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Anna Cho,Danbi Yoon,Jiyoung Park,Jeong Seok Cha,Jiho Yoo 한국구조생물학회 2023 Biodesign Vol.11 No.4
Over 300 polypeptide substrates can undergo catalysis by the constitutively active Ser/Thr kinase, human casein kinase 2 alpha (hCK2α). Quercetin, a naturally occurring polyphenolic compound, is well-known for inhibiting hCK2α, thereby regulating cellular signaling pathways. In this study, we crystallized the hCK2α-quercetin complex to elucidate the inhibitory mechanism of quercetin on hCK2α through the complex structure. The hanging drop vapor diffusion method was employed for crystallizing the hCK2α-quercetin complex, and the resulting crystal diffracted to a resolution of 2.11 Å. X-ray diffraction data analysis revealed that the crystal of the hCK2α-quercetin complex belonged to the P43212 space group, with unit cell dimensions of a = b = 127.604 Å, c = 124.314 Å, and α = β = γ = 90.00°. In an initial density map, quercetin was bound well into hCK2α.
Cho, Anna,Kim, Su Jin,Lim, Byung Chan,Hwang, Hee,Park, June Dong,Kim, Gi Beom,Jin, Dong-Kyu,Lee, Jeehun,Ki, Chang Seok,Kim, Ki Joong,Hwang, Yong Seung,Chae, Jong-Hee SAGE Publications 2012 Journal of child neurology Vol.27 No.3
<P>Pompe disease is an autosomal recessive disorder caused by lysosomal acid α-glucosidase deficiency. Infantile-onset Pompe disease presents with cardiomyopathy and hypotonia, leading to premature death. This article describes 7 infantile Pompe disease cases and provides their molecular bases and clinical outcomes after enzyme replacement therapy for the first time in Korea. Molecular genetic analyses revealed the presence of 9 different mutations, including 5 novel mutations (c.2171C>A, c.2774C>T, c.1582_3de12, c.1261_1263Tms, and c.1322_1326+9de114). The most common mutation in these 7 patients was c.1316T>A (28%). Four patients received intravenous recombinant human acid α-glucosidase therapy for 2 years, on average, without significant side effects during the treatment course. They all exhibited increased muscle power, with considerable improvement in cardiac function. Pompe disease is heterogeneous regarding both clinical features and molecular characteristics. Early identification of Pompe disease is very important, considering that enzyme replacement therapy is a safe and effective treatment for early-onset patients.</P>
Cho, Young-Chang,Lee, In-Seon,Seo, Huiyun,Ju, Anna,Youn, Deokkyu,Kim, Younghyun,Choun, Jaehee,Cho, Sayeon SPANDIDOS PUBLICATIONS 2014 MOLECULAR MEDICINE REPORTS Vol.10 No.5
<P>Numerous Euphorbiaceae plants have been used for the treatment of diseases, including liver diseases, asthma and rheumatism. The present study evaluated the effect of methanol extracts from Euphorbia cooperi (MEC), a member of the Euphorbiaceae plant family, on the production of inflammatory cytokines interleukin (IL)?6 and tumor necrosis factor (TNF)?α, nitric oxide (NO) as well as the activation of mitogen?activated protein kinase and nuclear factor (NF)?κB signaling. Non?cytotoxic concentrations of MEC significantly reduced the production of NO and IL?6, but not TNF?α, in lipopolysaccharide (LPS)?stimulated RAW 264.7 macrophages. The decreased production of NO by MEC was due to alleviated expression of inducible NO synthase. Reporter assays with cells treated with MEC demonstrated reduced activator protein?1 (AP-1) activity, while NF?κB activity was not reduced. Furthermore, the phosphorylation levels of c?Jun N?terminal kinase (JNK) and p38 were suppressed by MEC while phosphorylation levels of inhibitor of κB were not reduced by MEC, suggesting that MEC?mediated inactivation of JNK and p38 is the underlying regulatory mechanism for inflammatory mediators in LPS?stimulated RAW 264.7 macrophages.</P>
Anna Cho,Soo Yeon Kim,Jin Sook Lee,Byung Chan Lim,Hunmin Kim,Hee Hwang,Jong-Hee Chae 대한의학유전학회 2020 대한의학유전학회지 Vol.17 No.2
Purpose: Congenital myasthenic syndrome (CMS) is a clinically and genetically heterogeneous group of disorders characterized by impaired neuromuscular transmission. This study aims to provide the clue for early diagnosis and improved therapeutic strategies in CMS. Materials and Methods: Through the targeted panel sequencing including twenty CMS causative genes, eleven patients were genetically confirmed and enrolled in this study. A retrospective medical record review was carried out for the clinical and laboratory data analysis. Results: The age of patients ranged from 5 to 23 years, with the median age of 16 years. The peak age at onset of symptoms was the neonatal period. Seven out of the eleven patients were symptomatic at birth. The most commonly reported initial finding was generalized hypotonia with poor sucking and crying. Mean time to accurate diagnosis was 9.3±5.0 years. Total fifteen different variants in seven genes associated with CMS (DOK7, AGRN, RAPSN, CHRNE, COLQ, SLC5A7, and GFPT1) were identified. Conclusion: We describe the clinical and genetic characteristics of CMS patients and treatment outcome in a single tertiary center. High clinical suspicion and timely molecular diagnosis is particularly important for the tailored therapy to maximize clinical improvement in CMS.
청소년의 팬덤활동과 학교생활적응 관계에서 기본심리욕구와 공동체의식의 이중 매개효과연구
조안나 ( Anna Cho ),이은경 ( Eunkyoung Lea ) 사단법인 아시아문화학술원 2020 인문사회 21 Vol.11 No.6
본 연구는 청소년의 팬덤문화를 이해하고, 팬덤문화가 청소년의 삶에서 어떤 영향을 미치는지 알아보고자 하였다. 이를 위해 팬덤활동과 기본심리욕구, 공동체의식, 학교생활적응을 변인으로 선정하였다. 팬덤활동의 영향을 살펴보기 위해 첫째, 팬덤활동이 학교생활적응과의 관계에서 기본심리욕구가 매개효과를 보이는지 살펴보았다. 둘째, 팬덤활동이 학교생활적응과의 관계에서 공동체의식이 매개효과를 갖는지 살펴보았다. 셋째, 팬덤활동과 학교생활적응의 관계에서 기본심리욕구와 공동체의식은 이중매개 효과를 갖는지 살펴보았다. 연구분석은 총 592명의 자료를 토대로 팬덤활동, 기본심리욕구, 공동체의식, 학교생활적응 간의 상관관계를 확인한 뒤, 구조방정식으로 연구모형을 검증하였다. 그리고 bootstrapping을 통해 매개효과를 검증하였다. 그 결과 팬덤활동과 학교생활적응의 관계에서 기본심리욕구, 공동체의식이 이중매개 효과를 가진다는 것을 확인하였다. 본 연구는 청소년이 주도하는 팬덤문화에 대한 긍정적 영향을 밝혀 균형 잡힌 시각의 필요성을 제안하고, 추후 연구에서 고려되어야 할 사항 등을 제시하였다. The purpose of this study is to understand the fandom culture which is known as youth culture and review what effect it has on the life of adolescents. In order to examine the effect of fandom activities, it was examined whether the basic psychological needs had a mediation effect on the relationship between the fandom activities and the school adjustment. Second, it was examined whether the sense of community had a mediation effect on the relationship between the fandom activities and the school adjustment. Lastly, it was examined whether the basic psychological needs and the sense of community showed double mediation effects on the relationship between the fandom activities and the school adjustment. For the research analysis, the correlation between the fandom activities, basic psychological needs, sense of community, and school adjustment was examined based on the data from 592 students. The research model was verified using a structural equation and the mediation effect was verified through bootstrapping. The result of this study it was confirmed that the basic psychological needs and the sense of community had double mediation effects on the relationship between the fandom activities and the school adjustment. This study has significant implications as follows: positive effect of fandom culture led by adolescents was determined and it was shown as necessary to have a balanced viewpoint on the adolescents’ fandom culture. In addition, various matters that need to be considered in a future study were presented.
언어행위이론의 관점에서 본 하나님 나라의 윤리적 수행을 위한 기독교 생활에서의 도덕적 행위자로서의 성령
조안나 ( Cho Anna ) 한국조직신학회 2018 한국조직신학논총 Vol.51 No.-
이 논문은 언어행위이론을 통하여 성서적 윤리의 해석학적 접근을 소개함으로써 말씀이신 성령 하나님이 어떻게 신자들 안에서 도덕적인 행위자로서 역사하는지, 성령의 사역을 통해 어떻게 그리스도인이 하나님의 말씀에 반응하는지를 보여준다. 이 접근법은 언어행위이론의 관점에서 하나님 나라가 하나님의 자발적 참여 행위와 관련이 있다는 이해에서 출발하여 기독교윤리에서 그리스도인의 삶의 성령의 역사가 하나님의 수행 행위에 대한 신학적 이해와 신자들에게 미치는 영향을 어떻게 설명할 수 있는지에 대해 논의한다. 언어행위이론의 초점은 하나님 나라와 하나님의 백성에 대한 하나님의 통치와 관련하여 “협력적 사회참여”(CSP)의 원칙과 일상생활에서의 윤리적인(신앙적인) 반응으로서의 그리스도인들을 책임을 고려한다. This article presents how the Holy Spirit, the Word of God works in the believers as a moral agent not simply as a helper, and believer’s response to the Word of God through the work of the Holy Spirit in our lives as Christian moral conduct. This approach emerges from an understanding of God’s selfinvolving activity as the presence of the kingdom of God in the present world in the light of speech act theory (abbreviated as SAT). This paper discusses how the work of the Holy Spirit in Christian ethics can enhance theological understanding of God’s performative action and its effects on the believers. The focus in SAT considers the principle of “Co-Operative Social Participation”(CSP) in relation to God’s sovereignty for God’s kingdom and God’s people, and the responsibility of Christians as ethical response in ordinary life.