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박범석,명남숙,이형주,박홍석,한철우,구수권,Park, Beom-Seok,Myung, Nam-Sook,Lee, Hyoung-Ju,Park, Hong-Seok,Han, Cheol-Woo,Koo, Soo-Kweon 대한기관식도과학회 2009 大韓氣管食道科學會誌 Vol.15 No.2
Background and Objectives : Peritonsillar abscess is one of the most common illnesses m the ENT field, though its prevalence has been drastically reduced with the development of antibiotics and appropriate early treatment. We analyzed recent clinical characteristics of peritonsillar abscess and compared them with ones of 7 and 14 years ago respectively. Materials and Methods : Sixty-six cases of peritonsillar abscess from 2006 through 2008 were investigated retrospectively and compared with results of 7 and 14 years ago on various clinical factors. Results : Peritonsillar abscess was prevalent in men in their 20s and 30s. Mean period from symptom onset to visit to hospital tended to decrease(5.2 days) but admission days has increased(7.4 days). Body temperature on admission was lower than that of previous studies($36.4^{\circ}C$). Bacteria were isolated in 26 cases(74.2%) out of 35 cases in which culture had been performed. The most common cultured organism was a-hemolytic streptococcus and $\beta$-hemolytic streptococcus that had been most frequently cultured 14 years ago wasn't detected in this study. Conclusion : We found some changes of clinical features in peritonsillar abscess when compared with previous researches. Although there were some differences in cultured organism, antibiotics used commonly-cephalosporin, aminoglycoside, quinolone - were still effective for their eradication.
박범석(Beom Seok Park),유성구(Sung Goo Yoo),정길도(Kil To Chong) 제어로봇시스템학회 2011 제어·로봇·시스템학회 논문지 Vol.17 No.3
In the bilateral tele-operation system, time delay may be a critical problem. Even if system modeling error or time delay occurs, when applied to wave transformation system, the system"s stability can be achieved. Using the characterisitc b which is an important parameter of wave transformation, the system can display robust performance for time delay. However, since assuming and that the time delay was fixed developing a theory, a stability cannot be guaranteed about the time varying delay. Therefore, In the paper, Therefore in this paper, we studied for the method that controls this by applying the fuzzy algorithm which surveyed the time-varying delay characterisitcs and can adjust the b according to it adaptively.
애호박(C. moschata)에서 흰가루병 저항성에 대한 QTL 분석 및 연관 분자표지 개발
박범석(Beom-Seok Park),장시영(Siyoung Jang),유의수(Yeisoo Yu),최경자(Gyung Ja Choi),강병철(Byoung-Cheorl Kang),서상기(SangKi Seo) 한국원예학회 2020 원예과학기술지 Vol.38 No.5
이 연구에서는 우리나라의 중요 박과 작물인 애호박(동양계 호박, Cucurbita moschata)의 재배와 생산에 큰 피해를 주는 흰가루병(Podosphaera xanthii)의 저항성 유전자좌를 연구하였다. 홍익바이오(주)의 애호박 육종 소재 중에서 흰가루병 감수성 계통(TG201, ♀)과 저항성 계통(TG10, ♂)을 선정하고, 교배를 통하여 F2 집단을 만들었다. 그 중에 204개체를 대상으로 흰가루병 검정, GBS(genotyping-by-sequencing) 분석, SNP 유전지도 작성, QTL 분석을 수행하였다. 흰가루병 저항성 유전자좌는 TG10의 염색체 3번의 6.9 ‑ 7.3Mb 부분에 매핑되었다. 그리고 양친 유전체의 이 400kb 영역 내의 DNA 삽입/결실(indel)을 조사하고 7세트의 PCR 분자표지를 제작하였으며 F2 개체, 육종 소재 및 시판 품종을 대상으로 그 유효성을 검증하였다. 또한 실험에 사용된 애호박 양친의 유전체 염기서열 정보를 생산하고 해독하여 단일염기다형성(SNP) 분석을 수행하였다. 흰가루병 저항성 애호박 품종 육성 가계에 근거한 비교유전체 분석을 통하여 TG10이 갖고 있는 흰가루병 저항성 유전자좌 영역은 C. okeechobeensis subsp. martinezii로부터 이입된 염색체 토막의 일부임을 밝혔다. 본 연구에서 생산된 애호박 유전체 정보와 SNP 변이 데이터, 흰가루병 저항성 유전자좌 정보와 indel PCR 분자표지는 박과 식물의 연구와 개발에 유용하게 이용 될 것으로 기대된다. Cucurbita moschata, an economically and nutritionally important vegetable in Korea, is seriously damaged in fruit quality and productivity by powdery mildew fungus (Podosphaera xanthii). To understand genetic bases of the powdery mildew disease resistance, an F2 population was developed from a cross between TG201 (C. moschata, susceptible, female parent) and TG10 (resistant, male parent) heirloom from Hongikbio Inc. Randomly selected 204 F2 individuals were assayed against powdery mildew pathogen, and construction of genetic map and QTL analysis were conducted using SNPs derived from genotyping-by-sequencing (GBS) method. The single major QTL was located in 6.9 ‑ 7.3 Mb region of TG10 chromosome 3. Within the 400 kb region, we investigated DNA insertion and deletion (indel) variations between TG201 and TG10 genome, and successfully designed seven sets of indel PCR markers. The functional validity of the powdery mildew resistance markers was confirmed with F2 individuals, breeding lines, and commercial varieties. From genomic sequence comparison on the basis of the breeding history, we also could clarify that the powdery mildew resistance region was introduced from C. okeechobeensis subsp. martinezii to C. moschata. Moreover, whole genome assemblies of two heirloom parents and genome-wide SNP/indel information were produced and are expected to be utilized as a genome resource for study of genus Cucurbita. The results and information of this study will be useful for genetics researches and breeding practices of C. moschata.