasidium in Mice
Hyeung-Sik Lee,Kun-Ju Yang,Hyun-Dong Shin,Bok-Ryeon Park,Chang-Woo Son,Hee-Jeong Jang,Dong-Chan Park,Young-Mi Jung,Sae-Kwang Ku 한국독성학회 2005 Toxicological Research Vol.21 No.4
This study was conducted to obtain the acute information of the oral dose toxicity of Polycan - originated from Aureobasidium pullulans SM-2001 (half of the dry material is -1,/1,6-glucans), a UV induced mutant of A. pullulans, having various pharmacological effects, in male and female mice. In order to calculate 50% lethal dose (LD_(50)), approximate LD and target organs, test article was administered twice by oral gavage to male and female ICR mice at total 1000, 500 and 250 ㎎/㎏. The mortality and changes on body weight, clinical signs and gross observation were monitored during 14 days after dosing. As the results, we could not find any mortalities, clinical signs, changes in the body weight and gross findings. The results obtained in this study suggest that the Polycan is non-toxic in mice and is therefore likely to be safe for clinical use. The LD_(50) and approximate LD in mice after single oral dose of Polycan were considered over 1000 ㎎/㎏, respectively.
Single Oral Dose Toxicity Studies of Polycan, b-Glucan Originated from Aureobasidium in Mice
Hyeung-Sik Lee,Kun-Ju Yang,Hyun-Dong Shin,Bok-Ryeon Park,Chang-Woo Son,Hee-Jeong Jang,Dong-Chan Park,Young-Mi Jung,Sae-Kwang Ku 한국독성학회 2005 Toxicological Research Vol.21 No.4
This study was conducted to obtain the acute information of the oral dose toxicity of Polycan - originated from Aureobasidium pullulans SM-2001 (half of the dry material is -1,3/1,6-glucans), a UV induced mutant of A. pullulans, having various pharmacological effects, in male and female mice. In order to calculate 50% lethal dose (LD50), approximate LD and target organs, test article was administered twice by oral gavage to male and female ICR mice at total 1000, 500 and 250 mg/kg. The mortality and changes on body weight, clinical signs and gross observation were monitored during 14 days after dosing. As the results, we could not find any mortalities, clinical signs, changes in the body weight and gross findings. The results obtained in this study suggest that the Polycan is non-toxic in mice and is therefore likely to be safe for clinical use. The LD50 and approximate LD in mice after single oral dose of Polycan were considered over 1000 mg/kg, respectively.
Local Irritation Test of 3 Types of β-Glucan after Subcutaneous Injection in Rats
Hyeung-Sik Lee,Hyung-Rae Cho,Kun-Ju Yang,Hyun-Dong Shin,Bok-Ryeon Park,Hee-Jeong Jang,Kwang-Ho Cho,Hyeong-Dong Kim,Sae-Kwang Ku 한국실험동물학회 2006 Laboratory Animal Research Vol.22 No.4
The objective of the present study is to detect the potency of skin irritation of 3 types of β-glucan: Polycan, Tinocare GL and SC-glucan, after a subcutaneous injection at 2 g/㎏, respectively. Test articles were given single subcutaneous injection at the shaving back of rat one point per rat and they were sacrificed at 7 days after injection. Histopathological changes on the injection sites were observed with histomorphometry, the thickness of encapsulation and percentages of collagenous tissues in encapsulation regions. As results of subcutaneous injection of all three types of β-glucan, encapsulations consisted of inflammatory cells and connective tissues caused by skin irritation and foreign body reactions, were observed with microangiogenesis restricted to the injection sites. The most severe histopathological changes were detected in the SC-glucan and then in order of Tinocare GL and Polycan. Therefore, it is considered that the potency of the skin irritant caused by β-glucan is quite differed from their origin and they showed relatively lower irritation because the changes related to the irritation and foreign body reactions were restricted to the injection sites. Among three types of β-glucan tested in the present study, Polycan showed the lowest irritation and SC-glucan showed the highest skin irritation.
Lee, Hyeung-Sik,Cho, Hyung-Rae,Yang, Kun-Ju,Moon, Seung-Bae,Park, Bok-Ryeon,Shin, Hyun-Dong,Jang, Hee-Jeong,Kim, Lin-Su,Ku, Sae-Kwang Korean Society of ToxicologyKorea Environmental Mu 2008 Toxicological Research Vol. No.
In this research the genotoxic effect of $Polycan^{TM}$ ${\beta}$-glucans originated from Aureobasidium pullulans SM-2001, was evaluated using the mouse micronucleus test. $Polycan^{TM}$ was administered once a day for 2 days by oral gavage to male ICR mice at doses of 1000, 500 and 250 mg/kg. Cyclophosphamide was used as a known genotoxic agent in a positive control group. The appearance of a micronucleus is used as an index for genotoxic potential. The results obtained indicated that $Polycan^{TM}$ shows no genotoxicity effect up to 1000 mg/kg dosing levels. In addition, it is also considered that there were no problems from cytotoxicity of $Polycan^{TM}$ tested in this study because the polychromatic erythrocyte ratio was detected as > 0.47 in all tested groups.
이형식,Hyung-Rae Cho,Kun-Ju Yang,Seung-Bae Moon,Bok-Ryeon Park,Hyun-Dong Shin,Hee-Jeong Jang,Lin-Su Kim,구세광 한국독성학회 2008 Toxicological Research Vol.24 No.1
In this research the genotoxic effect of PolycanTM β-glucans originated from Aureobasidium pullulans SM-2001, was evaluated using the mouse micronucleus test. PolycanTM was administered once a day for 2 days by oral gavage to male ICR mice at doses of 1000, 500 and 250 mg/kg. Cyclophosphamide was used as a known genotoxic agent in a positive control group. The appearance of a micronucleus is used as an index for genotoxic potential. The results obtained indicated that Polycan TM shows no genotoxicity effect up to 1000 mg/kg dosing levels. In addition, it is also considered that there were no problems from cytotoxicity of PolycanTM tested in this study because the polychromatic erythrocyte ratio was detected as > 0.47 in all tested groups.
Single Oral Dose Toxicity Studies of Polycan, β-Glucan Originated from Aureobasidium in Mice
Lee, Hyeung-Sik,Yang, Kun-Ju,Shin, Hyun-Dong,Park, Bok-Ryeon,Son, Chang-Woo,Jang, Hee-Jeong,Park, Dong-Chan,Jung, Young-Mi,Ku, Sae-Kwang Korean Society of ToxicologyKorea Environmental Mu 2005 Toxicological Research Vol.21 No.4
This study was conducted to obtain the acute information of the oral dose toxicity of Polycan - originated from Aureobasidium pullulans SM-2001 (half of the dry material is -1,3/1,6-glucans), a UV induced mutant of A. pullulans, having various pharmacological effects, in male and female mice. In order to calculate $50\%$ lethal dose $(LD_{50})$, approximate LD and target organs, test article was administered twice by oral gavage to male and female ICR mice at total 1000, 500 and 250mg/kg. The mortality and changes on body weight, clinical signs and gross observation were monitored during 14 days after dosing. As the results, we could not find any mortalities, clinical signs, changes in the body weight and gross findings. The results obtained in this study suggest that the Polycan is non-toxic in mice and is therefore likely to be safe for clinical use. The L050 and approximate $(LD_{50})$ in mice after single oral dose of Polycan were considered over 1000 mg/kg, respectively.
면역세포에서 Bioconversion 전후 제주 감귤 과피 추출물의 항염증 효과
서지은(Jieun Seo),임희진(Heejin Lim),장윤희(Yun-Hee Chang),박혜련(Hye-Ryeon Park),한복경(Bok-Kyung Han),정중기(Jung-Ky Jeong),최경숙(Kyoung-Sook Choi),박수범(Su-Beom Park),최혁준(Hyuk-Joon Choi),황진아(Jinah Hwang) 한국식품영양과학회 2015 한국식품영양과학회지 Vol.44 No.3
감귤류와 감귤류의 과피는 오랜 기간 동양의학의 약재로 사용되어 왔고 최근에는 생과와 주스로 많이 소비되고 있다. 하지만 감귤류 가공 공정 시 많은 과피 부산물이 발생하므로 활용방안이 필요하다. 감귤류의 과피에는 플라바논(flavanone)이 풍부하며 이 플라바논의 형태 중 배당체보다 비배당체의 체내 흡수가 더 효과적이므로 비배당체가 생리적 효과가 더 뛰어나다. Bioconversion(물질전환)은 cytolase에 의해 narirutin과 naringin은 naringenin으로, hesperidin은 hesperetin으로 각각 전환되며, 본 연구는 감귤의 과피에 다량 존재하는 플라바논을 물질전환 한 뒤 면역세포에서 항산화 및 항염증 효과를 확인하였다. 물질전환 후에 감귤 과피 추출물의 전자공여능이 농도 의존적으로 높아지는 것을 확인하였고, 면역세포인 RAW264.7에 200, 500 μg/mL 감귤 bioconversion 전(CU)?후(CU-C) 과피 추출물을 4시간 동안 처리한 후 LPS(1 μg/mL, 8시간)를 처리하였다. 염증 관련 효소인 iNOS와 COX-2의 mRNA와 단백질 발현을 확인한 결과 물질전환과 관계없이 감귤 과피 추출물이 LPS에 의해 유도된 iNOS와 COX-2의 mRNA와 단백질 발현을 농도 의존적으로 감소시켰지만 물질전환 전보다 후 추출물의 억제 효과가 더 높았다. iNOS에 의해 생성되는 NO 역시 감귤 과피 추출물이 LPS에 의해 유도된 NO 생성을 억제시켰다. 본 연구 결과는 감귤 과피 추출물이 항산화와 항염증 생리활성을 보였지만 cytolase를 이용하여 물질전환 한 감귤 과피 추출물이 물질전환 전보다 이러한 생리활성이 강화됨을 보임으로써 향후 감귤류 부산물로 폐기되어온 감귤류 과피가 산화적 스트레스와 염증반응에 기인하는 만성질환을 위한 기능성 소재로 활용이 가능할 것으로 기대된다. 감귤 과피 추출물의 in vitro 상에서 검증된 항염증 효능이 향후에 in vivo 상에서 여러 염증 조직에 미치는 영향에 대한 추가 검증이 필요하다고 사료된다. Citrus and its peels, which are by-products from juice and/or jam processing, have long been used in Asian folk medicine. Citrus peels show an abundant variety of flavanones, and these flavanones have glycone and aglycone forms. Aglycones are more potent than glycones with a variety of physiological functions since aglycone absorption is more efficient than glycones. Bioconversion with cytolase converted narirutin and naringin into naringenin and hesperidin into hesperetin. Therefore, this study aimed to investigate the anti-oxidant and anti-inflammatory effects of bioconversion of Citrus unshiu (CU) peel extracts with cytolase (CU-C) in RAW264.7 cells. HPLC chromatograms showed that CU and CU-C had 23.42% and 29.39% total flavonoids, respectively. There was substantial bioconversion of narirutin to naringenin and of hesperidin to hesperetin. All citrus peel extracts showed DPPH scavenging activities in a dose-dependent manner, and CU-C was more potent than intact CU. RAW264.7 cells were pre-treated with 0∼500 μg/mL of citrus peel extracts for 4 h and then stimulated by 1 μg/mL of lipopolysaccharide (LPS) for 8 h. All citrus peel extracts showed decreased mRNA levels and protein expression of LPS-induced inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in a dose-dependent manner. Especially, CU-C markedly inhibited mRNA and protein expression of iNOS and COX-2 compared to intact citrus peel extracts. All citrus peel extracts showed decreased NO production by iNOS activity. This result suggests that bioconversion of citrus peel extracts with cytolase may provide potent functional food materials for prevention of chronic diseases attributable to oxidation and inflammation by boosting the anti-inflammatory effects of citrus peels.
Hyeung-Sik Lee,Hyung-Rae Cho,Kun-Ju Yang,Seung-Bae Moon,Bok-Ryeon Park,Hyun-Dong Shin,Hee-Jeong Jang,Lin-Su Kim,Sae-Kwang Ku 한국독성학회 2008 Toxicological Research Vol.24 No.1
In this research the genotoxic effect of Polycan™ β-glucans originated from Aureobasidium pullulans SM-2001, was evaluated using the mouse micronucleus test. Polycan™ was administered once a day for 2 days by oral gavage to male ICR mice at doses of 1000, 500 and 250 mg/kg. Cyclophosphamide was used as a known genotoxic agent in a positive control group. The appearance of a micronucleus is used as an index for genotoxic potential. The results obtained indicated that Polycan™ shows no genotoxicity effect up to 1000 mg/kg dosing levels. In addition, it is also considered that there were no problems from cytotoxicity of Polycan™ tested in this study because the polychromatic erythrocyte ratio was detected as > 0.47 in all tested groups.