Impact of Interferon-Based Treatment on Quality of Life and Work Related Productivity from the Korean Cohort in the MOSAIC Study

( Sang Hoon Ahn ),( Won Hyeok Choe ),( Yoon Jun Kim ),( Jeong Heo ),( Dorota Latarska-smuga ),( Jiho Kang ),( Seung Woon Paik ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Chronic Hepatitis C Virus (HCV) infection increases the risk for progressive liver disease, hepatocellular carcinoma and negatively impacts the patient’s quality of life. HCV treatment is evolving with direct acting antivirals but IFN based therapy has been the standard of care for many years and remains available in some countries. The MOSAIC study aims to characterize patients with chronic HCV infection and assess the impact of IFN-containing treatment on health-related quality of life, work related productivity and health care utilization. Methods: MOSAIC is an international prospective multicenter observational study that has been conducted in 20 countries. Consecutive patients with chronic HCV infection were enrolled and those who initiated an IFN based regimen were prospectively followed for 48 weeks. We report results from the Korean cohort Results: 100 patients were enrolled: 86 were treatment naïve and 14 were treatment experienced. 33 patients initiated an IFN based regimen: 6 patients started IFN + RBV, 26 patients started Peg-IFN + RBV, none started Peg-IFN + RBV + DAA and 1 patient received other treatment. Among the treated cohort, demographic and disease characteristics were the following: the mean age was 54.5 years; 14 patients were male. 14 had minimal or no fibrosis, 2 portal fibrosis, 3 bridging fibrosis and 6 patients suffered from cirrhosis. HCV Genotype distribution was as follows: genotype 1: 11; genotype 2: 19 and genotype 3: 3. Table 1 describes the results at baseline and changes over 4, 12 and 48 weeks and end-of-treatment (EOT) for the quality of life and work productivity outcome measures (EQ-5D-5L, HCV-PRO and WPAI). Conclusions: Results from the Korean cohort of the MOSAIC study show a moderate trend for deterioration of health-related quality of life and work productivity associated with IFN based treatment for patients with chronic HCV infection during treatment period. Acknowledgements: The design, study conduct, analysis, and financial support of MOSAIC study were provided by AbbVie. AbbVie participated in the interpretation of data, review, and approval of the content of the abstract. All authors had access to all relevant data and participated in writing, review, and approval of this abstract. Medical writing support was provided by Olivier Van de Steen of Medeor-consulting, funded by AbbVie. Disclosures: Sang Hoon Ahn: served as an advisor and lecturer for Bristol-Myers Squibb, Gilead Sciences, F.Hoffmann-La Roche, Merck, AbbVie, and has received unrestricted grants from Bristol-Myers Squibb, Gilead Sciences, and F. Hoffmann-La Roche for investigator- initiated trials Won Hyeok Choe: Nothing to disclosure Yoon Jun Kim: Nothing to disclosure Jeong Heo: received a grant from GSK; Research support from BMS, and Roche; Advisor for Abbvie, BMS, Gilead Sciences, Pharma Essentia, SillaJen, and Johnson & Johnson. Dorota Latarska-Smuga, Jiho Kang: are employees of AbbVie, Inc. and may hold stock or stock options. Seung Woon Paik: received grant and research support from AbbVie, BMS, Gilead, GSK, Merck, Novartis, and Roche

A Literature Analysis on Medicinal Use and Research of Cannabis in the Meiji Era of Japan

Ahn, Byung-Soo,Kang, Seokhyun,Lee, Kyung Hoon,Kim, Seoyoon,Park, Jin Sung,Seo, Hyung-Sik KOREAN PHARMACOPUNCTURE INSTITUTE 2020 Journal of pharmacopuncture Vol.23 No.3

Cannabis is a historical plant which has been used as a medicine in East Asia. These days, there are active debates about using cannabis in clinical field. Collecting and comparing cannabis research articles which had been published in the Opening of Japan to spot the interactions between the traditional medicine of Japan, Rangaku which was established in Edo Period and the European medicine which is transferred after Perry Expedition is academically meaningful. This study searched publications, which were listed on Open-Access databases by Dec. 11^th, 2019. We collected research articles which had been published from January 3^rd, 1867 to July 30^th, 1912 also known as Meiji era and uploaded on OpenAccess databases. Our searching databases were J-stage, CiNii (Scholarly and Academic Information Navigator), Tokyo Metropolitan Library, The National Diet Library, IRDB (Institutional Repositories DataBase) and KAKEN (Grant-in-Aid for Scientific Research Database). Searching keywords were cannabis, hemp and all their Japanese synonyms and available combinations. We selected final 15 studies which met every selection criteria in the 346,393 collected studies. Cannabis was prescribed in Meiji era of Japan to alleviate pain and cure the digestive, respiratory, urinary, and nervous system diseases such as indigestion, asthma, tuberculosis, gonorrhea and its complications, insomnia, and nervous prostration. Cannabis was medically used in Meiji era of Japan and the reporting and sharing of its clinical effect was published on the medical journals like present days. There were already Cannabis regulations in that era, but its medicinal use was more liberated than nowadays. It may be a chance to reconsider the current legal system, which strictly controls the use of Cannabis.

Enhanced Equivalent Circuit Modeling for Li-ion Battery Using Recursive Parameter Correction

Sung-Tae Ko,Jung-Hoon Ahn,Byoung Kuk Lee 대한전기학회 2018 Journal of Electrical Engineering & Technology Vol.13 No.3

This paper presents an improved method to determine the internal parameters for improving accuracy of a lithium ion battery equivalent circuit model. Conventional methods for the parameter estimation directly using the curve fitting results generate the phenomenon to be incorrect due to the influence of the internal capacitive impedance. To solve this phenomenon, simple correction procedure with transient state analysis is proposed and added to the parameter estimation method. Furthermore, conventional dynamic equation for correction is enhanced with advanced RC impedance dynamic equation so that the proposed modeling results describe the battery dynamic characteristics more exactly. The improved accuracy of the battery model by the proposed modeling method is verified by single cell experiments compared to the other type of models.

Role of Nitric Oxide in Pepsinogen Secretion from Rat Gastric Chief Cells

SUNG, Dae Suk,SEO, Dong Wan,CHOI, Don Woong,AHN, Seong Hoon,HONG, Sung Youl,LEE, Hoi Young,HAN, Jeung Whan,LEE, Hyang Woo 성균관대학교 약학연구소 1999 成均藥硏論文集 Vol.11 No.-

Abstract-Nitric oxide (NO), a cellular messenger synthesized from L-arginine by NO synthase (NOS, EC.1.14.13.39), is considered to be a regulator of gastric secretion. In the present study, the role of NO in the regulation of exocrine secretion was investigated in rat gastric chief cells. Treatment of chief cells with carbachol resulted in an increase in the arginine conversion to citrulline, the amount of NO_X, the release of pepsinogen, and the level of cGMP. Especially, carbachol-stimulated increase of arginine to citrulline transformation, the amount of NO_X, cGMP level and the release of pepsinogen were partially reduced by the natural NOS inhibitor, N^G-monomethyl-L-arginine (MMA) and N^G,N^G-dimethyl-L-arginine (DMA). Furthermore, MMA-and DMA-induced decrease of pepsinogen secretion showed dose-dependent pattern. Activation of NOS is one of the early events in receptor-mediated cascade of reactions in gastric chief cells and NO, not completely, but partially mediates gastric secretion. Agonist-stimulated pepsinogen secretion in chief cells has been considered to be mediated in adenosine 3',5'-cyclic monophosphate pathway and/or guanosine 3',5'-cyclic monophosphate (cGMP) pathway. Taken together, the above results suggest that partial decrease of exocrine secretion following treatment of NOS inhibitor may result from the inactivation of NOS and subsequent guanylate cyclase, and NO/cGMP pathway may play a pivotal role in exocrine secretion.

Identification of Interleukin-1, Tumor Necrosis Factor-α, and Interleukin-6 Expression in Lungs from Pigs Naturally Infected with <i>Mycoplasma hyopneumoniae</i> by <i>In situ</i> Hybridization

AHN, Kyoung Kyu,KWON, Donghyeok,JUNG, Kwonil,HA, Yooncheol,SEO, Man Jun,KIM, Sung-Hoon,KIM, Mi-Young,CHO, Kyung-Dong,LEE, Bog-Hieu,CHAE, Chanhee Japanese Society of Veterinary Science 2009 The Journal of veterinary medical science Vol.71 No.4

<P>The detection and distribution of interleukin-1 (IL-1), tumor necrosis factor-α (TNF-α) and IL-6 were studied, by <I>in situ </I>hybridization with a non-radioactive digoxigenin-labeled probe, in formalin-fixed, paraffin-embedded lung tissue from 10 pigs naturally infected with <I>Mycoplasma hyopneumoniae</I>. The morphology of host cells was preserved despite the relatively high temperature required during the incubation procedure. Examination of three serial sections from each of the 10 lung samples showed that the three cytokines closely resembled each other in respect of cellular distribution. Three inflammatory cytokines are expressed in response to <I>M. hyopneumoniae </I>infection, with IL-6 localized primarily to peribronchiolar lymphoid hyperplastic tissues, and both IL-1 and TNF-α expressed in alveolar macrophages. Although statistically non-significant, IL-1 (<I>r</I>=0.5744, <I>p</I>=0.0883) showed potentially important correlation with histopatholgical lesions. No other potentially clinically important correlations (<I>r</I>>0.30) were observed between any of the other cytokines (TNF-α; <I>r</I>=0.2045, <I>p</I>=0.5603 and IL-6; <I>r</I>=-0.06607, <I>p</I>=0.8651) and histopathological lesion score. The results suggest that inflammatory cytokines are associated with the development of pneumonia in<I> M. hyopneumoniae</I> infection and may contribute to disease severity.</P>

Stemness Evaluation of Mesenchymal Stem Cells from Placentas According to Developmental Stage: Comparison to Those from Adult Bone Marrow

Sung, Hwa Jung,Hong, Soon Cheol,Yoo, Ji Hyun,Oh, Jee Hyun,Shin, Hye Jin,Choi, In Young,Ahn, Ki Hoon,Kim, Sun Haeng,Park, Yong,Kim, Byung Soo The Korean Academy of Medical Sciences 2010 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.25 No.10

<P>This study was done to evaluate the stemness of human mesenchymal stem cells (hMSCs) derived from placenta according to the development stage and to compare the results to those from adult bone marrow (BM). Based on the source of hMSCs, three groups were defined: group I included term placentas, group II included first-trimester placentas, and group III included adult BM samples. The stemness was evaluated by the proliferation capacity, immunophenotypic expression, mesoderm differentiation, expression of pluripotency markers including telomerase activity. The cumulative population doubling, indicating the proliferation capacity, was significantly higher in group II (<I>P</I><0.001, 31.7±5.8 vs. 15.7±6.2 with group I, 9.2±4.9 with group III). The pattern of immunophenotypic expression and mesoderm differentiation into adipocytes and osteocytes were similar in all three groups. The expression of pluripotency markers including ALP, SSEA-4, TRA-1-60, TRA-1-81, Oct-4, and telomerase were strongly positive in group II, but very faint positive in the other groups. In conclusions, hMSCs from placentas have different characteristics according to their developmental stage and express mesenchymal stemness potentials similar to those from adult human BMs.</P>

Effects of Patterned Sapphire Substrates on Piezoelectric Field in Blue-Emitting InGaN Multiple Quantum Wells

Sang-Mook Kim,Hwa Sub Oh,Jong Hyeob Baek,Kwang-Ho Lee,Gun Young Jung,Jae-Ho Song,Ho-Jong Kim,Byung-Jun Ahn,Dong Yanqun,Jung-Hoon Song IEEE 2010 IEEE electron device letters Vol.31 No.8

<P>The strain and piezoelectric fields in InGaN blue light-emitting diodes on a GaN layer, which is grown on a planar sapphire substrate or patterned sapphire substrates (PSSs), such as a microsized PSS and a nanosized PSS (NPSS), are investigated by micro-Raman spectroscopy and electroreflectance (ER) spectroscopy. The obtained piezoelectric field in InGaN multiple quantum wells (QWs) grown on the planar substrate is 0.83 MV/cm, and it is 0.70 MV/cm for the case of the NPSS. These results are attributed to the fact that the GaN layers on the PSSs have a smaller residual strain compared to that on the planar sapphire, and thus, strain reduction in the GaN layer can reduce the piezoelectric field in the InGaN QWs grown on top of it.</P>

Increased Extracellular Survivin in the Synovial Fluid of Rheumatoid Arthritis Patients: Fibroblast-like Synoviocytes as a Potential Source of Extracellular Survivin

Ahn, Joong Kyong,Oh, Ji-Min,Lee, Jaejoon,Bae, Eun-Kyung,Ahn, Kwang-Sung,Cha, Hoon-Suk,Koh, Eun-Mi Springer-Verlag 2010 INFLAMMATION Vol.33 No.6

Preparation and characterization of anhydrous polymer electrolyte membranes based on poly(vinyl alcohol-co-ethylene) copolymer

Ahn, Sung Hoon,Lee, Do Kyoung,Seo, Jin Ah,Kim, Jong Hak,Lee, Ki Bong Springer-Verlag 2010 IONICS -KIEL- Vol.16 No.5

In vitro and in vivo pharmacokinetic characterization of LMT-28 as a novel small molecular interleukin-6 inhibitor

Ahn, Sung-Hoon,Heo, Tae-Hwe,Jun, Hyun-Sik,Choi, Yongseok Asian Australasian Association of Animal Productio 2020 Animal Bioscience Vol.33 No.4

Objective: Interleukin-6 (IL-6) is a T cell-derived B cell stimulating factor which plays an important role in inflammatory diseases. In this study, the pharmacokinetic properties of LMT-28 including physicochemical property, in vitro liver microsomal stability and an in vivo pharmacokinetic study using BALB/c mice were characterized. Methods: LMT-28 has been synthesized and is being developed as a novel therapeutic IL-6 inhibitor. The physicochemical properties and in vitro pharmacokinetic profiles such as liver microsomal stability and Madin-Darby canine kidney (MDCK) cell permeability assay were examined. For in vivo pharmacokinetic studies, pharmacokinetic parameters using BALB/c mice were calculated. Results: The logarithm of the partition coefficient value (LogP; 3.65) and the apparent permeability coefficient values (P_app; 9.7×10^-6 cm/s) showed that LMT-28 possesses a moderate-high cell permeability property across MDCK cell monolayers. The plasma protein binding rate of LMT-28 was 92.4% and mostly bound to serum albumin. The metabolic half-life (t_1/2) values of LMT-28 were 15.3 min for rat and 21.9 min for human at the concentration 1 μM. The area under the plasma drug concentration-time curve and C_max after oral administration (5 mg/kg) of LMT-28 were 302±209 h·ng/mL and 137±100 ng/mL, respectively. Conclusion: These data suggest that LMT-28 may have good physicochemical and pharmacokinetic properties and may be a novel oral drug candidate as the first synthetic IL-6 inhibitor to ameliorate mammalian inflammation.