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Kyoung Jin Park,Yong Min Kim,Eui Sung Choi,Anandharaj Arunkumar,Hye Ryun Kim,Seung Ryul Kim,Sung Jin Lee,Hak Kyo Lee,Joong Kook Choi 한국유전학회 2008 Genes & Genomics Vol.30 No.4
Glucocorticoids including Dexamethasone (DEX) are often used to control imflammatory responses but whose long term use at high dose can impair the bone growth. However, its underlying mechanisms associated with the osteopathogenesis remains poorly characterized. In differentiation media containing ITS1 and/or BMP4, ATDC5 chondroprogenitor cells go through early chondrogenic differentiation process to exhibit cellular condensation and nodule formation. In this study employing Alcian blue staining, mouse Illumina microarray and RT-PCR techniques, we attempted (1) to investigate whether DEX can influence on early chondrogenic step, and (2) to characterize differential expression of genes that may contribute to the side effect. Our data show that DEX could interfere with early condensation process and induce the expression of genes belonging to integrin and notch signaling pathways. Based on recent reports demonstrating the cooperation of both signaling pathways in cell adhesion, we propose that DEX may modulate the differentiation of chondroprogenitor cells by influencing Notch and integrin signaling activities.
Chavan Priyanka Yashwant,Vijay Rajendran,Srinivasan Krishnamoorthy,Baskaran Nagarathinam,Ashish Rawson,Arunkumar Anandharaj,Vignesh Sivanandham 한국식품과학회 2023 Food Science and Biotechnology Vol.32 No.6
The present study evaluated antibiotic resistance (ABR) in bacteria isolated from different food wastes viz., meat slaughterhouses, dairy and restaurants. About 120 strains isolated from the food waste were subjected to ABR screening. More than 50% of all the strains were resistant to Vancomycin, Neomycin and Methicilin, which belong to third-generation antibiotics. Two lactic acid bacteria (LAB) free of ABR were chosen to be used as starter cultures in media formulated from food waste. Food waste combination (FWC-4) was found to be on par with the nutrient broth in biomass production. The non-ABR LAB strains showed excellent probiotic properties, and in the fed-batch fermentation process, adding a nitrogen source (soya protein) enhanced the microbial biomass (3.7 g/l). Additionally, exopolysaccharide production was found to be 2.3 g/l. This study highlights the ABR incidence in food waste medium and its economic advantage for starter culture biomass production.