법랑모세포섬유-치아종으로부터 발생한 법랑모세포섬유육종 -증례 보고-

Bazarsad Shadavlonjid,Eunae Cho,Woong Nam,Hyun Sil Kim,Jong In Yook,Jin Kim 대한구강악안면병리학회 2017 대한구강악안면병리학회지 Vol.41 No.1

Ameloblastic fibrosarcoma (AFS) is an extremely rare malignant odontogenic tumor characterized with benign ameloblastic cells islands and malignant mesenchymal component. While two-thirds of AFS seem to arise de novo, but one-third develops from recurrent ameloblastic fibroma (AF) or ameloblastic fibro-odontomas (AFO). Pathological distinction of malignant transformation is essential for appropriate treatment. The patient was a 28 years old man. Since the primary tumor was excised, the mass recurred 2 years later. The recurrent tumor was diagnosed as AFS. Chief complaint was pain in the right mandible. Computer tomography finding revealed multilocular intrabony lesion with radiopaque substance in the primary lesion. In the recurrent lesion cortical bone destruction was found. Microscopically, both the primary and recurrent lesions showed benign ameloblastic follicles with myxoid or highly cellular mesenchymal proliferation. The histological difference between primary and recurrent lesions were that foci of dental hard tissue composed of enamel and dentin were found only in the primary lesion, whereas nuclear pleomorphism was aggrevated in the recurrent lesion. The histological criteria determining malignancy were discussed.

Ataxia-Telangiectasia-Mutated Protein Expression as a Prognostic Marker in Adenoid Cystic Carcinoma of the Salivary Glands

Shadavlonjid Bazarsad,김주영,Xianglan Zhang,김기열,이두영,유미현,김진 연세대학교의과대학 2018 Yonsei medical journal Vol.59 No.6

Purpose: Adenoid cystic carcinoma (ACC) is a high-grade malignant tumor of the salivary glands, clinically characterized by multiplerecurrences and late distant metastasis. Biological markers for assessing the prognosis of ACC have remained elusive. Thepurpose of this study was to investigate whether the protein expressions of ataxia telangiectasia mutated (ATM), p53, and ATMmediatedphosphorylated p53 are related to patient survival in ACC. Materials and Methods: In this study, 48 surgical samples were used to assess the expressions of ATM and its downstream targetp53. Fisher’s exact test and Kaplan-Meier analysis were conducted to evaluate the role of ATM, p53, and phospho-p53 (S15) proteinexpressions in predicting patient survival and distant metastasis. Results: Myb expression was positive in 85.4% of ACCs, but did not reflect patient survival rate. In contrast, low expression of ATMin cancer cells was significantly correlated with poor survival rate (p=0.037). Moreover, under positive p53 expression, low expressionof ATM was highly predictive of poor survival in ACC (p=0.017). Conclusion: These data indicate that combined assessment of ATM and p53 expression can serve as a useful prognostic markerfor assessing survival rate in patients with ACC of the salivary glands.

Effect of Acer tegmentosum Maxim. Extracts on Acute Hepatitis and Fatty Liver in Rats

Soo Young Choe, Yoonhee Seo, Davaa Bazarsad 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.2

This study was conducted in order to investigate the effects of Acer tegmentosum Maxim. extract (ATE) in prevention of liver injury. After oral administration of ATE to SD rats, liver injuries were induced by treatment with CCl4, galactosamine, or ethionine. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), triglyceride, and cholesterols in blood were used as indicators of liver damage. When acute hepatitis was induced by CCl4 or galactosamine, ATE-fed rats showed a lower level of AST and ALT in plasma than ATE-unfed rats. In the case of ethionine-induced fatty liver, triglyceride levels in plasma were reduced in ATE-fed rats, compared with ATE-unfed rats. These results indicate that Acer tegmentosum Maxim. extract protected against hepatic failure.

Finite Step Method for the Constrained Optimization Problem in Phase Contrast Microscopic Image Restoration

Adiya, Enkhbolor,Yadam, Bazarsad,Choi, Heung-Kook Korea Multimedia Society 2014 The journal of multimedia information system Vol.1 No.1

The aim of microscopic image restoration is to recover the image by applying the inverse process of degradation, and the results facilitate automated and improved analysis of the image. In this work, we consider the problem of image restoration as a minimization problem of convex cost function, which consists of a least-squares fitting term and regularization terms with non-negative constraints. The finite step method is proposed to solve this constrained convex optimization problem. We demonstrate the convergence of this method. Efficiency and restoration capability of the proposed method were tested and illustrated through numerical experiments.

Effect of Acer tegmentosum Maxim. Extracts on Acute Hepatitis and Fatty Liver in Rats

Yoonhee Seo,Davaa Bazarsad,최수영 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.2

This study was performed to investigate the preventing effects to liver injury of Acer tegmentosum Maxim. extract (ATE). After oral administration ATE to SD rats, liver injuries were induced by CCl4, galactosamine or ethionine treatments. The aspartate aminotransferase (AST), alanine aminotransferase (ALT), triglyceride and cholesterols in blood were used as indicators of liver damage. When acute hepatitis was induced by CCl4 or galactosamine, ATE-fed rats showed low level of AST and ALT in plasma than the ATE-unfed rats. In case of ethionine-induced fatty liver, the triglyceride in plasma were shown to reduced level in ATE-fed rats than ATE-unfed rats. These results indicate that Acer tegmentosum Maxim. extract protected hepatic failure.

Nomogram for risk prediction of malignant transformation in oral leukoplakia patients using combined biomarkers

Zhang, Xianglan,Kim, Ki-Yeol,Zheng, Zhenlong,Bazarsad, Shadavlonjid,Kim, Jin Elsevier 2017 Oral oncology Vol.72 No.-

<P><B>Abstract</B></P> <P><B>Objective</B></P> <P>Squamous cell carcinomas (SCC) are the most common malignancies in the oral mucosa; these carcinomas have been preceded by potentially malignant oral disorders (PMODs), mostly oral leukoplakia (OL). No specific biomarker has been widely accepted for predicting the risk of malignant transformation of PMODs. The aim of this study was to develop an accurate prediction model for the malignant transformation of OL using clinical variables and candidate biomarkers.</P> <P><B>Materials and methods</B></P> <P>To achieve this goal, 10 candidate biomarkers that had previously been reported as useful molecules were investigated: P53, Ki-67, P16, β-catenin, c-jun, c-met, insulin like growth factor II mRNA-binding protein (IMP-3), cyclooxygenase (COX-2), podoplanin (PDPN) and carbonic anhydrase 9 (CA9). For this study, malignant transformed (n=22, median interval of malignant conversion: 3.3years) and untransformed (n=138) OL specimens with median follow-up period of 11.3years (range: 4.6–23.2years) were immunohistochemically stained.</P> <P><B>Results</B></P> <P>Using univariate Cox regression analysis, all biomarkers were proven to be significant for predicting malignant transformation in OL. To reach the highest prediction accuracy, the repeated simulation was performed, revealing that the combination of P53 and CA9 with the clinical factors including age and degree of dysplasia achieved the highest prediction accuracy. We constructed a nomogram with the identified prognostic factors for predicting the 5-, 10-, and 15-year progression free survival of OL.</P> <P><B>Conclusions</B></P> <P>The proposed nomogram may be useful for the accurate and individual prediction of the transformation to SCC in OL patients and may help clinicians offer appropriate treatments and follow up.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A nomogram was created for predicting progression free survival of oral leukoplakia. </LI> <LI> Predictive nomogram consisted of molecular markers and clinical factors. </LI> <LI> P53 and CA9 were significant as molecular markers. </LI> <LI> Age and dysplasia grade were significant as clinical factors. </LI> </UL> </P>

Genetic Distinctness of the Korean Red-backed Vole (Myodes regulus) from Korea, Revealed by the Mitochondrial DNA Control Region

Koh, Hung-Sun,Yang, Beong-Kug,Lee, Bae-Keun,Jang, Kyung-Hee,Bazarsad, Davaa,Park, Nam-Jeong The Korean Society of Systematic Zoology 2010 Korean Journal of Systematic Zoology Special Issue Vol.26 No.3

To identify Korean red-backed voles (Myodes regulus) from Korea by mitochondrial DNA (mtDNA) sequencing, we obtained mtDNA control region sequences of 17 red-backed voles from Korea and northeast China, and these sequences were compared with the corresponding haplotypes of Myodes obtained from GenBank. We identified five red-backed voles from Mt. Changbai and Harbin as M. rufocanus and another three redbacked voles from Harbin as M. rutilus, respectively. Moreover, nine red-backed voles from Korea, showing the average nucleotide distance of 0.66% among nine haplotypes, were different from other species of Myodes, and the average distance between nine haplotypes of red-backed voles from Korea and seven haplotypes of M. rufocanus was 6.41%, whereas the average distance between nine haplotypes of red-backed voles from Korea and five haplotypes of M. rutilus was 14.8%. We identified the red-backed voles from Korea as M. regulus, and found that M. regulus is distinct in its mtDNA control region sequences as well, although we propose further analyses with additional specimens from East Asia using nuclear and mtDNA markers to confirm the distinctness of M. regulus.

Genetic Distinctness of the Korean Red-backed Vole (Myodes regulus) from Korea, Revealed by the Mitochondrial DNA Control Region

Hung Sun Koh,Beong Kug Yang,Bae Keun Lee,Kyung Hee Jang,Davaa Bazarsad,Nam Jeong Park 한국동물분류학회 2010 Animal Systematics, Evolution and Diversity Vol.26 No.3

To identify Korean red-backed voles (Myodes regulus) from Korea by mitochondrial DNA (mtDNA) sequencing, we obtained mtDNA control region sequences of 17 red-backed voles from Korea and northeast China, and these sequences were compared with the corresponding haplotypes of Myodes obtained from GenBank. We identified five red-backed voles from Mt. Changbai and Harbin as M. rufocanus and another three redbacked voles from Harbin as M. rutilus, respectively. Moreover, nine red-backed voles from Korea, showing the average nucleotide distance of 0.66% among nine haplotypes, were different from other species of Myodes, and the average distance between nine haplotypes of red-backed voles from Korea and seven haplotypes of M. rufocanus was 6.41%, whereas the average distance between nine haplotypes of red-backed voles from Korea and five haplotypes of M. rutilus was 14.8%. We identified the red-backed voles from Korea as M. regulus, and found that M. regulus is distinct in its mtDNA control region sequences as well, although we propose further analyses with additional specimens from East Asia using nuclear and mtDNA markers to confirm the distinctness of M. regulus.