Apoptosis-inducing effect and structural basis of Polygonatum cyrtonema Lectin and chemical modification properties on its mannose-binding sites

( Bo Liu ),( Xiao Chao Xu ),( Yan Cheng ),( Jian Huang ),( Yan Hong Liu ),( Zhen Liu ),( Ming Wei Min ),( He Jiao Bian ),( Jing Chen ),( Jin Ku Bao ) 생화학분자생물학회 2008 BMB Reports Vol.41 No.5

A novel approach of ship wakes target classification based on the LBP-IBPANN algorithm

Bo, Liu,Yan, Lin,Liang, Zhang Techno-Press 2014 Ocean systems engineering Vol.4 No.1

The detection of ship wakes image can demonstrate substantial information regarding on a ship, such as its tonnage, type, direction, and speed of movement. Consequently, the wake target recognition is a favorable way for ship identification. This paper proposes a Local Binary Pattern (LBP) approach to extract image features (wakes) for training an Improved Back Propagation Artificial Neural Network (IBPANN) to identify ship speed. This method is applied to sort and recognize the ship wakes of five different speeds images, the result shows that the detection accuracy is satisfied as expected, the average correctness rates of wakes target recognition at the five speeds may be achieved over 80%. Specifically, the lower ship's speed, the better accurate rate, sometimes it's accuracy could be close to 100%. In addition, one significant feature of this method is that it can receive a higher recognition rate than the nearest neighbor classification method.

Influence of Vehicle Load Mode on the Response of an Asymmetrically-Loaded Deep Excavation

Bo Liu,Dingwen Zhang,Peisheng Xi 대한토목학회 2019 KSCE JOURNAL OF CIVIL ENGINEERING Vol.23 No.8

At present, the research on the influence of vehicle load mode on response of asymmetrically-loaded deep excavation is limited. Based on a deep excavation which is adjacent to the expressway and is subjected to the asymmetric load induced by the weight of embankment and the vehicle load together, this paper presented several vehicle load conversion methods firstly. Then a numerical modelling was performed to simulate the response of deep excavation considering the above methods. Next, a field monitoring of response of deep excavation was performed to verify the simulation results. By comparing the simulated and monitored results, the optimum vehicle load mode was recommended. The results indicate that the vehicle load has a considerable influence on the response of deep excavation. For this study, the equivalent thickness of soil layer method and the improved equivalent thickness of soil layer method are recommended to treat the vehicle load. This paper also analysed the influence factor of the improved equivalent thickness of soil layer method and found the improvement effect of this method rapidly decreases with the increase of retaining wall height. For a very high retaining wall, the improvement effect of this method is limited.

Recognition and Usage of Sunscreen by Women in Yunnan Province, China

Bo Liu,Sungkwan An 한국피부과학연구원 2021 아시안뷰티화장품학술지 Vol.19 No.4

목적: 본 연구에서는 중국 운남성 지역을 중심으로 화장품 소비가 가장 많은 10대-40대 여성들이 자외선 및 자외선차단제에 대 한 인식도와 사용 실태, 구매 경로 등을 조사하고자 한다. 방법: 온라인 설문조사 서비스인 Wenjuanxing (Changsha Ranxing Information Technology Co., Ltd, China)을 이용하여 총 22문항으로 구성된 설문지를 배포하여 수집된 자료를 통계 프로그램을 이 용하여 빈도분석 및 교차분석을 실시하였다. 결과: 설문에 참여한 99.2%의 여성은 자외선이 피부에 유해하다는 인식을 가지고 있 으며, 모든 연령층에서 동일하게 색소침착, 노화촉진, 일광화상 순의 사유로 유해하다고 인지한 것으로 나타났다. 결론: 본 연구는 중국 남부 지역으로 진출을 희망하는 한국 화장품 기업이 자외선차단제를 기획할 때 참고할 수 있는 기초 자료를 제공하였다는 점 에서 상당한 의의가 있다고 판단된다 Purpose: In this study, we surveyed 1,325 women ranging in age from 10s to 40s and living in Yunnan province, China to examine their awareness regarding the harmfulness of ultraviolet (UV) rays, and their usage and preference of sunscreen. Methods: Questionnaires composed of a total of 22 questions were distributed using the online survey service Wenjuanxing. The data collected were analyzed through frequency analysis and crossover analysis using a statistics program. Results: Awareness that UV rays are harmful to the skin was present in 99.2% of the subjects. All age groups perceived the harmfulness of UV rays due to the same reasons, which were pigmentation, promotion of premature skin aging, and sunburn. Similarly, all age groups perceived that UV rays are harmful throughout the year. Conclusion: Awareness of the effects of UV rays helps Korean cosmetics companies to market and design sales strategies for sunscreen products in the southern region of China. This survey provided data specific to Yunnan regarding women's preferences, thereby facilitating comparative analysis with other regions in China.

GUI design exploration software for microwave antennas

Bo Liu,Alexander Irvine,Mobayode O. Akinsolu,Omer Arabi,Vic Grout,Nazar Ali 한국CDE학회 2017 Journal of computational design and engineering Vol.4 No.4

Optimizers in commercial electromagnetic (EM) simulation software packages are the main tools for performing antenna design exploration today. However, these general purpose optimizers are facing challenges in optimization efficiency, supported optimization types and usability for antenna experts without deep knowledge on optimization. Aiming to fill the gaps, a new antenna design exploration tool, called Antenna Design Explorer (ADE), is presented in this paper. The key features are: (1) State-of-the-art antenna design exploration methods are selected and embedded, addressing efficient antenna optimization (critical but unable to be solved by existing tools) and multiobjective antenna optimization (not available in most existing tools); (2) Human-computer interaction for the targeted problem is studied, addressing various usability issues for antenna design engineers, such as automatic algorithmic parameter setting and interactive stopping criteria; (3) Compatibility with existing tools is studied and ADE is able to co-work with existing EM simulators and optimizers, combining advantages. A case study verifies the advantages of ADE.

Inhibitors of the Pseudomonas aeruginosa quorum-sensing regulator, QscR

Liu, Hai-Bo,Lee, Joon-Hee,Kim, Jung Sun,Park, Sunghoon Wiley Subscription Services, Inc., A Wiley Company 2010 Biotechnology and bioengineering Vol.106 No.1

<P>QscR is a quorum-sensing (QS) signal receptor that controls expression of virulence genes in the prevalent opportunistic pathogen, Pseudomonas aeruginosa. Unlike the previously reported LuxR-type QS receptor proteins, that is, LasR and TraR, QscR can be obtained as an apo-protein that can reversibly form an active complex in vitro with its cognate signal molecule, 3-oxododecanoyl-homoserine lactone (3OC12-HSL), and subsequently bind to target promoter DNA sequences. To search for potential QS inhibitors, an in vitro gel retardation assay was developed using the purified QscR. Both the in vitro assay and the in vivo cell-based assay using QscR-overproducing recombinant strains were applied in the screening process. Furanones were chosen for testing the activity as QS inhibitors because they have been reported to strongly inhibit expression of QS-related genes in Agrobacterium tumefaciens. Among more than a hundred furanones tested, three compounds showed strong and dose-dependent inhibitory effects on QscR in both assays. One compound in particular, designated as F2, could completely inhibit the 3OC12-HSL-dependent QscR activity in vitro at a concentration of 50-fold molar excess over 3OC12-HSL. However, with the furanones F3 and F4, which are structurally similar to F2 but with a nitro group instead of the amine moiety, significantly decreased activities were observed. These results suggest that (i) the in vitro assay is a sensitive and reliable tool for screening QS inhibitors, and (ii) furanones are potentially important QS inhibitors for many LuxR-type receptor proteins. Biotechnol. Bioeng. 2010; 106: 119–126. © 2010 Wiley Periodicals, Inc.</P>

SADEA-II:Ageneralizedmethodforefficient global optimization ofantennadesign

Bo Liu,Slawomir Koziel,Nazar Ali 한국CDE학회 2017 Journal of computational design and engineering Vol.4 No.2

Efficiency improvementisofgreatsignificance forsimulation-drivenantennadesignoptimizationmethodsbasedonevolutionaryalgorithms(EAs). Thetwomainefficiency enhancementmethodsexploitdata-drivensurrogatemodelsand/ormulti-fidelity simulationmodelstoassistEAs. However, optimizationmethodsbasedonthelattereitherneedadhoclow-fidelity modelsetuporhavedifficulties inhandlingproblemswithmore thanafewdesignvariables,whichisamainbarrierforindustrialapplications.Toaddressthisissue,ageneralizedthreestagemulti-fidelitysimulation-model assistedantennadesignoptimizationframeworkisproposedinthispaper.Themainideasincludeintroductionofanoveldatamining stagehandlingthediscrepancybetweensimulationmodelsofdifferent fidelities, andasurrogate-model-assistedcombinedglobalandlocal searchstageforefficient high-fidelity simulationmodel-basedoptimization.ThisframeworkisthenappliedtoSADEA,whichisastate-of-the-art surrogate-model-assistedantennadesignoptimizationmethod,constructingSADEA-II.ExperimentalresultsindicatethatSADEA-IIsuccessfully handlesvariousdiscrepancybetweensimulationmodelsandconsiderablyoutperformsSADEAintermsofcomputationalefficiencywhile ensuringimproveddesignquality.

Twisted-fin parametric study to enhance the solidification performance of phase-change material in a shell-and-tube latent heat thermal energy storage system

Bo Liu,Mahdi Jasim M,Rahbari Alireza,Majdi Hasan Sh,Xin Yi,Yaïci Wahiba,Talebizadehsardari Pouyan 한국CDE학회 2022 Journal of computational design and engineering Vol.9 No.6

Phase change material (PCM) is considered as one of the most effective thermal energy storage (TES) systems to balance energy supply and demand. A key challenge in designing efficient PCM-based TES systems lies in the enhancement of heat transmission during phase transition. This study numerically examines the privilege of employing twisted-fin arrays inside a shell-and-tube latent heat storage unit to improve the solidification performance. The presence of twisted fins contributes to the dominating role of heat conduction by their curved shapes, which restricts the role of natural convection but largely aids the overall heat-transfer process during solidification. The heat-discharge rate of twisted-fin configuration is increased by ∼14 and ∼55% compared to straight fin and no fin configurations—leading to a reduction in the solidification duration by ∼13 and ∼35%, respectively. The solidification front at various times has also been assessed through a detailed parametric study over the fin height, fin pitch number, and fin thickness. Over the range of values assumed, the fin height is the most dominant parameter – increasing the heat-retrieval rate from 10.0 to 11.4 W and decreasing the discharge time from above 3600 to 2880 s by varying the fin height from 2.5 to 7.5 mm.

A Survey on the Establishment and Application of Social Capital Partner Selection System for the New Profit PPP Project

Bo Liu,Ju-qin Shen,Zhao-jian Meng,Fu-hua Sun 대한토목학회 2018 KSCE JOURNAL OF CIVIL ENGINEERING Vol.22 No.10

As the economy in China enters the new normal, Public-Private Partnerships have been an important measure for alleviating financial tensions and improving the administrative efficiency of the government. Based on the mode of open tendering for the selection of social capital partners for the new profit project, the open tendering procedures were analyzed. In addition, based on an improved TOPSIS model, the evaluation index system for the selection conducts a comprehensive evaluation of six aspects: reputation and performance, water pricing factor, financing program, construction program, operation and maintenance program, and transfer program.

MicroRNA-708-3p as a potential therapeutic target via the ADAM17-GATA/STAT3 axis in idiopathic pulmonary fibrosis

Bo Liu,Rongrong Li,Jinjin Zhang,Chao Meng,Jie Zhang,Xiaodong Song,Changjun Lv 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-

MicroRNAs (miRNAs) are important diagnostic markers and therapeutic targets for many diseases. However, the miRNAs that control the pathogenesis of idiopathic pulmonary fibrosis (IPF) and act as potential therapeutic targets for the disease are rarely studied. In the present study, we analyzed the function and regulatory mechanism of microRNA-708-3p (miR-708-3p) and evaluated this marker’s potential as a therapeutic target in IPF. The clinical and biological relevance of fibrogenesis for miR-708-3p was assessed in vivo and in vitro, specifically in matching plasma and tissue samples from 78 patients with IPF. The data showed that the miR-708-3p levels decreased during fibrosis and inversely correlated with IPF. The experiments showed that the decreased miR-708 promoter activity and primer-miR-708(pri-miR-708) expression were the potential causes. By computational analysis, a dual luciferase reporter system, rescue experiments and a Cignal Finder 45-Pathway system with siADAM17 and a miR-708-3p mimic, we identified that miR-708-3p directly regulates its target gene, a disintegrin and metalloproteinase 17 (ADAM17), through a binding site in the 3′ untranslated region, which depends on the GATA/STAT3 signaling pathway. Finally, an miR-708-3p agomir was designed and used to test the therapeutic effects of the miR-708-3p in an animal model. Small-animal imaging technology and other experiments showed that the dynamic image distribution of the miR-708-3p agomir was mainly concentrated in the lungs and could block fibrogenesis. In conclusion, the miR-708-3p– ADAM17 axis aggravates IPF, and miR-708-3p can serve as a potential therapeutic target for IPF.