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Arun Asif,박성혁,Afaque Manzoor Soomro,Muhammad Asad Ullah Khalid,Abdul Rahim Chattikatikatuveli Salih,강보혜,Faheem Ahmed,김경환,최경현 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.98 No.-
In microfluidics, the emergingfield of microphysiological systems (MPS) is overcoming the challenge ofphysiological irrelevancy by animal models for drug discovery and development. Liver function iscritically influenced by drugs owing to its role in drug metabolism and detoxification. Human serumalbumin (HSA) is one of the most important secreted biomarkers which indicate normal liver function. Amicrofluidic albumin immunosensor was developed to be integrated with liver-on-a-chip MPS forcontinuous feedback over disease modeling and treatment. A gold-electrode based electrochemicalimmunosensor was established by anti-HSA antibody immobilization. The liver MPS was found to beefficient for live monitoring of disease modelling and drug treatment over the period of 6 days. Thesystem emulated and analyzed real-time toxicity modeling with HSA sensing. The detection limit ofintegrated sensor was 1 mg/ml with successive reproducibility. The proposed sensor was also validatedwith metabolic biomarkers’ assays. Molecular assays supported the sensor monitoring and depicted liverinjury and recovery. The liver MPS with combined albumin sensor chip may be a promising platform tomimic real-time drug assessment.
Irfana Moideen Kolangare,Arun Mohan Isloor,Asif Ali Qaiser,Ahmed Fauzi Ismail,Mohd Sohaimi Abdullah 한국화학공학회 2018 Korean Journal of Chemical Engineering Vol.35 No.6
This work deals with a simple and eco-friendly approach for the development of ultrafiltration membranes for the separation of environmentally hazardous substances from the water source. Polysulfone and sulfonated polyphenylsulfone blend ultrafiltration membranes were fabricated by the non-solvent induced phase inversion technique. Prepared membranes were characterized for their morphology, hydrophilicity, porosity, filtration and antifouling properties. The blend membranes with 15 wt% of sPPSU demonstrated the best performance with water flux of 190.33 Lm2h1 and flux recovery ratio of 86.56%. The effect of aq. glycine betaine (GB) coagulation bath on the membrane property and performance was studied and compared with commonly used additives such as NaCl and NMP. The GB in coagulation bath exhibited better flux and performance with protein rejection of 66.3%, 74.0% and 91.2% for trypsin, pepsin, and bovine serum albumin, respectively, and heavy metal rejection of 75.2% and 87.6% for polymer enhanced ultrafiltration of Cd2+ and Pb2+ ions, respectively.
Sushanth Rao Aroor,Kaiz S. Asif,Jennifer Potter-Vig,Arun Sharma,Bijoy K. Menon,Violiza Inoa,Cynthia B. Zevallos,Jose G. Romano,Santiago Ortega-Gutierrez,Larry B. Goldstein,Dileep R. Yavagal 대한뇌졸중학회 2022 Journal of stroke Vol.24 No.1
Mechanical thrombectomy (MT) is the most effective treatment for selected patients with an acute ischemic stroke due to emergent large vessel occlusions (LVOs). There is an urgent need to identify and address challenges in access to MT to maximize the numbers of patients who can benefit from this treatment. Barriers in access to MT include delays in evaluation and accurate diagnosis of LVO leading to inappropriate triage, logistical delays related to availability of facilities and trained interventionalists, and financial hurdles that affect treatment reimbursement. Collection of regional data related to these barriers is critical to better understand current access gaps and a measurable access score to thrombectomy could be useful to plan local public health intervention.