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RISS 인기검색어
- 검색키워드
- 저자 : B. Winkler (검색결과 4 건)
- 무료
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- 유료
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Nonlinear analysis of connectors applied on concrete composite constructions
B. Winkler,P. Bianchi,M. Siemers 한국계산역학회 2006 Computers and Concrete, An International Journal Vol.3 No.2
To place concrete overlays has become a standard application in the strengthening and rehabilitation of concrete structures such as bridges, tunnels, parking decks and industrial buildings. In general, connectors are used to ensure a monolithic behavior of the two concrete layers. Within the framework of the development of a new connector wedge splitting tests and shear tests were performed, in addition nonlinear finite element analyses were applied to investigate the load transfer behavior of the connectors for different prototypes. The numerical simulation results were compared to experimental data. The computed load-displacement curve demonstrates good correspondence with the curves obtained in the experiments, and the experimental crack patterns are reasonably simulated by the computed crack propagation. Both numerical and experimental investigations on the wedge splitting test and on the shear test served as basis for the development of new type of connectors.
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Towards Green 3D-Microfabrication of Bio-MEMS Devices Using ADEX Dry Film Photoresists
Michael Markus Roos,Andreas Winkler,Madeleine Nilsen,Siegfried B. Menzel,Steff en Strehle 한국정밀공학회 2022 International Journal of Precision Engineering and Vol.9 No.1
Current trends in miniaturized diagnostics indicate an increasing demand for large quantities of mobile devices for health monitoring and point-of-care diagnostics. This comes along with a need for rapid but preferably also green microfabrication. Dry film photoresists (DFPs) promise low-cost and greener microfabrication and can partly or fully replace conventional silicon- technologies being associated with high-energy demands and the intense use of toxic and climate-active chemicals. Due to their mechanical stability and superior film thickness homogeneity, DFPs outperform conventional spin-on photoresists, such as SU-8, especially when three-dimensional architectures are required for micro-analytical devices (e.g. microfluidics). In this study, we utilize the commercial epoxy-based DFP ADEX to demonstrate various application scenarios ranging from the direct modification of microcantilever beams via the assembly of microfluidic channels to lamination-free patterning of DFPs, which employs the DFP directly as a substrate material. Finally, kinked, bottom-up grown silicon nanowires were integrated in this manner as prospective ion-sensitive field-effect transistors in a bio-probe architecture directly on ADEX substrates. Hence, we have developed the required set of microfabrication protocols for such an assembly comprising metal thin film deposition, direct burn-in of lithography alignment markers, and polymer patterning on top of the DFP.
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Integrated Navigation and Sense & Avoid Systems for Micro Aerial Vehicles
P,Vö,rsmann,S,Winkler,J,-B,Park 한국항해항만학회 2006 한국항해항만학회 학술대회논문집 Vol.1 No.-
The paper deals with integrated navigation and sense & avoid systems for small unmanned aerial vehicles (UAV). First an introduction to the current UAV activities of the institute is given. It is followed by an overview about the integrated navigation system developed for small UAVs. The system is based on a tightly-coupled GPS/INS architec-ture. But instead of using delta-ranges, time-differenced carrier phases are used to aid the INS. Finally, results from navigation filter validation in flight tests are presented. After that an overview about sense and avoid strategies for application in small unmanned aircraft is given. From this a guideline for developing such a system for the institute’s UAVs is presented.
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Review of COVID-19 Therapeutics by Mechanism: From Discovery to Approval
Choi Hee Sun,Choi A Young,Kopp Jeffrey B.,Winkler Cheryl A.,Cho Sung Kweon 대한의학회 2024 Journal of Korean medical science Vol.39 No.14
The global research and pharmaceutical community rapidly mobilized to develop treatments for coronavirus disease 2019 (COVID-19). Existing treatments have been repurposed and new drugs have emerged. Here we summarize mechanisms and clinical trials of COVID-19 therapeutics approved or in development. Two reviewers, working independently, reviewed published data for approved COVID-19 vaccines and drugs, as well as developmental pipelines, using databases from the following organizations: United States Food and Drug Administration (US-FDA), European Medicines Agency (EMA), Japanese Pharmaceutical and Medical Devices Agency (PMDA), and ClinicalTrials.gov. In all, 387 drugs were found for initial review. After removing unrelated trials and drugs, 66 drugs were selected, including 17 approved drugs and 49 drugs under development. These drugs were classified into six categories: 1) drugs targeting the viral life cycle 2) Anti-severe acute respiratory syndrome coronavirus 2 Monoclonal Antibodies, 3) immunomodulators, 4) anti-coagulants, 5) COVID-19-induced neuropathy drugs, and 6) other therapeutics. Among the 49 drugs under development are the following: 6 drugs targeting the viral life cycle, 12 immunosuppression drugs, 2 immunostimulants, 2 HIF-PHD targeting drugs, 3 GM-CSF targeting drugs, 5 anti-coagulants, 2 COVID-19-induced neuropathy drugs, and 17 others. This review provides insight into mechanisms of action, properties, and indications for COVID-19 medications.
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