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Comparative proteomics and global genome-wide expression data implicate role of ARMC8 in lung cancer
Amin, Asif,Bukhari, Shoiab,Mokhdomi, Taseem A,Anjum, Naveed,Wafai, Asrar H,Wani, Zubair,Manzoor, Saima,Koul, Aabid M,Amin, Basit,Qurat-ul-Ain, Qurat-ul-Ain,Qazi, Hilal,Tyub, Sumira,Lone, Ghulam Nabi,Q Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.9
Background: Cancer loci comprise heterogeneous cell populations with diverse cellular secretions. Therefore, disseminating cancer-specific or cancer-associated protein antigens from tissue lysates could only be marginally correct, if otherwise not validated against precise standards. Materials and Methods: In this study, 2DE proteomic profiles were examined from lysates of 13 lung-adenocarcinoma tissue samples and matched against the A549 cell line proteome. A549 matched-cancer-specific hits were analyzed and characterized by MALDI-TOF/MS. Results: Comparative analysis identified a total of 13 protein spots with differential expression. These proteins were found to be involved in critical cellular functions regulating pyrimidine metabolism, pentose phosphate pathway and integrin signaling. Gene ontology based analysis classified majority of protein hits responsible for metabolic processes. Among these, only a single non-predictive protein spot was found to be a cancer cell specific hit, identified as Armadillo repeat-containing protein 8 (ARMC8). Pathway reconstruction studies showed that ARMC8 lies at the centre of cancer metabolic pathways. Conclusions: The findings in this report are suggestive of a regulatory role of ARMC8 in control of proliferation and differentiation in lung adenocarcinomas.
Khan, Nauman Rauf,Khan, Amna Nauman,Bashir, Saira,Khan, Ayyaz Ali,Suleman, Bilquis A.,Chaudhry, Saima Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.3
P63 is a gene product required in cell cycle regulation which plays vital roles in tumor differentiation. Aims of the present study were to assess the frequency, pattern, sensitivity and specificity of two p63 protein clones P63 4A4 and P63 4A4+Y4A3 in squamous cell carcinomas (SCCs). Thirty cases of head and neck region SCC diagnosed on the basis of H&E staining were examined along with 60 cases of head and neck region biopsies other than squamous cell carcinoma, negative on H&E staining, were taken as control. Immunostaining was performed on slides according to the Thermo Scientific UltraVision LP detection System. P63 4A4+Y4A3 clone is more sensitive 96.6% in comparison to 86% in P63 4A4 with having greater NPV of 98.3%. The results signify the importance of P63 4A4+Y4A3 marker over the old markers and may be used as a confirmatory marker of squamous cell carcinoma.
Hyun A Jang,May Moe Oo,Dae-Gyu Kim,Ha-Yeon Yoon,Mi-Reu Kim,Kyo-Sang Lee,Khaing Shwe Zin Thinn,Saima Arif,Jia Guo Geng,Ji-Young Min,Dong Jun Lim,허윤영,오상근 한국원예학회 2020 Horticulture, Environment, and Biotechnology Vol.61 No.5
Grape ripe rot is a fungal disease, which is almost inextinguishable particularly before and after harvest in most vineyards. The management of this disease largely depends on the breeding of resistant varieties. Thus, the search for resistant varietiesshould parallel the molecular analysis of the markers associated with disease resistance. Here, we tested the leaf inoculationassay of Colletotrichum acutatum and C. gloeosporioides by inoculating them into 350 grapevine varieties. As a resultof the phenotypes common to both species, 119 varieties (34%) were classifi ed as resistant. Consequently, we discoveredthe locus with nucleotide-binding sites and carboxyterminal leucine-rich repeat regions ( NBS-LRR ) associated with graperipe rot resistance through genotyping-by-sequencing and genome-wide association study. Ultimately, we identifi ed theVitis vinifera Colletotrichum resistance protein ( VvCRP ) markers from chromosome 3, which belongs to the CC-NBS-LRRtype, as disease-resistant proteins. These markers were verifi ed as the melting peak, and their chromatograms of nucleotidesequences were visualized in each single nucleotide polymorphism (SNP) loci. All the SNP markers diff erentiated successfullythe resistant from the susceptible cultivars. Interestingly, we also found that a resistant cultivar named Bailey AlicanteA has a heterozygous genotype, substantiating its potential usefulness for crops such as grapevine with many hybrids. Altogether,our results indicate that VvCRP markers can be utilized to distinguish grape ripe rot-resistant cultivars, particularlyin crossbreeding populations.
Hussein Nazar K,Qaraad Mohammed,Amjad Souad,Farag M.A.,Hassan Saima,Mirjalili Seyedali,Elhosseini Mostafa A 한국CDE학회 2023 Journal of computational design and engineering Vol.10 No.4
The paper addresses the limitations of the Moth-Flame Optimization (MFO) algorithm, a meta-heuristic used to solve optimization problems. The MFO algorithm, which employs moths' transverse orientation navigation technique, has been used to generate solutions for such problems. However, the performance of MFO is dependent on the flame production and spiral search components, and the search mechanism could still be improved concerning the diversity of flames and the moths' ability to find solutions. The authors propose a revised version called GMSMFO, which uses a Novel Gaussian mutation mechanism and shrink MFO to enhance population diversity and balance exploration and exploitation capabilities. The study evaluates the performance of GMSMFO using the CEC 2017 benchmark and 20 datasets, including a high-dimensional intrusion detection system dataset. The proposed algorithm is compared to other advanced metaheuristics, and its performance is evaluated using statistical tests such as Friedman and Wilcoxon rank-sum. The study shows that GMSMFO is highly competitive and frequently superior to other algorithms. It can identify the ideal feature subset, improving classification accuracy and reducing the number of features used. The main contribution of this research paper includes the improvement of the exploration/exploitation balance and the expansion of the local search. The ranging controller and Gaussian mutation enhance navigation and diversity. The research paper compares GMSMFO with traditional and advanced metaheuristic algorithms on 29 benchmarks and its application to binary feature selection on 20 benchmarks, including intrusion detection systems. The statistical tests (Wilcoxon rank-sum and Friedman) evaluate the performance of GMSMFO compared to other algorithms. The algorithm source code is available at https://github.com/MohammedQaraad/GMSMFO-algorithm.
Siyal Sajid Hussain,Javed Muhammad Sufyan,Ahmad Awais,Sajjad Muhammad,Batool Saima,Khan Abdul Jabbar,Akram Shakeel,Alothman Asma A.,Alshgari Razan A.,Najam Tayyaba 한국물리학회 2021 Current Applied Physics Vol.31 No.-
The development of smart structured cathode materials for supercapacitors (SCs) has sparked tremendous interest. However, the appropriate design to achieve high capacitance and energy density-based cathode materials remains a major problem for energy storage systems. This article describes the effective synthesis of selfsupported 3D micro-flowers composed of ultrathin nanowires array of Co3O4 on Ni foam (NF) using hydrothermal conditions (Co3O4@NF). The mesoporous Co3O4@NF with a high surface area, providing a rich active state for the Faraday redox reaction and increasing the diffusion rate of the electrolyte ions. The optimized Co3O4@NF-16h electrode exhibited supreme electrochemical performance by delivering a high specific capacitance of 1878, (1127) and 1200 (720 C g 1) F g 1 at 1.0 and 20 A g 1, respectively. The Co3O4@NF electrode retained good capacitance stability of 91% over 10000 cycles at 20 A g 1 with excellent rate-performance of 67% at 20 folded high current values. The obtained results for the Co3O4@NF electrode are presented the enhanced pseudocapacitive performance, indicating the substantial potential for high-performance supercapacitor applications.
Saima Nazish,Rizwana Shahid,Azra Zafar,Foziah Alshamrani,Abdullah Al Sulaiman,Majed Alabdali,Danah Aljaafari,Esraa Al Wabar,Fahd A Alkhamis 대한신경과학회 2018 Journal of Clinical Neurology Vol.14 No.3
Background and Purpose The objective of this study was to determine the frequencies of different clinical presentations and the phenotypic spectrum of multiple sclerosis (MS). Methods This cross-sectional study was performed in the Neurology Department of King Fahd Hospital of University Alkhobar in the Kingdom of Saudi Arabia (KSA). Data of 190 MS patients who fulfilled the McDonald criteria were retrieved from medical records and analyzed. Results The age at disease onset was 26.27±8.2 years (mean±SD) and disease duration was 6.38±5.10 years. The male-to-female ratio was 1:1.6. Optic neuritis and myelitis were the most-frequent first clinical presentations. Sensory (73.1%), motor (61%), and visual (58.4%) symptoms were the most-frequent established clinical symptoms. Relapsing-remitting multiple sclerosis (RRMS) was present in 75% of the cases. Supratentorial T2-weighted white-matter lesions and deep-gray-matter or juxtacortical lesions were the most-frequent magnetic resonance imaging (MRI) lesions, comprising 28% and 23.7% of all MRI lesions observed in 93.6% and 79.4% of the cases, respectively. The scores on the Expanded Disability Status Scale were within the range of 1.0–5.5 in 82.1% of the patients. There were 145 (76.3%) patients taking interferon β therapy. Conclusions MS presenting in the hospital setting is more common in KSA than reported previously, and the number of diagnosed cases in increasing. It is therefore an emerging and disabling neurological illness in KSA with clinical characteristics not dissimilar to those in other middle eastern countries. A decrease in the frequency of patients with secondary progressive multiple sclerosis (SPMS) indicates either that more new cases of RRMS are being diagnosed or that adequate treatments of RRMS are preventing the evolution to SPMS. Further larger and populationwide epidemiological and clinical studies with the long-term follow-up of MS patients are required to better assess the clinical spectrum of MS in KSA.
Ambreen A. Khan,Saima Muhammad,R. Ellahi,Q. M. Zaigham Zia 한국자기학회 2016 Journal of Magnetics Vol.21 No.2
In this paper, the peristaltic flow of Psedoplastic fluid with variable viscosity in an asymmetric channel is examined. The bionic effects by means of magnetohydrodynamics (MHD) are taken into account. The assumptions of long wave length and low Reynolds number are taken into account. The basic equations governing the flow are first reduced to a set of ordinary differential equation by using appropriate transformation for variables and then solve by using perturbation method. The effect of physical parameters on the pressure rise, velocity and pressure gradient are illustrated graphically. The trapping phenomenon is analyzed through stream lines. A suitable comparison has also been made as a limiting case of the considered problem.
Muzamal Hussain,Saima Akram,Mohamed A. Khadimallah,Madeeha Tahir,Shabir Ahmad,Mohammed Alsaigh,Abdelouahed Tounsi 국제구조공학회 2023 Steel and Composite Structures, An International J Vol.48 No.6
This work considered an optimal control formulation in the sense of Caputo derivatives. The optimality of the fractional optimal control problem. The tumor immune interaction in fractional form provides an excellent tool for the description of memory and hereditary properties of inter and intra cells. So the interaction between effector-cells, tumor cells and are modeled by using the definition of Caputo fractional order derivative that provides the system with long-time memory and gives extra degree of freedom. In addiltion, existence and local stability of fixed points are investigated for discrete model. Moreover, in order to achieve more efficient computational results of fractional-order system, a discretization process is performed to obtain its discrete counterpart. Our technique likewise allows the advancement of results, such as return time to baseline that are unrealistic with current model solvers.