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Two New α-Pyrones and Other Components from the Cladodes of Opuntia dillenii
Ying Kun Qiu,Yan Yan Zhao,De Qiang Dou,Bi Xia Xu,Ke Liu 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.6
The aqueous ethanolic extract from the fresh cladodes of Opuntia dillenii HAW. was found to show anti-inflammatory activity. Two new α-pyrones, named opuntioside II (1) and opuntioside III (2), were isolated from the extract together with six known compounds. The structures of the new compounds were determined on the basis of chemical and physicochemical evidence.
Two New ${\alpha}$-Pyrones and Other Components from the Cladodes of Opuntia dillenii
Qiu, Ying-Kun,Zhao, Yan-Yan,Dou, De-Qiang,Xu, Bi-Xia,Liu, Ke 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.6
The aqueous ethanolic extract from the fresh cladodes of Opuntia dillenii HAW. was found to show anti-inflammatory activity. Two new ${\alpha}$-pyrones, named opuntioside II (1) and opuntioside III (2), were isolated from the extract together with six known compounds. The structures of the new compounds were determined on the basis of chemical and physicochemical evidence.
Corrosion behavior of biodegradable magnesium alloy by MAF treatment
Xinzhe Gao,Yifan Yang,Bi Ying Shi,Chun Yu Dai,ChuanYao Zhai,Bing Cheng Zhao,Heng Bo Jiang 대한치과재료학회 2021 대한치과기재학회 학술대회 Vol.2021 No.4
Introduction. Magnesium and magnesium alloys, with mismatched degradation rates and products that are expected to support the effects being issues that need to be overcome, are hindered from clinical application. The coating preparation plays an active role in tackling this problem. The purpose of this work is to observe the corrosion control by the MAF coating in vitro and in vivo. Method. The MgF2 layer was prepared on the surface of AZ31 magnesium alloy by MAF method at 190 V DC in HF·H<sub>2</sub>O (46%) solution. The magnesium alloy samples before and after the treatment were compared by scanning electron microscopy (SEM) observation. The coating structure and constituents were confirmed using cross-sectional SEM, energy-dispersive X-ray spectroscopy (EDS) and X-ray diffraction (XRD) analysis. Potentiodynamic polarization (PDP) was utilized for electrochemical evaluation of corrosion potential and current density. 6-week-old male rats were used as experimental subjects for in vivo experiments. The volume changes and surface morphology of the corroded samples were dynamically monitored using micro-CT for 16 weeks. Results. The distribution of coating elements observed by EDS is dominated by magnesium and fluorine. The XRD analysis shows that the prepared coatings are mainly MgF2 crystals. The coating was observed by SEM to be uniformly dense and coral-like. The results of the PDP experiments showed that the coated samples had lower corrosion current density and corrosion potential. Comparison of the two groups of in vivo experiments revealed that the rate of volume change decreased in the coated samples and the density change during micro-CT observation was less than that of the uncoated group. Conclusions. Effective coatings were prepared on the surface of AZ31 magnesium alloy using the MAF method. This coating was also validated the potential to control the corrosion rate and corrosion process of magnesium alloy by both in vitro and in vivo evaluation systems.
Efficacy and Safety of Bevacizumab in Chinese Patients with Metastatic Colorectal Cancer
Zhu, Li-Ming,Zhao, Ya-Zhen,Ju, Hai-Xing,Liu, Lu-Ying,Chen, Lei,Liu, Bi-Xia,Xu, Qi,Luo, Cong,Ying, Jie-Er,Yang, Yun-Shan,Zhong, Hai-Jun Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.16
Objective: To evaluate the efficacy and safety of bevacizumab in the treatment of patients with metastatic colorectal cancer (mCRC). Methods: In a single-center, observational study of 91 Chinese patients with mCRC who received bevacizumab in combination with chemotherapy was conducted. Objective response rates (ORRs), progression-free survival (PFS), overall survival (OS) and adverse events were recorded, and the relationships between various clinical factors and PFS or OS were evaluated by Cox proportional hazards models. Results: Treatment with bevacizumab and chemotherapy was effective and tolerable. Univariate analysis showed that PFS and OS were significantly associated with the Eastern Cooperative Oncology Group performance status (ECOG-PS) score, duration of bevacizumab exposure, and whether chemotherapy was continued after discontinuation of bevacizumab treatment. A multivariate analysis showed that the duration of bevacizumab exposure and whether chemotherapy was continued after discontinuation of bevacizumab were independent prognostic factors for PFS and OS. Conclusion: In Chinese mCRC population, the shorter the duration of exposure to bevacizumab and chemotherapy, the worse the prognosis is.