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      • Prostate Cancer Screening in a Healthy Population Cohort in Eastern Nepal: an Explanatory Trial Study

        Belbase, Narayan Prasad,Agrawal, Chandra Shekhar,Pokharel, Paras Kumar,Agrawal, Sudha,Lamsal, Madhab,Shakya, Vikal Chandra Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5

        Background: Prostate cancer features a substantial incidence and mortality burden, similarly to breast cancer, and it ranks among the top ten specific causes of death in males. Objective: To explore the situation of prostate cancer in a healthy population cohort in Eastern Nepal. Materials and Methods: This study was conducted in the Department of General Surgery at B. P. Koirala Institute of Health Sciences, Dharan, Nepal from July 2010 to June 2011. Males above 50 years visiting the Surgical Outpatient Department in BPKIHS were enrolled in the study and screening camps were organized in four Teaching District Hospitals of BPKIHS, all in Eastern Nepal. Digital rectal examination (DRE) was conducted by trained professionals after collecting blood for assessment of serum prostatic specific antigen (PSA). Trucut biopsies were performed for all individuals with abnormal PSA/DRE findings. Results: A total of 1,521 males more than 50 years of age were assessed and screened after meeting the inclusion criteria. The vast majority of individuals, 1,452 (96.2%), had PSA ${\leq}4.0$ ng/ml. Abnormal PSA (>4 ng/ml) was found in 58 (3.8%). Abnormal DRE was found in 26 (1.72%). DRE and PSA were both abnormal in 26 (1.72%) individuals. On the basis of raised PSA or abnormal DRE 58 (3.84%) individuals were subjected to digitally guided trucut biopsy. Biopsy report revealed benign prostatic hyperplasia in 47 (3.11%) and adenocarcinoma prostate in 11 (0.73%). The specificity of DRE was 66.0%with a sensitivity of 90.9% and a positive predictive value of 38.5%. The sensitivity of PSA more than 4ng/ml in detecting carcinoma prostate was 100% and the positive predictive value for serum PSA was 19.0% Conclusions: The overall cancer detection rate in this study was 0.73% and those detected were locally advanced. Larger community-based studies are highly warranted specially among high-risk groups.

      • GI Surgery

        ( Narayan Prasad Belbase ),( Aditya Kumar Jalan ),( Hari Upadhyay ),( Rohit Mishra ),( Mukesh Karki ),( Sujit Kumar ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1

        Aims: The aim of this study was to determine the outcome of liver injuries managed operatively or non-operatively and predict factors affecting morbidity and mortality. Methods: This was a retrospective study of 40 liver injuries managed in the department of Surgical Gastroenterology at College of Medical Sciences over a period of 2 years. The liver injury was classified in accordance with the American Association for the Surgery of Trauma liver injury scoring scale. Patients were divided into two groups those managed operatively or non-operatively and were compared in terms of demographic profile and outcome. Results: Forty patients were analyzed. The mean age of the patients was 29.95years. Male predominance was seen with 72.5% of the cases. Road traffic accidents were the commonest mode of injury seen in 72.5% cases. The mean Revised Trauma Score (RTS) and Injury severity score (ISS) were 7.11and 22.58. The mean systolic BP, hospital stay and ICU stay were 93.80 mm of mercury, 11.55 days and 3.55 days respectively. Twenty six patients (65%) were initially managed non-operatively and 14 patients were managed operatively. Five patients had to be converted to operative management for hemodynamic instability. Mortality was 7.6% in patient undergoing non-operative management and 21.43% in patients managed operatively. Low systolic BP at presentation, low RTS score, high ISS score, high AST, ALT and prothrombin time were significantly associated with operative management and mortality. Conclusions: Patients with hemodynamic instability, low RTS score, high ISS score, high liver enzymes have high likelihood of operative management.

      • HYBRID VOLTERRA SYSTEM WITH TWO TYPES OF IMPULSES

        Park, Jong-Seo,S.A. Belbas,Kim, Seon-Yu 晋州敎育大學校 科學敎育硏究院 2006 科學敎育硏究 Vol.29 No.-

        본 연구의 목적은 충격을 받는 조건이 두 가지 유형과 다중 적분을 갖는 볼테라 적분 방정식의 어떤 특성을 포함하는 방정식의 색다른 부류를 조직적으로 확립하고 분석해 보고자 한다. 여기서 우리는 반복하는 방법에 의하여 주어진 조건의 적분방정식에 대한 해의 존재성과 유일성을 구조적으로 밝히는데 그 목적이 있다. 본 논문을 통한 발전적인 연구가 수행되면 여러 가지 자연현상을 모델화하여 적용함으로 인해 이론적인 부분뿐만 아니라 응용적인 면에서 아주 많이 적용될 것으로 생각되며 전자공학, 자동제어, 생물학, 의학 등의 다양한 실생활의 문제에 활용이 가능한 충분한 가치가 있으리라 생각한다. In this paper, we formulate and analyze a novel class of equations that contain some of the characteristics of Volterra intergral equations with multiple integrals and two types of impulsive terms. We will give a constructive proof of existence and uniqueness of solutions by an iteration method.

      • KCI등재

        A Hybrid Volterra-Type Equation with Two Types of Impulses

        S. A. Belbas,박종서 한국수학교육학회 2006 純粹 및 應用數學 Vol.13 No.2

        We formulate and analyze a hybrid system model that involves Volterra integral operators with multiple integrals and two types of impulsive terms. We give a constructive proof, via n iteration method, of existence and uniqueness of solutions.

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