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연구논문(硏究論文)(재록(再錄)) : 의약화학 ; 2,4,6-삼치환 피리딘: 합성, 토포이소미라제 1 및 2 저해활성, 세포독성과 구조활성관계
알준바스넷 ( Arjun Basnet ),프리텀다빠 ( Pritam Thapa ),라다깔끼 ( Radha Karki ),나영화 ( Young Hwa Na ),장영동 ( Yurng Dong Jahng ),정병선 ( Byeong Seon Jeong ),정태천 ( Tae Cheon Jeong ),이종순 ( Chong Soon Lee ),이응석 ( Eung Seo 영남대학교 약품개발연구소 2007 영남대학교 약품개발연구소 연구업적집 Vol.17 No.-
이상규,전태원,Arjun Basnet,정혜광,이응석,정태천 대한약학회 2006 Archives of Pharmacal Research Vol.29 No.11
1-Furan-2-yl-3-pyridin-2-yl-propenone (FPP-3) has been characterized to have an anti-inflammatory activity through the inhibition of the production of nitric oxide and tumor necrosis factor- α. In the present studies, the phase 1 metabolism of FPP-3 was investigated in rat liver microsomes and cytosols. When FPP-3 was incubated with rat liver microsomes and cytosols in the presence of NADPH, 2 major peaks were detected on a liquid chromatography/electrospray ionization-mass spectrometry. Two metabolites (i.e., M1 and M2) were characterized as reduced forms on propenone: M1 (1-furan-2-yl-3-pyridin-2-yl-propan-1-one) was the initial metabolite and M2 (1-furan-2-yl-3-pyridin-2-yl-propan-1-ol) was a secondary alcohol believed to be formed from M1.
Lee, Sang-Kyu,Jeon, Tae-Won,Basnet, Arjun,Jeong, Hye-Gwang,Lee, Eung-Seok,Jeong, Tae-Cheon The Pharmaceutical Society of Korea 2006 Archives of Pharmacal Research Vol.29 No.11
1-Furan-2-yl-3-pyridin-2-yl-propenone (FPP-3) has been characterized to have an anti-inflammatory activity through the inhibition of the production of nitric oxide and tumor necrosis $factor-{\alpha}$. In the present studies, the phase 1 metabolism of FPP-3 was investigated in rat liver microsomes and cytosols. When FPP-3 was incubated with rat liver microsomes and cytosols in the presence of NADPH. 2 major peaks were detected on a liquid chromatography/electrospray ionization-mass spectrometry. Two metabolites (i.e., M1 and M2) were characterized as reduced forms on propenone: M1 (1-furan-2-yl-3-pyridin-2-yl-propan-1-one) was the initial metabolite and M2 (1-furan-2-yl-3-pyridin-2-yl-propan-1-ol) was a secondary alcohol believed to be formed from M1.