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Chu, Sang Hui,Baek, Ji Won,Kim, Eun Sook,Stefani, Katherine M.,Lee, Won Joon,Park, Yeong-Ran,Youm, Yoosik,Kim, Hyeon Chang The Korean Society for Preventive Medicine 2015 Journal of Preventive Medicine and Public Health Vol.48 No.1
Objectives: Controlling blood pressure is a key step in reducing cardiovascular mortality in older adults. Gender differences in patients' attitudes after disease diagnosis and their management of the disease have been identified. However, it is unclear whether gender differences exist in hypertension management among older adults. We hypothesized that gender differences would exist among factors associated with hypertension diagnosis and control among community-dwelling, older adults. Methods: This cross-sectional study analyzed data from 653 Koreans aged ${\geq}60years$ who participated in the Korean Social Life, Health, and Aging Project. Multiple logistic regression was used to compare several variables between undiagnosed and diagnosed hypertension, and between uncontrolled and controlled hypertension. Results: Diabetes was more prevalent in men and women who had uncontrolled hypertension than those with controlled hypertension or undiagnosed hypertension. High body mass index was significantly associated with uncontrolled hypertension only in men. Multiple logistic regression analysis indicated that in women, awareness of one's blood pressure level (odds ratio [OR], 2.86; p=0.003) and the number of blood pressure checkups over the previous year (OR, 1.06; p=0.011) might influence the likelihood of being diagnosed with hypertension. More highly educated women were more likely to have controlled hypertension than non-educated women (OR, 5.23; p=0.013). Conclusions: This study suggests that gender differences exist among factors associated with hypertension diagnosis and control in the study population of community-dwelling, older adults. Education-based health promotion strategies for hypertension control might be more effective in elderly women than in elderly men. Gender-specific approaches may be required to effectively control hypertension among older adults.
( Sang Min Yoon ),( Baek-yeol Ryoo ),( So Jung Lee ),( Jong Hoon Kim ),( Ji Hoon Shin ),( Jihyun An ),( Han Chu Lee ),( Young-suk Lim ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Patients with hepatocellular carcinoma (HCC) showing macroscopic vascular invasion (MVI) bear an extremely poor prognosis. Sorafenib is the sole treatment option for advanced stage HCC with MVI with unsatisfactory response rate and survival benefit. Combined transarterial chemoembolization (TACE) plus external beam radiotherapy (RT) has shown promising results in these patients by observational studies. Here, we report the efficacy and safety of TACE plus RT compared to sorafenib in patients with advanced HCC and MVI. Methods: This study was a randomized, open-label trial at an academic tertiary care center. Between July 2013 and October 2016, 90 treatment-naive patients with liver-confined HCC showing MVI were randomly assigned to receive sorafenib (400 mg twice-daily; n = 45; sorafenib group) or TACE (every 6 weeks) plus RT (within 3 weeks after the first TACE; n = 45; TACE+RT group). Primary endpoint was 12-week the progression-free survival (PFS) rate by intention-to-treat analysis. Radiologic response was assessed by independent review according to Response Evaluation Criteria in Solid Tumors (version 1.1). Crossover of treatment was permitted after confirming disease progression. Results: Patients were 33 to 82 years of age, and 85.6% were male. All patients had portal vein invasion of HCC and Child- Pugh class A liver function. The median maximal tumor diameter was 9.7 cm. Most (78.9%) patients had multiple lesions. At week 12, the PFS rate was significantly higher in the TACE+RT group than the sorafenib group (86.7% vs. 34.3%; P<0.001). The TACE+RT group showed significantly higher radiologic response rate (33.3% vs. 2.2% at 24 weeks; P<0.001), significantly longer median time to disease progression (31 weeks vs. 11.7 weeks; P<0.001), and significantly longer overall survival (55 weeks vs. 43 weeks; P=0.04), compared with the sorafenib group. No patients in the TACE+RT group discontinued treatment due to hepatic decompensation. Conclusions: In patients with advanced HCC showing MVI, first-line treatment with TACE+RT was well-tolerated and provided improved progression-free survival, objective response rate, time to disease progression, and overall survival, compared with sorafenib.
쾌속조형재료의 강도예측모델 - Fused Deposition Modeling (FDM)
안성훈 ( Sung Hoon Ahn ),이선영 ( Sun Young Lee ),백창일 ( Chang Il Baek ),추원식 ( Won Shik Chu ) 한국복합재료학회 2002 Composites research Vol.15 No.6
쾌속조형(Rapid Prototyping)기술은 다양한 형태의 재료를 사용하여 초기모형을 제작할 수 있다. Stratasys사의 FDM은 플라스틱 재료로 조형물을 제작하는 대표적인 쾌속조형공정이다. 또한 FDM으로 제작된 부품들은 하중을 받는 구조용 재료로도 사용된다. FDM은 약 300㎛ 두께의 가는 필라멘트의 형태로 일정한 방향으로 재료를 적층하므로, FDM으로 제작된 부품들은 이방성 재료의 성질을 나타낸다. 본 연구에서는 FDM 부품의 인장강도를 예측하기 위한 해석방법을 제시하고자 한다. 복합재를 위한 Classical Lamination Theory를 사용하여 컴퓨터 코드를 작성하였다. FDM 제품의 파괴를 예측하기 위하여 계산코드에 Tsai-Wu failure criterion 이론을 도입하였다. 해석방법에 의해 예상되는 인장강도와 실제 실험으로 얻은 수치를 비교하였다. 예상치가 측정치에 근사한 값을 보이므로 본 계산식의 타당성이 입증되었다. 덧붙여서 FDM의 강도계산과 설계규칙이 웹기반의 제안서비스(FDMAS)에서 제공된다. Rapid Prototyping(RP) technologies provide the ability to fabricate initial prototypes from various model materials. Stratasys` Fused Deposition Modeling(FDM) is a typical 게 process that can fabricate prototypes out of plastic materials, and the parts made from FDM were often used as load-carrying elements. Because FDM deposits materials in about 300㎛ thin filament with designated orientation, parts made from FDM show anisotropic material properties. In this paper an analytic model was proposed to predict the tensile strength of FDM parts. Applying the Classical Lamination Theory, which was developed for laminated composite materials, a computer code was implemented. Tsai-Wu failure criterion was added to the code to predict the failure of the FDM parts. The tensile strengths predicted by the analytic model were compared with experimental data. The data and prediction agreed reasonably well to prove the validity of the model. In addition, a web-based advisory service(FDMAS) was developed to provide strength prediction and design rules for FDM parts.
Genetic overexpression of COMP-Ang1 impairs BM microenvironment and induces senescence of BM HSCs
Kook, Sung-Ho,Sim, Hyun-Jaung,Hwang, Jae-Won,Baek, Young-Hyun,Kim, Chun-Chu,Lee, Jeong-Hoon,Cho, Eui-Sic,Lee, Jeong-Chae Elsevier 2018 Biochemical and biophysical research communication Vol.499 No.3
<P><B>Abstract</B></P> <P>Supplemental Angiopoietin 1 (Ang1) exerts its therapeutic potential on microvascular regression-associated diseases, and this potential is linked with the function of hematopoietic stem cells (HSCs). However, the underlying mechanisms of the effect of enhanced angiogenesis on the modulation of HSCs are not yet defined. Here, we generated transgenic mice expressing <B>C</B>artilage <B>O</B>ligomeric <B>M</B>atrix <B>P</B>rotein (COMP)-Ang1 in keratin 14-expressing cells. The mutant animals expressed excessive angiogenic characteristics in the skin and bone marrow (BM) along with redder skin with more numerous and branched vessels compared with their wild-type (WT) littermates. The mutants displayed reduced long bone formation and osteoclast activity than did WT littermates and had fewer CD150<SUP>+</SUP>CD48<SUP>−</SUP> <B>L</B>ineage<SUP>−</SUP> <B>S</B>ca-1<SUP>+</SUP>c-<B>K</B>it<SUP>+</SUP> (LSK) cells in the BM. The mutants also exhibited greater senescence-associated (SA) β-gal activity, p16<SUP>INK4a</SUP> protein expression, and superoxide anion levels in CD150<SUP>+</SUP>CD48<SUP>−</SUP>LSK cells in the BM. Furthermore, transplantation assay revealed that the mutant-derived LSK cells were inferior to the cells derived from WT littermate in inducing competitive repopulating capacity in the recipients. Collectively, our results demonstrate that persistent and prolonged administration of COMP-Ang1 by inducible transgenic expression mediates excessive angiogenesis in the body and impairs BM microenvironment, eventually leading to senescence of BM HSCs.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Transgenic mice expressing COMP-Ang1 in keratin 14-expressing cells were generated. </LI> <LI> The mutant expressed excessive angiogenic characteristics in the skin and BM. </LI> <LI> The mutants displayed impaired BM microenvironment with low osteoclast activity. </LI> <LI> Collectively, genetic COMP-Ang1 overexpression induces senescence of BM HSCs. </LI> </UL> </P>
Hyung-Jin Baek,Tae-Hun Ryu,So youn Won,Jae-Kwang Kim,Soo In Sohn,Sang-Woo Kim,Sang-Mi Chu,Myoung Rae Cho,Jae-Kyung Song,Yong-Moon Jin 한국작물학회 2008 한국작물학회 학술발표대회 논문집 Vol.2008 No.10
A gene flow has been tested from transgenic herbicide-resistant Chinese cabbage to major crops in Cruciferae. Hybridizations were made between transgenic Basta-resistant Chinese cabbage and non-transgenic Chinese cabbage, B. napus, B. juncea and Brassicoraphanus(B. campestris × Raphanus sativus, 2n=4x=38) with honey-bee mediated fertilization. Progeny populations were selected by Basta herbicide. The F1 hybrids with pat gene were again self-pollinated or cross-pollinated with nontransgenic Chinese cabbage and rape naturally or artificially. Pod setting ratio were compared as a tentative parameter for potential gene flow. Key agronomic characters were compared among the F1 hybrid populations obtained. In the days to flowering after cold treatment, the F1 hybrids of Brassicoraphanus x B. campestris and B. napus x B. campestris(GM) were the shortest (75 days), and the GM Chinese cabbage and the F1 hybrid of B. juncea x B. campestris(GM) were 87 and 93 days, respectively. In the stem length, the F1 hybrid of Brassicoraphanus x B. campestris was the longest(175 cm), and followed by the F1 hybrid of B. napus x B. campestris(GM), the F1 hybrid of B. juncea x B. campestris(GM) in order. The naturally occurring pod setting ratios were fluctuated seriously among individual and segregation lines. Natural pod setting of the transgenic Chinese cabbage was 10 to 19 %. The F1 hybrid of B. napus x B. campestris(GM) showed the ratio of 4-11%. However, the F1 hybrids of B. juncea x B. campestris and Brassicoraphanus x B. campestris(GM) did not produced seeds. The F1 hybrids with pat gene were hybridized with nontransgenic Chinese cabbage and rape by artificial bud pollination to test potential gene flow. All cross combinations except Brassicoraphanus produced seeds and the pod setting ratios ranged from 35 to 100 percentages. Thus, the potentials of the gene flow from Chinese cabbage with pat gene to the order specise in the same gene interspecies or intergeneric species and from the F1 hybrids with pat gene to nontransgenic Chinese cabbage and rape were detected. Herbicide resistant test to the acquired seeds by natural and artificial pollinations including honey-bee mediated fertilization using the same materials is going on.