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Mohammed Faruk,Sani Ibrahim,Ahmed Adamu,Abdulmumini Hassan Rafindadi,Yahaya Ukwenya,Yawale Iliyasu,Abdullahi Adamu,Surajo Mohammed Aminu,Mohammed Sani Shehu,Danladi Amodu Ameh,Abdullahi Mohammed,Saad 대한장연구학회 2018 Intestinal Research Vol.16 No.1
Background/Aims: Colorectal cancer (CRC) is now a major public health problem with heavy morbidity and mortality in rural Africans despite the lingering dietary fiber-rich foodstuffs consumption. Studies have shown that increased intake of dietary fiber which contribute to low fecal pH and also influences the activity of intestinal microbiota, is associated with a lowered risk for CRC. However, whether or not the apparent high dietary fiber consumption by Africans do not longer protects against CRC risk is unknown. This study evaluated dietary fiber intake, fecal fiber components and pH levels in CRC patients. Methods: Thirty-five subjects (CRC=21, control=14), mean age 45 years were recruited for the study. A truncated food frequency questionnaire and modified Goering and Van Soest procedures were used. Results: We found that all subjects consumed variety of dietary fiber-rich foodstuffs. There is slight preponderance in consumption of dietary fiber by the control group than the CRC patients. We also found a significant difference in the mean fecal neutral detergent fiber, acid detergent fiber, hemicellulose, cellulose and lignin contents from the CRC patients compared to the controls (P <0.05). The CRC patients had significantly more fecal pH level than the matched apparently healthy controls (P =0.017). Conclusions: The identified differences in the fecal fiber components and stool pH levels between the 2 groups may relate to CRC incidence and mortality in rural Africans. There is crucial need for more hypothesis-driven research with adequate funding on the cumulative preventive role of dietary fiber-rich foodstuffs against colorectal cancer in rural Africans “today.” (Intest Res 2018;16:99-108)
Lamidi Ibrahim Yusuf,Mikail Hudu Garba,Adamu Sani,Akefe Isaac Oluwatobi,Tijjani Mohammed Bashir,Salihu Sabo Isa,Olatunji Aisha Omobolanle,Hassan Abdussalam,Daniel Nubwa,Adegoke Victoria Aderonke 한국독성학회 2021 Toxicological Research Vol.37 No.4
This study aims at investigating the protective effects of flavonoid fractions of diosmin and hesperidin in mitigating subchronic lead acetate-induced biochemical, oxidative stress, and histopathological alterations in adult male Wistar rats. Forty animals were randomly assigned into five groups, each consisting of eight animals. Group I animals was treated with deionised water only, group II, IV, and V were administered lead acetate 90 mg/Kg body weight (1/20th of the LD50), groups III, and IV was administered Daflon (100 mg/Kg), while group V was administered Daflon (200 mg/Kg), 30 min prior treatment with lead acetate. All treatments lasted for 42 days. Blood lead levels, electrolyte parameters, zinc protoporphyrin (ZPP) levels, activities of antioxidant enzymes, and histopathology of vital organs, were evaluated following standard practice. Sub-chronic lead acetate exposure induced a decrease in levels of serum electrolytes, and activities of antioxidant enzymes, while blood lead levels, ZPP, and malondialdehyde levels were increased. Lead exposure also instigated marked variation in histopathology of vital organs. Conversely, co-treatment with graded doses of daflon improved the levels of blood lead, electrolytes, ZPP, activities of antioxidant enzymes, and histopathology of vital organs. Data obtained from the current study indicate that rats exposed to sub-chronic doses of lead acetate show increased blood lead levels, electrolyte imbalance, alongside impairment in ZPP levels, activities of antioxidant enzymes, and histopathology, while pretreatment using daflon mitigated the ensued perturbations. This, therefore, suggests that consumption of foods enriched with flavonoid fractions of diosmin and hesperidin may be beneficial for individuals inhabiting lead-polluted environments.
Tajudeen Olanrewaju Yahaya,Abdulgafar Bala Ibrahim,Abdulrahman Sani Kalgo,Mutiyat Kehinde Adewale,Chikelu Chinelo Emmanuela,Baliqees Abdulkadir,Adamu Zainab Fari,Asiya Koko Attahiru,Abdullahi Saadatu 환경독성보건학회 2024 환경독성보건학회지 Vol.39 No.2
The global occurrence of microplastics and their poorly understood health implications underscore the need for scientific investigation. This study aimed to assess the effects of microplastics exposure. Twenty-five (25) albino rats (Rattus norvegicus) were divided into five (5) groups, each consisting of five rats. Group 1 (the negative control) received normal feed; group 2 (the positive control) was administered a 10 % lead acetate solution; and groups 3, 4, and 5 were administered 1 %, 5 %, and 10 % microplastic solutions, respectively. The rats were monitored for 28 days, after which blood samples were taken for hematological and lipid profiles as well as liver and kidney function parameters. The results revealed dose-dependent significant (p < 0.05) alterations in the health indices of the treated rats and the positive control compared with the negative control. Specifically, the hematological parameters, including the white blood cells (WBC) and its subtypes, were reduced, indicating immunosuppressive effects, and the red blood cells (RBC), hemoglobin (HGB), hematocrit (HCT), platelets, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) were reduced, indicating anemia. The 1 % and 5 % microplastic solutions raised the lipid profiles of the treated rats, including total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL), while the 10 % concentration decreased them, causing hyperlipidemia and hypolipidemia, respectively. The liver function parameters, including total protein (TP), albumin (ALB), aspartate transaminase (AST), alanine transaminase (ALT), and alkaline phosphatase (ALP), were elevated, indicating liver damage. Elevation of kidney function parameters, including sodium ion (Na+), potassium ion (K+), chloride ion (Cl-), urea, and creatinine (CRT), were noticed, suggesting kidney injuries. It can be inferred from these results that microplastics are toxic. Hence, human exposure to microplastics should be reduced to a minimum.