http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Engineered Probiotics for the Management of Congenital Metabolic Diseases: A Systematic Review
Meisam Barati,Erfan Mosharkesh,Amir Hossein Tahmassian,Maryam Khodaei,Masoumeh Jabbari,Ali Kalhori,Mohsen Alipour,Afshin Abdi Ghavidel,Sajad Khalili-Moghadam,Anwar Fathollahi,Sayed Hossein Davoodi 한국식품영양과학회 2024 Preventive Nutrition and Food Science Vol.29 No.1
Engineered probiotics (EPs) can be used to treat/manage chronic and congenital diseases. However, to the best of our knowledge, no systematic review has evaluated the effects of EPs on congenital metabolic disorders in murine models and human subjects. Thus, the present study systematically reviewed interventional studies that assessed the effects of EPs on congenital metabolic disorders. PubMed, Web of Science, and Scopus databases were searched up to February 2023 to retrieve related publications. Seventy-six articles were obtained in the primary step. After screening the titles/abstracts based on the inclusion and exclusion criteria, 11 papers were included. Finally, only seven articles were included after performing full-text evaluation. The included articles evaluated the effects of EPs on managing phenylketonuria (PKU, n=4) and hyperammonemia (n=3). Moreover, these studies examined mice and/or rats (n=6), monkeys (n=1), and humans (n=2). Studies on EPs and hyperammonemia revealed that some wild strains such as Lactobacillus plantarum have an innate ammonia-hyper-consuming potential; thus, there was no need to manipulate them. However, manipulation is needed to obtain a phenylalanine- metabolizing strain. In conclusion, EPs can be used to manage or treat congenital metabolic diseases including PKU.