Anticancer Activity of Acacia nilotica (L.) Wild. Ex. Delile Subsp. indica Against Dalton's Ascitic Lymphoma Induced Solid and Ascitic Tumor Model

Sakthive, K.M.,Kannan, N.,Angeline, A.,Guruvayoorappan, C. Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.8

The aim of the present investigation was to evaluate the effect of A.nilotica extract against Dalton's ascitic lymphoma (DAL) induced solid and ascitic tumors in BALB/c mice. Experimental animals received A.nilotica extract (10 mg/kg.bw) intraperitoneally for 10 and 14 consecutive days before induction of solid and ascitic tumors, respectively. Treatment with A.nilotica extract significantly decreased the development of tumor and percentage increase in body weight when compared to DAL induced solid tumor control group, also increasing the life span, restoring the total white blood cell count and hemoglobin content and significantly decreasing the levels of serum aspartate transaminase (SGPT), alanine transaminase (SGOT), alkaline phosphatase (ALP), gamma glutamyl transferase (GGT) and nitric oxide (NO) when compared to DAL induced ascitic tumor controls. The treatment also reduced significantly the cellular glutathione (GSH) and nitric oxide levels in treated animals. Histopathological studies also confirmed protective influence. The outcome of the present work indicates that A.nilotica extract could be used as natural anticancer agent for human health.

Leaking Thoracic Aorta Aneurysm Causing Pleural Effusion: A Potential Disaster

( Khai Lip Ng ),( Hema Yamini Devi A ),( P Yamarmuty ),( Kunji Kannan A/l Sivaraman Kannan ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-

Introduction Thoracentesis is the first step in diagnosing a unilateral pleural effusion. Although malignancy remains the most common cause of a hemoserous effusion, we must be aware of other causes such as uremia, pulmonary infarction, post cardiac injury syndrome etc. We report a rare case of leaking thoracic aortic aneurysm masquerading as a unilateral hemoserous pleural effusion. Case Report A 79-year-old female with underlying hypertension, dyslipidemia and chronic kidney disease presented with a 2-weeks history of cough and dyspnea. She also reported a weight loss of 5 kilograms in 1 month. A Chest X-Ray (CXR) on presentation revealed a large left pleural effusion. She has exudative effusion based on Light's criteria. pleural fluid culture and cytology was negative. As her main differential diagnosis was malignancy, she was subjected to pleuroscopy to obtain a tissue diagnosis. During pleuroscopy, 1 liter of hemoserous fluid was drained. Apart from thickened parietal pleura, a large cystic mass was seen adhered to the parietal pleura posteriorly. Biopsies were taken from the parietal pleura and decision was made not to biopsy or aspirate the cystic mass during pleuroscopy. Computed tomography of the thorax done few weeks later showed a large thoracic aorta aneurysm with multiple penetrating atherosclerotic ulcers and mural thrombus. There was no pleural or lung mass detected. Patient was counseled for surgical repair but opted for conservative management. Discussion and conclusion Leaking thoracic aneurysm is an uncommon but potentially dangerous cause of hemoserous pleural effusion. A blind thoracentesis or biopsy of the cystic mass during pleuroscopy would have led to rupture of the aneurysm. Depending on the clinical context, it is safer to obtain a CT thorax prior to pleuroscopy when dealing with undiagnosed pleural effusion.

Manganese-titanium-oxide-hydroxide-supported palladium nanostructures - A facile electrocatalysts for the methanol, ethylene glycol and xylitol electrooxidation

Kannan, R.,Kim, A.R.,Nahm, K.S.,Yoo, D.J. Pergamon Press ; Elsevier Science Ltd 2016 International journal of hydrogen energy Vol.41 No.16

<P>The formation of organic poisoning intermediate species during fuel (alcohol) oxidation over a noble-metal catalyst electrode retards the electrooxidation reaction. To address this problem, we report the synthesis of a manganese-titanium-oxide-hydroxide-supported palladium nanocatalyst (Pd@MTOH), whereby a hydrothermal reaction is followed by an in situ reduction process. The physical characterizations confirm the formation of Pd NPs and a mixed-valance MTOH. The voltammetric-study results for the Pd@MTOH show a high level of electrochemical activity toward alcohol (methanol, ethylene glycol, and xylitol), and oxidation toward the Pd@MnOOH and Pd@C electrodes. At the Pd@MTOH electrode, the poisonous intermediate species that were formed during alcohol electrooxidation were successfully removed at a higher forward potential; the excellent catalytic activity, better intermediate tolerance, and sound long-term stability of the Pd@MTOH electrode can be credited to the uniform dispersion of the Pd NPs and the support (MTOH). This work outlines a facile method for the fabrication of a catalyst with a high electrochemical performance and great potential in alcohol fuel-cell applications. Copyright (C) 2016, Hydrogen Energy Publications, LLC. Published by Elsevier Ltd. All rights reserved.</P>

One-pot synthesis and electrocatalytic performance of Pd/MnOx/graphene nanocomposite for electrooxidation of ethylene glycol

Kannan, R.,Kim, A.R.,Nahm, K.S.,Yoo, D.J. Pergamon Press ; Elsevier Science Ltd 2015 International journal of hydrogen energy Vol.40 No.35

In this study, low-loading palladium nanoparticles (Pd NPs) were prepared on a graphene oxide-manganese oxide (GR/MO) support using a one-pot, eco-friendly ''green'' process. The GR/MO-Pd nanocomposite was characterized by powder X-ray diffraction, Raman, scanning microscopy and transmission electron microscopy. The elemental composition was determined using energy dispersive X-ray spectroscopy, and the electronic state of the materials was characterized by X-ray photoelectron spectroscopy. The GR/MO-Pd nanocomposite exhibited high electrocatalytic activity towards ethylene glycol oxidation in alkaline medium. The GR/MO-Pd electrode demonstrated a forward anodic peak current density of 3.8 mA/cm<SUP>2</SUP>, which was higher than both MO-Pd and GR-Pd electrodes. This excellent catalytic activity, low onset potential, better intermediate tolerance and good long-term stability of the GR/MO-Pd electrode could be attributed to the uniform dispersion of Pd NPs over the GR/MO support. This work outlines a new method for simple, fast and eco-friendly fabrication of a catalyst with high electrochemical performance and potential in alcohol fuel cell applications.

3D graphene-mixed metal oxide-supported carbon?palladium quantum dot nanoarchitectures - A facile bifunctional electrocatalyst for direct ethylene glycol fuel cells and oxygen evolution reactions

Kannan, R.,Kim, A.R.,Kim, J.S.,Yoo, D.J. Pergamon Press ; Elsevier Science Ltd 2016 International journal of hydrogen energy Vol.41 No.40

<P>Nanoarchitectured carbon-palladium quantum dot (C-Pd)-supported manganese-titanium oxide/3D graphene (MTOx-3DG) catalyst is developed using a two-step process, for ethylene glycol fuel cells and oxygen evolution reactions. About 10 nm-sized carbon shell and a 5 nm-sized Pd catalyst over an MTOx-3DG support is established by the facile green chemical approach. The C-Pd-MTOx-3DG nanoarchitectured catalyst possesses excellent electrocatalytic activity with the peak current density of 23.8 mA/cm(2) for ethylene glycol electrooxidation. In addition, MTOx-3DG support material helps to remove the poisonous intermediates formed during the ethylene glycol electrooxidation. We addressed this point by suitable method in which about 80% of the poisonous compounds are removed, with the help of a supporting material at higher forward potential regions. In addition to that the formation of Pd adatoms and synergism of mixed metal atoms helped to effectively oxidize the fuel. The physical and chemical analyses show that the prepared C-Pd-MTOx-3DG electrocatalyst is nanostructured, with excellent catalytic activity, better intermediate tolerance, and sound long-term stability of the catalyst, attributed to the uniform dispersion of the Pd QDs and excellent interaction between the noble metal catalyst and the support. The present study sketches a simple and novel electrocatalyst for direct ethylene glycol fuel cells. (C) 2016 Published by Elsevier Ltd on behalf of Hydrogen Energy Publications LLC.</P>

Crossover from negative to positive magnetoresistance in the double quantum well system with different starting disorder

Kannan, E S,Karamad, M,Kim, Gil-Ho,Farrer, I,Ritchie, D A IOP Pub 2010 Journal of physics, an Institute of Physics journa Vol.22 No.4

<P>Magnetotransport measurements were performed in two widely separated double quantum well systems with different starting disorders. In the weak magnetic field regime, a crossover from negative to positive magnetoresistance in the longitudinal resistivity was observed in the system with weak disorder when the electron densities in the neighboring wells were significantly unbalanced. The crossover was found to be the result of the exchange-energy-assisted interactions between the electrons occupying the lowest subbands in the neighboring wells. In the case of the system with strong disorder short range scattering dominated the scattering process and no such transition in longitudinal resistivity in the low magnetic field regime was observed. However, at high magnetic fields, sharp peaks were observed in the Hall resistance due to the interaction between the edge states in the quantum Hall regime. </P>

Nitrogen and sulfur co-doped graphene counter electrodes with synergistically enhanced performance for dye-sensitized solar cells

Kannan, A.,Zhao, J.,Jo, S.,Kang, Y.,Kim, D. W. Royal Society of Chemistry 2014 Journal of Materials Chemistry A Vol.2 No.31

Electrochemical reduction behavior of K2[Ni(II)(CN)(4)] complex in 1-butyl-3-methylimidazolium hexafluorophosphate at different electrodes

( Kannan Karunakaran ),( A. G. Ramu ),문일식 한국공업화학회 2016 한국공업화학회 연구논문 초록집 Vol.2016 No.0

The electrochemical redox behavior in RTIL is emerging field to understand how ionic liquid behave on the mediator? Though, many metal complexes such as Ni(Salen), Co(Salen), Ni(byp) have been widely investigated in the RTIL their solubility restricts to use in industrial applications. Cyanide ligand with metalation is a simple and strongest especially higly soluble nature. Based on this idea we have investigated reduction behavior of [Ni(CN)4](2-) complex in the 1-butyl-3-methylimidazolium hexa fluoro phosphate ([bmim]PF6) RTIL at various electrode like Graphite, DSA, Ti. The effect of temperature, scan rate, and concentration of the Ni complex were analysed to derive electrochemical parameters towards industrial application.

Generation Expansion Planning for a Real-world Power System: Aiming Towards Cost and Environmental Emission Minimization by Penetrating Huge Renewable Energy Sources

Amosedinakaran S.,Mala K.,Bhuvanesh A.,Kannan S.,Karuppasamy Pandiyan M. 대한전기학회 2021 Journal of Electrical Engineering & Technology Vol.16 No.6

A power system planning must involve the Electricity demand forecasting (EDF) and Generation expansion planning (GEP) for better operation. The optimal plan should consider both qualitative and quantitative factors such as error, cost and reliability of the power system. In this study, EDF and GEP problem have been solved till the year 2030 for Tamil Nadu, an Indian state. The formulation of EDF problem has been modeled based on the input variables such as population, Gross State domestic product (GSDP) and per capita income, and has been solved using Genetic algorithm (GA), Artifi cial immune system (AIS) and Diff erential evolution (DE). While analyzing the results of EDF problem, DE provides optimal result with Minimum mean absolute percentage error (MAPE). Continually, short term (6-year) and long term (12-year) GEP problem have been solved using DE by considering minimization of cost and environmental eff ects as the main objectives. To achieve these objectives, Renewable Energy Sources (RES) have been integrated in diff erent penetration levels such as 0–10%, 10–20%, 20–30%, 30–40%, and 40–50% on GEP problem and its impacts have been investigated. The results of DE have been validated with Dynamic Programing (DP). The outcomes of the study have assisted the power system planners while decision making in introducing Renewable Energy Sources (RES) on a real-world power system.

Highly ordered copper oxide (Cu2O) nanopillar arrays using template assisted electrodeposition technique and their temperature dependent electrical characteristics

A. Venkatesan,E.S. Kannan 한국물리학회 2017 Current Applied Physics Vol.17 No.5

Highly ordered Copper Oxide (Cu2O) nanopillars were successfully grown inside the porous anodized alumina (AAO) template by electrodeposition technique. To liberate the AAO template to get the free standing nanopillars, several etching trials were conducted using sodium hydroxide (NaOH) solution of varying concentration (ranging from 1 M to 5 M) and reaction time (8e60 min). On investigating the etched samples using scanning electron microscope, it was found that the sample treated with 1 M NaOH for 60 min yielded AAO template free standing vertically aligned nanopillars. Resistances of these nanopillars were found to be three orders of magnitude greater than the thin film which was used as a control sample. The temperature dependent (180e300 K) current-voltage (I-V) measurement on nanopillars showed non-linear characteristics which was analyzed using back to back schottky diode model and thermionic field emission (TFE) theory. Our calculations revealed that the carrier transport is diffusive (mean free path ¼ 8.9 nm < < length of nanopillars ¼ 4 mm) in nature and the existence of defect sites with activation energies of 0.3 and 0.6 eV which acts as hole traps. This present work demonstrates a reliable technique for realizing vertically aligned Cu2O nanopillars which could find application in solar cell, gas sensors, Li ion batteries, and memory devices.