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- 저자 : Bazarsad Shadavlonjid (검색결과 3 건)
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Shadavlonjid Bazarsad,김주영,Xianglan Zhang,김기열,이두영,유미현,김진 연세대학교의과대학 2018 Yonsei medical journal Vol.59 No.6
Purpose: Adenoid cystic carcinoma (ACC) is a high-grade malignant tumor of the salivary glands, clinically characterized by multiplerecurrences and late distant metastasis. Biological markers for assessing the prognosis of ACC have remained elusive. Thepurpose of this study was to investigate whether the protein expressions of ataxia telangiectasia mutated (ATM), p53, and ATMmediatedphosphorylated p53 are related to patient survival in ACC. Materials and Methods: In this study, 48 surgical samples were used to assess the expressions of ATM and its downstream targetp53. Fisher’s exact test and Kaplan-Meier analysis were conducted to evaluate the role of ATM, p53, and phospho-p53 (S15) proteinexpressions in predicting patient survival and distant metastasis. Results: Myb expression was positive in 85.4% of ACCs, but did not reflect patient survival rate. In contrast, low expression of ATMin cancer cells was significantly correlated with poor survival rate (p=0.037). Moreover, under positive p53 expression, low expressionof ATM was highly predictive of poor survival in ACC (p=0.017). Conclusion: These data indicate that combined assessment of ATM and p53 expression can serve as a useful prognostic markerfor assessing survival rate in patients with ACC of the salivary glands.
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법랑모세포섬유-치아종으로부터 발생한 법랑모세포섬유육종 -증례 보고-
Bazarsad Shadavlonjid,Eunae Cho,Woong Nam,Hyun Sil Kim,Jong In Yook,Jin Kim 대한구강악안면병리학회 2017 대한구강악안면병리학회지 Vol.41 No.1
Ameloblastic fibrosarcoma (AFS) is an extremely rare malignant odontogenic tumor characterized with benign ameloblastic cells islands and malignant mesenchymal component. While two-thirds of AFS seem to arise de novo, but one-third develops from recurrent ameloblastic fibroma (AF) or ameloblastic fibro-odontomas (AFO). Pathological distinction of malignant transformation is essential for appropriate treatment. The patient was a 28 years old man. Since the primary tumor was excised, the mass recurred 2 years later. The recurrent tumor was diagnosed as AFS. Chief complaint was pain in the right mandible. Computer tomography finding revealed multilocular intrabony lesion with radiopaque substance in the primary lesion. In the recurrent lesion cortical bone destruction was found. Microscopically, both the primary and recurrent lesions showed benign ameloblastic follicles with myxoid or highly cellular mesenchymal proliferation. The histological difference between primary and recurrent lesions were that foci of dental hard tissue composed of enamel and dentin were found only in the primary lesion, whereas nuclear pleomorphism was aggrevated in the recurrent lesion. The histological criteria determining malignancy were discussed.
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Zhang, Xianglan,Kim, Ki-Yeol,Zheng, Zhenlong,Bazarsad, Shadavlonjid,Kim, Jin Elsevier 2017 Oral oncology Vol.72 No.-
<P><B>Abstract</B></P> <P><B>Objective</B></P> <P>Squamous cell carcinomas (SCC) are the most common malignancies in the oral mucosa; these carcinomas have been preceded by potentially malignant oral disorders (PMODs), mostly oral leukoplakia (OL). No specific biomarker has been widely accepted for predicting the risk of malignant transformation of PMODs. The aim of this study was to develop an accurate prediction model for the malignant transformation of OL using clinical variables and candidate biomarkers.</P> <P><B>Materials and methods</B></P> <P>To achieve this goal, 10 candidate biomarkers that had previously been reported as useful molecules were investigated: P53, Ki-67, P16, β-catenin, c-jun, c-met, insulin like growth factor II mRNA-binding protein (IMP-3), cyclooxygenase (COX-2), podoplanin (PDPN) and carbonic anhydrase 9 (CA9). For this study, malignant transformed (n=22, median interval of malignant conversion: 3.3years) and untransformed (n=138) OL specimens with median follow-up period of 11.3years (range: 4.6–23.2years) were immunohistochemically stained.</P> <P><B>Results</B></P> <P>Using univariate Cox regression analysis, all biomarkers were proven to be significant for predicting malignant transformation in OL. To reach the highest prediction accuracy, the repeated simulation was performed, revealing that the combination of P53 and CA9 with the clinical factors including age and degree of dysplasia achieved the highest prediction accuracy. We constructed a nomogram with the identified prognostic factors for predicting the 5-, 10-, and 15-year progression free survival of OL.</P> <P><B>Conclusions</B></P> <P>The proposed nomogram may be useful for the accurate and individual prediction of the transformation to SCC in OL patients and may help clinicians offer appropriate treatments and follow up.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A nomogram was created for predicting progression free survival of oral leukoplakia. </LI> <LI> Predictive nomogram consisted of molecular markers and clinical factors. </LI> <LI> P53 and CA9 were significant as molecular markers. </LI> <LI> Age and dysplasia grade were significant as clinical factors. </LI> </UL> </P>
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