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이소연,권기상,고영화,권오유,Lee, Soyeon,Kwon, Kiang,Ko, Younghwa,Kwon, O-Yu Korean Society of Life Science 2021 생명과학회지 Vol.31 No.6
This study identified genomic factors associated with endoplasmic reticulum protein (ERp)29 gene expression in a genome-wide association study (GWAS) of genetic variants, including single-nucleotide polymorphisms (SNPs). In total, 373 European genes from the 1000 Genomes Project were analyzed. SNPs with an allelic frequency of less than or more than 5% were removed, resulting in 5,913,563 SNPs including in the analysis. The following expression quantitative trait loci (eQTL) from the long noncoding RNA LOC105372577 were strongly associated with ERp29 expression: rs6138266 (p<4.172e10), rs62193420 (p<1.173e10), and rs6138267 (p<2.041e10). These were strongly expressed in the testis and in the brain. The three eQTL were identified through a transcriptome-wide association study (TWAS) and showed a significant association with ERp29 and osteosarcoma amplified 9 (OS9) expression. Upstream sequences of rs6138266 were recognized by ChIP-seq data, while HaploReg was used to demonstrate how its regulatory DNA binds upstream of transcription factor 1 (USF1). There were no changes in the expression of OS9 or USF1 following ER stress.
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이소연(주저자) ( Lee Soyeon(주저자) ),김나영(공동저자) ( Kim Nayeong(공동저자) ),이소연(교신저자) ( Lee Soyeon(교신저자) ) 디자인융복합학회 2018 디자인융복합연구 Vol.17 No.6
Although women’s status in society have been improving, the existing space for women’s main activities is still perceived as limited in scope. In this respect, this study analyzes the domestic literature on women’s space and discusses the space for women with intent to gain some implications for further studies on space associated with women. Articles on women’s space were sub-classified in light of keywords, years of publication, sites, purposes, methods and journal categories, followed by network and frequency analyses. In addition, focus group interview was conducted to explore a new orientation for further studies. The degree centrality was found high in such keywords as ‘women’s clinics’, ‘CPTED’, ‘women-friendly cities’ and ‘femininity’. In addition, there is a paucity of studies on women’s space. Recent studies have diversified the scope of women’s space. At the same time, macroscopic ‘urban’ approaches to women’s space have lately been emerging. Finally, the focus group interview on women’s space highlighted the needs to further studies about ‘femininity, ‘maternity’, and ‘gender equality’ in space, and ‘safe environment’.
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