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      • SCOPUSKCI등재
      • KCI등재

        The influence of convoy loading on the optimized topology of railway bridges

        Arne Jansseune,Wouter De Corte 국제구조공학회 2017 Structural Engineering and Mechanics, An Int'l Jou Vol.64 No.1

        This paper presents the application of topology optimization as a design tool for a steel railway bridge. The choice of a steel railway bridge is dictated by the particular situation that it is suitable for topology optimization design. On the one hand, the current manufacturing techniques for steel structures (additive manufacturing techniques not included) are highly appropriate for material optimization and weight reduction to improve the overall structural efficiency, improve production efficiency, and reduce costs. On the other hand, the design of a railway bridge, especially at higher speeds, is dominated by minimizing the deformations, this being the basic principle of compliance optimization. However, a classical strategy of topology optimization considers typically only one or a very limited number of load cases, while the design of a steel railway bridge is characterized by relatively concentrated convoy loads, which may be present or absent at any location of the structure. The paper demonstrates the applicability of considering multiple load configurations during topology optimization and proves that a different and better optimal layout is obtained than the one from the classical strategy.

      • KCI등재

        A Term-based Language for Resource-Constrained Project Scheduling and its Complexity Analysis

        Arne Kutzner,Pok-Son Kim 한국지능시스템학회 2012 INTERNATIONAL JOURNAL of FUZZY LOGIC and INTELLIGE Vol.12 No.1

        We define a language RS, a subclass of the scheduling language RSV (resource constrained project scheduling with variant processes). RS involves the determination of the starting times for ground activities of a project satisfying precedence and resource constraints, in order to minimize the total project duration. In RS ground activities and two structural symbols (operators) ‘seq’ and ‘pll’ are used to construct activity-terms representing scheduling problems. We consider three different variants for formalizing the RS-scheduling problem, the optimizing variant, the number variant and the decision variant. Using the decision variant we show that the problem RS is NP-complete. Further we show that the optimizing variant (or number variant) of theRS-problem is computable in polynomial time iff the decision variant is computable in polynomial time.

      • KCI등재후보

        Stroke Genetics: A Review and Update

        Arne Lindgren 대한뇌졸중학회 2014 Journal of stroke Vol.16 No.3

        Stroke genetics includes several topics of clinical interest, including (1) molecular genetic variations affecting risk of monogenic stroke syndromes; (2) molecular genetic variations affecting risk of common stroke syndromes, sometimes with specific effects on risk of specific main types of stroke or subtypes of ischemic and hemorrhagic stroke; (3) genetics of conditions associated with stroke risk e.g. white matter hyperintensities, atrial fibrillation and hypertension; (4) hereditary causes of familial aggregation of stroke; (5) epigenetic impact on protein expression during acute brain injury; (6) genetic influence on stroke recovery; and (7) pharmacogenetics. Genetic research methods include candidate gene studies; Genome Wide Association Studies; family studies; RNA and protein analyses; and advanced computer-aided analytical methods to detect statistically significant associations. Several methods that could improve our knowledge of stroke genetics are being developed e.g.: Exome content analysis; Next-generation sequencing; Whole genome sequencing; and Epigenetics. During 2012-2014, several Single Nucleotide Polymorphisms (SNPs) have been related to common ischemic stroke risk. Certain SNPs have been associated with risk of specific ischemic stroke subtypes such as large vessel disease and cardiac embolism, particular subtypes of intracerebral hemorrhage (ICH), especially lobar ICH, and with prognosis after ICH. Large international studies on stroke recovery and exome content are ongoing. Advanced mathematical models have been used to study how several SNPs can act together and increase stroke risk burden. Such efforts require large numbers of patients and controls, which is achieved by co-operation in large international consortia such as the International Stroke Genetics Consortium. This overview includes an introduction to genetics, stroke genetics in general, and different genetic variations that may influence stroke risk. It presents some of the latest reports on stroke genetics published in high impact journals. The role of pharmacogenetics, the current clinical situation, and future prospects will also be discussed.

      • KCI등재

        Elastic Failure of Locally Supported Silos with U-shaped Longitudinal Stiffeners

        Arne Jansseune,Wouter De Corte,Jan Belis 대한토목학회 2015 KSCE JOURNAL OF CIVIL ENGINEERING Vol.19 No.4

        For practical considerations, thin-walled steel silos are often supported by a limited number of discrete equidistant supports around their circumference. In such cases, large loads are transferred to the limited number of supports, causing locally high axial compressive stress concentrations. A possible solution is to add a partial-height U-shaped longitudinal stiffener above each support. Such stiffeners create a more gradual transmission of vertical loads to the supports, increasing the maximum failure load. This paper aims to map the influence of the dimensions of such longitudinal stiffeners on the failure behaviour of a thin-walled silo. Both the parameters of the cross-section and the height of the stiffeners are discussed. All the results and the findings are based on geometrically and material nonlinear analyses - GMNA - performed with finite element software. The simulations indicate that, in general, thin-walled silos will fail by pure elastic buckling in the unstiffened silo wall above the terminations of the longitudinal stiffeners. However, this is only true if the cross-section of the stiffeners, and to a lesser degree the moment of inertia, is sufficiently large in order that the longitudinal stiffeners can absorb the supporting loads. In contrast, for longitudinal stiffeners with a small cross-section, the silo structure will fail by premature elasto-plastic collapse of the stiffeners itself at significantly lower load levels. Furthermore, the height of the stiffeners and the degree of support - the circumferential width of the supports and the stiffeners is equal to each other - are the most important geometrical parameters which are beneficial to reach a maximum load level for a specific silo. Finally, the buckling behaviour and the failure load are hardly influenced by radial width and the thickness of the longitudinal stiffeners.

      • KCI등재

        Chromosomal instability is more frequent in metastasized than in non-metastasized pulmonary carcinoids but is not a reliable predictor of metastatic potential

        Arne Warth,Esther Herpel,Sabine Krysa,Hans Hoffmann,Philipp A. Schnabel,Peter Schirmacher,Gunhild Mechtersheimer,Hendrik Bläker 생화학분자생물학회 2009 Experimental and molecular medicine Vol.41 No.5

        Pulmonary carcinoids are infrequent neoplasms of the lung that normally display a less aggressive biological behavior compared to small cell and non-small cell lung cancers. Approximately 15-25% of carcinoids, in particular atypical carcinoids, show lymph node metastasis and have a worse prognosis than their non-metastasized counterparts. To date, there is no morphological or molecular marker that may help to differentiate between carcinoids that metastasize and carcinoids of identical differentiation that show only local tumor growth. In this study, we analyzed 7 metastasized and 10 non-metastasized pulmonary carcinoids for chromosomal and microsatellite instability in order to determine whether microsatellite instability or chromosomal imbalances are associated with metastasis. Due to the rare occurrence of metastasized carcinoids we compared our results of chromosomal instability with the hitherto published comparative genomic hybridization (CGH) profiles of pulmonary carcinoids, for which information about the absence or presence of metastasis was available. While microsatellite instability was not detected we found chromosomal instability as a common event in pulmonary carcinoids with an increase of frequency and extent of chromosomal alterations in atypical and metastasized carcinoids. These findings are in accordance with the collected and herein compiled data of previous studies and indicate increasing numbers of chromosomal imbalances to play a role in the sequential process of tumor development and metastasis. Pulmonary carcinoids are infrequent neoplasms of the lung that normally display a less aggressive biological behavior compared to small cell and non-small cell lung cancers. Approximately 15-25% of carcinoids, in particular atypical carcinoids, show lymph node metastasis and have a worse prognosis than their non-metastasized counterparts. To date, there is no morphological or molecular marker that may help to differentiate between carcinoids that metastasize and carcinoids of identical differentiation that show only local tumor growth. In this study, we analyzed 7 metastasized and 10 non-metastasized pulmonary carcinoids for chromosomal and microsatellite instability in order to determine whether microsatellite instability or chromosomal imbalances are associated with metastasis. Due to the rare occurrence of metastasized carcinoids we compared our results of chromosomal instability with the hitherto published comparative genomic hybridization (CGH) profiles of pulmonary carcinoids, for which information about the absence or presence of metastasis was available. While microsatellite instability was not detected we found chromosomal instability as a common event in pulmonary carcinoids with an increase of frequency and extent of chromosomal alterations in atypical and metastasized carcinoids. These findings are in accordance with the collected and herein compiled data of previous studies and indicate increasing numbers of chromosomal imbalances to play a role in the sequential process of tumor development and metastasis.

      • A Small Scale Registry Concept for Microcontroller Configuration

        Arne Kutzner(아네 쿠츠너),Pok-Son Kim(김복선) 한국지능시스템학회 2012 한국지능시스템학회 학술발표 논문집 Vol.22 No.2

        We propose a registry concept that is optimized with respect to the special architectural and computational aspects of microcontroller centered systems. Our registry concept is self-contained, allows the realization of hierarchically organized configuration environments and is minimal regarding the consumption of volatile memory. The proposed model allows the distribution of different parts of the registry over different kinds of memory as e.g. EEPROM and Flash. Using an imperative programming language the central registry access algorithm can be transparently implemented as a singular function construct. For import and export purposes our model supports the XML representation of registries. We report about a practical implementation in the context of a microcontroller based system for model railway control.

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